{"title":"Inflammasomes – A Mini-Review","authors":"M. Mahmud, M. K. Jing, A. Idris","doi":"10.2174/1573395511666150706181159","DOIUrl":"https://doi.org/10.2174/1573395511666150706181159","url":null,"abstract":"","PeriodicalId":35403,"journal":{"name":"Current Immunology Reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1573395511666150706181159","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68100108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Editorial (Thematic Issue: Biomarkers of Impaired Innate and Adaptive Immunity in Health and Disease)","authors":"C. Czerkinsky","doi":"10.2174/157339551201160330130810","DOIUrl":"https://doi.org/10.2174/157339551201160330130810","url":null,"abstract":"","PeriodicalId":35403,"journal":{"name":"Current Immunology Reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68099801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jenny U Johansson, Nathaniel S Woodling, Ju Shi, Katrin I Andreasson
{"title":"Inflammatory Cyclooxygenase Activity and PGE<sub>2</sub> Signaling in Models of Alzheimer's Disease.","authors":"Jenny U Johansson, Nathaniel S Woodling, Ju Shi, Katrin I Andreasson","doi":"10.2174/1573395511666150707181414","DOIUrl":"https://doi.org/10.2174/1573395511666150707181414","url":null,"abstract":"<p><p>The inflammatory response is a fundamental driving force in the pathogenesis of Alzheimer's disease (AD). In the setting of accumulating immunogenic Aß peptide assemblies, microglia, the innate immune cells of the brain, generate a non-resolving immune response and fail to adequately clear accumulating Aß peptides, accelerating neuronal and synaptic injury. Pathological, biomarker, and imaging studies point to a prominent role of the innate immune response in AD development, and the molecular components of this response are beginning to be unraveled. The inflammatory cyclooxygenase-PGE<sub>2</sub> pathway is implicated in pre-clinical development of AD, both in epidemiology of normal aging populations and in transgenic mouse models of Familial AD. The cyclooxygenase-PGE<sub>2</sub> pathway modulates the inflammatory response to accumulating Aß peptides through actions of specific E-prostanoid G-protein coupled receptors.</p>","PeriodicalId":35403,"journal":{"name":"Current Immunology Reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1573395511666150707181414","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34917076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Inflammatory Mechanisms of Injury and Recovery after Intracerebral Hemorrhage","authors":"Matthew D. Hammond and Lauren H. Sansing","doi":"10.2174/1573395511666150707181143","DOIUrl":"https://doi.org/10.2174/1573395511666150707181143","url":null,"abstract":"","PeriodicalId":35403,"journal":{"name":"Current Immunology Reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68099710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Immunological Mechanisms of Neuropsychiatric Lupus","authors":"K. C. Sinclair, Jonathan J. Miner, A. Kim","doi":"10.2174/1573395511666150707181943","DOIUrl":"https://doi.org/10.2174/1573395511666150707181943","url":null,"abstract":"","PeriodicalId":35403,"journal":{"name":"Current Immunology Reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68099724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}