THE NEW ARMENIAN MEDICAL JOURNAL最新文献

{"title":"A study of Iranian traditional dairy beverage (Richal Shiri) and investigation into some properties of its isolated lactic acid bacteria","authors":"F. Karimpour, F.N. Tkhruni, K. Karapetyan, S. Afroughi, A. Peikar, M. Gohargani, N. Tabatabei, B. Ebrahimzadeh Koor, S.O. Salehi","doi":"10.56936/18290825-2023.17.1-63","DOIUrl":"https://doi.org/10.56936/18290825-2023.17.1-63","url":null,"abstract":"Richal is a traditional fermented dairy beverage that has a long history in the Iranian encyclopedia. This beverage contains whole milk, natural starter, herbs and salt. It can be produced in three different forms, Shiri (from milk), Masti (from yogurt), and Dooghi (from drinking yogurt). The present study was an investigation into the characteristic features of the lactic acid bacteria isolated from Richal Shiri. After preparing the traditional fermented beverage was investigated and several tests such as determining lactic acid and pH were performed on it. Next, lactic acid bacteria and yeasts were isolated from the traditional fermented beverage sample and cultured in different media such as fermented whole or skim milk, at different times temperatures and test cultures. Some strains had anti-bacterial activity against sporogenous microflora S. typhimurium G-38, B. subtilis 17-89, В. Thuringensis 69-6. Eleven Lactic acid bacteria strains were isolated; ten of them were Gram-positive, cocci, and one of them was Gram-positive, Bacillus. Ten strains were catalase-negative and one was catalase positive; the lactic acid bacteria had antibacterial activity by the determination which measuring zone diameters of bacterial growth inhibition. The functions of strains were different but the differences were not significant (p≥0.3). Between the 3 groups, however, B. subtilis 17-89 had the best function. According to the results, Richal Shiri has some lactic acid bacteria strains with anti-bacterial activity and the ability to ferment milk as a starter culture. The isolated fermented milk, according to its properties, may introduce a new functional food product for development in the food industry. These bacteria will be used in future investigations.","PeriodicalId":353660,"journal":{"name":"THE NEW ARMENIAN MEDICAL JOURNAL","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135784475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accounts of adverse neonatal effects in preterm prelabor rupture of membranes: anticipating maternal platelet indices and C-reactive protein as effective biomarkers","authors":"D. Sai Bhavana, G. Shyamala, B. Sujatha","doi":"10.56936/18290825-2023.17.1-84","DOIUrl":"https://doi.org/10.56936/18290825-2023.17.1-84","url":null,"abstract":"Present study aimed at determining maternal platelet indices in preterm prelabor rupture of membranes with adverse neonatal consequences. Comparing maternal C-reactive protein efficacy and platelet indices in predicting outcomes. Herein, 82 women with preterm prelabor rupture of membranes and 78 women with spontaneous preterm labor were studied. All women undertook complete blood count tests. The group of preterm prelabor rupture of membranes undertook additional C-reactive protein tests. Neonatal outcome data were compiled post-delivery, and results were compared. C-reactive protein efficacy and platelet indices helped in predicting neonatal outcomes in the group of preterm prelabor rupture of membranes using receiver operating characteristic curve analysis. Women with preterm prelabor rupture of membranes had increased levels of mean platelet volume (8.41 vs. 7.66; p<0.0001), platelet crit (0.223 vs. 0.194; p=0.002), and higher prevalence of early-onset neonatal sepsis (19.5% vs. 2.6%; p<0.001) compared to those with spontaneous preterm labor. In the group of preterm prelabor rupture of membranes, mean platelet volume, platelet crit, and C-reactive protein were significantly associated with respiratory distress syndrome and early-onset neonatal sepsis. The cut-off values mean platelet volume ≥ 8.55fL, platelet crit of ≥0.255%, and C-reactive protein of 5mg/L predicted respiratory distress syndrome with an area under the curve of 0.84, 0.92 and 0.72, the sensitivity of 83%, 91%, and 62%, and specificity of 78.1%, 92.2%, and 68.2%, respectively. The cut-off values of mean platelet volume ≥ 9.05 fL, platelet crit of ≥0.283%, and C-reactive protein of 6mg/L predicted early-onset neonatal sepsis with an area under the curve of 0.86, 0.90 and 0.65, sensitivity of 87.5%, 93%, and 56%, and specificity of 75%, 85%, and 66%, respectively. Maternal mean platelet volume and platelet crit are useful predictors of neonatal respiratory distress syndrome and early-onset neonatal sepsis in mothers with preterm prelabor rupture of membranes and werebetter predictors of neonatal outcomes than C-reactive protein.","PeriodicalId":353660,"journal":{"name":"THE NEW ARMENIAN MEDICAL JOURNAL","volume":"271 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135829506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cortical thickness and cortical volume measurements of the cingulate gyrus in Sudanese young adult using BrainSuite","authors":"Ahmed Wegdan, Aladin Saad, Samy Ahmed, Mohammed H. Karrar Alsharif, Amani Elfaki","doi":"10.56936/18290825-2023.17.1-70","DOIUrl":"https://doi.org/10.56936/18290825-2023.17.1-70","url":null,"abstract":"Cingulate gyrus is a part of the limbic lobe. Anatomically and functionally, the cingulate gyrus is subdivided into four areas: the anterior cingulate cortex, midcingulate cortex, posterior cingulate gyrus, and the retrosplenial part. The variety of autonomic functions, such as regulating heart rate and blood pressure and having a major role in cognitive function, also has a function in emotional cognition. The present study aims to measure cortical thickness and cortical volume in apparently healthy young adult Sudanese. In this cross-sectional study, randomly selected individuals (30 males, 30 females) among the Sudanese population, aged between 20-40 years, and who had normal brain magnetic resonance images were included in the study. All study participants underwent magnetic resonance imaging, and measurements of the cingulate gyrus were assessed using BrainSuite software. Analysis was conducted using Statistical Package for the Social Sciences, version 28, and p-values less than 0.05 were considered significant. For the right cingulate gyrus, the mean cortical thickness and cortical volume were 4.0 mm and 20.9 cm3, respectively. The mean cortical thickness and volume in the left cingulate gyrus were 4.0 mm and 22.3 cm3, respectively. The cortical volume of the left cingulate gyrus was statistically significantly larger than the right (p=0.04). The right and left cingulate gyrus cortical volumes of males were significantly larger than that of females (p=0.001), while the cortical thickness showed an insignificant difference (p=0.3). The cortical volume of the cingulate gyrus was not statistically related to age or body mass index. The left cingulate gyrus’s total volume is larger than that of the right cingulate gyrus, and there is no significant difference in cortical thickness. Age and body mass index do not affect cortical volume and thickness.","PeriodicalId":353660,"journal":{"name":"THE NEW ARMENIAN MEDICAL JOURNAL","volume":"66 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135829505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Sural Nerve Amplitude and Sural/Radial Amplitude Ratio in Electrodiagnosis of patients with neuropathy in Type 2 diabetes","authors":"Gholamreza Shamsaei, Mehrnoosh Zakerkish, Davood Kashipazha, Maryam Moradi, Hossein Zakizadeh","doi":"10.56936/18290825-2023.17.1-77","DOIUrl":"https://doi.org/10.56936/18290825-2023.17.1-77","url":null,"abstract":"Diabetic neuropathy is the most common and bothersome diabetes mellitus complication, leading to considerable morbidity and mortality. The results of these studies and the importance of early detection and prevention of polyneuropathy in diabetic patients motivated the authors to carry out the present study. In this cross-sectional study all consecutive patients with type 2 diabetes mellitus were referred to the Endocrinology Clinic at Golestan Hospital in Ahvaz, Iran. The Nihon Kochden gadget was utilized on all patients, who were all examined by an individual. Average sensory amplitude was defined as greater than 6 V for the sural nerve and greater than 15 V for the radial nerve. In the present investigation, a sural/radial nerve amplitude ratio greater than or equal to 21 percent was considered normal. In total, 80 subjects were included in the analysis, there is a non-significant direct correlation between the sural nerve and sural/radial nerve amplitude ratio, to diagnose patients with and without neuropathy (p=0.625). Moreover, there is a non-significant direct correlation between the sural nerve and sural/radial nerve amplitude ratio with the body mass index of patients with diabetes, and this correlation is negligible (p&gt;0.05). The findings demonstrated that sural/radial nerve amplitude ratio was a promising method for detecting neuropathy in patients with type 2 diabetes. Also, sural nerve and sural/radial nerve amplitude ratio had a significant inversion relationship with age and duration of diabetes for detecting diabetic neuropathy in type 2 diabetes patients","PeriodicalId":353660,"journal":{"name":"THE NEW ARMENIAN MEDICAL JOURNAL","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135784474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Holothurin And Caspofungin-Induced Alterations In Ttoll-Like Receptor 4expression In The Vagina Of Rattus Norvegicus Wistar With Candidiasis","authors":"Nurdiana N., Winarsih S., Tri Endharti A., Handayani S.","doi":"10.56936/18290825-2023.17.3-11","DOIUrl":"https://doi.org/10.56936/18290825-2023.17.3-11","url":null,"abstract":"Abstract Toll-like receptor 4 is a marker that indicates whether or not tissues have immunological or pro-inflammatory responses. Candida albicans has the potential to aggravate the tissue that makes up the epithelium. After candidiasis, the antifungal properties of holothurin and caspofungin have the ability to block toll-like receptor 4. A total of 48 white rats Rattus norvegius Wistar were divided into four positive control groups (P1) and given topical C. albicans after being grown in yeast extract peptone dextrose in the vagina of white rats Rattus norvegius Wistar. P2 and P3 groups were given 3500 g holothurin and 140 g caspofugin topically in the vagina of animal models at 12-, 24-, and 48-hour intervals. Immunofluorescence was used to analyse the study results both quantitatively and qualitatively by attaching the imaging. After that, the data was processed using the SPSS statistical software version 23. Toll-like receptor 4 expression decreased significantly in the treatment group compared to the positive control group (p0.05). This demonstrates that holothurin (P1) and caspofungin (P2) treatments reduced toll-like receptor 4 expression in C. albicans at 0.25 and 6.375 at 12 hours, 0.62 and 3. at 24 hours, and 1.68 and 4.18 at 48 hours. The mean difference in toll-like receptor 4 expression in the positive control group, on the other hand, did not differ statistically when compared to the negative (healthy) control group. This demonstrates that the treatment group’s holothurin and caspofungin have the potential to reduce toll-like receptor 4 expression. Holothurin has a potential effect compared to caspofungin on experimental animals with candidiasis experiencing significant changes in suppressing the number of toll-like receptor 4 in vaginal epithelial tissue of Rattus norvegicus Wistar","PeriodicalId":353660,"journal":{"name":"THE NEW ARMENIAN MEDICAL JOURNAL","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135263511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Graves diseases with severe progressive ophthalmopathy after thyroidectomy. Case report.","authors":"R. Markosyan, H.N. Babayan","doi":"10.56936/18290825-2022.16.2-100","DOIUrl":"https://doi.org/10.56936/18290825-2022.16.2-100","url":null,"abstract":"Graves’ disease is an autoimmune disease that may consist of hyperthyroidism, goiter, orbitopathy, and occasionally a dermopathy referred to as pretibial or localized myxedema. Graves’ disease is caused by autoantibodies that bind to the thyrotropin receptor, stimulating growth of the thyroid and overproduction of thyroid hormone. Clinical manifestations of Graves’ disease include diffuse goiter and symptoms and signs resulting from hyperthyroidism.\u0000Thyroid hormones excess affects several different body systems, and for this reason, signs and symptoms associated with Graves’ disease can vary strongly, and significantly influence the general well-being. Common symptoms are: tremor, heat sensitivity and warm, weight loss even if with normal eating habits, anxiety and irritability, enlargement of the thyroid gland, alterations in menstrual cycles, erectile dysfunction or decreased libido, fatigue, frequent bowel movements, palpitations, and others. Graves’ orbitopathy is present in about 30-50% of patients with Graves disease. Graves’ orbitopathy is an autoimmune disease of the retroocular tissues occurring in patients with Graves’ disease.We present the clinical case report with progressive ophthalmopathy after a total thyroidectomy. In our case after surgery his ophthalmopathy did not regress and, in fact, was progressive. In the vast majority of cases of Grave’s ophthalmopathy, the periorbital edema regresses significantly after a total thyroidectomy. This patient’s ophthalmopathy did not regress after surgery even the ophtalmopathy progressed. Only after initiation of pulsatile therapy of 500 mg of methylprednisolone weekly did the ophthalmopathy regress noticeably.","PeriodicalId":353660,"journal":{"name":"THE NEW ARMENIAN MEDICAL JOURNAL","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128651549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hospital Admissions Due to Short-term Exposure to Air Pollution: A scoping review","authors":"S. Ebrahimi, H. Motamed, H. Kalantar, A. Kalantari, F. Rahim","doi":"10.56936/18290825-2022.16.2-76","DOIUrl":"https://doi.org/10.56936/18290825-2022.16.2-76","url":null,"abstract":"Context: Annually thousands of people lose their lives due to air pollution. Today, air pollution in most countries, especially developing countries, is a public health problem and millions of dollars spent to treat patients who admitted to the emergency department due to exposure to air pollutants. Study on hospital admissions is a method for the impact survey of ambient air pollution on a human. Evidence Acquisition: In this study reviewed the effects of air pollutants (No2, SO2, PM2.5, PM10, CO, PAH and VOCs) on human health, with a focus on hospital admission after short-term exposure. In the articles literature that reviewed Short-term exposure to ambient air pollutants including No2, SO2, PM2.5, PM10 and CO led to hospital admission (except for PAH and VOCs). We systematically searched international datasets to identify relevant studies, including PubMed, Scopus, Cochrane library, CINAHL, ISI Web of Science, Science Direct from inception, PROSPERO and EMBASE using medical purposed subject headings (Mesh) terms. Result: The most common cause of hospital admission after short-term exposure to air pollution was cardiovascular and respiratory diseases. The health effects of air pollution on studied groups in dry and warm weather were higher than in wet and cold weather. In studies with more pollutants, the share of each pollutant in hospital admission was clearer. Conclusion: The costs of treatment were far higher than the cost of prevention. The effectiveness of preventive methods was more than therapeutic methods. The history of exposure to ambient air pollutants and their impact on hospital admission rate due to short-term exposure to air pollutants require separate studies in this field. More accurate identification of the toxicological mechanisms seemed to be necessary after the short-term exposure to deal with acute poisoning due to air pollution.","PeriodicalId":353660,"journal":{"name":"THE NEW ARMENIAN MEDICAL JOURNAL","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126350573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevention and treatment of drug-induced liver injury in patients with breast cancer and ovarian cancer","authors":"E. V. Maksimova, I. L. Kliaritskaia, E. I. Grigorenko, Y. Moshko","doi":"10.56936/18290825-2022.16.3-78","DOIUrl":"https://doi.org/10.56936/18290825-2022.16.3-78","url":null,"abstract":"Introduction: Drug-induced liver injury is one of the most serious problems in hepatology. In most cases the abolition of the “causative” drug is a sufficient condition for the reverse development of pathological changes. However, in the case of chemotherapy for cancer patients, the abolition of hepatotoxic drug is impossible without creating an immediate or delayed threat to the patient’s life. \u0000Objective: To develop optimal schemes for the prevention and treatment of drug-induced liver injury by studying of its characteristics of with various chemotherapy regimens in patients with breast cancer and ovarian cancer.\u0000Material and methods: The screening group included 291 patients who underwent chemotherapy courses for breast cancer and ovarian cancer. The diagnosis and type of drug-induced liver injury was based on laboratory data (alanine aminotransferase and/or alkaline phosphatase increased above 2 norms) and the exclusion of other etiologies of liver diseases. Chemotherapy hepatotoxicity was assessed using the Shaposhnikov scale. The degree of hepatic encephalopathy was determined using a critical flicker frequency test. Depending on chemotherapy mode, groups of the patients were divided into subgroups: cyclophosphamide + Methotrexate+ Fluorouracil, Doxorubici + Cyclophosphamide, Epirubicin + Cyclophosphamide + 5-fluorouracil, Paclitaxel + Cisplatin, Carboplatin + Cyclophosphamide. According to the type of drug-induced liver injury, patients with cholestatic type received preparations, with cytolytic type – S-adenosylmethionine for 8 weeks.\u0000Results and its discussion: It was found that the most common side effect of chemotherapy is leukopenia, anemia and increase in level of alanine aminotransferase and alkaline phosphatase. The use of ursodeoxycholic acid and S-adenosylmethionine as an accompanying therapy significantly reduces the level of alanine aminotransferase and alkaline phosphatase degree of hepatotoxicity and hepatic encephalopathy, clinical improves the quality of life of patients and contributes to a more rapid elimination of symptoms of astheno-vegetative, dyspeptic and pain syndromes.\u0000Conclusion: It has been proven that the use of a differentiated approach to the choice of a hepatoprotector: S-adenosylmethionine in hepatocellular type, ursodeoxycholic acid - in cholestatic type of drug-induced liver injury for 8 weeks in patients with oncological profile allowed to carry out the planned therapy without deviations from the protocol.","PeriodicalId":353660,"journal":{"name":"THE NEW ARMENIAN MEDICAL JOURNAL","volume":"146 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132669291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical treatment of visceral and renal abdominal artery aneurysms of various etiology","authors":"M. Кhanchi, A. Matkerimov, A. Tergeussizov, T. Demeuov, M. Zhakubayev, M. Khanchi, A. Baubekov, N. Yerkinbayev, A. Saduakas, R. Makkamov","doi":"10.56936/18290825-2022.16.2-104","DOIUrl":"https://doi.org/10.56936/18290825-2022.16.2-104","url":null,"abstract":"Visceral artery aneurysms are detected when complications occur or accidentally during examination for other diseases gastrointestinal tract, aimed at determining the functional significance.\u0000Over the past 10 years, we have observed 31 patients with abdominal visceral artery aneurysms, 10 patients had renal aneurysms, 15 had splenic arteries, hepatic artery and pancreatoduodenal artery aneurysms – in one case. The combination of aneurysms – in 2 cases: in one case – the renal artery with the splenic artery, in the other – the renal artery and the abdominal trunk. The patients ranged in age from 24 to 78 years, the average age is 43±6.5.\u0000Previously, infection was considered the most common cause of splenic artery aneurysms in 10 cases, with most patients complaining of fever, abdominal pain and a pulsating mass in the abdomen. And two patients with splenic artery aneurysm noted abdominal trauma. 3 had atherosclerotic changes. The causes of renal artery aneurysms are atherosclerosis in 6 cases, fibromuscular dysplasia in 2 cases, and Nonspecific aortoarteritis in 2 cases. Also, atherosclerotic etiology is present in aneurysms of the external iliac arteries aneurysms.\u0000Reconstructions on hepatobiliary aneurysms were performed in 6 (20%) cases, in 5 cases - resection with end-to-end anastomosis and in 2 cases - resection of splenic artery aneurysm, resection of splenic artery aneurysms with autovenous patch, clipping of splenic artery aneurysms – in 2 cases (6.5%), endovascular techniques were applied in 18 cases (58%).\u0000In 2 cases, nephroectomy was performed due to the spread of the aneurysm into the kidney gate and the lack of conditions for reconstruction.\u0000In the immediate and long-term (after 6 months and 3 years) postoperative period, the preservation of organ function in reconstructive and ligating methods of surgical treatment is the same.\u0000Signs of ischemia and impairment in the immediate postoperative period were not observed with reconstructive and ligating methods of surgical treatment.\u0000The choice of treatment method depends on the severity of the patient’s condition, clinical manifestations, as well as the localization of the aneurysm and its morphology. Preference is given to endovascular techniques, which are not traumatic enough and provide a good long-term result. However, in each case, the patient’s management tactics are individual, the choice of the optimal method of treatment of visceral artery aneurysms is based on data from the entire spectrum of possible diagnostic manipulations.","PeriodicalId":353660,"journal":{"name":"THE NEW ARMENIAN MEDICAL JOURNAL","volume":"190 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124214975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined administration of Dienogest and Levonorgestrel – Releasing Intrauterine System Mirena","authors":"K. Tokhunts, A. Khudaverdyan, N.B. Abgaryan, N. Nahapetyan, V. Manvelyan","doi":"10.56936/18290825-2022.16.3-86","DOIUrl":"https://doi.org/10.56936/18290825-2022.16.3-86","url":null,"abstract":"Objectives: Intrauterine hormone-releasing systems are now widely applied to treat metrorrhagia (polymenorrhea), endometrial hyperplasia and adenomyosis. \u0000In previous works we found that risk factors for expulsion of intrauterine device, besides the deformation of the uterine cavity, was the expansion of uterine cavity area > 9 cm2, associated with increased distance between tubal angles >4.5 cm and after the insertion of Levonorgestrel-releasing Intrauterine System (Mirena), among the patients with indicated parameters of uterine cavity, the expulsion reached 90%. Another widely used medicine for treatment of metrorrhagia (polymenorrhea), endometrial hyperplasia and adenomyosis is dienogest (Vizanna). The objective of this study is to explore the influence of combined administration of dienogest and Levonorgestrel- releasing Intrauterine System with the purpose of prevention of complications and side effects of the Intrauterine System.\u0000Study design: This prospective study includes 32 patients with previous Levonorgestrel-releasing Intrauterine System expultions whom Dienogest 2mg daily has been administered within 6 months. \u0000Results: Ultrasound transformation of a myometrium and uterine cavity in 6 months after Vizanna administration was manifested by minimization of uterine cavity and reduction of distance between tubal angles. Mirena was inserted to these patients again. \u0000Within 12 months of monitoring any case of expulsion was not observed.\u0000Conclusions: According to the data received, the combined consistent and simultaneous administration of Dienogest and Mirena reduces the possibility of Intrauterine System expulsion and decreases side effects of the Intrauterine System.\u0000Implication statement: Combined consistent and simultaneous administration of Dienogest and Levonorgestrel-releasing Intrauterine System was used for prevention of complications of Intrauterine System","PeriodicalId":353660,"journal":{"name":"THE NEW ARMENIAN MEDICAL JOURNAL","volume":"72 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127129436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}