Hss Journal最新文献

{"title":"The Hospital for Special Surgery Center for Regenerative Medicine: Clinical Registries, Basic and Translational Research, and Education Programs.","authors":"Scott A Rodeo, Daniel de la Huerta Meza, Jonathan Kirschner, Jessica Andres Bergos","doi":"10.1177/15563316251353511","DOIUrl":"https://doi.org/10.1177/15563316251353511","url":null,"abstract":"","PeriodicalId":35357,"journal":{"name":"Hss Journal","volume":" ","pages":"15563316251353511"},"PeriodicalIF":1.6,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12264238/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144660560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metformin Modulates Oxidative Stress in Murine Mesenchymal Stem Cells In Vitro and Alleviates Corticosteroid-Induced Inflammation and Impairment of Bone Formation.","authors":"Issei Shinohara, Yosuke Susuki, Masatoshi Murayama, Qi Gao, Mehmet Sertac Cekuc, Yasemin Sude Ergul, Mayu Morita, Alexa K Pius, Chao Ma, Simon Kwoon-Ho Chow, Stuart B Goodman","doi":"10.1177/15563316251351031","DOIUrl":"10.1177/15563316251351031","url":null,"abstract":"<p><strong>Background: </strong>Long-term use of corticosteroids is a known risk factor for various bone diseases. Corticosteroids disrupt the balance between oxidative and glycolytic energy metabolism, increase oxidative stress and reactive oxygen species (ROS) associated with prolongation of inflammation, cell apoptosis, deficits in mesenchymal stem cells (MSCs), and osteoclast differentiation. Metformin, a drug for diabetes, has antioxidant properties by inhibiting nicotinamide adenine dinucleotide phosphate oxidase, which promotes the production of ROS.</p><p><strong>Purpose: </strong>We sought to evaluate the effects of corticosteroid and metformin administration on MSCs in vitro.</p><p><strong>Methods: </strong>Primary bone marrow MSCs were collected from 20 mice. We evaluated prednisolone's effects on cell proliferation, oxidative stress, osteogenic differentiation, and mineralization, followed by metformin's effect on corticosteroid-induced reduction in bone formation. Metformin (1, 10, 100 µM) was tested with prednisolone 3 ng/mL. Cytokines were assessed by Luminex.</p><p><strong>Results: </strong>Prednisolone at 3 ng/mL significantly reduced cell proliferation, while 10 µM metformin restored it. Prednisolone increased oxidative stress and was reversed by metformin in a concentration-dependent manner, particularly at 100 µM. Osteogenic differentiation and mineralization were significantly impaired with prednisolone but improved with metformin at 10 and 100 µM. As for inflammatory cytokines, interleukin-1β (IL-1β) expression was increased by prednisolone administration and suppressed by metformin. Conversely, IL-6 and monocyte chemotactic protein-1 were suppressed by prednisolone.</p><p><strong>Conclusion: </strong>This in vitro study found that corticosteroid-associated decrease in osteogenic potential of murine MSCs was associated with elevated oxidative stress that can be alleviated by metformin; further studies are needed to validate these findings in vivo and with human-derived MSCs.</p>","PeriodicalId":35357,"journal":{"name":"Hss Journal","volume":" ","pages":"15563316251351031"},"PeriodicalIF":1.6,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12255654/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144638301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical Site Infection After Posterior Lumbar Instrumented Fusions.","authors":"Kasra Araghi, Tejas Subramanian, Takashi Hirase, Tomoyuki Asada, Chad Z Simon, Olivia C Tuma, Troy B Amen, Austin C Kaidi, Gregory S Kazarian, Yusef Jordan, Eric Mai, Pratyush Shahi, Alexandra P Grizas, Harvinder S Sandhu, Russel C Huang, James E Dowdell, Francis C Lovecchio, Han Jo Kim, Todd J Albert, Sravisht Iyer, Sheeraz A Qureshi","doi":"10.1177/15563316251348440","DOIUrl":"10.1177/15563316251348440","url":null,"abstract":"<p><p><i>Background:</i> Minimally invasive surgery (MIS) has shown the potential in reducing surgical site infection (SSI); however, its impact on instrumented lumbar fusion procedures remains unclear. <i>Purpose:</i> We sought to investigate the difference in SSI rates for open, mini-open, and MIS techniques in patients who underwent posterior lumbar instrumented fusions. <i>Methods:</i> We conducted a retrospective review of all patients at a single academic institution who underwent instrumented 1- or 2-level posterior lumbar fusion between January 2019 and June 2022. Cases were allocated to 1 of 3 mutually exclusive surgical cohorts (MIS, mini, or open). SSIs were diagnosed based on the National Healthcare Safety Network criteria. <i>Results:</i> A total of 1352 patients were reviewed for a total of 1382 lumbar fusion operations included in this study. The mean age was 61.5 ± 12.8 years, and the mean body mass index was 28.7 ± 5.67 kg/m². The largest cohort was open (39.3%, 543), followed by mini (33.1%, 458) and MIS (27.6%, 381). Thirteen patients (0.94%) developed an SSI. There were no statistically significant differences in the infection rates between the cohorts; SSI rates were MIS (0.3%, 1), mini (1.1%, 5), and open (1.3%, 7). Twelve (92%) of the patients with an SSI underwent a subsequent irrigation and debridement procedure; on average, this occurred 42.2 ± 25 days postoperatively. <i>Conclusions:</i> This retrospective review found that 0.94% of patients developed an SSI following a 1- or 2-level posterior lumbar instrumented fusion. Although the observed SSI rate in the open cohort was 4 times higher than in the MIS cohort, the sample sizes were insufficient to determine statistically significant differences between the 3 surgical approaches. Nonetheless, our data suggests that all 3 techniques evaluated had exceptionally low infection rates.</p>","PeriodicalId":35357,"journal":{"name":"Hss Journal","volume":" ","pages":"15563316251348440"},"PeriodicalIF":1.6,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12245822/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144627334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone Marrow Aspirate Concentrate With Hip Arthroscopy in a Heterogenous Group of Patients May Result in Improved Patient-Reported Outcomes: A Systematic Review.","authors":"Michael S Lee, Nicholas J Pettinelli, Jack Gagné, Justin Zhu, Mackenzie Norman, Louise Atadja, Ronak J Mahatme, Scott Fong, Jay Moran, Stephen M Gillinov, Wasif Islam, Nancy Park, Andrew E Jimenez","doi":"10.1177/15563316251349543","DOIUrl":"10.1177/15563316251349543","url":null,"abstract":"<p><strong>Introduction: </strong>There is little literature reporting on the efficacy of bone marrow aspirate concentrate (BMAC) in conjunction with hip arthroscopy.</p><p><strong>Purpose: </strong>We sought to systematically review the literature on BMAC use following hip arthroscopy, in particular, whether its use results in improved patient-reported outcome measures (PROMs).</p><p><strong>Methods: </strong>The Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines were followed when querying PubMed, Cochrane Central Register of Controlled Trials, and Scopus in January 2023. Articles were included if they reported on pre- and postoperative outcomes for patients undergoing hip arthroscopy with concomitant BMAC and were written in English.</p><p><strong>Results: </strong>Five articles were included in the review. A total of 252 hips undergoing BMAC and hip arthroscopy performed between 2010 and 2020 were evaluated. The average age of patients in the studies ranged between 32.8 and 48.5 years. All studies reported improved postoperative PROM scores compared to preoperative outcome scores after BMAC and hip arthroscopy. Two studies reported survivorship of 100% and 85.7%. All 5 studies conducted a subanalysis between BMAC and hip arthroscopy and a control group. Three studies reported superior outcomes in the BMAC and hip arthroscopy group, while another study reported findings that trended toward favoring the BMAC and hip arthroscopy group but that did not reach statistical significance.</p><p><strong>Conclusion: </strong>BMAC may improve outcomes in patients undergoing hip arthroscopy. However, due to the small sample size and lack of standardized control groups, the results of this systematic review are inconclusive.</p>","PeriodicalId":35357,"journal":{"name":"Hss Journal","volume":" ","pages":"15563316251349543"},"PeriodicalIF":1.6,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12226518/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144576483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal Radiographical Changes Following Minimally Invasive Ablation and Cementoplasty of Osteolytic Vertebral Metastases: A Retrospective Study.","authors":"Will Jiang, Sangmin Lee, Donghao Gan, Igor Latich","doi":"10.1177/15563316251346485","DOIUrl":"10.1177/15563316251346485","url":null,"abstract":"<p><p><i>Background:</i> For orthopedic oncology patients who are poor candidates for open spine surgery, minimally invasive radiofrequency ablation and cementoplasty (RFA/C) is becoming increasingly popular for managing osteolytic vertebral metastases. <i>Purpose:</i> We sought to characterize long-term changes in vertebral body radiographical parameters and potential risk of adjacent fractures occurring. <i>Methods:</i> A single-institution, retrospective study of all patients receiving RFA/C for osteolytic thoracic or lumbar vertebral body metastases from 2017 to 2023 was conducted. Vertebral body integrity was assessed by column height changes (anterior, middle, and posterior 1/3), local vertebral angle, and indirect bone mass assessment (at 3, 6, 12, and 24 months postoperatively). The latter was assessed via Hounsfield unit (HU) changes on axial computed tomography. Adjacent vertebral fractures were defined as within 3 vertebral levels above or below index site. Treatment history including radiation therapy was tracked. <i>Results:</i> A total of 54 vertebral levels (26 patients; mean age 59.8 ± 19.0 years; 18 females) were included (mean follow-up 15.8 ± 13.8 months). HU (bone mass proxy) stabilized after RFA/C. Except for middle column height increasing at 3 months, no column height or local angle deformity changes were detected. Adjacent fracture occurred in 4 patients (15.4%); all 4 demonstrated systemic cancer progression. <i>Conclusions:</i> Our findings suggest that RFA/C may provide effective long-term stabilization of the index site that is maintained for at least 1 year postoperatively. All patients who experienced an adjacent fracture occurrence demonstrated radiographic evidence of cancer progression surrounding the treatment sites that appeared unrelated to the procedure itself.</p>","PeriodicalId":35357,"journal":{"name":"Hss Journal","volume":" ","pages":"15563316251346485"},"PeriodicalIF":1.6,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12204986/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144529985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eczema Is Not Associated with an Increased Risk of Postoperative Infection Following Arthroscopic Knee Surgeries: A Retrospective Matched Case-Control Study.","authors":"Olivia C Tracey, Ruth H Jones, Akshitha Adhiyaman, Emilie Lijesen, Daniel W Green, Moira M McCarthy, Andy O Miller, Peter D Fabricant","doi":"10.1177/15563316251347295","DOIUrl":"10.1177/15563316251347295","url":null,"abstract":"<p><p><i>Background:</i> Prior studies have suggested a possible association between eczema and postoperative surgical site infections (SSI) following anterior cruciate ligament reconstruction (ACL-R), presumably due to higher rates of staphylococcal colonization in patients with eczema. <i>Purpose:</i>We sought to determine if patients with a history of eczema are at an increased risk for postoperative SSI following ACL-R, medial patellofemoral ligament reconstruction (MPFL-R), and/or knee arthroscopy. <i>Methods:</i>We conducted a retrospective matched case-control study of patients aged 5 to 25 years who underwent ACL-R, MPFL-R, and/or knee arthroscopy from February 1, 2016 to February 8, 2023 at a single tertiary care facility. Cases of postoperative infection were identified as those requiring surgical irrigation and debridement (I&D) and/or postoperative oral antibiotics or had a documented visit for postoperative infection with an infectious disease specialist within 6 months of the indexed procedure. Cases and controls were matched 1:2 based on sex, age ±1 year, body mass index ±1 kg/m², and primary Current Procedural Terminology code. Preoperative diagnosis of eczema and postoperative diagnosis of infection were compared between cases and controls. <i>Results:</i>Three hundred patients were analyzed (mean age 18.2 ± 3.8 years); 4% of both cases and controls had a history of eczema. Patients with postoperative SSI did not have greater odds of having an eczema diagnosis preoperatively compared to matched controls. Overall, 32% of cases required an I&D procedure; these patients did not have greater odds of having an eczema diagnosis preoperatively compared to matched controls. <i>Conclusion:</i>This retrospective matched case-control study suggests that a prior or current diagnosis of eczema is not associated with SSI following ACL-R, MPFL-R, or knee arthroscopy in patients aged 5 to 25 years. <b>Level of Evidence:</b> Level III: Case-Control Study.</p>","PeriodicalId":35357,"journal":{"name":"Hss Journal","volume":" ","pages":"15563316251347295"},"PeriodicalIF":1.6,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12204983/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144529984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uniportal Endoscopic Microdiscectomy Is an Effective Treatment Option for Far-Lateral Lumbar Disk Herniations.","authors":"Austin C Kaidi, Joshua Zhang, Tejas Subramanian, Chad Simon, Eric Mai, Adin Ehrlich, Prerana Katiyar, Gregory Kazarian, Patawut Bovonratwet, Evan Sheha, James Dowdell, Sheeraz A Qureshi, Sravisht Iyer","doi":"10.1177/15563316251346443","DOIUrl":"10.1177/15563316251346443","url":null,"abstract":"<p><p><i>Background:</i> Far-lateral lumbar disk herniation (FLLDH) poses a surgical challenge given the difficulty in visualizing the pathology with traditional techniques. Endoscopic microdiscectomy is a novel technique for the treatment of FLLDH with decreased soft tissue disruption. <i>Purposes</i>: We sought to compare the efficacy of tubular versus endoscopic microdiscectomy for FLLDH. <i>Methods</i>: A retrospective cohort study was performed that included patients undergoing uniportal endoscopic or tubular decompression for FLLDH over a 5-year period. The primary outcome was patient-reported outcome measures (PROMs). Secondary outcomes included operative time, intraoperative radiation, length of stay (LOS), and reoperation/complication rates. Comparisons between non-paired continuous variables were done with a 2-tailed independent sample <i>t-</i>test. Categorical variables were compared with a χ² or a Fisher exact test. Significance was assumed at <i>P</i> < .05. <i>Results</i>: We identified 135 patients, 64 having undergone endoscopic and 71 tubular microdiscectomy. There were no differences in operative times (67.7 vs 68.2 minutes) or LOS (945.5 vs 911.1 minutes). Endoscopic microdiscectomy was associated with increased total fluoroscopy time (105.92 vs 34.66 seconds) and intraoperative radiation dose (33.68 vs 19.12 mGy). Postoperatively, both groups had statistically significant improvements in all PROMs at early and late follow-up. There was no difference in the magnitude of improvement or the rate of postoperative complications/reoperations between the groups. <i>Conclusion</i>: This retrospective review found that endoscopic microdiscectomy and tubular decompression were effective techniques for the treatment of FLLDH, showing significant improvement in postoperative PROMs and no differences in postoperative complications. However, endoscopic microdiscectomy is associated with increased intraoperative radiation exposure.</p>","PeriodicalId":35357,"journal":{"name":"Hss Journal","volume":" ","pages":"15563316251346443"},"PeriodicalIF":1.6,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12179109/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144477127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of Transfemoral Osseointegration for Patients With Prior Amputation to Manage Infected Total Knee Arthroplasty.","authors":"Tyler D DeSena, LaYow C Yu, S Robert Rozbruch, Taylor J Reif, Jidapa Wongcharoenwatana, Jason S Hoellwarth","doi":"10.1177/15563316251343034","DOIUrl":"10.1177/15563316251343034","url":null,"abstract":"<p><p><i>Background:</i> Management of total knee arthroplasty (TKA) periprosthetic joint infection (PJI) can prompt knee fusion or transfemoral amputation, both associated with poor mobility. The titanium transcutaneous osseointegrated nail (TiTON) provides superior mobility versus traditional socket prostheses but has been minimally studied for amputees with prior TKA PJI. <i>Purpose</i>: This study investigated the complications and mobility experience of 9 transfemoral osseointegration patients whose initial amputation was for TKA PJI management. <i>Methods</i>: A retrospective review of a prospectively maintained registry was conducted of 9 patients whose unilateral transfemoral osseointegration was performed following TKA PJI. Complications associated with the implantation of the titanium implant were noted, specifically antibiotic prescription or any additional surgery. K-level mobility performance before and after osseointegration was also compared. <i>Results</i>: Three patients (33.3%) had management for an infectious concern: 2 had a 10-day course of oral doxycycline for periportal drainage, and 1 had operative debridement with implant retention. No other complications (periprosthetic fracture, implant removal, and additional amputation) occurred. Eight patients (88.9%) improved their K-level, while 1 remained at K3. None declined. All achieved at least K2. Three patients were wheelchair-bound (K0) before osseointegration and achieved K3 or better. <i>Conclusions</i>: While infection may occur in patients who have TiTON following TKA PJI, our findings suggest that it does not seem inevitable, severe, or likely to further disable the patient. We noted meaningful mobility improvement that was common and lasting. Although our sample was small, we suggest that TiTON seems safe and reasonable to offer to patients seeking improved mobility and quality of life after amputation for TKA PJI management. Further study is warranted.</p>","PeriodicalId":35357,"journal":{"name":"Hss Journal","volume":" ","pages":"15563316251343034"},"PeriodicalIF":1.6,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12176782/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144477126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating Artificial Intelligence and Virtual Reality in Orthopedic Surgery: A Comprehensive Review.","authors":"Robert Koucheki, Johnathan R Lex, Michael Brock, Danny P Goel","doi":"10.1177/15563316251345479","DOIUrl":"10.1177/15563316251345479","url":null,"abstract":"<p><p>Artificial intelligence (AI) and virtual reality (VR) are being used in orthopedic surgery, with goals of enhancing surgical precision, trainee education, patient engagement, and personalized surgical strategies. AI-based predictive modeling, automated computer vision and image analytics, and robotic surgery are changing orthopedic preoperative planning and intraoperative decision-making, with the ultimate aim of improving postoperative outcomes through reduced variability in surgery. VR technologies are being used in orthopedic surgical simulations to provide safe environments for skill development in surgical trainees, helping them practice complex procedures before performing live surgeries. VR platforms are also being studied in-patient rehabilitation, focusing on interactive and gamified approaches that could enhance patients' adherence, recovery, and outcomes. Major pitfalls and challenges that need to be addressed include technical and logistical barriers, ethical concerns surrounding patient data privacy, and resistance to change among surgeons, trainees, and scientists. Improved infrastructure, standardized protocols, and further research to validate the long-term benefits will be imperative for the integration of AI and VR technologies into clinical and surgical workflows.</p>","PeriodicalId":35357,"journal":{"name":"Hss Journal","volume":" ","pages":"15563316251345479"},"PeriodicalIF":1.6,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12176799/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144477125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of AI on the Development of Multimodal Wearable Devices in Musculoskeletal Medicine.","authors":"Gage Olson, Isabel Hansmann-Canas, Zahra Karimi, Amirhossein Yazdkhasti, Ghazal Shabestanipour, Hamid Ghaednia, Joseph H Schwab","doi":"10.1177/15563316251344945","DOIUrl":"10.1177/15563316251344945","url":null,"abstract":"<p><p>As wearables are becoming an increasingly important part of wellness and everyday life for many people, their potential in healthcare is also expanding, particularly in personalized and remote healthcare. However, many wearables lack sophistication, relying on simple sensors such as accelerometers and pulse meters to measure heart rate, body composition, and daily activity. Such basic metrics are insufficient for musculoskeletal disease diagnosis, which requires more detailed, multimodal neuromusculoskeletal monitoring. A major challenge in wearables development is the need for precise electromechanical signal measurements, which are difficult to obtain with low-cost systems. Artificial intelligence (AI) holds promise in addressing these analytical challenges and enabling the creation of affordable, sophisticated wearables. While AI has been used for decades in engineering, its clinical application is still emerging, creating an opportunity for the development of AI-enhanced wearables capable of clinical diagnosis. AI can enhance data generated by various sensor types in wearable devices (such as accelerometers, electrical, optical, and acoustic sensors), enabling clinicians to monitor and diagnose complex conditions that require multiple sensing modalities. This review explores current wearable technologies, ongoing research in AI-enhanced wearables, the potential for AI to advance wearable technologies in healthcare, and the future directions in the development of multimodal wearables.</p>","PeriodicalId":35357,"journal":{"name":"Hss Journal","volume":" ","pages":"15563316251344945"},"PeriodicalIF":1.6,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12158963/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}