Indonesian Journal of Clinical Pharmacy最新文献_第2页

Effectiveness of Inhaled Antibiotics in Ventilator Associated Pneumonia: A Systematic Review and Meta-Analysis 吸入抗生素治疗呼吸机相关性肺炎的有效性:系统回顾和荟萃分析

Indonesian Journal of Clinical Pharmacy Pub Date : 2022-03-30 DOI: 10.15416/ijcp.2022.11.1.51

Beryl Bayanaka, F. Herawati, R. Yulia

{"title":"Effectiveness of Inhaled Antibiotics in Ventilator Associated Pneumonia: A Systematic Review and Meta-Analysis","authors":"Beryl Bayanaka, F. Herawati, R. Yulia","doi":"10.15416/ijcp.2022.11.1.51","DOIUrl":"https://doi.org/10.15416/ijcp.2022.11.1.51","url":null,"abstract":"Inhaled antibiotics are adjunct to ventilator-associated pneumonia (VAP) therapy because they are delivered directly to the infection site of the lungs, while intravenous (IV) antibiotics work systematically. The Food and Drug Administration (FDA) and the European Medicine Agency have approved several inhaled antibiotics for cystic fibrosis treatment. However, none have been approved for VAP use, even with supporting evidence. Therefore, this study aimed to evaluate the effect of inhaled antibiotics as adjuvant therapy with IV or substitute in the treatment of VAP. The effect was measured based on clinical cure, microbial cure, and mortality. This study is a literature review and meta-analysis using a randomized control trial (RCT) design. The parameters measured were a clinical cure, microbial cure, and mortality. Furthermore, the literature search was conducted using the PubMed database. The included articles’ quality was assessed using the Critical Appraisal Skill Program (CASP) checklist and the journal’s reputation. Furthermore, 7 studies were included in the final review and meta-analysis. The results showed that the meta-analysis of inhaled antibiotics as adjuvant or substitution therapy is negative on clinical cure rates (RR=1,07; 95% CI=0,86–1,32) and mortality (RR=1,09; 95% CI=0,83–1,43). The analysis of inhaled antibiotics as adjuvant therapy was positive in microbiological cure (RR=1,56; 95% CI=1,13–2,17) but has no benefit as substitution therapy (RR=1,21; 95% CI=0,86–1,71). It can be concluded that using inhaled antibiotics as adjuvant therapy or monotherapy is ineffective in improving the clinical cure rate and mortality of VAP patients while using it as an adjuvant alone can eradicate microbes better.","PeriodicalId":351729,"journal":{"name":"Indonesian Journal of Clinical Pharmacy","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126201345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictors of Tolvaptan Response as a Therapy Optimization Strategy in Heart Failure Patients: A Narrative Review 托伐普坦作为心力衰竭患者治疗优化策略的预测因素:叙述性综述

Indonesian Journal of Clinical Pharmacy Pub Date : 2022-03-30 DOI: 10.15416/ijcp.2022.11.1.66

H. W. Risni, R. Sauriasari, Oriza Satifa

{"title":"Predictors of Tolvaptan Response as a Therapy Optimization Strategy in Heart Failure Patients: A Narrative Review","authors":"H. W. Risni, R. Sauriasari, Oriza Satifa","doi":"10.15416/ijcp.2022.11.1.66","DOIUrl":"https://doi.org/10.15416/ijcp.2022.11.1.66","url":null,"abstract":"Heart failure (HF) is an end-stage condition of all heart disease and is associated with significant mortality, morbidity, and health expenses. Tolvaptan, a V2 receptor antagonist, is being used in many countries as an adjunct to the diuretic therapy of HF. Although it has been proven effective and safe, some patients do not respond well to the medication. Since there are indications that a specific population can achieve this therapy’s optimal effect, it is essential to identify responders and predictors to develop individual treatment plans. Therefore, this study provides an overview of the effect of tolvaptan and predictors of response that can be used as a strategy in optimizing the treatment of HF. The article searching process was conducted through PubMed, Google Scholar, and Scopus, including predictors, heart failure, and tolvaptan. The predictors identified in the study were urine osmolality, U-AQP2/PAVP, age, serum creatinine, BUN, BUN/Cr, UUN/BUN, UNa/UCr, BNP, AVP/PAC, CKD, HFpEF, and echocardiographic parameters. The variation in results is caused by differences in response definition, patient characteristics, and the types of variables analyzed. Implementing some of these predictors in countries with inadequate hospital facilities and health insurance coverage is complicated. Therefore, the use of response predictors, at any rate, is expected to assist health professionals in considering the risks and benefits of HF therapy.","PeriodicalId":351729,"journal":{"name":"Indonesian Journal of Clinical Pharmacy","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128673244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potential Drug-Drug Interaction in the Intensive Care Unit: An Observational Study at a Hospital in Bandung 重症监护病房潜在的药物-药物相互作用:万隆一家医院的观察性研究

Indonesian Journal of Clinical Pharmacy Pub Date : 2022-03-30 DOI: 10.15416/ijcp.2022.11.1.41

I. Pradipta, Dimo Pratama, Hanifahzin Khatami, Julisiana Sanggelorang

{"title":"Potential Drug-Drug Interaction in the Intensive Care Unit: An Observational Study at a Hospital in Bandung","authors":"I. Pradipta, Dimo Pratama, Hanifahzin Khatami, Julisiana Sanggelorang","doi":"10.15416/ijcp.2022.11.1.41","DOIUrl":"https://doi.org/10.15416/ijcp.2022.11.1.41","url":null,"abstract":"The hospital’s Intensive Care Unit (ICU) is at the forefront of treating emergency patients requiring intensive care. The comprehensive, fast, and accurate medication in the unit causes the incidence of drug-drug interactions (DDI’s) and can lead to therapeutic failures in patients. Therefore, this study aimed to describe potential (DDIs) in the ICU of a hospital in Bandung. A descriptive observational study was performed in a hospital in Bandung from 1st to 31st March 2021. The drug use report observed the use of medics in the ICU. Furthermore, the potential DDI’s were identified using a drug interaction checker. It was validated using the textbook and another reputable checker. There are twenty-one types of drugs commonly used in the study setting, and the analysis showed twenty-two potential DDI’s. The interaction consists of three significant DDI’s, including dexamethasone-levofloxacin, phenytoin-nicardipine, and phenytoin-nimodipine, while the others are moderate. The majority of them generally affect the blood pressure and nervous system. Health care providers should observe the high incidence of DDI’s when selecting and monitoring drugs in the ICU. Further study is needed to explore the potential of other drugs that can minimize the interaction effect. Therefore, it is expected to improve ICU patients’ safety in adverse drug reaction situations.","PeriodicalId":351729,"journal":{"name":"Indonesian Journal of Clinical Pharmacy","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130014672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative Analysis of the Quality of Life of Schizophrenic Patients between Combination Therapy of Risperidone-Haloperidol and Clozapine-Risperidone-Haloperidol in a Mental Health Hospital in West Kalimantan Province 西加里曼丹省某精神病院利培酮-氟哌啶醇与氯氮平-利培酮-氟哌啶醇联合治疗精神分裂症患者生活质量的比较分析

Indonesian Journal of Clinical Pharmacy Pub Date : 2022-03-30 DOI: 10.15416/ijcp.2022.11.1.1

Y. Anggriani, Diana Khairunisa, W. Wilson, N. Andayani

{"title":"Comparative Analysis of the Quality of Life of Schizophrenic Patients between Combination Therapy of Risperidone-Haloperidol and Clozapine-Risperidone-Haloperidol in a Mental Health Hospital in West Kalimantan Province","authors":"Y. Anggriani, Diana Khairunisa, W. Wilson, N. Andayani","doi":"10.15416/ijcp.2022.11.1.1","DOIUrl":"https://doi.org/10.15416/ijcp.2022.11.1.1","url":null,"abstract":"Schizophrenia is one of the most complex mental disorders that can burden individuals and families, and it requires long-term treatment since it is a chronic disease that can potentially relapse. Therefore, this study compared the Health-Related Quality of life (HRQoL) of schizophrenic patients receiving a combination of antipsychotic therapy of risperidone and haloperidol (RH) antipsychotic therapy to clozapine, risperidone, and haloperidol (CRH). This was an observational cohort, prospective, pre-post observation study of schizophrenic inpatients at the Mental Hospital of West Kalimantan Province in the stable and discharge phases. Data were collected prospectively from March–May 2020, and consecutive sampling was conducted on 95 respondents. The Indonesian version of The 5-Level European Quality of Life 5 Dimensions (EQ5D-5L) questionnaire was filled by nurses and patients simultaneously to measure the HRQoL. The pre-therapy analysis performed at the stable phase using the Mann-Whitney test showed no difference in HRQoL between RH and CRH groups (p>0.05). Meanwhile, during the discharge phase (post-therapy), the HRQoL of the RH and CRH groups was not significantly different (p>0.05). The Wilcoxon test showed a significant difference in the RH and CRH groups from the beginning of the patients’ stable phase to the discharge (p<0.05). Therefore, there is a significant difference between RH and CRH combination therapy as well as the HRQoL improvement of schizophrenic patients.","PeriodicalId":351729,"journal":{"name":"Indonesian Journal of Clinical Pharmacy","volume":"283 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122506265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness and Safety of Baricitinib as a Covid-19 Drug Candidate: A Systematic Review Baricitinib作为Covid-19候选药物的有效性和安全性:一项系统评价

Indonesian Journal of Clinical Pharmacy Pub Date : 2022-03-30 DOI: 10.15416/ijcp.2022.11.1.78

Y. S. Rahayu, Andi Anggriani, H. Habibie, Elly Wahyudin, M. A. Bahar

{"title":"Effectiveness and Safety of Baricitinib as a Covid-19 Drug Candidate: A Systematic Review","authors":"Y. S. Rahayu, Andi Anggriani, H. Habibie, Elly Wahyudin, M. A. Bahar","doi":"10.15416/ijcp.2022.11.1.78","DOIUrl":"https://doi.org/10.15416/ijcp.2022.11.1.78","url":null,"abstract":"Baricitinib is an approved selective JAK1/JAK2 inhibitor that can potentially inhibit IL-6 as the primary driver of COVID-19-related cytokine storm syndrome. Therefore, this study aimed to assess the effectiveness and safety of baricitinib therapy in COVID-19 patients. It was reported following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The search for eligible articles reporting the efficacy and safety of baricitinib on COVID-19 patients, published up to May 2021, was conducted using PubMed and Embase. The research protocol was registered at PROSPERO (CDR42021235282), and data were presented in a metasynthetic (descriptive) manner. Out of 878 identified articles, seven were eligible and consisted of three randomized clinical trials, one quasi-experimental study, two before-after (pre-post) studies, and one cross-sectional study. The articles suggested that baricitinib could improve the clinical conditions of COVID-19 patients indicated by negative PCR test results, improve breathing quality, and decrease: ICU requirements, length of hospital stay, as well as the risk of death. The trial studies showed that this inhibitor works better with a loading dose of 8 mg, continued with 4 mg daily. Baricitinib could also produce synergistic effects with standard therapy such as corticosteroid and remdesivir. Therefore, it is a promising candidate therapy for COVID-19 patients, but since the number and methodological quality of the studies are low, further and better research is needed to ascertain its potential use on COVID-19.","PeriodicalId":351729,"journal":{"name":"Indonesian Journal of Clinical Pharmacy","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125114055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of Aromatherapy Effect of Lavender and Rosemary to Stress in Adults 薰衣草与迷迭香对成人应激的芳香疗法效果比较

Indonesian Journal of Clinical Pharmacy Pub Date : 2022-03-30 DOI: 10.15416/ijcp.2022.11.1.33

Ni Made Maharianingsih, Ni Made W. Ariasanti

{"title":"Comparison of Aromatherapy Effect of Lavender and Rosemary to Stress in Adults","authors":"Ni Made Maharianingsih, Ni Made W. Ariasanti","doi":"10.15416/ijcp.2022.11.1.33","DOIUrl":"https://doi.org/10.15416/ijcp.2022.11.1.33","url":null,"abstract":"Stress is a change condition caused by severe demands, and it occurs at all ages, depending on responsibility as adults. Furthermore, lavender and rosemary aromatherapy can be used to alleviate the effects. Therefore, this study aimed to compare the effectiveness of lavender and rosemary aromatherapy in managing stress in adults. This was a quasi-experimental two-group pre-post test design study conducted in May 2021. A total of 70 adult subjects were selected through purposive sampling, divided into two groups: one receiving lavender and the other rosemary aromatherapy interventions for 7 days. The stress level was measured by the Depression, Anxiety, and Stress Scale 42 (DASS-42) questionnaire. The results showed average stress before the administration of lavender on the subjects from the first group to be 23.5, after which it was observed to decrease by 8.97%, 18.90%, and 34.14% on the third, fifth, and seventh day, respectively. Meanwhile, in the second group, the average stress before the given intervention of rosemary aromatherapy was 22.14, which was observed to decrease by 12.91%, 25.36%, and 51.14% on the third, fifth, and seventh day, respectively. The Mann-Whitney U test showed a higher reduction in stress levels (p=0.000) after using rosemary aromatherapy. It is concluded that rosemary aromatherapy is more effective (p=0.000) in reducing stress in adults than in lavender.","PeriodicalId":351729,"journal":{"name":"Indonesian Journal of Clinical Pharmacy","volume":"143 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115018562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Community Pharmacists’ Recommendations in Handling a Self-Medication Request for Bloody Diarrhea: A Survey in an Indonesian Urban Setting 社区药剂师在处理带血性腹泻自我用药请求中的建议:印度尼西亚城市环境中的一项调查

Indonesian Journal of Clinical Pharmacy Pub Date : 2021-12-30 DOI: 10.15416/ijcp.2021.10.4.289

Yustina Octafelia, A. Rahem, A. P. Setiadi, Y. Wibowo, Cecilia Brata, E. Setiawan, Steven V. Halim

{"title":"Community Pharmacists’ Recommendations in Handling a Self-Medication Request for Bloody Diarrhea: A Survey in an Indonesian Urban Setting","authors":"Yustina Octafelia, A. Rahem, A. P. Setiadi, Y. Wibowo, Cecilia Brata, E. Setiawan, Steven V. Halim","doi":"10.15416/ijcp.2021.10.4.289","DOIUrl":"https://doi.org/10.15416/ijcp.2021.10.4.289","url":null,"abstract":"Diarrhea is one of the medical problems frequently found in the community. Pharmacists should determine the conditions treatable with over-the-counter medications and those that need urgent referral to a doctor, such as bloody diarrhea. Therefore, this study aimed to determine the appropriateness of the pharmacists' recommendations when responding to self-medication requests in the case of adult bloody diarrhea. This cross-sectional study was conducted from October to December 2019 using a questionnaire consisting of participants' characteristics and newly developed acute bloody diarrhea scenarios in adults. The quality and content of the questionnaire was validated by the experts in clinical pharmacy, public health, and pharmacists. The data obtained from 84 pharmacists with the response rate of 38.71% were analyzed descriptively. About 89.29 % of the pharmacists were female between 24 to 34 years. Referral to a doctor was the most suitable recommendation; however, only 23 pharmacists (34.52%) recommended this method. Some recommended antibiotics, such as metronidazole, cotrimoxazole, or thiamphenicol. Most pharmacists have not provided appropriate recommendations for a scenario related to bloody diarrhea in adults. Therefore, further research should be conducted to identify the required variables by the community pharmacists to make an appropriate recommendation as a response towards minor ailments in the community, especially medical referrals.","PeriodicalId":351729,"journal":{"name":"Indonesian Journal of Clinical Pharmacy","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125930105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Characteristic and Antibiotic Patterns among Coronavirus Disease 2019 In-patient Wava Husada Hospital Malang 马朗瓦瓦胡萨达医院2019年冠状病毒病住院患者临床特征及抗生素使用模式

Indonesian Journal of Clinical Pharmacy Pub Date : 2021-12-30 DOI: 10.15416/ijcp.2021.10.4.321

Ardiyatul I. Kelana, Z. Ikawati, C. Wiedyaningsih

{"title":"Clinical Characteristic and Antibiotic Patterns among Coronavirus Disease 2019 In-patient Wava Husada Hospital Malang","authors":"Ardiyatul I. Kelana, Z. Ikawati, C. Wiedyaningsih","doi":"10.15416/ijcp.2021.10.4.321","DOIUrl":"https://doi.org/10.15416/ijcp.2021.10.4.321","url":null,"abstract":"Coronavirus Disease 2019 (COVID-19) is an infection caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), which resulted in the clinical manifestation of pneumonia. A virus mainly causes pneumonia COVID-19, but bacterial co-infection plays a role in increasing mortality. This case series aimed to identify clinical characteristics and antibiotic use in treating COVID-19 patients at Wava Husada Hospital Malang. Data of a total sample of 21 patients selected from March to August 2020 showed moderate to severe infection and was further analyzed descriptively. The mean age of patients was 52±13 years, and 62% were men. Meanwhile, the most common symptoms were shortness of breath and cough with 81% and 76.2%, respectively. Several symptoms found include fever, diarrhea, nausea/vomiting, dizziness, and anorexia at 57.1%, 19%, 33.3%, 14.3%, and 4.8%. The patients had radiological features of pneumonia, where most of them had normal leukocyte and low lymphocyte counts. Additionally, 76.2% or 16 patients received antibiotic monotherapy, and 23.8% or 5 patients received the combination. Levofloxacin is the most commonly administered antibiotics, either single or combined, with a median duration of 11 days. Patients' length of stay ranged from 12 to 24 days; where 71.4% were discharged home, and 28.6% died. Procalcitonin measurement should be attempted as a stewardship strategy for using antibiotics in COVID-19 patients.","PeriodicalId":351729,"journal":{"name":"Indonesian Journal of Clinical Pharmacy","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128079992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Humanistic Outcome of Cervical Cancer Patients Using Cisplatin-Vincristine-Bleomycin Regimen 宫颈癌患者使用顺铂-长春新碱-博莱霉素方案的人文预后

Indonesian Journal of Clinical Pharmacy Pub Date : 2021-12-30 DOI: 10.15416/ijcp.2021.10.4.249

S. Suwendar, A. Fudholi, T. Andayani, H. Sastramihardja

{"title":"Humanistic Outcome of Cervical Cancer Patients Using Cisplatin-Vincristine-Bleomycin Regimen","authors":"S. Suwendar, A. Fudholi, T. Andayani, H. Sastramihardja","doi":"10.15416/ijcp.2021.10.4.249","DOIUrl":"https://doi.org/10.15416/ijcp.2021.10.4.249","url":null,"abstract":"Humanistic outcomes such as quality of life are very important parameters for assessing the success of chemotherapy. Therefore, this study aimed to evaluate the impact of using the cisplatin-vincristin-bleomycin regimen before and after chemotherapy on quality of life. It was conducted using a cross-sectional design in inpatients at Dr. Hasan Sadikin Bandung from June 2015 to March 2016. The data were taken prospectively by field observation. The patient's quality of life was measured using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) questionnaire. Furthermore, the difference in domain values before and after chemotherapy was evaluated statistically by paired t-test (p<0.05). The results show an increase in all aspects of the functional domain, except social functions. There was a tendency to reduce the symptom domain except for decreased appetite (p=0.009). The domain of global health status increased significantly after chemotherapy (p=0.000). Overall, using the cisplatin-vincristin-bleomycin regimen for three cycles improves the quality of life of cervical cancer patients.","PeriodicalId":351729,"journal":{"name":"Indonesian Journal of Clinical Pharmacy","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116685049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Clinical Pharmacist’s Role in Optimizing Therapy through Drug-Related Problems Identification 临床药师在通过药物相关问题识别优化治疗中的作用

Indonesian Journal of Clinical Pharmacy Pub Date : 2021-12-30 DOI: 10.15416/ijcp.2021.10.4.303

Liana Debora, Eni Susanti, S. Suharjono

{"title":"Clinical Pharmacist’s Role in Optimizing Therapy through Drug-Related Problems Identification","authors":"Liana Debora, Eni Susanti, S. Suharjono","doi":"10.15416/ijcp.2021.10.4.303","DOIUrl":"https://doi.org/10.15416/ijcp.2021.10.4.303","url":null,"abstract":"Clinical pharmacists play an important role in a clinical setting as part of a team. Drug-related problem (DRP) is the main part pharmacist should focus on to achieve the optimal therapy for patients. Therefore, this study aimed to investigate the role of clinical pharmacy in a private hospital of West Java, Indonesia, and describe the prevalence of DRPs and several factors associated with the risk of DRPs. The clinical pharmacist's monthly report was obtained from June to August 2020. Furthermore, problems, causes, and types of DRP were identified using PCNE Classification V9.1. Drug classes and other factors related to DRP were also investigated. This was a descriptive study with a retrospective approach to medical records, where 240 DRPs were identified in 157 patients. Approximately 4.45% experienced DRP, especially in ICU at 45.83% and Stroke Unit or SU-IC at 25.42%. The most common DRPs were incomplete drug treatment, drug interaction, and dose adjustment. Antimicrobial, cardiovascular agents, and PPI were the most commonly involved. In the linear regression analysis, length of stay and number of therapy significantly affect DRP. In this study, pharmacists intervented each DRP, with 57% accepted as fully and partially implemented by the physicians. A total of 22% of interventions ended with unknown status due to limited follow-up time. Meanwhile, reviews on medication by clinical pharmacists lead to improvement in drug treatment. The implementation of clinical pharmacy services shows many DRPs to be prevented and increases therapy optimization.","PeriodicalId":351729,"journal":{"name":"Indonesian Journal of Clinical Pharmacy","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116121881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1