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Precision Medicine in Cancers and Non-Communicable Diseases最新文献

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Precision medicine in oncology: An overview 肿瘤精准医学:综述
Precision Medicine in Cancers and Non-Communicable Diseases Pub Date : 2018-09-03 DOI: 10.1201/9781315154749-1
Fazilet Yılmaz, S. Yilmaz, E. Gunduz, M. Gunduz
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引用次数: 0
Precision medicine for colorectal cancer 结直肠癌精准医疗
Precision Medicine in Cancers and Non-Communicable Diseases Pub Date : 2018-09-03 DOI: 10.1201/9781315154749-5
C. Hızel, S. Tüzmen, A. Amirfallah, G. C. Kocal, Duygu Abbasoğlu, H. Onat, Y. Yıldırım, Y. Baskın
{"title":"Precision medicine for colorectal cancer","authors":"C. Hızel, S. Tüzmen, A. Amirfallah, G. C. Kocal, Duygu Abbasoğlu, H. Onat, Y. Yıldırım, Y. Baskın","doi":"10.1201/9781315154749-5","DOIUrl":"https://doi.org/10.1201/9781315154749-5","url":null,"abstract":"Colorectal cancer (CRC) is the most commonly diagnosed cancer in Europe. Because CRC is also a major cause of cancer-related deaths worldwide, a lot of research has been dedicated to the discovery and development of biomarkers to improve the diagnostic process and to predict treatment outcomes. Up till now only a few biomarkers are recommend by expert panels. The currently used TNM criteria, however, cause substantial under- and overtreatment of CRC patients. Consequently, there is a growing need for new and e ffi cient biomarkers to ensure optimal treatment allocation. The ideal biomarker is one that can easily be introduced in clinical practice, able to identify patients who can be spared from treatment or capable of identifying patients who will bene fi t from therapy, ultimately resulting in precision medicine in the future. With this review we aimed to provide an overview of a number of frequently studied biomarkers in CRC and at the same time we will emphasize the di ffi culties and controversies that with-hold the clinical introduction of these biomarkers. We will discuss both prognostic and predictive markers of chemotherapy, aspirin therapy as well as overall therapy toxicity. Currently, only mutant KRAS, mutant BRAF, MSI and the Onco type DX Colon Cancer Assay are used in clinical practice. Other biomarker studies showed insu ffi cient evidence to introduce these biomarkers in clinical practice. Divergent patient selection criteria, absence of validation studies, and a large number of single biomarker studies are possibly responsible. We therefore advice future studies to focus on combining key markers rather than analyzing only one marker, standardizing study protocols and to validate the results in independent study cohorts followed by prospective clinical trials.","PeriodicalId":350592,"journal":{"name":"Precision Medicine in Cancers and Non-Communicable Diseases","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115330140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Precision medicine in multiple sclerosis 多发性硬化症的精准医疗
Precision Medicine in Cancers and Non-Communicable Diseases Pub Date : 2018-09-03 DOI: 10.1201/9781315154749-15
Shoaib Ahmad
{"title":"Precision medicine in multiple sclerosis","authors":"Shoaib Ahmad","doi":"10.1201/9781315154749-15","DOIUrl":"https://doi.org/10.1201/9781315154749-15","url":null,"abstract":"","PeriodicalId":350592,"journal":{"name":"Precision Medicine in Cancers and Non-Communicable Diseases","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123700510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Precision medicine in ovarian carcinoma 卵巢癌的精准医学
Precision Medicine in Cancers and Non-Communicable Diseases Pub Date : 2018-09-03 DOI: 10.1201/9781315154749-8
Shailendra Dwivedi, P. Purohit, Radhieka Misra, Jeewan Ram Vishnoi, A. Goel, P. Pareek, S. Khattri, Praveen Sharma, S. Misra, K. Pant
{"title":"Precision medicine in ovarian carcinoma","authors":"Shailendra Dwivedi, P. Purohit, Radhieka Misra, Jeewan Ram Vishnoi, A. Goel, P. Pareek, S. Khattri, Praveen Sharma, S. Misra, K. Pant","doi":"10.1201/9781315154749-8","DOIUrl":"https://doi.org/10.1201/9781315154749-8","url":null,"abstract":"","PeriodicalId":350592,"journal":{"name":"Precision Medicine in Cancers and Non-Communicable Diseases","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125837169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Precision medicine in osteoporosis and bone diseases 骨质疏松症和骨病的精准医学
Precision Medicine in Cancers and Non-Communicable Diseases Pub Date : 2018-09-03 DOI: 10.1201/9781315154749-13
F. Kazanci, F. Kazancı, M. R. Yiğitoğlu, M. Gunduz
{"title":"Precision medicine in osteoporosis and bone diseases","authors":"F. Kazanci, F. Kazancı, M. R. Yiğitoğlu, M. Gunduz","doi":"10.1201/9781315154749-13","DOIUrl":"https://doi.org/10.1201/9781315154749-13","url":null,"abstract":"","PeriodicalId":350592,"journal":{"name":"Precision Medicine in Cancers and Non-Communicable Diseases","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114122081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Precision medicine in diabetes mellitus 糖尿病的精准医学
Precision Medicine in Cancers and Non-Communicable Diseases Pub Date : 2018-09-03 DOI: 10.1201/9781315154749-14
S. Selvarajan, Akila Srinivasan, Nishanthi Anandabaskar, S. Kamalanathan, M. George
{"title":"Precision medicine in diabetes mellitus","authors":"S. Selvarajan, Akila Srinivasan, Nishanthi Anandabaskar, S. Kamalanathan, M. George","doi":"10.1201/9781315154749-14","DOIUrl":"https://doi.org/10.1201/9781315154749-14","url":null,"abstract":"","PeriodicalId":350592,"journal":{"name":"Precision Medicine in Cancers and Non-Communicable Diseases","volume":"77 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125001780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Breast cancer epigenetic targets for precision medicine 精准医学的乳腺癌表观遗传学靶点
Precision Medicine in Cancers and Non-Communicable Diseases Pub Date : 2018-09-03 DOI: 10.1201/9781315154749-7
R. Dumitrescu
{"title":"Breast cancer epigenetic targets for precision medicine","authors":"R. Dumitrescu","doi":"10.1201/9781315154749-7","DOIUrl":"https://doi.org/10.1201/9781315154749-7","url":null,"abstract":"","PeriodicalId":350592,"journal":{"name":"Precision Medicine in Cancers and Non-Communicable Diseases","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134008514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Precision medicine in coronary artery disease 冠状动脉疾病的精准医学
Precision Medicine in Cancers and Non-Communicable Diseases Pub Date : 2018-09-03 DOI: 10.1201/9781315154749-11
M. George, L. Goenka, S. Selvarajan
{"title":"Precision medicine in coronary artery disease","authors":"M. George, L. Goenka, S. Selvarajan","doi":"10.1201/9781315154749-11","DOIUrl":"https://doi.org/10.1201/9781315154749-11","url":null,"abstract":"","PeriodicalId":350592,"journal":{"name":"Precision Medicine in Cancers and Non-Communicable Diseases","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122075828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Precision medicine in acute myeloid leukemia 急性髓性白血病的精准治疗
Precision Medicine in Cancers and Non-Communicable Diseases Pub Date : 2018-09-03 DOI: 10.1201/9781315154749-10
O. Fuchs
{"title":"Precision medicine in acute myeloid leukemia","authors":"O. Fuchs","doi":"10.1201/9781315154749-10","DOIUrl":"https://doi.org/10.1201/9781315154749-10","url":null,"abstract":"","PeriodicalId":350592,"journal":{"name":"Precision Medicine in Cancers and Non-Communicable Diseases","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123885843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Customized DNA–directed precision nutrition to balance the brain reward circuitry and reduce addictive behaviors 定制的dna定向精确营养，以平衡大脑奖励回路，减少成瘾行为
Precision Medicine in Cancers and Non-Communicable Diseases Pub Date : 2018-09-03 DOI: 10.1201/9781315154749-17
K. Blum, M. Febo, E. Braverman, Mona Li, L. Fried, R. L. Waite, Zsolt Demotrovics, William B Downs, D. Barh, B. Steinberg, T. McLaughlin, R. Badgaiyan
{"title":"Customized DNA–directed precision nutrition to balance the brain reward circuitry and reduce addictive behaviors","authors":"K. Blum, M. Febo, E. Braverman, Mona Li, L. Fried, R. L. Waite, Zsolt Demotrovics, William B Downs, D. Barh, B. Steinberg, T. McLaughlin, R. Badgaiyan","doi":"10.1201/9781315154749-17","DOIUrl":"https://doi.org/10.1201/9781315154749-17","url":null,"abstract":"","PeriodicalId":350592,"journal":{"name":"Precision Medicine in Cancers and Non-Communicable Diseases","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126020662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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