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The role of signal pathways and receptors in various layers of mucosa in overactive bladder 膀胱过度活动症粘膜各层信号通路和受体的作用
中国组织工程研究 Pub Date : 2021-09-18 DOI: 10.12307/2021.126
Li Wen, Chen Yuelai
{"title":"The role of signal pathways and receptors in various layers of mucosa in overactive bladder","authors":"Li Wen, Chen Yuelai","doi":"10.12307/2021.126","DOIUrl":"https://doi.org/10.12307/2021.126","url":null,"abstract":"","PeriodicalId":35055,"journal":{"name":"中国组织工程研究","volume":"25 1","pages":"4230"},"PeriodicalIF":0.0,"publicationDate":"2021-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45738444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transcranial direct current stimulations at bilateral brain motor areas elevate maximum output power of both lower limbs 经颅直流电刺激双侧脑运动区可提高双下肢最大输出功率
中国组织工程研究 Pub Date : 2021-09-18 DOI: 10.12307/2021.106
HuiLi HuiLi, Li Danyang, Nie Qiu, Niakan Lili, Chen Yiyi
{"title":"Transcranial direct current stimulations at bilateral brain motor areas elevate maximum output power of both lower limbs","authors":"HuiLi HuiLi, Li Danyang, Nie Qiu, Niakan Lili, Chen Yiyi","doi":"10.12307/2021.106","DOIUrl":"https://doi.org/10.12307/2021.106","url":null,"abstract":"","PeriodicalId":35055,"journal":{"name":"中国组织工程研究","volume":"25 1","pages":"4180"},"PeriodicalIF":0.0,"publicationDate":"2021-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46266367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Animal models of femoral head necrosis: classification and application 股骨头坏死动物模型的分类与应用
中国组织工程研究 Pub Date : 2021-09-18 DOI: 10.12307/2021.123
Wei Wei, Lou Pengqiang, Hou Decai
{"title":"Animal models of femoral head necrosis: classification and application","authors":"Wei Wei, Lou Pengqiang, Hou Decai","doi":"10.12307/2021.123","DOIUrl":"https://doi.org/10.12307/2021.123","url":null,"abstract":"","PeriodicalId":35055,"journal":{"name":"中国组织工程研究","volume":"25 1","pages":"4211"},"PeriodicalIF":0.0,"publicationDate":"2021-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48340273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hypertrophic fibrosis of the ligamentum flavum: signaling pathways and molecular level characteristics 黄韧带肥厚性纤维化的信号通路和分子水平特征
中国组织工程研究 Pub Date : 2021-09-18 DOI: 10.12307/2021.128
Fang Xiaoqian, C. Feng, Liang Xiongqin, G. Sen, Yang Xinqiang
{"title":"Hypertrophic fibrosis of the ligamentum flavum: signaling pathways and molecular level characteristics","authors":"Fang Xiaoqian, C. Feng, Liang Xiongqin, G. Sen, Yang Xinqiang","doi":"10.12307/2021.128","DOIUrl":"https://doi.org/10.12307/2021.128","url":null,"abstract":"摘要 背景:黄韧带的肥厚纤维化被认为是造成腰椎椎管狭窄症的主要原因。近年来,多有研究报道黄韧带肥厚纤维化与多种生长因子、微小 RNA及关键信号通路相关。 目的:通过细读国内外相关文献,以期为黄韧带组织肥厚纤维化分子水平及信号通路的研究进展做一系统综述。 方法:采用以下检索词:腰椎椎管狭窄症;黄韧带肥厚;黄韧带增生;黄韧带纤维化;细胞因子;蛋白;信号通路;微小RNA;lumbar spinal stenosis;hypertrophy of ligamentum flavum;ligamentum flavum hyperplasia;fibrosis of ligamentum flavum;cell factor;protein; signal path;microRNA,检索知网数据库、维普数据库、万方数据平台、PubMed数据库、Biosos Preview数据库及Web Of Science数据库, 并手工检索,收集有关研究黄韧带组织肥厚纤维化的基础实验,检索时限设为建库至2020-06-30。严格按照纳入标准对所检索文献进行 筛选,共纳入15篇有关的基础实验文献进行综述探讨。 结果与结论:现有的实验研究,可以发现在黄韧带组织肥厚纤维化的过程中,存在有多种生长因子及miRNA参与表达并表现出活性增加的 现象,同时发现有关键信号通路参与调控黄韧带组织的纤维化过程。因此,有理由推测黄韧带增生纤维化是多种生物学过程协同参与、 多维作用的共同结果;但影响的纤维化程度在目前尚未确定,未来仍需进一步行基础研究以探索验证。 关键词:黄韧带;肥厚;纤维化;分子水平;基础实验;生长因子;微小RNA;信号通路 缩略语:基质金属蛋白酶组织抑制剂:tissue inhibitor of metalloproteinases,TIMPs;丝裂原活化蛋白激酶:mitogen activated protein kinase,MAPK","PeriodicalId":35055,"journal":{"name":"中国组织工程研究","volume":"25 1","pages":"4243"},"PeriodicalIF":0.0,"publicationDate":"2021-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46869400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Human placenta derived mesenchymal stem cell gel promotes the healing of radiation skin damage in SD rats 人胎盘源性间充质干细胞凝胶促进SD大鼠辐射皮肤损伤愈合
中国组织工程研究 Pub Date : 2021-09-08 DOI: 10.12307/2021.007
Xu Xiaoming, C. Yan, S. Qian, Yuanyuan Lu, Guo Jiaming, Zhang Lijuan, Geng Jie, Dong Jian
{"title":"Human placenta derived mesenchymal stem cell gel promotes the healing of radiation skin damage in SD rats","authors":"Xu Xiaoming, C. Yan, S. Qian, Yuanyuan Lu, Guo Jiaming, Zhang Lijuan, Geng Jie, Dong Jian","doi":"10.12307/2021.007","DOIUrl":"https://doi.org/10.12307/2021.007","url":null,"abstract":"","PeriodicalId":35055,"journal":{"name":"中国组织工程研究","volume":"25 1","pages":"3976"},"PeriodicalIF":0.0,"publicationDate":"2021-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43588871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alpl gene affects the therapeutic effect of bone marrow mesenchymal stem cells on ulcerative colitis Alpl基因对骨髓间充质干细胞治疗溃疡性结肠炎疗效的影响
中国组织工程研究 Pub Date : 2021-09-08 DOI: 10.12307/2021.006
Zhang Lishu, Li Anqi, He Xiaoning, Jin Yan, L. Bei, Jin Fang
{"title":"Alpl gene affects the therapeutic effect of bone marrow mesenchymal stem cells on ulcerative colitis","authors":"Zhang Lishu, Li Anqi, He Xiaoning, Jin Yan, L. Bei, Jin Fang","doi":"10.12307/2021.006","DOIUrl":"https://doi.org/10.12307/2021.006","url":null,"abstract":"","PeriodicalId":35055,"journal":{"name":"中国组织工程研究","volume":"25 1","pages":"3970"},"PeriodicalIF":0.0,"publicationDate":"2021-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42503950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fate decision of mesenchymal stem cells in bone microenvironment 骨微环境中间充质干细胞命运的决定
中国组织工程研究 Pub Date : 2021-09-08 DOI: 10.12307/2021.018
Zhang Chunxi, L. Xiang, Z. Yuxiang, Liu Zhen, Yang Yuquan, J. Hao
{"title":"Fate decision of mesenchymal stem cells in bone microenvironment","authors":"Zhang Chunxi, L. Xiang, Z. Yuxiang, Liu Zhen, Yang Yuquan, J. Hao","doi":"10.12307/2021.018","DOIUrl":"https://doi.org/10.12307/2021.018","url":null,"abstract":"","PeriodicalId":35055,"journal":{"name":"中国组织工程研究","volume":"25 1","pages":"4045"},"PeriodicalIF":0.0,"publicationDate":"2021-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46018127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Significance and possibility of stem cells and multiple cell derived exosomes in the treatment of chronic respiratory diseases 干细胞和多细胞衍生外泌体在慢性呼吸系统疾病治疗中的意义和可能性
中国组织工程研究 Pub Date : 2021-09-08 DOI: 10.12307/2021.019
Y. Dan, Xu Guanglan, Z. Mei, Li-li Jiao, Lin Guosheng, Wang Guangyao, Lingling Hao, Zheng Manli, Li Yuanling
{"title":"Significance and possibility of stem cells and multiple cell derived exosomes in the treatment of chronic respiratory diseases","authors":"Y. Dan, Xu Guanglan, Z. Mei, Li-li Jiao, Lin Guosheng, Wang Guangyao, Lingling Hao, Zheng Manli, Li Yuanling","doi":"10.12307/2021.019","DOIUrl":"https://doi.org/10.12307/2021.019","url":null,"abstract":"","PeriodicalId":35055,"journal":{"name":"中国组织工程研究","volume":"25 1","pages":"4053"},"PeriodicalIF":0.0,"publicationDate":"2021-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42781518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison on the curative effect of human placenta-derived mesenchymal stem cells and induced islet-like cells in gestational diabetes mellitus rats 人胎盘源性间充质干细胞与诱导胰岛样细胞治疗妊娠糖尿病大鼠的疗效比较
中国组织工程研究 Pub Date : 2021-09-08 DOI: 10.12307/2021.008
G. Shan, Hu Dongjing, H. Haiman, Jia Jingqiao, Meng-Ying Fei
{"title":"Comparison on the curative effect of human placenta-derived mesenchymal stem cells and induced islet-like cells in gestational diabetes mellitus rats","authors":"G. Shan, Hu Dongjing, H. Haiman, Jia Jingqiao, Meng-Ying Fei","doi":"10.12307/2021.008","DOIUrl":"https://doi.org/10.12307/2021.008","url":null,"abstract":"摘要 背景:妊娠期糖尿病易对孕产妇和胎儿的健康造成严重损害,探索安全有效的妊娠期糖尿病预防和治疗手段成为妇产科学的重要研究方向 之一。 目的:对比人胎盘间充质干细胞和胰岛样细胞对妊娠期糖尿病大鼠的治疗效果,为其用于临床研究治疗妊娠期糖尿病提供理论依据。 方法:在无菌条件下提取人胎盘组织中的人胎盘间充质干细胞,将其诱导分化为胰岛样细胞,采用流式细胞术检测分化过程中巢蛋白和胰 岛素的表达,采用双硫腙染色法检测胰岛样细胞团中锌离子表达。将雌性SD大鼠随机分为5组:正常孕鼠组、妊娠期糖尿病鼠未干预组、 妊娠期糖尿病鼠生理盐水干预组、妊娠期糖尿病鼠人胎盘间充质干细胞干预组、妊娠期糖尿病鼠胰岛样细胞干预组,每组10只。采用妊 娠前喂食高糖高脂饮食和妊娠后腹腔注射链脲佐菌素的方法建立妊娠期糖尿病模型,建模成功后,尾静脉注射1 mL含6×10个人胎盘间充 质干细胞或胰岛样细胞的生理盐水悬液,分别于妊娠第6,12,18天检测各组孕鼠体质量和空腹血糖,妊娠第18天检测孕鼠血清脂联素水 平。 结果与结论:1在人胎盘间充质干细胞诱导分化为胰岛样细胞过程中,胰岛素水平逐渐增高;巢蛋白表达水平先上升后逐渐下降;在诱导 分化的第28天形成胰岛样细胞团;2人胎盘间充质干细胞和胰岛样细胞均能使妊娠期糖尿病鼠血糖降低,体质量升高,脂联素水平升高; 妊娠第18天,与人胎盘间充质干细胞干预组相比,胰岛样细胞干预组大鼠体质量上升、血糖降低、脂联素水平升高效果更明显;3结果表 明,人胎盘间充质干细胞和胰岛样细胞均能有效治疗妊娠期糖尿病鼠,由人胎盘间充质干细胞诱导分化的胰岛样细胞治疗效果更优。 关键词:干细胞;胎盘间充质干细胞;胰岛样细胞;诱导分化;妊娠期糖尿病;血糖;脂联素","PeriodicalId":35055,"journal":{"name":"中国组织工程研究","volume":"25 1","pages":"3981"},"PeriodicalIF":0.0,"publicationDate":"2021-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44911308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Finite element biomechanical study of full endoscopic fenestration decompression for cervical spondylotic myelopathy 全内窥镜开窗减压治疗脊髓型颈椎病的有限元生物力学研究
中国组织工程研究 Pub Date : 2021-08-28 DOI: 10.12307/2021.091
L. Jinyu, Ding Yiwei, Lu Zheng-Cao, Gao Tianjun, Cui Hong-Peng, L. Wen, Du Wei, Ding Yu
{"title":"Finite element biomechanical study of full endoscopic fenestration decompression for cervical spondylotic myelopathy","authors":"L. Jinyu, Ding Yiwei, Lu Zheng-Cao, Gao Tianjun, Cui Hong-Peng, L. Wen, Du Wei, Ding Yu","doi":"10.12307/2021.091","DOIUrl":"https://doi.org/10.12307/2021.091","url":null,"abstract":"","PeriodicalId":35055,"journal":{"name":"中国组织工程研究","volume":"25 1","pages":"3850"},"PeriodicalIF":0.0,"publicationDate":"2021-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42177014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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