中国组织工程研究最新文献

{"title":"Effects of miRNA in self-renewal, multidirectional differentiation, fate and function regulation of bone marrow mesenchymal stem cells","authors":"Cui Shuaishuai, Y. Xiaohong","doi":"10.12307/2022.017","DOIUrl":"https://doi.org/10.12307/2022.017","url":null,"abstract":"","PeriodicalId":35055,"journal":{"name":"中国组织工程研究","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45243524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biological characteristics and immunoregulation of exosomes derived from mesenchymal stem cells","authors":"G. Jia, D. Qionghua, L. Ze, L. Siyi, G. Yuhua, B. Chunyu","doi":"10.12307/2022.150","DOIUrl":"https://doi.org/10.12307/2022.150","url":null,"abstract":"BACKGROUND: Clarifying the synthesis and regulation of exosomes derived from mesenchymal stem cells is of great significance to the research and application of exosomes in the future. OBJECTIVE: To summarize the biological characteristics in exosomes derived from different mesenchymal stem cells and the role of these exosomes in the immune regulation, which hopes to find new breakthroughs in the study of exosomes in the future and provide ideas for cell-free therapy. METHODS: The articles were searched on PubMed, CNKI and Wanfang using the keywords of “stem cells, mesenchymal stem cells, exosomes, immunomodulation, inflammatory mediator, biological characteristics of exosomes, biological characteristics of mesenchymal stem cells, regeneration” in Chinese and English. Finally, 105 articles were included for review. RESULTS AND CONCLUSION: Mesenchymal stem cells are a type of pluripotent stem cells that exist widely in various tissues of the body. Mesenchymal stem cells not only have stem cell characteristics, but also play an important role in the immunosuppressive properties. Mesenchymal stem cells had been clinically applied for the treatment of many diseases. Therefore, mesenchymal stem cells were used to manage novel coronavirus pneumonia, and had ideal treatment effect. Exosomes are endosome-derived nanometer-scale vesicles (40–200 nm in diameter). Exosomes derived from mesenchymal stem cells have the same immune regulation function as its maternal cells, including that carrying immunosuppressive factors, promoting macrophages polarization into M2 type, preventing differentiation of pro-inflammatory T cell subsets and inhibiting antigen presentation. © 2022, Publishing House of Chinese Journal of Tissue Engineering Research. All rights reserved.","PeriodicalId":35055,"journal":{"name":"中国组织工程研究","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66006427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kyphoplasty with high viscosity bone cement for the treatment of stage III Kümmell disease without neurological symptoms: restoration of vertebral body height, reduction of kyphoplasty and restoration of column sagittal sequence.","authors":"焱 张云庆 刘 勇 芮 敏 刘上楼 石","doi":"10.12307/2022.192","DOIUrl":"https://doi.org/10.12307/2022.192","url":null,"abstract":"BACKGROUND: Percutaneous kyphoplasty is widely used in the treatment of stage I and II Kummell disease, which can rapidly relieve pain, stabilize vertebral body and correct kyphosis;however, the treatment of stage III Kummell disease is still controversial. OBJECTIVE: To evaluate the clinical outcome of kyphoplasty with high-viscosity bone cement for treatment of stage III Kummell disease without neurologic symptoms. METHODS: Twenty-eight patients (11 males and 17 females, aged 57-82 years) with stage III Kummell disease without neurologic symptoms were admitted to Jiangyin People’s Hospital from May 2016 to May 2019, in which T11 vertebral body in 6 cases and T12 vertebral body in 14 cases, L1 vertebral body in 5 cases and L2 vertebral body in 3 cases were treated by kyphoplasty with high viscosity bone cement. At 1 day after operation and 1 year after follow up, postoperative pain and improvement of life ability were evaluated by the Visual Analogue Scale and Oswestry Disability Index. The recovery of vertebral height and correction of kyphosis were measured with X-ray films. The study was approved by the Ethics Committee of Jiangyin People’s Hospital, approval No. [2017](021). RESULTS AND CONCLUSION: (1) Totally 28 patients were followed up for 12-22 months. No serious complications such as wound infection or pulmonary embolism were found during treatment. Asymptomatic cement leakage occurred in three patients. Adjacent vertebral fracture was encountered in 1 patient at 3 months after operation, and healed after kyphoplasty. (2) Visual Analogue Scale, Oswestry Disability Index, and kyphotic angle were lower at 1 day and 1 year after operation than those before operation in 28 patients (P < 0.05). The height of anterior, middle and posterior edges of vertebral body at 1 day and 1 year after operation was higher than that before operation (P < 0.05). (3) The results showed that kyphoplasty with high-viscosity bone cement can relieve back pain, improve viability, retain the vertebral body height, reduce kyphosis, and restore spinal alignment, and is an effective method for treatment of stage III Kummell disease. (English) [ABSTRACT FROM AUTHOR] 背景：经皮球囊扩张椎体后凸成形能够快速缓解疼痛、稳定椎体、矫正脊柱后凸畸形，被广泛用于Ⅰ期、Ⅱ期Kummell病的治疗，但对于 Ⅲ期Kummell病的治疗方法目前尚存在争议。 目的：探讨高黏度骨水泥椎体后凸成形治疗无神经症状Ⅲ期Kummell病的疗效。 方法：选择2016年5月至2019年5月江阴市人民医院收治的无神经症状Ⅲ期Kummell病患者28例，其中男11例，女17例，年龄57-82岁；病 变椎体集中于胸腰段，其中T11椎体6例，T12椎体 14例，L1椎体5例，L2椎体3例，均接受高黏度骨水泥椎体后凸成形治疗。术后1 d及1年随 访时，采用目测类比评分和Oswestry功能障碍指数评价患者术后疼痛和生活能力改善情况，拍摄正、侧位X射线片测量椎体高度恢复和后 凸畸形矫正情况。研究获得江阴市人民医院伦理委员会批准，批件号：[2017]伦审研第(021)号。 结果与结论：①28例患者均顺利完成手术并完成随访，随访12-22个月，治疗过程中未出现伤口感染、肺栓塞等严重并发症，3例发生骨 水泥椎间隙渗漏，未引起临床症状；1例术后3个月出现邻近椎体骨折，行椎体后凸成形治疗后治愈；②28例患者术后1 d、术后1年时的目 测类比评分、Oswestry功能障碍指数评分与局部后凸角均低于术前(P < 0.05)，术后1 d、术后1年时的椎体前缘、中间及后缘高度均高于术 前(P < 0.05)；③结果表明，高黏度骨水泥椎体后凸成形可有效缓解患者腰背痛、改善患者生活能力、恢复椎体高度、减小后凸畸形、恢复 脊柱矢状序列，是治疗无神经症状Ⅲ期Kummell病的有效方法之一. (Chinese) [ABSTRACT FROM AUTHOR] Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo zu zhi gong cheng yan j","PeriodicalId":35055,"journal":{"name":"中国组织工程研究","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66006035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between preoperative magnetic resonance imaging findings and bone cement leakage after percutaneous vertebral augmentation.","authors":"李洪伟 郑 欣 朱先任 侯万星","doi":"10.12307/2022.083","DOIUrl":"https://doi.org/10.12307/2022.083","url":null,"abstract":"BACKGROUND: Studies have shown that the endplate injuries in patients with osteoporotic vertebral compression fracture are related to the intradiscal cement leakage after percutaneous vertebral augmentation. OBJECTIVE: To investigate the correlation between preoperative magnetic resonance imaging findings and intradiscal cement leakage after percutaneous vertebral augmentation, and to analyze whether endplate fractures and adjacent intervertebral disc injuries affect the incidence of intradiscal cement leakage. METHODS: Totally 182 patients with single-level osteoporotic vertebral compression fractures admitted to the Affiliated Hospital of Xuzhou Medical University from September 2018 to December 2019 were selected, of which 110 received percutaneous kyphoplasty treatment, 72 cases received percutaneous vertebroplasty treatment. According to the preoperative magnetic resonance imaging images, the condition of the adjacent intervertebral disc injury and endplate fracture of the fractured vertebral body was evaluated. According to whether there is intradiscal cement leakage after the operation, the patients were divided into a leakage group (n=32) and a non-leakage group (n=150). A univariate analysis was performed on the correlation between the patient’s age, gender, surgical spinal level, surgical method, endplate fracture, adjacent intervertebral disc injury and intradiscal cement leakage, and then a multivariate binary logistics regression model analysis was performed. The study was approved by the Medical Ethics Committee of the Affiliated Hospital of Xuzhou Medical University. RESULTS AND CONCLUSION: (1) Of the 182 patients, 63 had endplate fractures and 98 had adjacent intervertebral disc injuries. In all patients, 32 cases of intradiscal cement leakage occurred after percutaneous vertebral augmentation;the leakage rate of the endplate fracture group was higher than that of the non-endplate fracture group (P 0.05). (3) The binary logistics regression analysis showed that the endplate fracture was the independent risk factor for intradiscal cement leakage after percutaneous vertebral augmentation;adjacent intervertebral disc injury, age, gender, surgical method, and surgical spinal level were not the risk factors for intradiscal cement leakage. (4) Related analysis showed that there was a significant correlation between the endplate fracture and the intervertebral disc injury (r=0.47, P=0.000). (5) The results showed that the endplate fracture found in the preoperative magnetic resonance imaging was a risk factor for intradiscal cement leakage, and the intervertebral disc injury was not the influence factor of intradiscal cement leakage;the intervertebral disc injury was significantly related to the endplate fracture in osteoporotic vertebral compression fractures patients. (English) [ABSTRACT FROM AUTHOR] 背景：有研究表明，骨质疏松性椎体压缩骨折患者伴随的终板损伤与经皮椎体强化后骨水泥椎间盘渗漏有关。 目的：探讨经皮椎体强化后骨水泥椎间盘渗漏与术前MRI发现的相关性，分析终板骨折及邻近椎间盘损伤对骨水泥椎间盘渗漏的影响。 方法：选择2018年9月至2019年12月徐州医科大学","PeriodicalId":35055,"journal":{"name":"中国组织工程研究","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66006416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nrf2-ARE regulated neurovascular interaction is involved in neural repair after spinal cord injury","authors":"Tan Rongbang, Wei Bo, Li Guangsheng","doi":"10.12307/2021.302","DOIUrl":"https://doi.org/10.12307/2021.302","url":null,"abstract":"","PeriodicalId":35055,"journal":{"name":"中国组织工程研究","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44781664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypoxia-inducible factor and coronary heart disease: antagonism and protection","authors":"Zhang Qunhui, Liu Yimei, Zhang Dejun","doi":"10.12307/2021.307","DOIUrl":"https://doi.org/10.12307/2021.307","url":null,"abstract":"","PeriodicalId":35055,"journal":{"name":"中国组织工程研究","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47820717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of transport distraction osteogenesis in reconstruction of mandibular segmental defects","authors":"Sun Chengli, Zhu Songsong, Li Yunfeng","doi":"10.12307/2021.288","DOIUrl":"https://doi.org/10.12307/2021.288","url":null,"abstract":"","PeriodicalId":35055,"journal":{"name":"中国组织工程研究","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43974539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanism of Inulae flos in the treatment of osteoporosis: an analysis based on network pharmacology","authors":"An Yang, Liao Yinan, Xie Chengxin, Liang Qinglong, H. Ge, Jin Xin, Yingxue Dong","doi":"10.12307/2021.297","DOIUrl":"https://doi.org/10.12307/2021.297","url":null,"abstract":"","PeriodicalId":35055,"journal":{"name":"中国组织工程研究","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47422129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation methods of animal models of femoral head necrosis: merits and demerits","authors":"Lou Pengqiang, Wei Wei, Hou Decai","doi":"10.12307/2021.226","DOIUrl":"https://doi.org/10.12307/2021.226","url":null,"abstract":"","PeriodicalId":35055,"journal":{"name":"中国组织工程研究","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45196829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of total flavone of Rhizoma Drynariae on the coupling of angiogenesis and osteogenesis in bone remodeling through notch signaling pathway","authors":"Huang Minling, Lu Zhaoqi, Shen Zhen, Li Haixiong, Feng Junjie, Huang Feng, Jiang Ziwei, Cai Qunbin","doi":"10.12307/2021.213","DOIUrl":"https://doi.org/10.12307/2021.213","url":null,"abstract":"","PeriodicalId":35055,"journal":{"name":"中国组织工程研究","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45316117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}