Revista mexicana de urologia最新文献

{"title":"Factores asociados a complicaciones en pacientes sometidos a nefrolitotomía percutánea","authors":"J.E. Ceballos-López,&nbsp;R. Carvajal-García,&nbsp;R. Galeana-Ruiz,&nbsp;F. González-González,&nbsp;E.J. Mendoza-Villanueva,&nbsp;J.A. Martínez-Manzo,&nbsp;J.C. Ibarra-Camacho,&nbsp;K. Trujillo-Ríos,&nbsp;L. Villalpando Gómez","doi":"10.1016/j.uromx.2016.01.008","DOIUrl":"10.1016/j.uromx.2016.01.008","url":null,"abstract":"<div><h3>Background</h3><p>Percutaneous nephrolithotomy (PNL) is the standard procedure for kidney stones larger than 2<!--> <!-->cm, thus displacing open surgery. The incidence of complications varies from 12.5 to 52.5%, the main ones being fever and bleeding.</p></div><div><h3>Aim</h3><p>To identify the factors associated with complications in patients that underwent PNL, in accordance with the Clavien-Dindo classification.</p></div><div><h3>Materials and methods</h3><p>A retrospective, correlational, descriptive, cross-sectional study was conducted. We reviewed 104 patients that underwent PNL within the time frame of 2008 and 2014.</p></div><div><h3>Results</h3><p>One hundred and four patients were included in the study and there were 38 complications. In accordance with the Clavien-Dindo classification there were grade I (19), grade II (10), grade IIIA (8), and grade IVA (1) complications. The most frequent complication was postoperative bleeding in 11 patients. The complications were related to residual stones (p<!--> <!-->=<!--> <!-->0.032). A grade 2 or higher complication was more likely when the lower calyx was affected (p<!--> <!-->=<!--> <!-->0.027). We found a relation between bleeding and surgery duration<!--> <!-->&gt;<!--> <!-->100<!--> <!-->min (p<!--> <!-->=<!--> <!-->0.019).</p></div><div><h3>Conclusions</h3><p>The Clavien-Dindo classification is a useful tool for standardizing and reporting complications in PNL. Surgery duration<!--> <!-->&gt;<!--> <!-->100<!--> <!-->min increased the risk for postoperative bleeding and complications were associated with residual stones.</p></div>","PeriodicalId":34909,"journal":{"name":"Revista mexicana de urologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.uromx.2016.01.008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117172575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Penectomía parcial como tratamiento para el cáncer de pene localizado, Hospital Juárez de México","authors":"A.F. Sánchez-Bermeo,&nbsp;G. Martínez-Carrillo,&nbsp;J. Torres-Aguilar,&nbsp;J. Bernal-Hernández","doi":"10.1016/j.uromx.2016.01.009","DOIUrl":"https://doi.org/10.1016/j.uromx.2016.01.009","url":null,"abstract":"<div><h3>Background</h3><p>Cancer of the penis presents in individuals between 50 and 70 years of age, representing only 2-5% of the urogenital tumors in men. However, its incidence varies in some Latin American countries (Paraguay, Brazil) and in Puerto Rico, in which it has been reported to reach 10% of the neoplasias affecting men. Surgery for cancer of the penis is mutilating and significantly affects the quality of life of these patients. We describe herein our management of the disease, in accordance with histopathologic stage, proposing less radical management together with oncologic treatment.</p></div><div><h3>Aim</h3><p>To present our current management of localized cancer of the penis.</p></div><div><h3>Clinical case</h3><p>A 42-year-old man presented with a suspicious lesion on the penis plus phimosis. The lesion was biopsied and the intraoperative histopathologic study was negative for neoplasia. Lesion excision and circumcision were carried out. The definitive histopathology study was positive for malignancy and a second surgery (partial penectomy) was performed.</p></div><div><h3>Conclusions</h3><p>We underline the importance of a correct histopathologic report for aiding the surgeon in determining the most viable surgery in each case, taking into account the medical, legal, psychologic, and social aspects of this type of pathology. We also confirm that good outcome is achieved through adequate surgical management of early-stage disease, as reported in the medical literature.</p></div>","PeriodicalId":34909,"journal":{"name":"Revista mexicana de urologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.uromx.2016.01.009","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92056856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PCUMex survey: Controversies in the management of prostate cancer among Mexican urologists","authors":"C.I. Villeda-Sandoval,&nbsp;J.A. Rivera-Ramírez,&nbsp;G. Romero-Veléz,&nbsp;A. Lisker-Cervantes,&nbsp;R.A. Castillejos-Molina,&nbsp;M.S. de Zavaleta","doi":"10.1016/j.uromx.2015.12.007","DOIUrl":"10.1016/j.uromx.2015.12.007","url":null,"abstract":"<div><h3>Background</h3><p>Prostate cancer is the first cause of mortality related to malignancy in Mexican men. Common clinical practice has to be evaluated in order to gain a picture of reality apart from the guidelines.</p></div><div><h3>Aim</h3><p>To analyze clinical practice among urologists in Mexico in relation to prostate cancer management and to compare the results with current recommendations and guidelines.</p></div><div><h3>Methods</h3><p>We collected the data from 600 urologists, members of the <em>Sociedad Mexicana de Urología</em>, who were invited by email to answer a survey on their usual decisions when managing controversial aspects of prostate cancer patients.</p></div><div><h3>Results</h3><p>Quinolones were the most common antibiotic used as prophylaxis in prostate biopsy (75.51%); 10–12 cores were taken in more than 65% of prostate biopsies; and 18.27% of the participants performed limited pelvic lymphadenectomy. Treatment results showed that 10.75% of the urologists surveyed preferred radical prostatectomy as monotherapy in high-risk patients with extraprostatic extension and 60.47% used complete androgen deprivation in metastatic prostate cancer.</p></div><div><h3>Conclusions</h3><p>There are many areas of opportunity for improvement in our current clinical practice for the management of patients with prostate cancer.</p></div>","PeriodicalId":34909,"journal":{"name":"Revista mexicana de urologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.uromx.2015.12.007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122623650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Características de los casos incidentes de cáncer de próstata en los últimos 5 años en un hospital de tercer nivel en México","authors":"A.A. Cayetano-Alcaraz,&nbsp;J.A. Ramírez-Rivera,&nbsp;M. Sotomayor-de-Zavaleta,&nbsp;R.A. Castillejos-Molina,&nbsp;F. Gabilondo-Navarro,&nbsp;G. Feria-Bernal,&nbsp;F.T. Rodríguez-Covarrubias","doi":"10.1016/j.uromx.2015.11.007","DOIUrl":"10.1016/j.uromx.2015.11.007","url":null,"abstract":"<div><h3>Background</h3><p>In 2008 in Mexico, prostate cancer (CaP) held first place as cause of death due to malignant tumors in men.</p></div><div><h3>Objectives</h3><p>To describe the clinical and pathologic characteristics of the incident cases of CaP and their treatment.</p></div><div><h3>Material and methods</h3><p>A descriptive analysis of the new hospital cases of CaP within the time frame of 2010 to 2014 was conducted.</p></div><div><h3>Results</h3><p>A total of 238 cases were documented, of which 128 (53.8%) were localized disease, 32 (13.4%) were locally advanced disease, and 78 (32.8%) were metastatic disease. The mean age of disease presentation was 66.7 years (SD<!--> <!-->±<!--> <!-->8.8). The diagnostic methods employed were prostate biopsy in 208 (87.4%) cases, transurethral resection of the prostate (TURP) in 5 (2.1%), lymph node biopsy in 18 (7.6%), and prostate-specific antigen (PSA) plus digital rectal examination in 18 (7.6%). Mean PSA levels were 16<!--> <!-->ng/ml in localized disease, 15.7<!--> <!-->ng/ml in locally advanced disease, and 389<!--> <!-->ng/ml in metastatic disease. The surgical procedures in relation to the cancer were radical prostatectomy (RP) in 153 (64.3%) patients, de-obstructing prostate resection in 12 (5%), and orchiectomy in 11 (4.6%). The main oncologic medical treatment in accordance with CaP extension was androgen deprivation therapy for metastatic disease in 93.6% of the cases, radiotherapy in 62.5% of the cases of locally advanced disease, and chemotherapy in 17.9% of the cases of metastatic disease.</p></div><div><h3>Discussion</h3><p>The results suggest the need to implement strategies that enable early identification of this pathology.</p></div><div><h3>Conclusions</h3><p>More than half of the men diagnosed with CaP at a tertiary care hospital in Mexico had localized disease and more than 60% had high-grade tumors.</p></div>","PeriodicalId":34909,"journal":{"name":"Revista mexicana de urologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.uromx.2015.11.007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126107496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factores asociados al fracaso en la colocación de catéteres doble J en pacientes con uropatía obstructiva por cáncer","authors":"I. Jiménez-Vázquez ,&nbsp;I.A. Reyes-García ,&nbsp;A.R. Aragón-Tovar ,&nbsp;G.C. Palacios-Saucedo ,&nbsp;A. García-Mendoza ,&nbsp;A. Michel-Chávez ,&nbsp;M.E. Huitrado-Duarte","doi":"10.1016/j.uromx.2015.10.005","DOIUrl":"10.1016/j.uromx.2015.10.005","url":null,"abstract":"<div><h3>Aim</h3><p>To analyze the clinical, imaging, and surgical factors that are associated with failed double-J stent placement in patients with obstructive uropathy due to cancer.</p></div><div><h3>Materials and methods</h3><p>An analytic, cross-sectional study was conducted. The variables analyzed were: age, sex, oncologic diagnosis, clinical stage, diagnostic time course, treatment received, preoperative laboratory studies (Hb, leuc, Cr, BUN, urea), imaging studies (US or CAT), and the surgical attempt to place the double-J stent. A comparative analysis was done between the failed and successful placement groups. Statistical analysis was carried out using the Mann-Whitney U test and the chi-square test, and finally, the odds ratio with a 95% confidence interval was employed.</p></div><div><h3>Results</h3><p>Of the 48 patients, 27 had failed double-J stent placement and 21 had successful placement. Risk factors for failed placement were elevated preoperative levels of urea<!--> <!-->≥<!--> <!-->40<!--> <!-->mg/dL (OR: 16.67, CI: 2.66-134.92 [<em>P</em> <!-->=<!--> <!-->.0001]), creatinine ≥ 2<!--> <!-->mg/dL (OR:7.27, CI:1.41-42.25 [<em>P</em> <!-->=<!--> <!-->.004]), and BUN ≥ 40<!--> <!-->mg/dL (OR:4.00, CI: 0.93-18.06 [<em>P</em> <!-->=<!--> <!-->.031]) and a low Hb level ≤ 9<!--> <!-->mg/dL (OR:6.32, CI:1.37-21.55 [<em>P</em> <!-->=<!--> <!-->.005]), as well as a deformed trigone (OR:3.29, IC:1.18-9.19 [<em>P</em> <!-->=<!--> <!-->.002]).</p></div><div><h3>Conclusions</h3><p>Elevated preoperative levels of creatinine, urea, and BUN, and a deformed bladder trigone are markers for failed double-J stent placement.</p></div>","PeriodicalId":34909,"journal":{"name":"Revista mexicana de urologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.uromx.2015.10.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124184546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regresión de metástasis óseas en cáncer de próstata metastásico resistente a castración","authors":"R. Cortez-Betancourt ,&nbsp;M. Pelayo-Nieto ,&nbsp;E. Linden-Castro ,&nbsp;I.A. Ramírez-Galindo ,&nbsp;E.D. Rubio-Arellano ,&nbsp;R.C. Rodríguez-Alvarado ,&nbsp;A. González-Serrano ,&nbsp;J.G. Sierra-Sosa ,&nbsp;D. Espinosa-Perezgrovas ,&nbsp;J.A. Morales-Covarrubias","doi":"10.1016/j.uromx.2015.12.002","DOIUrl":"10.1016/j.uromx.2015.12.002","url":null,"abstract":"<div><h3>Introduction</h3><p>There have been significant modifications in metastatic castration-resistant prostate cancer management in the last decade, with great changes in the treatment paradigm, even though the disease will ultimately continue to progress despite the currently available treatments.</p></div><div><h3>Case report</h3><p>A 72-year-old man diagnosed with castration-resistant prostate cancer underwent a bone scintigram that identified metastatic bone lesions. He was treated with abiraterone, with clinical and biochemical response. Follow-up revealed regression of bone metastasis documented in the bone scintigram.</p></div><div><h3>Conclusions</h3><p>This clinical case shows the particularity of apparent bone lesion regression in the context of metastatic castration-resistant prostate cancer after treatment with abiraterone acetate that also showed sustained clinical and biochemical response.</p></div>","PeriodicalId":34909,"journal":{"name":"Revista mexicana de urologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.uromx.2015.12.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129787821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utilidad de la escala S.T.O.N.E. como herramienta de predicción terapéutica en cirugía intrarrenal retrógrada","authors":"I.A. Ramírez-Galindo,&nbsp;A. Alías-Melgar,&nbsp;M. Pelayo-Nieto,&nbsp;E. Linden-Castro,&nbsp;G. Rembis-Ávila,&nbsp;G. Villela-Segura,&nbsp;C. Nájar-Pini,&nbsp;R. Cortez-Betancourt","doi":"10.1016/j.uromx.2016.01.001","DOIUrl":"10.1016/j.uromx.2016.01.001","url":null,"abstract":"<div><h3>Background</h3><p>Retrograde intrarenal surgery (RIS) for the treatment of kidney stones has increased in the last few years. The S.T.O.N.E. score has been described as a reproducible tomographic evaluation tool enabling the complexity of urinary calculi to be estimated, thus establishing predictive factors for therapeutic success.</p></div><div><h3>Aim</h3><p>To determine the factors that influence the success of RIS in the treatment of kidney stones in 95 patients at a tertiary care hospital in Mexico City, in relation to the S.T.O.N.E. score calculation and the value of each of the stone variables in the corresponding preoperative tomographic study.</p></div><div><h3>Material and methods</h3><p>In a sample of 95 patients, those that were stone-free and those that presented with residual stones after a single RIS event were identified. The S.T.O.N.E. score was calculated through a preoperative tomographic evaluation. The correlation between the S.T.O.N.E. score and residual stone status was identified through the Pearson test and the individual impact of each of the stone variables was determined through the logistic regression test.</p></div><div><h3>Results</h3><p>A total of 64 patients were stone-free and 31 patients presented with significant lithiasis. Analysis of the logistic regression test revealed stone size (<em>P</em> <!-->=<!--> <!-->.0127), number (<em>P</em> <!-->=<!--> <!-->.0400), and density (<em>P</em> <!-->=<!--> <!-->.0079) as predictive factors for stone-free status.</p></div><div><h3>Conclusions</h3><p>The preoperative evaluation with the S.T.O.N.E. score is a predictive tool for RIS therapeutic success. Identification of the variables having greater therapeutic impact will enable better patient selection for RIS as surgical treatment.</p></div>","PeriodicalId":34909,"journal":{"name":"Revista mexicana de urologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.uromx.2016.01.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131938133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"¿Quimioterapia adyuvante en cáncer de pene? Más preguntas que respuestas","authors":"E.I. Bravo-Castro ,&nbsp;E.A. Linden-Castro ,&nbsp;M.A. Jiménez-Ríos","doi":"10.1016/j.uromx.2015.11.008","DOIUrl":"10.1016/j.uromx.2015.11.008","url":null,"abstract":"","PeriodicalId":34909,"journal":{"name":"Revista mexicana de urologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.uromx.2015.11.008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122143802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estudio comparativo de adenomectomía prostática laparoscópica y abierta. ¿Cuál ofrece mejores resultados?","authors":"V.M. Pérez Manzanares ,&nbsp;F. Salinas González ,&nbsp;R.A. García Vásquez ,&nbsp;J. Arriaga Aguilar ,&nbsp;M.C. Candia Plata","doi":"10.1016/j.uromx.2016.01.007","DOIUrl":"10.1016/j.uromx.2016.01.007","url":null,"abstract":"<div><h3>Background</h3><p>Standard management of benign prostatic hyperplasia in large volume adenomas is open surgery. With the advent a little over a decade ago of minimally invasive techniques for prostatic adenoma, this trend is changing.</p></div><div><h3>Aim</h3><p>Given that there are few comparative studies establishing a real difference between open and laparoscopic surgery, the aim of our study was to objectively evaluate their advantages.</p></div><div><h3>Methods</h3><p>A total of 82 patients were analyzed. They were diagnosed with benign prostatic hyperplasia and were consecutively operated upon. Twenty-four of the patients underwent laparoscopic surgery and 58 had open surgery.</p></div><div><h3>Results</h3><p>There was significant difference in relation to patient weight (&lt;0.001), which was greater in the laparoscopic adenomectomy group (LA). The two groups had similar results in regard to preoperative studies such as PSA, IPSS, prostate size, and uroflowmetry. The surgical indications were also similar and the most frequent indication was acute urinary retention. Surgery duration was longer in the LA group with statistical significance (127.2 vs. 90.9<!--> <!-->min; <em>P</em>≤0.001) and intraoperative blood loss and transfusions were significantly lower in the LA group, based on the Clavien-Dindo classification (450 vs. 738.8<!--> <!-->ml; <em>P</em>=0.009 and 0.45 vs. 0.25; <em>P</em>=0.039, respectively). There were no differences between the two procedures in relation to length of hospital stay, postoperative results, or complications (according to the Clavien-Dindo classification).</p></div><div><h3>Conclusions</h3><p>Both procedures had similar postoperative results and complications, but there was less blood loss and fewer transfusions with the laparoscopic procedure. Surgery duration was longer with the laparoscopic technique and there were no differences in relation to hospital stay.</p></div>","PeriodicalId":34909,"journal":{"name":"Revista mexicana de urologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.uromx.2016.01.007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123362850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acidosis tubular renal distal: diagnóstico en una unidad urológica","authors":"M.C. Cano-García ,&nbsp;M.S. Girón-Prieto ,&nbsp;M.A. Arrabal-Polo","doi":"10.1016/j.uromx.2015.12.006","DOIUrl":"10.1016/j.uromx.2015.12.006","url":null,"abstract":"","PeriodicalId":34909,"journal":{"name":"Revista mexicana de urologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.uromx.2015.12.006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130988103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}