D. Overby, Pei-Jung Wu, I. Kabakova, J. Ruberti, J. Sherwood, I. Dunlop, C. Paterson, P. Török
{"title":"Brillouin spectroscopy is insensitive to stiffness after correcting for the influence of water content in hydrogels (Conference Presentation)","authors":"D. Overby, Pei-Jung Wu, I. Kabakova, J. Ruberti, J. Sherwood, I. Dunlop, C. Paterson, P. Török","doi":"10.1117/12.2507841","DOIUrl":"https://doi.org/10.1117/12.2507841","url":null,"abstract":"","PeriodicalId":348521,"journal":{"name":"Optical Elastography and Tissue Biomechanics VI","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114816882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Matthew R. Ford, Ibrahim Seven, W. Dupps, Vinicius S. DeStefano
{"title":"In vivo measurements of normal, keratoconic, and post crosslinked keratoconic human cornea with optical coherence elastography (Conference Presentation)","authors":"Matthew R. Ford, Ibrahim Seven, W. Dupps, Vinicius S. DeStefano","doi":"10.1117/12.2507996","DOIUrl":"https://doi.org/10.1117/12.2507996","url":null,"abstract":"","PeriodicalId":348521,"journal":{"name":"Optical Elastography and Tissue Biomechanics VI","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114199704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Passive elastography: from organ to cell (Conference Presentation)","authors":"S. Catheline","doi":"10.1117/12.2516534","DOIUrl":"https://doi.org/10.1117/12.2516534","url":null,"abstract":"Elastography, sometimes referred as seismology of the human body, is an imaging modality recently implemented on medical ultrasound systems. It allows to measure shear waves within soft tissues and gives a tomography reconstruction of the shear elasticity. This elasticity map is useful for early cancer detection. A general overview of this field is given in the first part of the presentation as well as latest developments. The second part, is devoted to the application of time reversal or noise correlation technique in the field of elastography. The idea, as in seismology, is to take advantage of shear waves naturally present in the human body due to muscles activities to construct shear elasticity map of soft tissues. It is thus a passive elastography approach since no shear wave sources are used. In the third part some examples are provided using ultrasounds, MRI or optic to detect shear waves and reconstruct a speed tomography in a human liver, thyroid, brain, in a mouse eye and a single cell.","PeriodicalId":348521,"journal":{"name":"Optical Elastography and Tissue Biomechanics VI","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127088393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Brecken J. Blackburn, M. Motavalli, Matthew R. Ford, J. Welter, J. Mansour, A. Rollins
{"title":"Ex vivo measurement of biaxial strain distribution in articular cartilage with optical coherence tomography\u0000 (Conference Presentation)","authors":"Brecken J. Blackburn, M. Motavalli, Matthew R. Ford, J. Welter, J. Mansour, A. Rollins","doi":"10.1117/12.2509681","DOIUrl":"https://doi.org/10.1117/12.2509681","url":null,"abstract":"Introduction: Optical coherence tomography (OCT) is a high-resolution imaging modality which can be used to acquire detailed elastograms of biological tissue. In this investigation, we demonstrate the use of OCT to generate µm-scale strain maps of articular cartilage (AC) under compressive and shear deformations. AC is a dense connective tissue which provides a low-friction surface in synovial joints. The specific alignment of collagen fibrils and proteoglycans (which contribute primarily to shear and compressive stiffness, respectively) give rise to depth-dependent mechanical properties. \u0000\u0000Methods: Six 6mm diameter samples of articular cartilage were harvested from a calf femur. A custom-designed biaxial loading apparatus applied compressive and shear displacements. Three-dimensional images of the tissue were obtained using a spectral-domain OCT system as the sample was loaded at constant rate of displacement. Both speckle-tracking and phase-shift methods were used to generate strain maps from these images. \u0000\u0000Results: Under both shear and compressive loading, clear differences in local strain distribution were observed between the superficial, transitional, and radial zones of the cartilage. In shear, the superficial/transitional zones are stiffest while in compression these regions are more compliant than the radial zone. These distributions correspond with existing literature and the known orientation of collagen in the AC. \u0000\u0000Conclusion: It is feasible to rapidly acquire strain maps in AC using OCT. This technique may be extended to high-throughput screening to nondestructively determine the functionality and failure modes of engineered AC as compared to native tissue.","PeriodicalId":348521,"journal":{"name":"Optical Elastography and Tissue Biomechanics VI","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129832983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}