SVU International Journal of Medical Sciences最新文献_第6页

Safety and Efficacy of Ombitasvir, Paritaprevirand Ritonavir Combination with Ribavirin for Treatment of Chronic Hepatitis C Virus in Advanced Kidney Diseases Patients in Upper Egypt Ombitasvir、paritaprevir和Ritonavir联合利巴韦林治疗上埃及晚期肾病患者慢性丙型肝炎病毒的安全性和有效性

SVU International Journal of Medical Sciences Pub Date : 2023-01-01 DOI: 10.21608/svuijm.2022.149784.1340

H. Mahmoud, M. Alemam, Z. Ahmed, H. Osman

{"title":"Safety and Efficacy of Ombitasvir, Paritaprevirand Ritonavir Combination with Ribavirin for Treatment of Chronic Hepatitis C Virus in Advanced Kidney Diseases Patients in Upper Egypt","authors":"H. Mahmoud, M. Alemam, Z. Ahmed, H. Osman","doi":"10.21608/svuijm.2022.149784.1340","DOIUrl":"https://doi.org/10.21608/svuijm.2022.149784.1340","url":null,"abstract":"Background: Formerly, treating hepatitis C virus (HCV) infection in individuals suffering from chronic renal disease was challenging due to the toxicity of interferon (IFN). Ombitasvir, paritaprevir, and ritonavir are examples of safe and effective pan-genotypic direct-acting antiviral (DAA) regimens that make it easier for individuals with chronic kidney disease to treat their hepatitis C virus (HCV). Objectives: To assess the effectiveness and safety of Omibtasvir, paritaprevir, and ritonavir when used in conjunction with Ribavirin for the treatment of hepatitis C patients who have end-stage kidney disease. Patients and methods: 100 individuals with severe renal illnesses and chronic hepatitis C virus were included in this cross-sectional investigation. The estimated glomerular filtration rate (eGFR) was calculated after each patient underwent a thorough medical history, physical examination, and laboratory testing that included a complete blood count, ALT, AST, and kidney function tests. Fibroscan and pelvic abdominal ultrasonography were carried out. The patients received ribavirin together with paritaprevir/ritonavir and ombitasvir (75/50/12.5mg) twice day for 12 weeks. Results : Sustained virologic response (SVR) was 83 % (83 patients) overall patients. Patients were divided into two groups according to sustained virologic response. Child Pugh-turcotte (CPT) score was higher in non responders when compared with responders (5.7 ± 0.4 vs 5.4 ± 0.4; P-value = 0.002). Regarding to Safety and tolerability of DAAs, no severe adverse events were reported during the present study with no discontinuing treatment due to adverse events. The most frequent adverse events were anemia, headache, pruritus, anorexia and malaise. Conclusion : OBV/PTV/RTV plus Ribavirin can be used in treatment of chronic HCV patients with ESRD with high virologic response and highly safety profile.","PeriodicalId":34789,"journal":{"name":"SVU International Journal of Medical Sciences","volume":"os-48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87247286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

To compare the Fetomaternal outcome of natural birth versus induced birth after previous one caesarean section: A prospective Observational study 比较前一次剖宫产后自然分娩与引产的胎母结局:一项前瞻性观察研究

SVU International Journal of Medical Sciences Pub Date : 2023-01-01 DOI: 10.21608/svuijm.2023.192946.1520

M. Chauhan, S. Gautam, Sunita Kumari, Anjali Gupta, S. Nanda

引用次数: 0

Spinal Anesthesia and Minimal Tissue Trauma Improve the Outcome of Elective Cesarean Section 脊髓麻醉和最小组织损伤可改善择期剖宫产的预后

SVU International Journal of Medical Sciences Pub Date : 2023-01-01 DOI: 10.21608/svuijm.2022.175551.1451

Mohamed Khashaba, Adel F. Al-Kholy, S. Salman

{"title":"Spinal Anesthesia and Minimal Tissue Trauma Improve the Outcome of Elective Cesarean Section","authors":"Mohamed Khashaba, Adel F. Al-Kholy, S. Salman","doi":"10.21608/svuijm.2022.175551.1451","DOIUrl":"https://doi.org/10.21608/svuijm.2022.175551.1451","url":null,"abstract":"Background: Immune balance is mandatory for proper postoperative (PO) courses and wound healing. Cesarean section is the commonest surgical procedure for females. The choice of anesthetic procedure may affect the mother and fetal outcomes. Objectives: Evaluation of the impact of general (GA) versus spinal anesthesia (SA) on parturient' cytokines' serum levels. Patients and methods: 73 and 59 parturients received GA and SA, respectively. Fetal APGAR scoring was determined at 1-min & 5-min PO. PO pain severity was evaluated using the numeric rating scale and the duration of analgesia was calculated. Blood samples (S1, S2, S3) were obtained for ELISA estimation of serum interleukins and tumor necrosis factor- α (TNF - α). The study outcome is the effect of the anesthetic procedure on serum cytokines levels. Results: Cytokines' levels were significantly higher in S2 and S3 than in S1 samples of all parturients with significantly higher levels in samples of GA patients. Percentages of change in serum cytokines' levels were higher with GA than with SA. Receiver operating characteristic (ROC) curve defined serum levels of TNF- α as the most cytokine affected by the anesthetic procedure. APGAR scores were significantly higher at 1-min and the duration of PO analgesia was significantly longer with SA. Conclusion: SA can lessen the surgery-induced release of inflammatory cytokines, while GA augments this effect. Moreover, neonatal and maternal outcomes were superior with SA than with GA.","PeriodicalId":34789,"journal":{"name":"SVU International Journal of Medical Sciences","volume":"62 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86880316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endometrioma Cystic Fluid Aspiration and Retained Ethanol Sclerotherapy might improve the systemic Immune Milieu 子宫内膜瘤囊性液体抽吸和保留乙醇硬化疗法可能改善全身免疫环境

SVU International Journal of Medical Sciences Pub Date : 2023-01-01 DOI: 10.21608/svuijm.2023.185178.1485

A. Hagras, M. Hagras, Amr Sharafeldeen

引用次数: 0

Skull Penetrating Stone due to falling from height: A Case Report 从高处坠落致颅骨穿石1例

SVU International Journal of Medical Sciences Pub Date : 2023-01-01 DOI: 10.21608/svuijm.2022.167431.1430

Ahmad Mokhtar Abodahab, Ebtsam Ahmed Mohammed Abdelbary

{"title":"Skull Penetrating Stone due to falling from height: A Case Report","authors":"Ahmad Mokhtar Abodahab, Ebtsam Ahmed Mohammed Abdelbary","doi":"10.21608/svuijm.2022.167431.1430","DOIUrl":"https://doi.org/10.21608/svuijm.2022.167431.1430","url":null,"abstract":": Background: Falling from height is a common condition that can occur in different age groups. Many types of injuries can occur due to it, such as skull fractures. Skull penetrating foreign bodies (other than fire arm injuries and explosives) are generally uncommon. Penetrating blunt objects is rare. CT is a useful modality in diagnosis of head trauma in general and in diagnosis of penetrating foreign bodies especially. Unlike magnetic resonance imaging which is useful in special cases of head trauma with a penetrating foreign body. Case Report: We present a case in which a child presented at Sohag University hospital with falling from a height less than 2 meters causing penetration of the frontal bone of the skull by a stone on the land, which is a very rare presentation. The patient presented with scalp bleeding, post-concussion and disturbed conscious level. Vital signs were normal. A Computed Tomography scan (Multislice CT – 8 slices) of the skull was done with 3D reformatted images. Conclusion: Head trauma from penetrating objects (other than knife stapes or fire arm injuries) is uncommon. Blunt object penetration is very uncommon. It can be serious or even fatal. CT is the best imaging modality for diagnosis of such lesions. Metallic artifacts can be a limitation of their role. Although the finding is almost diagnostic, still the history and clinical finding is the key for diagnosis as the shape and density of the stone in some sections could be similar to ivory osteoma.","PeriodicalId":34789,"journal":{"name":"SVU International Journal of Medical Sciences","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82387569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Wet Cupping Therapy on reducing blood pressure in primary hypertensive patients: A preliminary study 湿罐疗法对原发性高血压患者降压效果的初步研究

SVU International Journal of Medical Sciences Pub Date : 2023-01-01 DOI: 10.21608/svuijm.2022.175851.1453

A. M. Hassan, S. Kamel, A. Torad, Amgad Hazzaa, A. Salama

引用次数: 1

Role of Minerals in Childhood Epilepsy 矿物质在儿童癫痫中的作用

SVU International Journal of Medical Sciences Pub Date : 2023-01-01 DOI: 10.21608/svuijm.2022.156081.1378

Khaled Abdallah Abdelbasir, M. H. Hassan, Mahmoud Hasan Mahmoud, Ali Helmi Bakry

{"title":"Role of Minerals in Childhood Epilepsy","authors":"Khaled Abdallah Abdelbasir, M. H. Hassan, Mahmoud Hasan Mahmoud, Ali Helmi Bakry","doi":"10.21608/svuijm.2022.156081.1378","DOIUrl":"https://doi.org/10.21608/svuijm.2022.156081.1378","url":null,"abstract":"Background: The cornerstone of brain activity is changes in membrane voltage caused by ion fluxes through voltage and transmitter-gated channels. Therefore, electrochemical gradients across the membrane determine the direction and driving force for ion flow, which in turn establishes synaptic transmission and signal propagation parameters.Numerous methods create ion concentration gradients and specialised transporter proteins are among them. However, ionic fluxes via channels can alter transmembrane gradients during times of increased brain activity, which is projected to have an impact on the characteristics of ongoing synaptic transmission. Both healthy and unhealthy brain processes involve activity-induced alterations to ion concentration gradients. Patients with epilepsy display a variety of altered trace elements, electrolytes, and free radical scavenging enzyme statuses. Minerals play an important role in regulating ion concentration gradients through their various biological actions. Objectives: This review would contribute in increasing understanding of the role of minerals in childhood epilepsy and the different mechanisms by which different types of minerals modulate seizures in children. Conclusion: The serum level of various trace elements and heavy metals influences the impact of epilepsy. In infantile epilepsy, high calcium concentrations in epileptic neurons remain elevated during both the acute damage and chronic epilepsy phases, and they play a role in the maintenance of spontaneous recurrent seizures.","PeriodicalId":34789,"journal":{"name":"SVU International Journal of Medical Sciences","volume":"64 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80902996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Evolving phenotype of systemic lupus erythematosus patients and correlation with antibody against c1q: A review article 系统性红斑狼疮患者表型的演变及其与c1q抗体的相关性综述

SVU International Journal of Medical Sciences Pub Date : 2023-01-01 DOI: 10.21608/svuijm.2022.158094.1392

K. M. Zaki, M. Abdelkareem, W. Abady, A. Nafady, Zeinab Abd El Razek El Tieb

引用次数: 0

Ultra-sound guided supraclavicular brachial plexus block: The value of adjuvants: Review article 超声引导锁骨上臂丛阻滞:佐剂的价值:综述文章

SVU International Journal of Medical Sciences Pub Date : 2023-01-01 DOI: 10.21608/svuijm.2022.159934.1399

Ahmed Ismail Abdel Azeem, H. Mohamed, Salah Mostafa Asida, Mohammed Abdalrahman Soliman Ahmed

{"title":"Ultra-sound guided supraclavicular brachial plexus block: The value of adjuvants: Review article","authors":"Ahmed Ismail Abdel Azeem, H. Mohamed, Salah Mostafa Asida, Mohammed Abdalrahman Soliman Ahmed","doi":"10.21608/svuijm.2022.159934.1399","DOIUrl":"https://doi.org/10.21608/svuijm.2022.159934.1399","url":null,"abstract":"Background: Upper limb surgeries are frequently performed using peripheral nerve blocks, like ultra-sound guided supraclavicular brachial plexus block, which provides safe and effective anaesthesia. Search for safe and effective adjuvants to regional nerve blocks continues, with medication that increases the duration of analgesia although it has fewer side effects. Using of drugs as dexmedetomidine, opioids, ketamine, clonidine, midazolam, epinephrine, neostigmine, magnesium sulphate and dexamethasone along with local anaesthetics for this aim with different degrees of success. Objectives: This review research investigated safety and efficacy of various additives, namely dexmedetomidine, ketamine, fentanyl, and dexamethasone, when added to bupivacaine in ultrasound guided supraclavicular brachial plexus block in order to evaluate onset and duration of sensory and motor block, estimate sedation score, pain scale and total analgesic consumption and to investigate side effects when added to bupivacaine. Conclusion: This research implies that there is still to research about the of effect of different adjuvants added to bupivacaine in ultra-sound guided supraclavicular brachial plexus block.","PeriodicalId":34789,"journal":{"name":"SVU International Journal of Medical Sciences","volume":"185 1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81051816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Is the Oxidative DNA Damage Level of Human Lens Epithelial Cells Correlated with the Total Antioxidant Capacity (TAC) in Aqueous Extract of HLECs in Senile Cataract Patients? 老年性白内障患者晶状体上皮细胞DNA氧化损伤水平与总抗氧化能力(TAC)是否相关?

SVU International Journal of Medical Sciences Pub Date : 2023-01-01 DOI: 10.21608/svuijm.2022.165788.1422

Kranti S. Sorte Gawali, Avinash Jadhao, Manoj C. Lokhnade

{"title":"Is the Oxidative DNA Damage Level of Human Lens Epithelial Cells Correlated with the Total Antioxidant Capacity (TAC) in Aqueous Extract of HLECs in Senile Cataract Patients?","authors":"Kranti S. Sorte Gawali, Avinash Jadhao, Manoj C. Lokhnade","doi":"10.21608/svuijm.2022.165788.1422","DOIUrl":"https://doi.org/10.21608/svuijm.2022.165788.1422","url":null,"abstract":"Background: Various experimental evidence suggests that in cataract pathogenesis oxidative stress plays an important role in causing DNA damage, but there is still a lack of data on in vivo assessment of DNA damage and the role of antioxidants. Objectives: To measure the percentage of DNA damage and the total antioxidant capacity (TAC) of patients with cataracts directly in human lens epithelial cells and compare these with a control group followed by whether there is any statistical correlation between oxidative DNA damage and total antioxidant status in senile cataract patients. Patients and methods: A total number of capsulorhexis from thirty senile cataract cases aged 50-80 years, who were admitted to the ophthalmology ward of AVBRH for cataract surgery, were used for in vitro assessment of DNA damage in human lens epithelial cells by Comet assay and TAC assays. 12 controls were collected from healthy cadavers who or their relatives donated their eyes for TAC assays. Results : Oxidative DNA damage level of human lens epithelial cells is not correlated with the TAC in aqueous extract of HLECs in senile cataract patients . Conclusion: The conclusion in the present study should not be taken that supplementing antioxidants through diet has no role in the prevention of oxidative DNA damage against oxidants. There may be another mechanism may be responsible for oxidative DNA damage.","PeriodicalId":34789,"journal":{"name":"SVU International Journal of Medical Sciences","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78482184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0