Journal of Korean Society of Pediatric Endocrinology最新文献_第3页

Evaluation of Growth Status Using Serum IGF-I and IGFBP-3 in Children with Subclinical Hypothyroidism 应用血清igf - 1和IGFBP-3评价亚临床甲状腺功能减退症患儿的生长状况

Journal of Korean Society of Pediatric Endocrinology Pub Date : 2011-04-01 DOI: 10.6065/JKSPE.2011.16.1.31

J. Bae, B. Kwak, Sochung Chung

{"title":"Evaluation of Growth Status Using Serum IGF-I and IGFBP-3 in Children with Subclinical Hypothyroidism","authors":"J. Bae, B. Kwak, Sochung Chung","doi":"10.6065/JKSPE.2011.16.1.31","DOIUrl":"https://doi.org/10.6065/JKSPE.2011.16.1.31","url":null,"abstract":"Purpose : The aim of this study was to evaluate growth status using the insulin-like growth factor-I (IGF-I) and IGF-binding protein-3 (IGFBP-3) concentrations in children with subclinical hypothyroidism (SCH). Methods : The study included 93 SCH patients (33 males and 60 females, age 8.1±1.9 years) and 94 healthy control subjects (31 males and 63 females, age 8.0±0.7 years). Patients’ height and weight were measured, and their body mass index (BMI) and Z-scores were calculated. The relationship between growth parameters, including IGF-I and IGFBP-3 concentrations and thyroid functions (thyroid-stimulating hormone (TSH) and free thyroxine 4 (fT4) was explored. Results : Although weight and BMI were greater in SCH patients, the Z-score of height, weight and BMI, and serum IGF-I and IGFBP-3 levels in SCH children were not significantly different compared to the control. In SCH patients, TSH showed a negative correlation with weight Z-scores (r =-0.23, P =0.028) and BMI Z-scores (r =-0.21, P =0.048). FT4 showed a positive correlation with IGFBP-3. Conclusion : The positive correlation of fT4 and IGFBP-3 and the negative relationship between TSH and weight and BMI Z-scores in SCH children suggest that subnormal thyroid functions could be related to growth impairment. (J Korean Soc Pediatr Endocrinol 2011;16:31-37)","PeriodicalId":346664,"journal":{"name":"Journal of Korean Society of Pediatric Endocrinology","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116671754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of Cytokines in Sera from Type 1 Diabetic Patients at Diagnosis 1型糖尿病患者诊断时血清细胞因子分析

Journal of Korean Society of Pediatric Endocrinology Pub Date : 2011-04-01 DOI: 10.6065/JKSPE.2011.16.1.13

I. Yoon, C. Shin, S. Yang

引用次数: 0

A Familial Case of Kallmann Syndrome due to KAL1 Gene Complete Deletion 家族性KAL1基因完全缺失致Kallmann综合征1例

Journal of Korean Society of Pediatric Endocrinology Pub Date : 2011-04-01 DOI: 10.6065/JKSPE.2011.16.1.61

S. H. Lee, Seong Woo Han, Gu-Hwan Kim, H. Yoo, W. Chung

{"title":"A Familial Case of Kallmann Syndrome due to KAL1 Gene Complete Deletion","authors":"S. H. Lee, Seong Woo Han, Gu-Hwan Kim, H. Yoo, W. Chung","doi":"10.6065/JKSPE.2011.16.1.61","DOIUrl":"https://doi.org/10.6065/JKSPE.2011.16.1.61","url":null,"abstract":"Kallmann syndrome (KS) is characterized by the association of hypogonadotropic hypogonadism and anosmia. Although the vast majority of KS cases are sporadic, some X-linked recessive (KAL1), autosomal dominant (FGFR1), and autosomal recessive (most commonly GNRHR) modes of inheritance have been described. Two boys were referred to our department because of cryptorchidism and the absence of puberty. Upon laboratory evaluation they were diagnosed with hypogonadotropic hypogonadism. Agenesis of the olfactory bulbs was detected in radiologic tests, and total deletion of the KAL1 gene was detected through multiplex ligation-dependent probe amplification (MLPA). Although cryptorchidism was diagnosed in the siblings, only the older brother suffered from sensorineural hearing loss and right renal agenesis, a feature that had been reported in X-linked KS. We describe herein the clinical heterogeneity of two affected brothers who carry a complete deletion in KAL1; this is the first case of familial Kallmann syndrome due to the complete deletion of the KAL1 gene reported in Korea. (J Korean Soc Pediatr Endocrinol 2011;16:61-65)","PeriodicalId":346664,"journal":{"name":"Journal of Korean Society of Pediatric Endocrinology","volume":"449 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116433178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reassessment of GH Status and GH Therapy in Adults with Childhood-onset GHD: Transitional Care from Adolescence to Adulthood 儿童期GHD患者的生长激素状态和生长激素治疗的重新评估:从青春期到成年期的过渡护理

Journal of Korean Society of Pediatric Endocrinology Pub Date : 2011-04-01 DOI: 10.6065/JKSPE.2011.16.1.1

Jin-Ho Choi, H. Yoo

引用次数: 1

Drug Delivery Systems - associated with Pediatric Endocrinology 药物输送系统-与儿科内分泌学相关

Journal of Korean Society of Pediatric Endocrinology Pub Date : 2011-04-01 DOI: 10.6065/JKSPE.2011.16.1.7

Ji-Eun Lee

引用次数: 5

A Case of Idiopathic Infantile Hypercalcemia Treated with Intravenous Pamidronate Infusion 静脉滴注帕米膦酸钠治疗特发性婴儿高钙血症1例

Journal of Korean Society of Pediatric Endocrinology Pub Date : 2011-04-01 DOI: 10.6065/JKSPE.2011.16.1.51

Jiyun Park, I. Seong, Jeesuk Yu

引用次数: 0

A Case of Turner Syndrome Associated with Idiopathic Central Diabetes Insipidus 特纳综合征合并特发性中枢性尿崩症1例

Journal of Korean Society of Pediatric Endocrinology Pub Date : 2011-04-01 DOI: 10.6065/JKSPE.2011.16.1.56

Ben Kang, Hyeoun U Sung, Bok Ki Kim, Sin Young Park, S. Kim, Y. Kwon, M. Lim, Ji-Eun Lee

引用次数: 2

Serum IGF-1 and IGFBP-3 Levels in Central Precocious Puberty Girls Treated with Gonadotropin Releasing Hormone Agonist (GnRHa) 促性腺激素释放激素激动剂(GnRHa)治疗中枢性性性早熟女童血清IGF-1和IGFBP-3水平

Journal of Korean Society of Pediatric Endocrinology Pub Date : 2011-04-01 DOI: 10.6065/JKSPE.2011.16.1.20

K. Yi

{"title":"Serum IGF-1 and IGFBP-3 Levels in Central Precocious Puberty Girls Treated with Gonadotropin Releasing Hormone Agonist (GnRHa)","authors":"K. Yi","doi":"10.6065/JKSPE.2011.16.1.20","DOIUrl":"https://doi.org/10.6065/JKSPE.2011.16.1.20","url":null,"abstract":"Purpose : The purpose of this test was to investigate the changes of serum IGF-1 and IGFBP-3 levels during a one-year gonadotropin releasing hormone agonist (GnRHa) treatment in central precocious puberty (CPP) girls. Methods : From 2007 to 2009, 26 girls were enrolled in this study. They were diagnosed as having central precocious puberty and were treated with GnRHa (leuprolide actete) for one year. Their height, bone age, and serum IGF-1 and IGFBP-3 levels were evaluated every six months. Results : At the time of diagnosis, their mean serum IGF-1 and IGFBP-3 levels were 302.90±102.54 ng/mL and 3,103.58±705.08 ng/mL, respectively. At six month after treatment, the serum IGF-1 and IGFBP-3 levels were slightly decreased. One year later, IGF-1 concentrations were higher than before treatment and IGFBP-3 levels were lower (P =NS). This result, however, was not statistically significant. Conclusion : Gonadal suppression with gonadotropin releasing hormones inversely influenced circulating IGF-1 and IGFBP-3 levels. However, the serum IGF-1 and IGFBP-3 levels were maintained at relatively steady levels, preserving a normal height velocity. (J Korean Soc Pediatr Endocrinol 2011;16:20-23)","PeriodicalId":346664,"journal":{"name":"Journal of Korean Society of Pediatric Endocrinology","volume":"276 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124034400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Genetic Variations of GNRH1, GNRHR and GPR54 Genes in Korean Girls with Central Precocious Puberty 韩国中枢性性早熟女孩GNRH1、GNRHR和GPR54基因的遗传变异

Journal of Korean Society of Pediatric Endocrinology Pub Date : 2011-04-01 DOI: 10.6065/JKSPE.2011.16.1.38

J. Ko, Hae-sang Lee, Hyo Sung Lee, J. Hwang

{"title":"Genetic Variations of GNRH1, GNRHR and GPR54 Genes in Korean Girls with Central Precocious Puberty","authors":"J. Ko, Hae-sang Lee, Hyo Sung Lee, J. Hwang","doi":"10.6065/JKSPE.2011.16.1.38","DOIUrl":"https://doi.org/10.6065/JKSPE.2011.16.1.38","url":null,"abstract":"Purpose: Central precocious puberty (CPP) is defined as any sign of secondary sexual maturation appears at an age lower than two standard deviations of the mean for the average age. This process is driven by activation of hypothalamic gonadotropin releasing hormone (GnRH) secretion. Many genes expressed in the hypothalamus have been identified to play an important role in the onset and the progression of puberty. In this study, the GNRH1, its receptor (GNRHR), and kisspeptin receptor (GPR54) genes were scanned to investigate sequence alterations and their distribution in Korean girls with CPP. Methods: One hundred and one Korean girls with CPP were recruited as the case group and 51 normal Korean women as the control group. The DNAs were extracted and amplified by polymerase chain reaction (PCR), and the products were sequenced directly. Statistical analyses were performed, and P values of ˂ 0.05 were considered significant. Results: Four polymorphisms were identified; however, no pathological mutation was found. Two of the polymorphisms were previously reported, c.47G ˃ C in GNRH1, and c.1091T ˃ A in GPR54. However, the other two (c.196C ˃ T in GNRH1 and c.546T ˃ C in GNRHR) were novel. There was no polymorphism that was significantly associated with early onset or rapid progression of puberty. Conclusion: Although the size of our study population was relatively small, simple genetic variations in GNRH1, GNRHR, and GPR54 genes are not likely to be a substantial factor directly associated with the onset and progression of puberty. (J Korean Soc Pediatr Endocrinol 2011;16:38-45)","PeriodicalId":346664,"journal":{"name":"Journal of Korean Society of Pediatric Endocrinology","volume":"254 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115859149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

The Effect of IGFBP-3 on Adipokines and Gene Expression in Differentiated 3T3-L1 Adipocytes IGFBP-3对分化3T3-L1脂肪细胞中脂肪因子及基因表达的影响

Journal of Korean Society of Pediatric Endocrinology Pub Date : 2011-04-01 DOI: 10.6065/JKSPE.2011.16.1.24

H. Kim

引用次数: 1