{"title":"1型糖尿病患者诊断时血清细胞因子分析","authors":"I. Yoon, C. Shin, S. Yang","doi":"10.6065/JKSPE.2011.16.1.13","DOIUrl":null,"url":null,"abstract":"Results: Patients showed significantly higher levels of IL-1β (P ˂ 0.01), IL-10 (P ˂ 0.01), and TNF-α (P =0 .019), than the healthy controls. In 12 of 35 patients, the insulin autoantibody (IAA) was positive (34%) and the level of IAA was correlated with IL-10 (r = 0.454, P = 0.006), and TNF-α (r = 0.368, P = 0.030). Conclusion: These results suggest that IL-1β, TNF-α, and IL-10 play a role in the pathogenesis of T1DM, and the level of the IAA is correlated with IL-10 and TNF-α. (J Korean Soc Pediatr Endocrinol 2011;16:13-19)","PeriodicalId":346664,"journal":{"name":"Journal of Korean Society of Pediatric Endocrinology","volume":"85 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2011-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Analysis of Cytokines in Sera from Type 1 Diabetic Patients at Diagnosis\",\"authors\":\"I. Yoon, C. Shin, S. Yang\",\"doi\":\"10.6065/JKSPE.2011.16.1.13\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Results: Patients showed significantly higher levels of IL-1β (P ˂ 0.01), IL-10 (P ˂ 0.01), and TNF-α (P =0 .019), than the healthy controls. In 12 of 35 patients, the insulin autoantibody (IAA) was positive (34%) and the level of IAA was correlated with IL-10 (r = 0.454, P = 0.006), and TNF-α (r = 0.368, P = 0.030). Conclusion: These results suggest that IL-1β, TNF-α, and IL-10 play a role in the pathogenesis of T1DM, and the level of the IAA is correlated with IL-10 and TNF-α. (J Korean Soc Pediatr Endocrinol 2011;16:13-19)\",\"PeriodicalId\":346664,\"journal\":{\"name\":\"Journal of Korean Society of Pediatric Endocrinology\",\"volume\":\"85 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2011-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Korean Society of Pediatric Endocrinology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.6065/JKSPE.2011.16.1.13\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Korean Society of Pediatric Endocrinology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.6065/JKSPE.2011.16.1.13","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
结果:患者IL-1β (P小于0.01)、IL-10 (P小于0.01)、TNF-α (P = 0.019)水平明显高于健康对照组。35例患者中12例胰岛素自身抗体(IAA)阳性(34%)，IAA水平与IL-10 (r = 0.454, P = 0.006)、TNF-α (r = 0.368, P = 0.030)相关。结论:提示IL-1β、TNF-α、IL-10参与了T1DM的发病机制，IAA水平与IL-10、TNF-α水平相关。(韩国社会儿科内分泌杂志2011;16:13-19)
Analysis of Cytokines in Sera from Type 1 Diabetic Patients at Diagnosis
Results: Patients showed significantly higher levels of IL-1β (P ˂ 0.01), IL-10 (P ˂ 0.01), and TNF-α (P =0 .019), than the healthy controls. In 12 of 35 patients, the insulin autoantibody (IAA) was positive (34%) and the level of IAA was correlated with IL-10 (r = 0.454, P = 0.006), and TNF-α (r = 0.368, P = 0.030). Conclusion: These results suggest that IL-1β, TNF-α, and IL-10 play a role in the pathogenesis of T1DM, and the level of the IAA is correlated with IL-10 and TNF-α. (J Korean Soc Pediatr Endocrinol 2011;16:13-19)
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
