Timisoara Medical Journal最新文献_第4页

Metabolomics in Chronic Kidney Diseases: Here to Stay 代谢组学在慢性肾脏疾病:在这里停留

Timisoara Medical Journal Pub Date : 2021-02-01 DOI: 10.35995/TMJ20200208

Mihaela Patruica, F. Gadalean, A. Vlad, A. Sturza, D. Jianu, Lavinia Balint, Silvia Ienciu, L. Petrica, D. Muntean, C. Socaciu

{"title":"Metabolomics in Chronic Kidney Diseases: Here to Stay","authors":"Mihaela Patruica, F. Gadalean, A. Vlad, A. Sturza, D. Jianu, Lavinia Balint, Silvia Ienciu, L. Petrica, D. Muntean, C. Socaciu","doi":"10.35995/TMJ20200208","DOIUrl":"https://doi.org/10.35995/TMJ20200208","url":null,"abstract":"Chronic kidney disease (CKD) affects around 13% of the adult population, has become a considerable concern worldwide, and is characterized by inadequate renal clearance, resulting in the accumulation of various potential toxic compounds. Metabolomics, one of the many important parts of “omics” science, refers to the systematic study of metabolites in a living system and their changes because of pathophysiological and genetic modifications. The use of metabolomics in the nephrology field of research has offered a better understanding of the pathomechanisms of CKD. The most recent technologies used for the evaluation of plasma and urinary metabolites are nuclear magnetic resonance (NMR) and mass spectroscopy (MS). A major research direction of modern medicine is to develop new therapies and new biomarkers for the early diagnosis of patients with CKD. Experimental studies of renal metabolism unequivocally demonstrated that kidney function has a huge impact on several circulating metabolites. Moreover, metabolites themselves appear to have an essential role in CKD pathogenesis/complications, being recognized as potential biomarkers with prognostic, diagnostic, and therapeutic value for the disease. The present paper provides a bird’s eye view on metabolomics and a summary of the most recent studies of metabolomics carried out in patients with CKD.","PeriodicalId":34611,"journal":{"name":"Timisoara Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76197848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ring-Modified Triterpene Derivatives as Potential Pharmacological Active Compounds 环修饰三萜衍生物作为潜在的药理活性化合物

Timisoara Medical Journal Pub Date : 2021-02-01 DOI: 10.35995/TMJ20200207

A. Ulici, A. Milan, Marius Mioc, Roxana M. Ghiulai, Roxana Racoviceanu, Codruţa Şoica

引用次数: 3

Increase in Percentage of Seronegative Toxoplasma gondii and Cytomegalovirus in Pregnant Women: An Improvement in Hygienic Conditions in Certain Areas? 孕妇刚地弓形虫和巨细胞病毒血清阴性百分率上升:某些地区卫生条件改善?

Timisoara Medical Journal Pub Date : 2020-11-17 DOI: 10.35995/TMJ20200109

D. Navolan, Florin Gorun, C. Oancea, Ioana Ciohat, D. Malița, M. Craina

{"title":"Increase in Percentage of Seronegative Toxoplasma gondii and Cytomegalovirus in Pregnant Women: An Improvement in Hygienic Conditions in Certain Areas?","authors":"D. Navolan, Florin Gorun, C. Oancea, Ioana Ciohat, D. Malița, M. Craina","doi":"10.35995/TMJ20200109","DOIUrl":"https://doi.org/10.35995/TMJ20200109","url":null,"abstract":"(1) Background: Toxoplasma gondii and cytomegalovirus belong to a group of pathogens entities called TORCH agents. TORCH represents an acronym which derives from the name of a series of certain pathogenic agents (Toxoplasma gondii, Other agents, Rubella virus, Cytomegalovirus, Herpes virus). They could cross the placenta barrier and cause serious damage to the fetus if a primary infection occurs in a pregnant woman. Immunized women are relatively protected against a reinfection and the risk of a materno-fetal infection in these categories of pregnant women is considered low. (2) Aim of the study: To analyze changes in the percentage of pregnant women seronegative to Toxoplasma gondii and cytomegalovirus along a period of ten years, from 2008 to 2018. (3) Material and Methods: We studied the changes in percentage of seronegative Toxoplasma gondii and Cytomegalovirus pregnant women along two periods: 2008–2010 and 2015–2018. Only pregnant women with declared medium of provenience and unequivocal results were enrolled in the study. (4) Results: In urban areas, we found an increase in the percentage of pregnant women seronegative to Toxoplasma gondii (RR = 1.488, p < 0.0001), respectively to cytomegalovirus (RR = 1.985, p < 0.0001), from 2008–2010 to 2015–2018. A similar increasing trend was found also in rural areas: Toxoplasma gondii (RR = 1.136, p < 0.0322), respectively cytomegalovirus (RR = 1.088, p < 0.8265) but it did not reach a significant threshold for cytomegalovirus. (5) Conclusion: Our study showed that the percentage of women seronegative to Toxoplasma gondii and cytomegalovirus antibodies increases along a period of ten years, from 2008–2010 to 2015–2018, in both urban and rural areas. Probably, the main cause of this trend is represented by the improvement in hygienic condition and food quality control. These results present an argument for continuing the TORCH screening of pregnant women.","PeriodicalId":34611,"journal":{"name":"Timisoara Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90849341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Solid State Stability and Preformulation Studies for Acetylcholinesterase Inhibitor Drug Tacrine 乙酰胆碱酯酶抑制剂他克林的固体稳定性及制剂研究

Timisoara Medical Journal Pub Date : 2020-10-21 DOI: 10.35995/TMJ20200104

Denisa Cîrcioban, I. Ledeți, G. Vlase, T. Vlase, Adriana Ledeți

引用次数: 0

Association between Clinical Scores and Absence from Work after Knee Arthroscopy 膝关节镜检查后临床评分与缺勤的关系

Timisoara Medical Journal Pub Date : 2020-10-20 DOI: 10.35995/TMJ20200102

Marius Ioniţescu, R. Prejbeanu, D. Vermeşan, J. Pătrașcu, R. Onofrei, H. Haragus

{"title":"Association between Clinical Scores and Absence from Work after Knee Arthroscopy","authors":"Marius Ioniţescu, R. Prejbeanu, D. Vermeşan, J. Pătrașcu, R. Onofrei, H. Haragus","doi":"10.35995/TMJ20200102","DOIUrl":"https://doi.org/10.35995/TMJ20200102","url":null,"abstract":"(1) Background: To determine the association between patient-reported outcome measures and return to work after knee arthroscopy. (2) Material and Methods: Retrospective analysis of data on patients scheduled for knee arthroscopy in 2019 for which symptom severity was available using International Knee Documentation Committee subjective knee evaluation form (IKDC), Knee Disability And Osteoarthritis Outcome Score For Joint Replacement (KOOS JR), Tegner Lysholm scale and Euroqol EQ5D5L. Paid sick leave was retrieved from electronic patient records. (3) Results: 61 patients (mean age 46.44 ± 7.61 years, 28 (45.9%) males) met the inclusion criteria. All patients ultimately returned to work. Forty-six (75.41%) received a mean of 28.5 (range 7–68) days of paid medical leave after surgery. Of those, three patients were already on medical leave. There were no differences in demographics and clinical scores between patients who received paid sick leave and those who did not. No significant correlation was found between days of absence and clinical scores. (4) Conclusions: There was no association between absence from work and commonly used clinical scores in patients undergoing knee arthroscopy.","PeriodicalId":34611,"journal":{"name":"Timisoara Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78702562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0