One Health Risk Management最新文献

Knowledge, attitudes, and practices of parents regarding food diversification for children under 3 years old 父母关于3岁以下儿童食物多样化的知识、态度和做法

One Health Risk Management Pub Date : 2023-06-16 DOI: 10.38045/ohrm.2023.3.03

Ana ANI, Alina TIMOTIN, Oleg LOZAN

{"title":"Knowledge, attitudes, and practices of parents regarding food diversification for children under 3 years old","authors":"Ana ANI, Alina TIMOTIN, Oleg LOZAN","doi":"10.38045/ohrm.2023.3.03","DOIUrl":"https://doi.org/10.38045/ohrm.2023.3.03","url":null,"abstract":"Introduction. Children suffer the consequences of poor nutrition and improper eating practices for the rest of their lives. Every year, more than 3.4 million children under the age of 5 die due to inadequate feeding practices. Optimal nutrition decreases morbidity and mortality, reduces the risk of chronic diseases and promotes better development. Material and methods. A mixed study was conducted. Quantitative study: the survey was carried out, based on a sample of 423 adults from the Republic of Moldova, who have at least one child aged 3 years. The qualitative study involved 4 focus group meetings with different categories of participants (family doctors, paediatricians, parents) and an in-depth interview – with a representative of the Ministry of Health. Results. Aspects regarding the identification of barriers and opportunities for the development of parents’ skills in the process of diversifying the nutrition of children up to 3 years of age and the evaluation of parental knowledge, attitudes and practices were reflected. Conclusions. Although the proper nutrition for children aged 0-3 is currently being studied and argued, there are difficulties in the practical application of the diversification process, conditioned by: inadequate information of parents, lack of reliable evidence-based information sources, and the precarious socio-economic state currently existing in the country.","PeriodicalId":34509,"journal":{"name":"One Health Risk Management","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135622466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

VIOLENCE AGAINST AMBULANCE WORKERS: COMPARATIVE STUDY OF THE STATIONS OF YEREVAN AND GYUMRI. 针对救护人员的暴力:埃里温站与久姆里站的比较研究。

One Health Risk Management Pub Date : 2023-03-11 DOI: 10.38045/ohrm.2023.2.03

Meri Mkhitaryan, Artashes Tadevosyan

{"title":"VIOLENCE AGAINST AMBULANCE WORKERS: COMPARATIVE STUDY OF THE STATIONS OF YEREVAN AND GYUMRI.","authors":"Meri Mkhitaryan, Artashes Tadevosyan","doi":"10.38045/ohrm.2023.2.03","DOIUrl":"https://doi.org/10.38045/ohrm.2023.2.03","url":null,"abstract":"Introduction: According to the World Health Organization (WHO), violence is widespread in the world, about 1 million people dying from various forms of violence each year. Currently, violence in the workplace is increasing, especially in emergency department against medical personal.Purpose of the research: to study the perception of violence by medical workers in ambulance stations in the cities of Yerevan and Gyumri, to identify the types, causes and qualitative characteristics of the prevalence of violence against medical ambulance workers. Give a comparative description of the violence situation in Yerevan and Gyumri stations.Material and methods: Qualitative research was carried out among the medical staff of emergency stations of Yerevan and Gyumri cities using the in-depth interview method in 2021. The tool was the guide, the total number of participants was 61.Results: The survey found that violence against emergency workers was common: 42 out of the 61 participants reported about lifetime experience of any type of violent behavior of patients or their relatives. Among the types of violence, physical and psychological were mentioned most often.Conclusions: Violence is a common, frequent occurrence in the emergency department. Emergency medical personnel primarily perceive violence in its psychological and physical manifestations. Among the reasons are, in particular, the apparent delays of the emergency personnel, the nervous and mental overstrain of the abusers, and the use of alcohol.","PeriodicalId":34509,"journal":{"name":"One Health Risk Management","volume":"4 2","pages":"18-24"},"PeriodicalIF":0.0,"publicationDate":"2023-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10331821/pdf/nihms-1913357.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10170887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ROAD SAFETY KNOWLEDGE AND ATTITUDES AMONG DRIVERS. 驾驶员的道路安全知识和态度。

One Health Risk Management Pub Date : 2023-03-11 DOI: 10.38045/ohrm.2023.2.04

Svetlana Cociu, Olga Ioncu, Daniela Ciobanu, Serghei Cebanu

{"title":"ROAD SAFETY KNOWLEDGE AND ATTITUDES AMONG DRIVERS.","authors":"Svetlana Cociu, Olga Ioncu, Daniela Ciobanu, Serghei Cebanu","doi":"10.38045/ohrm.2023.2.04","DOIUrl":"https://doi.org/10.38045/ohrm.2023.2.04","url":null,"abstract":"Introduction: Road traffic injuries are a significant issue for society in the twenty-first century, but public health experts frequently ignore them despite the fact that massive and coor-dinated efforts are required for their effective and long-term prevention. Human factors and poor driving performance are the most significant contributors to car accidents globally, as shown by a series of studies exploring the causes of traffic road accidents. Since road safety is a key concern in developing countries, our research focuses on the car driver behavioral risk factors in the Republic of Moldova.Material and methods: A cross-sectional quantitative descriptive using a questionnaire was applied online via a Google form document among car drivers, between January-March 2022. Microsoft Excel was used for the statistical analyses.Results: The questionnaire was completed by 257 respondents above 18 years, of which 61.9% were female and 38.1% were male, mostly with a category B license (73.5%) and majority from urban area (87.5%). More than half (55.6%) mention that drove a car daily and 30% of them have a drive experience of more than ten years. Respondents express great concern (71.2%) about the issue of traffic accidents, and 76.3% think that unsafe roads are a key contributing factor. At least once being involved as a driver in road accidents where medical care was needed was mentioned by 2.7% of respondents.Conclusions: Educational programs and awareness campaigns about road safety among drivers and other vulnerable road users should be systematically organized.","PeriodicalId":34509,"journal":{"name":"One Health Risk Management","volume":"4 2","pages":"25-32"},"PeriodicalIF":0.0,"publicationDate":"2023-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10331824/pdf/nihms-1913483.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10190157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[PARENT'S KNOWLEDGE, ATTITUDES, AND PRACTICES REGARDING HOME-RELATED INJURES IN CHILDREN UNDER 5 YEARS OLD]. [父母对5岁以下儿童家庭伤害的知识、态度和做法]。

One Health Risk Management Pub Date : 2023-03-11 DOI: 10.38045/ohrm.2023.2.06

Angela Cazacu-Stratu, Svetlana Cociu, Alexandru Plamadeala, Madalina Coman

{"title":"[PARENT'S KNOWLEDGE, ATTITUDES, AND PRACTICES REGARDING HOME-RELATED INJURES IN CHILDREN UNDER 5 YEARS OLD].","authors":"Angela Cazacu-Stratu, Svetlana Cociu, Alexandru Plamadeala, Madalina Coman","doi":"10.38045/ohrm.2023.2.06","DOIUrl":"https://doi.org/10.38045/ohrm.2023.2.06","url":null,"abstract":"Introduction: Around 950,000 children and teenagers die each year as a result of injuries and violence throughout the world. The most common cause of death for children under the age of five is trauma that occurs in the home environment.Aim of the study:: To assess the knowledge, attitudes and practices of parents with children aged 0-5 years old regarding unintentional injuries among home environment.Materials and methods: Parents of children under five years old were asked to complete a survey between October and December 2021, which was distributed online via social media. The questionnaire contained 43 items and was analyzed using Microsoft Excel.Results: The questionnaire was completed by 300 parents with children up to 5 years old, mostly aged between 26-35 years old (72%), with high education (79,3%), of them 96% females, majority from urban areas (79,7%), with medium socio-economic status. Nearly 75% of respondents believe their child could get hurt at home, most commonly through an injury (42,7%), followed by ingesting foreign objects (22%). Falls were the primary cause of the majority of the child's accidents over the last year (60%) despite them being uncommon (54,7%) and infrequent (22%) in nature. Most often (54.7%), parents said that they see and hear their child all the time, but occasionally leave him for a short time. When their child suffered an injury at home, only 33,3% of parents sought medical attention.Conclusion: The results of this study will allow for a greater focus on young children's safety in the household. By identifying and emphasizing the knowledge, attitudes, and practices of parents with children 0-5 years old, we will be able to notify the necessary bodies and advise particular measures to prevent home environmental injuries.","PeriodicalId":34509,"journal":{"name":"One Health Risk Management","volume":"4 2","pages":"40-45"},"PeriodicalIF":0.0,"publicationDate":"2023-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10337692/pdf/nihms-1913481.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9816595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epidemiological features of traumatic brain injuries from a first-level trauma care national medical center in Georgia. 佐治亚州一家一级创伤护理国家医疗中心的脑外伤流行病学特征。

One Health Risk Management Pub Date : 2023-03-11 DOI: 10.38045/ohrm.2023.2.01

Nino Chikhladze, Freda Halliday, Nato Pitskhelauri, Alexander Tsiskaridze

{"title":"Epidemiological features of traumatic brain injuries from a first-level trauma care national medical center in Georgia.","authors":"Nino Chikhladze, Freda Halliday, Nato Pitskhelauri, Alexander Tsiskaridze","doi":"10.38045/ohrm.2023.2.01","DOIUrl":"10.38045/ohrm.2023.2.01","url":null,"abstract":"Introduction: Traumatic brain injuries is a significant public health issue in both developed and developing countries. In Georgia, traumatic brain injuries remains one of the leading causes of mortality and disability. Traumatic brain injuries affect families, communities and societies in Georgia and have far-reaching human, social and economic costs, manifested in increased emergency department visits, hospitalizations, disability and deaths.The aim of this study is to retrospectively analyze the epidemiological features of Traumatic Brain Injuries on the example of Medical Centre in Georgia which provides a first level trauma care for patients in the country.Materials and methods: Retrospective observational study was conducted from August 1 to October 31, 2018. The study included patients who were admitted with a Traumatic Brain Injuries diagnosis and S00-S09.0 codes (ICD 10). SPSS 20 was used for statistical analysis.Results: A total of 96 TBI-related hospitalizations were studied. 56.3% (n=54) of hospitalized patients were males. The average age of patients was 40.7 years. Furthermore, patients aged 25-44 years were more represented in the number of TBI-related hospitalizations (39.6%). 95.8% of all Traumatic brain injuries hospitalizations were as a result of unintentional injuries. Unintentional falls were shown to be the predominant mechanism of injury accounting for over half of TBI-related hospitalizations (56.2%). The second most common mechanism of injury is the road traffic injury, mostly occurring among males (63.9%).Conclusion: This study offers an insight into understanding the epidemiological features of Traumatic Brain Injuries on the example of the National Medical Center from Georgia.","PeriodicalId":34509,"journal":{"name":"One Health Risk Management","volume":"4 2","pages":"5-11"},"PeriodicalIF":0.0,"publicationDate":"2023-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10373446/pdf/nihms-1914856.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10278826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

STUDY OF DRIVER'S ATTITUDES TOWARDS ROAD SAFETY IN GEORGIA. 乔治亚州驾驶员对道路安全的态度研究。

One Health Risk Management Pub Date : 2023-03-11 DOI: 10.38045/ohrm.2023.2.07

Giorgi Chkhirodze, Nino Chkhaberidze, Nato Pitskhelauri, Giorgi Tskaroveli, Nino Chikhladze

{"title":"STUDY OF DRIVER'S ATTITUDES TOWARDS ROAD SAFETY IN GEORGIA.","authors":"Giorgi Chkhirodze, Nino Chkhaberidze, Nato Pitskhelauri, Giorgi Tskaroveli, Nino Chikhladze","doi":"10.38045/ohrm.2023.2.07","DOIUrl":"10.38045/ohrm.2023.2.07","url":null,"abstract":"Introduction: Road traffic injuries are a global public health challenges and a leading cause of death and disability. This study examines the relationships between road traffic accident involvement, driving behaviors, and drivers' attitudes towards traffic safety in Georgia.Material and methods: Behavior of 200 Georgian drivers were reported using a self-administered questionnaire. The criteria for inclusion in the study were residency of Georgia and at least one year of driving experience.Results: A total of 200 Georgian drivers were interviewed. 59% of study participants felt that the road safety had not improved at all over the past ten years. 94% of respondents were involved in a road traffic accident as a driver. 99% of male drivers and 84% of female drivers have been fined for speeding in the last three years. 95% of males and 51% of females have experienced driving under the influence of alcohol once, and 2% of males and 43% of females have never driven under the influence of alcohol.Conclusions: The study demonstrated that alcohol consumption, using mobile phones while driving and speeding are very common among drivers in Georgia.","PeriodicalId":34509,"journal":{"name":"One Health Risk Management","volume":"4 2","pages":"46-50"},"PeriodicalIF":0.0,"publicationDate":"2023-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10358184/pdf/nihms-1914841.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9911616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation between echocardiographic parameters of left ventricle and glycosylated hemoglobin in children with type 1 Diabetes Mellitus 1型糖尿病患儿左心室超声心动图参数与糖化血红蛋白的相关性

One Health Risk Management Pub Date : 2022-01-04 DOI: 10.38045/ohrm.2022.1.06

Valeriu Esanu, I. Palii

{"title":"Correlation between echocardiographic parameters of left ventricle and glycosylated hemoglobin in children with type 1 Diabetes Mellitus","authors":"Valeriu Esanu, I. Palii","doi":"10.38045/ohrm.2022.1.06","DOIUrl":"https://doi.org/10.38045/ohrm.2022.1.06","url":null,"abstract":"Introduction. Deterioration of left ventricular (LV) parameters in Diabetes Mellitus (DM) can occur in the absence of other heart problems. An association between glycosylated hemoglobin (HbA1c) and changes of the LV parameters in DM has been reported. However, data regarding this association model in children with Type 1 Diabetes Mellitus (T1DM) are limited. The purpose of the work was to investigate the association between HbA1c and the LV parameters in pediatric patients. \u0000Material and methods. The study was conducted on 28 children with T1DM ((aged 10 - 18 years, gender M (15)/F (13), duration ≥5 years). The clinical (standard medical examination) and paraclinical (biochemical dosage – HbA1c, echocardiography – LV functional and structural parameters) data was carried out. Statistical analysis used the SPSS version 20. \u0000Results. The correlational study between the HbA1c and the LV parameters revealed a statistically significant positive correlation coefficient with aortic root diameter (mm) (r=0.7**, p<0.001), left atrium (mm) (r=0.8**, p<0.001 LV diastolic diameter (mm) (r=0.7**, p<0.001), LV systolic diameter (mm) (r=0.7**, p<0.001), septal wall thickness (mm) (r=0.5*, p=0.036), posterior wall thickness (mm) (r=0.5*, p=0.032), LV diastolic volume (ml) (r=0.5*, p=0.025), LV systolic volume (ml) (r=0.6**, p=0.01), ejection fraction (%) (r=0.7**, p=0.001), fractional shortening (%) (r=0.6**, p=0.002). \u0000Conclusions. The results of the study show that in children with T1DM, the increase value of the HbA1c is associated with a consensual and proportional increase in the values of the parameters of the left ventricle. \u0000 ","PeriodicalId":34509,"journal":{"name":"One Health Risk Management","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88687417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mammal fauna of Chisinau airport, Republic of Moldova 摩尔多瓦共和国基希讷乌机场的哺乳动物群

One Health Risk Management Pub Date : 2021-12-27 DOI: 10.38045/ohrm.2022.1.07

V. Nistreanu, A. Larion

{"title":"Mammal fauna of Chisinau airport, Republic of Moldova","authors":"V. Nistreanu, A. Larion","doi":"10.38045/ohrm.2022.1.07","DOIUrl":"https://doi.org/10.38045/ohrm.2022.1.07","url":null,"abstract":"Introduction. Airport territories are large, containing a high variety of biotopes, mostly open type, and are relatively protected against intense human activity, thus creating favorable conditions for many mammal species that serve as trophic source for many bird species. \u0000Material and methods. The studies were performed during 2012-2014 on the territory of Chisinau airport and within the adjacent ecosystems. The mammals were recorded by direct observations, based on traces and trophic activity on routes ranging from 1 to 3 km. The small mammals were assessed with traps. The bat species were identified according to their flight pattern and using the ultrasound detector. \u0000Results. In the airport, 31 species of mammals were registered: 5 insectivore species, 7 bat species, 14 rodent species, 1 hare species and 4 carnivorous species. The most widespread, common and abundant were the rodents and the fox. Among small rodent species, the most abundant was Apodemus sylvaticus with 51.6%, followed by the Microtus arvalis (38.9%), while on the airport grassland, the field vole dominated with more than 60%. The diet of Athene noctua included predominantly Mus musculus with over 51%, followed by M. arvalis with 23.7%. 7 species are rare and 5 protected – bicolor shrew and 4 bat species. \u0000Conclusions. The airport territory and adjacent ecosystems provide favorable conditions for many mammal species. The presence of rodents favors the occurrence of rather high number of prey birds, which represent a threat for the safety of aircraft flights. The fox can pose direct threat to flight safety.","PeriodicalId":34509,"journal":{"name":"One Health Risk Management","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87735466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Fatty acid composition of drinking cow's milk trade networks of Kyiv 基辅贸易网络中饮用牛奶的脂肪酸组成

One Health Risk Management Pub Date : 2021-12-18 DOI: 10.38045/ohrm.2022.1.05

V. Danchuk, S. Midyk, V. Ushkalov, O. Iakubchak, I. Hryshchuk, L. Davydovska

{"title":"Fatty acid composition of drinking cow's milk trade networks of Kyiv","authors":"V. Danchuk, S. Midyk, V. Ushkalov, O. Iakubchak, I. Hryshchuk, L. Davydovska","doi":"10.38045/ohrm.2022.1.05","DOIUrl":"https://doi.org/10.38045/ohrm.2022.1.05","url":null,"abstract":"Introduction. There are several important aspects requiring a control of fatty acid composition in drinking milk distributed across the retail stores: milk is one of the main consumer products; fatty acids are the main energy substrates, involved in the synthesis of cellular structural components, whereas their interaction might impact the intensity of body growth and development; the fatty acid composition of milk varies depending on the diet and the animal's specific physiological state; in case of udder diseases, a change milk composition may occur; prevention of product counterfeiting distributed across the retail stores. \u0000Material and methods. The present research examined milk samples from five dairy producers that distribute their products across the retailing chains in Kyiv. Milk samples were collected to determine the fatty acid composition. Milk fat was extracted following the Folch method. The milk fatty acid content assessment was carried out by gas chromatography. \u0000Results. 20 fatty acids were identified in the tested milk samples. A higher level of saturated fatty acids was recorded in milk from \"Ferma\" and \"Selyanskoye for kids\" dairy producers. The highest content of unsaturated fatty acids was registered in products of “Ukrainskoe” and “Molokia” dairy trademarks. \u0000Conclusions. The fatty acid composition of the drinking cow’s milk distributed across trading networks in Kiev was found to be heterogeneous, by differing in the content of both long-chain saturated fatty acids and unsaturated fatty acids.","PeriodicalId":34509,"journal":{"name":"One Health Risk Management","volume":"94 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73567494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gold nanoparticles from magnetite for the detection of amyloid proteins in neurodegenerative diseases 来自磁铁矿的金纳米颗粒用于检测神经退行性疾病中的淀粉样蛋白

One Health Risk Management Pub Date : 2021-12-18 DOI: 10.38045/ohrm.2022.1.02

A. Ortiz, Zeyris Herrera, Johanna Moscoso

{"title":"Gold nanoparticles from magnetite for the detection of amyloid proteins in neurodegenerative diseases","authors":"A. Ortiz, Zeyris Herrera, Johanna Moscoso","doi":"10.38045/ohrm.2022.1.02","DOIUrl":"https://doi.org/10.38045/ohrm.2022.1.02","url":null,"abstract":"Introduction. Currently, neurodegenerative diseases (ND) are the fourth leading cause of death worldwide that pose a great challenge in the development of tools for early diagnosis. Thus, advances in science seek sensitive and selective detection systems and this manuscript will highlight the importance of nanotechnology. \u0000Material and methods. A literature review was conducted on the representative findings of NPs technologies in neurodegenerative diseases. Articles written in both English and Spanish were included. References between 2015-2021 were also taken into account. \u0000Results. One of the most representative techniques, AuNP was specifically implemented, together with a magnetic center composed of magnetite, which has as a specific ligand with a C-terminal cysteine domain present in the B-amyloid protein, which adhere directly to the surface of the NPs, characterizing the anomalous protein. Subsequently, by means of nanosensors capable of detecting and measuring different concentrations, these pathologies are identified at an early stage. \u0000Conclusions. Today, along with the advent of biotechnology, it has been possible to design techniques with NPs that allow the identification of specific mutations and provide diagnosis in individuals. In the investigative models of AuNP, it is possible to infer that the capabilities that make them representative focus on their magnetism and biofunctionality, by specifically binding to amyloid peptides and other ligands present in the protein, which are the major components of amyloid plaques used in these studies.","PeriodicalId":34509,"journal":{"name":"One Health Risk Management","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83635352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0