Acta Medica Lituanica最新文献

{"title":"Bioarchaeological Notes on the Commingled Human Remains Held in the Church of Saint Francis of Paola, Sant'Angelo di Brolo, Sicily, Italy.","authors":"Aurelija Kemežytė,&nbsp;Dario Piombino-Mascali","doi":"10.15388/Amed.2022.29.1.16","DOIUrl":"https://doi.org/10.15388/Amed.2022.29.1.16","url":null,"abstract":"<p><p>In this study, we examine human skeletal remains from the church of Saint Francis of Paola located in the small town of Sant'Angelo di Brolo, in the Italian region of Sicily. The preserved skeletal remains were temporarily transferred from their permanent resting place in the crypt for a macroscopic examination and evaluation. Various established methods were used to estimate age at death, sex, stature, any evidence of disease(s) as well as the fact that there was a minimum of 15 individuals. The findings were then subdivided into different groups of pathologies and recorded as individual cases. Amongst which, dental issues and cases of trauma were most prevalent. Additional conditions such as joint disease, congenital, metabolic and multifactorial disorders were also identified. The prevalence of dental decay indicates that the group's diet consisted largely of carbohydrates, and that their oral hygiene was poor. Furthermore, evidence of trauma and poor healing suggested that the town was isolated from the main medical centres of the island. Severe complications of traumas linked with a loss of movement and overall independence, as well as physical pain, must have had a significant impact on the lives of those affected.</p>","PeriodicalId":34365,"journal":{"name":"Acta Medica Lituanica","volume":"29 1","pages":"100-115"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9428651/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40351320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Exploratory Study of the Differences in Attitudes and Motives Regarding COVID-19 Plasma Donation.","authors":"Ashish Maheshwari,&nbsp;Mohit Varshney,&nbsp;Meenu Bajpai,&nbsp;Neeraj Raizada,&nbsp;Tarika Sharma","doi":"10.15388/Amed.2022.29.1.14","DOIUrl":"https://doi.org/10.15388/Amed.2022.29.1.14","url":null,"abstract":"<p><strong>Background: </strong>Understanding the attitude and motives and differences between voluntary and replacement blood donation is the key to the sustainable availability of this precious resource. This study aimed to assess the attitude and motives for convalescent plasma (CP) donation in the recovered COVID-19 plasma donors and further understand the differences between voluntary and replacement donation.</p><p><strong>Materials and methods: </strong>This prospective cross-sectional survey-based study was conducted among500 COVID-19 recovered blood donors who visited for CP donation at a tertiary care super-speciality centre in northern India. Data were collected using a structured questionnaire based on donor attitude, motives, and belief, which was validated by the experts of Psychiatry, Transfusion Medicine, and Epidemiology and was administered by the online medium.</p><p><strong>Results: </strong>The study's findings depicted that voluntary plasma donors were previously regular blood donors (36.8%) compared to replacement plasma donors (26.4%). Almost all voluntary donors (99.5%) showed altruistic reasons to donate plasma and expressed that donating plasma is a good way to save a life, and it was more than for replacement plasma donors (p=0.004). The motives of most voluntary plasma donors were to contribute to society, and they believed that donating plasma is a good way, while it was not the case for most replacement plasma donors (p=0.02). Voluntary donors were more eagerly willing to donate plasma to help COVID sufferers (40.9%) when compared to replacement donors (33.2%) (p=0.037).</p><p><strong>Conclusion: </strong>Most voluntary plasma donors were regular whole blood donors and were keen to contribute to society. Convalescent plasma donation during this time of grief and loss was considered a moral responsibility by voluntary donors. The impact of media was more highly perceived in voluntary plasma donors when compared to replacement donors.</p>","PeriodicalId":34365,"journal":{"name":"Acta Medica Lituanica","volume":"29 1","pages":"69-77"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9428638/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40350765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Caesarean Scar Pregnancy: A Case Report.","authors":"Vilius Rudaitis,&nbsp;Gailė Maldutytė,&nbsp;Jūratė Brazauskienė,&nbsp;Mykolas Pavlauskas,&nbsp;Dileta Valančienė","doi":"10.15388/Amed.2022.29.1.17","DOIUrl":"https://doi.org/10.15388/Amed.2022.29.1.17","url":null,"abstract":"<p><p>Caesarean scar pregnancy is a potentially life-threatening gynaecological condition, becoming more common due to steadily increasing rate of caesarean sections worldwide. More than one-third of women presenting with caesarean scar pregnancy are asymptomatic, but over the time if left untreated this condition can lead to the uterine rupture and massive maternal haemorrhage. Therefore it is necessary to diagnose and manage caesarean scar pregnancies properly at the beginning of the first trimester. We present the case of woman with three previous caesarean sections, who was diagnosed with complicated caesarean scar pregnancy and then successfully managed using surgical intervention.</p>","PeriodicalId":34365,"journal":{"name":"Acta Medica Lituanica","volume":"29 1","pages":"124-130"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9428636/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40351323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Creutzfeldt-Jakob Disease with Stroke-Like Symptoms: Case report.","authors":"Bünyamin Tosunoğlu,&nbsp;Sıddıka Sena Dilek,&nbsp;Ümmühanı Emektar,&nbsp;Tahir Kurtuluş Yoldaş","doi":"10.15388/Amed.2022.29.2.3","DOIUrl":"https://doi.org/10.15388/Amed.2022.29.2.3","url":null,"abstract":"<p><p>Creutzfeldt-Jakob disease (CJD) is a rare, progressive, and fatal prion disease. Often the first sign of CJD is rapidly progressive dementia, leading to memory loss, personality changes, and hallucinations. Myoclonus typically occurs in 90% of cases, but often may not be an initial symptom. Other frequently occurring psychiatric symptoms include depression, anxiety, paranoia, obsessive-compulsive symptoms, and psychosis. Speech disorder, loss of balance and coordination may also accompany. We present a case of CJD with sudden onset of right hemiparesis.</p>","PeriodicalId":34365,"journal":{"name":"Acta Medica Lituanica","volume":"29 2","pages":"171-175"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9799013/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41146338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experience with Dopamine Agonists in the Treatment of Prolactinomas.","authors":"Nadiya Ye Barabash,&nbsp;Tetiana M Tykhonova","doi":"10.15388/Amed.2022.29.2.15","DOIUrl":"https://doi.org/10.15388/Amed.2022.29.2.15","url":null,"abstract":"<p><p>The article is devoted to the conservative treatment of hyperprolactinemia of tumor origin. Cabergoline is considered as an effective treatment not only for microadenomas but also for large pituitary tumors which is illustrated by the clinical case of the patient P. The most important effects of cabergoline demonstrated in this clinical case are reduction in the size of the adenoma from macro to micro, reverse development of chiasmal syndrome with restoration of visual functions, achievement and maintenance of the target level of prolactin. Besides the article focused on the possible development of primary and secondary resistance to dopamine analogues. One of such difficult clinical scenarios is illustrated by the clinical case of patient M., who was treated with different dopamine analogues with the development of secondary dopamine resistance. Along with described in literature possible mechanisms for its development in our patient we also suggest the role of prolonged inadequate therapy with dopamine agonists, when the dose of the drug was not properly adjusted, despite not reaching the target prolactin level. The literature considers several ways of optimization of treatment in resistant patients but despite of this fact it remains one of unresolved problems in the management of patients with hyperprolactinemia.</p>","PeriodicalId":34365,"journal":{"name":"Acta Medica Lituanica","volume":"29 2","pages":"304-310"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9799005/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41154731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Overview of Leber Hereditary Optic Neuropathy.","authors":"Almina Stramkauskaitė,&nbsp;Ieva Povilaitytė,&nbsp;Brigita Glebauskienė,&nbsp;Rasa Liutkevičienė","doi":"10.15388/Amed.2022.29.1.19","DOIUrl":"https://doi.org/10.15388/Amed.2022.29.1.19","url":null,"abstract":"<p><p>Leber hereditary ptic neuropathy (LHON) is a disease of young adults with bilateral, painless, subacute visual loss. The peak age of onset of LHON is in the second and third decades of life. Men are 4 times more likely to be affected than women. In about 25-50% of cases, both eyes are affected simultaneously. In unilateral cases, the other eye is usually affected 2 to 3 months later. Visual acuity deteriorates to counting fingers or worse with a dense central or centrocecal scotoma. In the subacute phase, the optic disc may appear hyperemic with swelling of the peripapillary retinal nerve fibre layer, peripapillary telangiectasias, and increased vascular tortuosity. Ocular coherence tomography of the macula shows marked thinning of the ganglion cell complex even at this stage. The diagnosis of LHON is made in a subject with a consistent clinical history and/or one of three common pathogenic mitochondrial DNA (mtDNA) variants identified by molecular genetic testing. Idebenone was approved by the European Medicines Agency under exceptional circumstances for the treatment of LHON. Current evidence suggests some benefit to vision in a subset of affected individuals treated with idebenone, particularly when treated within the first year of onset of vision loss. In this article, we discuss aetiology, clinical features, diagnosis, differential dignosis, prognosis and treatment.</p>","PeriodicalId":34365,"journal":{"name":"Acta Medica Lituanica","volume":"29 1","pages":"9-18"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9428633/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40351232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Embryonal Rhabdomyosarcoma of the Biliary Tree as a Differential in a Paediatric Patient Presenting with Biliary Dilatation: Not Always a Choledochal Cyst.","authors":"Tara Prasad Tripathy,&nbsp;Yashwant Patidar,&nbsp;Karamvir Chandel,&nbsp;Annapoorani Varadarajan,&nbsp;Vikrant Sood,&nbsp;Shalini Thapar Laroia","doi":"10.15388/Amed.2021.29.1.2","DOIUrl":"https://doi.org/10.15388/Amed.2021.29.1.2","url":null,"abstract":"Abstract. Rhabdomyosarcoma is a soft tissue malignant musculoskeletal tumour and is the most prevalent soft-tissue sarcoma in the paediatric population. Although, Embryonal RMS of the biliary tree is a rare entity, however, it is the most common cause of paediatric malignant obstructive jaundice. We present a 4-year-old child who had symptoms of obstructive jaundice and palpable liver. The non-contrast magnetic resonance imaging and magnetic resonance cholangiopancreatography (MRCP) features were consistent with choledochal cyst. However, contrast enhanced computed tomography and PET CT images revealed biliary RMS as the differential diagnosis. Percutaneous biopsy followed by histopathology confirmed the diagnosis of embryonal biliary RMS. Since embryonal rhabdomyosarcoma is uncommonly recorded in the literature and can mimic the appearance of a choledochal cyst, this case report emphasises the necessity of keeping embryonal RMS as a differential in paediatric cases of obstructive jaundice.","PeriodicalId":34365,"journal":{"name":"Acta Medica Lituanica","volume":"29 1","pages":"112-117"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9428640/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40351319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gubernaculum and Epididymo-Testicular Descent: Review of the Literature.","authors":"Eleonora Ivanova,&nbsp;Beata Vincel,&nbsp;Gilvydas Verkauskas,&nbsp;Faruk Hadziselimovic","doi":"10.15388/Amed.2022.29.2.6","DOIUrl":"https://doi.org/10.15388/Amed.2022.29.2.6","url":null,"abstract":"<p><p>Cryptorchidism is a common disorder in boys that has been widely studied both experimentally and clinically. The role of the gubernaculum, a mesenchymal tissue extending from the fetal testis and epididymis to the developing scrotum, is still unclear. Even the name is debated: 'gubernaculum epididymis' or 'gubernaculum testis'. This review does not aim to provide a global overview of competing theories on testicular descent, but focuses on the role of the gubernaculum in epididymo-testicular descent. We identified four major pitfalls of gubernaculum research: the role of the gubernaculum, of insulin-like peptide 3, anti-Müllerian hormone, and androgens. The major critical issues were that the gubernaculum plays a guiding role for the epididymis, descending prior to the testis and expanding the inguinal canal; insulin-like peptide 3 is not as important for the process of descent in humans as the rate of insulin-like peptide 3 mutations is low; anti-Müllerian hormone plays no significant role in epididymo-testicular descent; androgens and gonadotropins play a crucial role in epididymo-testicular descent. The role of the epididymis in the complex process of gubernaculum, epididymis, and testis migration is underestimated and should be included in future research.</p>","PeriodicalId":34365,"journal":{"name":"Acta Medica Lituanica","volume":"29 2","pages":"201-210"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9799001/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41111331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric Hematopoietic Stem Cell Transplantation in Lithuania - 20 Years of Progress through Collaboration.","authors":"Jelena Rascon,&nbsp;Goda Elizabeta Vaitkevičienė,&nbsp;Sonata Šaulytė Trakymienė,&nbsp;Ramunė Pasaulienė","doi":"10.15388/Amed.Supp.2022.292.2","DOIUrl":"https://doi.org/10.15388/Amed.Supp.2022.292.2","url":null,"abstract":"Hematopoietic stem cell transplantation (HSCT) is a complex procedure that is curative for several fatal pediatric malignancies and non-malignant diseases. Despite its complexity, potential toxicity, and high costs HSCT has become a standard procedure worldwide for several decades. Pediatric HSCT programs encounter several specific challenges. The rarity and heterogeneity of primary diseases, result in an almost 10-fold inferior number of pediatric HSCT as compared to adults. In con-trast to the adult programs, where autologous HSCT is more common, allogeneic HSCT (that is more complex) prevails in pediatric setting which is underpinned by a higher number of inborn disorders transplanted in early childhood. In Here we summarize conference proceedings presented at the scientific event “Pediatric hematopoietic stem cell transplantation in Lithuania – 20 years of progress through collaboration”. The meeting held on September 22-23, 2022, in Vilnius and aimed at commemorating 20 years of the launch of the pediatric transplant program in Lithuania. The event pursued sharing the experience in the field of pediatric HSCT in the Baltic countries. Given a very in all three Baltic countries, and face an additional challenge in maintaining sufficient transplant volume and gaining experience. Several distinguished speakers from USA, Spain, UK and shared their expertise in the field and emphasized the crucial role of national and international collaboration to achieve progress in the management of this very rare and complex procedure that offers for otherwise fatal pediatric conditions. Background: Neuroblastoma (NB) is the most common extracranial solid tumor in childhood. High-risk NB still has a poor prognosis and requires complex aggressive therapy. For a decade, immunotherapy with dinutuximab – anti GD2 chimeric monoclonal antibody – was integrated into treatment protocols as a routine part of the treatment. However, drug administration is related to potentially severe adverse effects. Thus, its administration is recommended in experienced centers. We aim to describe the first Lithuanian experience with dinutuximab. Methods: We performed a retrospective analysis of patients with high-risk NB treated with dinutuximab at our institution in 2020-2022. Toxicity and treatment outcomes were evaluated. The data were retrieved from electronic and paper records. Results: in 2020-2022, four patients were treated with dinutuximab. Totally, 20 cycles were de-livered, 5 cycles in each patient. One patient received dinutuximab as the first-line treatment. In 3 children dinutuximab was administered as second-line therapy with a median of 18 months (range 9-21) after relapse. For the majority of patients, the treatment tolerance was acceptable. The main adverse events were fever (n = 4), vision impairment (n = 1) and capillary leak syndrome (n = 1). The adverse events were 1-2 degrees, so all patients completed the treatment. At the time of analysis, two patients remain","PeriodicalId":34365,"journal":{"name":"Acta Medica Lituanica","volume":"29 2","pages":"1-17"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9799012/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41158248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound Simulation for Training Trainees when the Luxury Becomes Essential: Opinion and Evidence Obtained during the Latvian Research Council Project Implementation.","authors":"Natālija Vedmedovska,&nbsp;Anda Ķīvīte-Urtāne,&nbsp;Ija Lisovaja,&nbsp;Laura Rācene,&nbsp;Līva Ķīse,&nbsp;Beāte Sārta,&nbsp;Agnija Vaska,&nbsp;Zane Rostoka,&nbsp;Violeta Bule,&nbsp;Ieva Pitkēviča,&nbsp;Dace Rezeberga","doi":"10.15388/Amed.2022.29.2.16","DOIUrl":"https://doi.org/10.15388/Amed.2022.29.2.16","url":null,"abstract":"<p><strong>Background: </strong>Simulation as a proxy tool for conditional clinical training became a powerful technique for introducing trainees to the ultrasound imaging world, allowing them to become a trained sonographer taking into consideration different rates of progress in completing a specific task against the time and ensuring the long-lasting maintenance of the obtained practical skills. Adding a costly, but effective high-fidelity simulator to the residency program justified the expense, demonstrating efficiency of training for improving the clinical performance and confidence of trainees.</p><p><strong>Materials and methods: </strong>A pilot study in Riga Maternity Hospital within the framework of the study \"Role of metabolome, biomarkers and ultrasound parameters in successful labor induction\" (Fundamental and Applied Research Programme lzp-2021/1-0300) was performed between March 1st 2022 and 31st April 2022. A virtual-reality simulator (ScanTrainer, Medaphor^TM, Cardiff, UK) was used with the teaching module for assessment of the uterine cervix. Five trainees in obstetrics and two young specialists included in the study. None of them had Fetal Medicine Foundation certificate of competence in the assessment of the uterine cervical lenght before. The time used on the simulator, the number of simulations and a mean confidence in cervical length assessment before and after simulation were recorded.</p><p><strong>Results: </strong>The study on assesment of uterine cervical lenght demonstrated statistically significant increase in confidence (p=0.008) and statistically significant decrease in time needed to complete correctly the same tasks for the trainees (p=0.008) that shows a positive learning curve over the time of training on ScanTrainer, Medaphor.</p><p><strong>Conclusions: </strong>The simple task allows to become a certified specialist in uterine cervical assessment in the short period of time. That support the productiveness of the simulation-based education. The training program should be updated taking into consideration simulation curriculum.</p>","PeriodicalId":34365,"journal":{"name":"Acta Medica Lituanica","volume":"29 2","pages":"311-319"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9799008/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41148806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}