Acta Medica Lituanica最新文献

{"title":"Possible Threats of IgA Vasculitis in Children: One Center Experience.","authors":"Eglė Lanzbergaitė-Manuilova, Skirmantė Rusonienė, Augustina Jankauskienė","doi":"10.15388/Amed.2024.31.2.4","DOIUrl":"10.15388/Amed.2024.31.2.4","url":null,"abstract":"<p><strong>Introduction: </strong>Immunoglobulin A vasculitis (IgAV) is the most common vasculitis in children. Although typically self-limiting, IgAV may result in serious complications. Our objective was to evaluate the incidence, clinical features, laboratory predictors and outcomes of IgA vasculitis with gastrointestinal (GI) and kidney involvement.</p><p><strong>Methods: </strong>Medical records of patients <18 years of age with newly diagnosed IgAV between 2013 and 2021 in a single center were analyzed. Demographic, clinical, laboratory data, and incidence of GI and kidney involvement data were analyzed. As laboratory predictors, neutrophil, lymphocyte, platelets count, mean platelet volume (MPV) and neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) were calculated.</p><p><strong>Results: </strong>240 patients with IgAV were included. GI involvement was in 104 patients (43.3%), whereas kidney involvment in 21 patients (8.8%). Age was the only variable associated with increased odds of kidney involvement (OR 3.5, 95% confidence interval 1.39-8.56, p=0.009). None of the laboratory predictors or other tested variables was associated with kidney involvement in univariable logistic regression. The neutrophil and lymphocyte count, NLR and PLR levels were found to be significantly higher in children with GI involvement. There were no bad outcomes: lethal outcome or chronic kidney disease for the patients with GI and kidney involvement in recent study. During two years of surveillance after IgAV diagnosis, 11 cases (4.6%) had indications for kidney biopsy and were diagnosed with IgAV nephritis.</p><p><strong>Conclusions: </strong>Older children were more likely to have kidney disease. Easy obtained laboratory parameters such as NLP, PLR could help to predict GI involvement in early disease stage, but had no value for predicting kidney involvement.</p>","PeriodicalId":34365,"journal":{"name":"Acta Medica Lituanica","volume":"31 2","pages":"254-263"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11887832/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of a Fibrous Omphalomesenteric Duct Remnant Causing an Intestinal Obstruction in an Adult.","authors":"Camille Tonneau, Jerome Herve, Benjamin Nebbot, Olivier Cappeliez, Sanjiva Pather, Thomas Saliba","doi":"10.15388/Amed.2024.31.2.1","DOIUrl":"10.15388/Amed.2024.31.2.1","url":null,"abstract":"<p><p>The omphalomesenteric canal (OMC) is an important embryonic structure that normally regresses during development. OMC remnant persistance is rare and can lead to complications such as small intestinal obstruction. We report the case of an 18-year-old male with flu-like symptoms, abdominal pain, fever, and a positive McBurney sign. A CT scan raised the suspicion of occlusion, prompting surgery, revealing a fibrous band from the umbilicus to the mesocolon around which the right colon and caecum were wrapped. OMC anomalies are generally encountered in children, with a large spectrum of possibilities causing various problems. Diagnosis is challenging, with symptoms often mimicking other conditions, often necessitating surgery to obtain a definitive diagnosis. Intestinal obstruction is a severe complication, necessitating urgent surgical resection. Radiological imaging mainly serves to prompt surgical intervention as it is limited in directly visualizing fibrous bands, with surgery remaining the best way to obtain a diagnosis, as well as allowing concomitant treatment.</p>","PeriodicalId":34365,"journal":{"name":"Acta Medica Lituanica","volume":"31 2","pages":"328-333"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11887824/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidental Discovery of Giant Ovarian Cysts During Autopsy. Case Analysis and Literature Review.","authors":"Justė Kazlauskaitė, Sigitas Chmieliauskas, Diana Vasiljevaitė, Sigitas Laima","doi":"10.15388/Amed.2024.31.2.16","DOIUrl":"10.15388/Amed.2024.31.2.16","url":null,"abstract":"<p><strong>Background: </strong>Cysts are called giant when they are >10 cm in diameter. Today the frequency of giant ovarian cysts is decreasing due to good diagnostic methods and regular gynecological examination. These cysts occur more frequently in women of reproductive and postmenopausal age. The most common giant cysts are benign serous cystadenomas. Diagnosing giant cysts can be hindered by nonspecific symptoms, the patient's reluctance to see a doctor and fear of surgery. The purpose of this study is to review the existing literature on this topic and describe three cases of giant cysts found at autopsy.</p><p><strong>Materials and methods: </strong>A literature review was conducted in the Medline (PubMed) database over a period of 10 years. The information concerning the examination of deceased individuals after their death was sourced from the database of the Lithuanian State Forensic Medicine Service. After the analysis of the deceased persons in the years 2015-2022 in the State Forensic Medicine Service, out of 1638 deceased persons, three cases of giant cysts were identified. These three cases were analyzed retrospectively. During these investigations, the circumstances of finding the scene, the results of the autopsy, and the data of additional toxicological and microscopic tests were evaluated.</p><p><strong>Results: </strong>A retrospective study of 3 cases confirms the fact that giant ovarian cysts are a rare phenomenon. In case 1, the corpse of a 75-year-old woman was examined, a 30x30x25 cm left ovarian cyst was found, the woman had chronic ischemic heart disease; case 2 was a 65-year-old woman with a 19x25x12 cm right ovarian cyst and deep vein thrombosis with pulmonary embolism; case 3 was a 62-year-old woman with a 40x30x30 cm right ovarian cyst and chronic ischemic heart disease. In all cases, giant ovarian cysts were incidental findings and not the primary cause of death. The described clinical cases corresponded to the characteristics of giant cysts indicated in the literature: appeared in the postmenopausal period, benign course, diagnosed in patients who did not seek medical attention.</p><p><strong>Conclusions: </strong>Thanks to good early diagnosis, ovarian cysts are diagnosed early, before they reach gigantic size, so giant cysts are extremely rare. Delayed diagnosis is related to reluctance of patients to consult doctors and confusion with ascites and obesity. They are usually benign, and the symptoms they cause are related to mass effect - pressure on nearby organs.</p>","PeriodicalId":34365,"journal":{"name":"Acta Medica Lituanica","volume":"31 2","pages":"394-403"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11887831/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postmortem Analysis of Ethyl Alcohol Concentration in Blood, Urine, Muscle and Bile.","authors":"Agnė Okulevičiūtė, Sigitas Chmieliauskas, Gabija Laubner-Sakalauskienė, Robertas Badaras, Sigitas Laima, Diana Vasiljevaitė, Jurgita Stasiūnienė","doi":"10.15388/Amed.2024.31.2.6","DOIUrl":"10.15388/Amed.2024.31.2.6","url":null,"abstract":"<p><strong>Introduction: </strong>The determination of ethyl alcohol concentration in body fluids is an important investigation in forensic practice. To avoid postmortem changes in blood alcohol concentration, the test substance must be transported in special media enriched with sodium fluoride or potassium oxalate. When interpreting changes in concentrations in the body, it is important to assess not only the blood but also other body fluids or tissues.</p><p><strong>Materials and methods: </strong>A retrospective study was conducted from 2016 to 2023, evaluating data from nonconsecutive 378 autopsies from the State Forensic Medical Service of Lithuania. The study analyzed ethyl alcohol concentrations in blood, urine, muscle and bile. Toxicological data were processed using R commander statistical software. The study aimed to assess the changes, patterns, and correlations of ethyl alcohol concentrations in different body fluids after death.</p><p><strong>Results: </strong>When the ethyl alcohol concentrations of the different body fluids from the autopsies were evaluated, the urine ethyl alcohol concentration was in 86% cases higher than the blood ethyl alcohol concentration, with a mean difference of 0.51‰. There is a strong correlation between blood and urine ethyl alcohol concentrations, r = 0.93, p < 0.05. The ethyl alcohol concentration in muscle was 75% higher than in blood with a mean difference of 0.06‰. Ethyl alcohol concentration in bile was 90% higher than in blood with a mean difference of 0.14‰. The difference between ethyl alcohol concentrations in bile and muscle was not significant, with a mean difference of 0.07‰.</p><p><strong>Conclusions: </strong>In addition to blood and urine, muscle and bile samples may be taken at autopsy to detect ethyl alcohol. The results of the study show that there may be differences in the levels of ethyl alcohol in different body fluids after death. These data are therefore important for the assessment of ethyl alcohol concentrations in both clinical and forensic practice.</p>","PeriodicalId":34365,"journal":{"name":"Acta Medica Lituanica","volume":"31 2","pages":"207-216"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11887834/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"figManagement of Renal Vascular Injuries by Angioembolization in a Low Resource Setting: A Case Series with Review of Literature.","authors":"Saifullah Khalid, Manzoor Ahmad, Ezaz Ahmed, Wasif Mohammad, AliImad Ali","doi":"10.15388/Amed.2024.31.2.24","DOIUrl":"10.15388/Amed.2024.31.2.24","url":null,"abstract":"<p><strong>Background: </strong>Renal vascular injuries, like renal artery pseudoaneurysms and arteriovenous fistulas, are rare but serious complications following renal procedures and trauma. Standard management requires costly microcatheters for angioembolization. This study investigates a cost-effective method using diagnostic catheters and affordable coils in a low-resource setting.</p><p><strong>Methods: </strong>We analyzed five patients from December 2023 to June 2024 who had persistent hematuria or hemoglobin drops after renal intervention or trauma. CT angiography identified their injuries, and angioembolization was performed with diagnostic catheters and coils, reducing procedural costs.</p><p><strong>Results: </strong>The use of diagnostic catheters and coils successfully managed all cases. Patients experienced resolution of hematuria and were discharged in 2-3 days. Follow-up over three months revealed no recurrence or significant renal function issues.</p><p><strong>Conclusion: </strong>Diagnostic catheters and coils offer an effective method for managing renal vascular injuries in resource-limited settings, achieving satisfactory outcomes with minimal morbidity.</p>","PeriodicalId":34365,"journal":{"name":"Acta Medica Lituanica","volume":"31 2","pages":"416-422"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11887838/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Accessory Extensor Digitorum Longus Muscle - a Rare Variation.","authors":"Saphal Lakshmi Pasupulati, Sanjit Satheesan, Piyush Saiyam, Saketh Chowdary, P K Sankaran, Kishore Sesham","doi":"10.15388/Amed.2024.31.2.2","DOIUrl":"10.15388/Amed.2024.31.2.2","url":null,"abstract":"<p><p>During the routine dissection of lower limb in a female cadaver of age 61 years, a rare variation in the extensor digitorum longus (EDL) muscle was noticed on the both legs. An EDL muscle with small belly dividing into two slips, which inserted on to the second and third digits on the right leg, whereas on the left leg divided into three slips, which inserted on to the second, third and fourth digits. There was also an accessory EDL muscle arising from the middle third of the medial surface of the fibula and inserted on to the fifth digit in the left foot, and it inserted on to the fourth and fifth digits in the right foot. To our knowledge, such variation hasn't been reported in literature and apprehension of such variations is important for surgeons and orthopaedicians with regards to contractures and surgical procedures concerning the anterior leg and dorsum of the foot.</p>","PeriodicalId":34365,"journal":{"name":"Acta Medica Lituanica","volume":"31 2","pages":"334-338"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11887829/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ankle and Distal Tibia Megaprostheses in Orthopedic Oncology: A Report of Two Cases and Review of the Literature.","authors":"Edoardo Ipponi, Martina Cordoni, Elena Bechini, Fabrizia Gentili, Fabio Cosseddu, Antonio D'Arienzo, Lorenzo Andreani","doi":"10.15388/Amed.2024.31.2.13","DOIUrl":"10.15388/Amed.2024.31.2.13","url":null,"abstract":"<p><strong>Background: </strong>The distal tibia is one of the rarest sites for the onset of malignant and locally aggressive bone tumors. When diagnosed, these lesions should undergo surgical resection with wide margins to eradicate the disease. In the era of limb-sparing surgery, several reconstructive approaches have been proposed and described in modern literature for reconstructing the distal tibia and the ankle. The 3D-printed custom-made prostheses represent an innovative and promising reconstructive option. Several authors highlighted that despite being expensive and prone to some complications such as talar collapse or loosening and soft tissue necrosis, the megaprostheses of the distal tibia could lead to good functional outcomes, also allowing a better range of motion compared to the most common arthrodesis.</p><p><strong>Materials and methods: </strong>We report two cases who suffered from malignant bone tumors localized in the distal tibia and treated with wide resections and the implant of 3D printed custom-made megaprostheses to replace the distal tibia and the ankle.</p><p><strong>Results: </strong>Both patients had excellent functional results (MSTS 30/30) one year after surgery. No local recurrence occurred during the patients' latest follow-up.</p><p><strong>Conclusions: </strong>Our results support the effectiveness of custom-made implants in replacing the distal tibia and the ankle in orthopedic oncology.</p>","PeriodicalId":34365,"journal":{"name":"Acta Medica Lituanica","volume":"31 2","pages":"372-381"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11887833/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-Injurious Behavior in Child and Adolescent Psychiatry Inpatient Units: Actual Aspects of the Complex Care Provision.","authors":"Sigita Lesinskienė, Mariam Afrahi, Kamilė Pociūtė","doi":"10.15388/Amed.2024.31.2.7","DOIUrl":"10.15388/Amed.2024.31.2.7","url":null,"abstract":"<p><strong>Background: </strong>Nonsuicidal self-injurious behavior in children and adolescents is a major concern that requires mental health professionals' attention. The aim of this study is to analyze clinical care aspects of children and adolescents who self-harm in psychiatric hospitals.</p><p><strong>Materials and methods: </strong>In 2023, 30 various specialists from five different child and adolescent psychiatric units in Lithuania were interviewed. The survey used a semistructured interview consisting of twelve questions related to complex clinical care methods of children and adolescents who self-harm. The interview responses were summarized and grouped into 5 categories: assessment and monitoring, methods and consequences of self-injury, safety measures, prevention and treatment, insights from staff.</p><p><strong>Results: </strong>Self-injurious behavior in psychiatric inpatient settings was managed through risk assessment, monitoring, communication, medication, counselling, removal of sharp objects, patient allocation, and a several of other methods such as safety contracts, rewards or alternate pain-inducing or self-harm mimicking stimuli. Despite the hospital's safety procedures patients frequently devised alternate methods to self-harm, such as hitting and scratching themselves and using nonspecific materials.</p><p><strong>Conclusions: </strong>The management of self-harm in children and adolescents psychiatric settings remains insufficient. Further research is needed to explore alternative ways of managing self-injurious behavior in child and adolescent psychiatric hospitals.</p>","PeriodicalId":34365,"journal":{"name":"Acta Medica Lituanica","volume":"31 2","pages":"275-287"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11887821/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and Electrophysiological Evaluation of Electrical Stimulation in Patients with Bell's Palsy.","authors":"Fatma Çelik, Aylin Ayyıldız, Selda Çiftci İnceoğlu, Figen Yılmaz, Mustafa Çelik, Banu Kuran","doi":"10.15388/Amed.2024.31.2.19","DOIUrl":"10.15388/Amed.2024.31.2.19","url":null,"abstract":"<p><strong>Background: </strong>The objective of this study is to assess the clinical and electrophysiological effectiveness of electrical stimulation in patients diagnosed Bell's palsy (BP), and to examine its impact on potential complications that may arise during the course of the illness.</p><p><strong>Methods: </strong>Thirty patients diagnosed with BP were enrolled and randomized into two treatment groups of 15 patients each. The treatment group (TG) received 15 sessions of electrical stimulation (ES), infrared, and exercise therapy, 5 days a week for 3 weeks, while the control group (CG) received sham ES, infrared, and exercise therapy. Evaluations were conducted by electromyography before treatment and at 1 and 3 months after the end of treatment for all patients.</p><p><strong>Results: </strong>When evaluating patients in both groups based on the side where the BP developed, electrophysiological examination showed an increase in the rate of synkinesis in both the TG and CG. However, there was no statistically significant difference between the two groups. The study found that ES did not reduce the presence of synkinesis in denervated muscles. However, the nerve conduction studies of the studied branches of the facial nerve showed a decrease in distal latencies and an increase in amplitudes of compound muscle action potentials, indicating that ES has a positive effect on nerve regeneration.</p><p><strong>Conclusion: </strong>ES resulted in a notable reduction in distal latency values within the treatment group. Additionally, ES was found to significantly alleviate depressive symptoms, although it did not result in an improvement in overall quality of life. Therefore, ES is considered a safe treatment method that can be used in the treatment of BP.</p>","PeriodicalId":34365,"journal":{"name":"Acta Medica Lituanica","volume":"31 2","pages":"302-314"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11887822/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regeneration of Rabbit Auricular Cartilage After the Intravenous Stem Cell Injection","authors":"P. Virych, N. Shuvalova, Anton F. Karas, Galina Karas, Svitlana Chaika, T. Kucherenko, Ganna Y. Minina, Marina Timchenko, Oleg Melnykov, Yurii Minin","doi":"10.15388/amed.2023.30.2.15","DOIUrl":"https://doi.org/10.15388/amed.2023.30.2.15","url":null,"abstract":"Background. The restoration of auricular cartilage is a major problem of otolaryngology. The low regenerative capacity of cartilage requires alternative approaches such as cell and tissue engineering. Stem cells are one of the ways to repair auricular cartilage damages. The aim of the investigation was the regeneration of an artificial defect of the auricular cartilage of rabbits after the intravenous injection of stem cells.Materials and Methods. The study was carried out on rabbits. A narrow strip of auricular cartilage was surgically removed. A previously prepared suspension of homologous mesenchymal stem cells (5 million) in 0.5 ml physiological solution was injected into the vein of the opposite ear. Tissue samples from the site of the injury were collected after 1, 2, and 3 months. Histological examinations of the tissues were carried out after staining with fuchsin-eosin, azure II–eosin, and according to Weigert. In addition, the amount of interleukin-6 (IL-6) and the transforming growth factor β1 (TGF-β1) in the blood serum were determined.Results. The main method of healing is the formation of a connective tissue scar. Yret, an increase of the number of fibroblasts and single islands of the newly formed auricular cartilage was found, which indicates the migration of the injected stem cells to the site of the damage and settling there. The intravenous injection of stem cells did not affect the secretion of pro-inflammatory IL-6, but significantly increased the amount of TGF-β1.Conclusions. We assume that regenerative processes were stimulated. Nevertheless, they were aimed at quickly restoring the tissue integrity through the typical stages of scar formation. The restoration of cartilage integrity requires additional regulatory factors which will determine the chondrogenic differentiation of stem cells.","PeriodicalId":34365,"journal":{"name":"Acta Medica Lituanica","volume":"99 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139249371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}