Rossiiskii parazitologicheskii zhurnal最新文献

{"title":"Complex drug kenocox against Eimeria spp. oocysts in turkeys","authors":"R. Safiullin, E. Chalysheva, E. O. Kachanova","doi":"10.31016/1998-8435-2023-17-2-290-299","DOIUrl":"https://doi.org/10.31016/1998-8435-2023-17-2-290-299","url":null,"abstract":"The purpose of the research is to test the efficacy of different concentrations of composite Kenocox against Eimeria spp. oocysts in turkeys in a laboratory experiment and under production conditions.Materials and methods. The anti-Eimeria activity of the new composite disinfection agent Kenocox was tested as compared with phenol in two stages. The first laboratory stage used 2, 4 and 6% Kenocox and 4% phenol as the base drug. The second stage used a bioassay with artificial infection of the young turkeys, and a production test was conducted on a poultry farm.Results and discussion. The conducted studies showed 92.96% intense-effectiveness of 2% Kenocox. 4 and 6% Kenocox showed 100% efficacy against sporulated Eimeria spp. oocysts, and the base 4 % phenol provided 74.98% efficacy. During the production test of 4% Kenocox on the turkey farm, 91.7% intense-effectiveness was detected.","PeriodicalId":34353,"journal":{"name":"Rossiiskii parazitologicheskii zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49519624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical experience with the use and efficacy evaluation of new Insacar Total C Plus for dogs and Insacar Total K Plus for cats","authors":"N. V. Makhvatova","doi":"10.31016/1998-8435-2023-17-2-265-275","DOIUrl":"https://doi.org/10.31016/1998-8435-2023-17-2-265-275","url":null,"abstract":"The purpose of the research is to study the efficacy of new multicomponent drugs for dogs and cats against arachnoentomosis and helminthosis.Materials and methods. The efficacy of new four-component Insacar Total C Plus Drops for Dogs and Insacar Total K Plus Drops for Cats was studied on target animal species. The experiment included 90 dogs and 82 cats including 38 dogs and 37 cats with monoinfection by ticks (Sarcoptes canis, Demodex canis, Notoedres cati, Otodectes cynotis, family Ixodidae), 39 dogs and 31 cats with monoinfection by insects (Ctenocephalides sp., Linognathus setosus, Trichodectes canis), 13 dogs and 14 cats with infection by helminths (Toxocara canis, T. cati, Toxascaris leonina, Taenia sp.), and 13 dogs and 10 cats with mixed infections. The drug was applied to the skin of the animals in dosages as specified in the instructions for use. The therapy effectiveness was monitored on days 14 and 28, and in case of Notoedres cati and Sarcoptes canis, on day 40.Results and discussion. The efficacy of multicomponent drugs against monoinfections with insects, ixodid ticks, ticks of the genus Demodex and helminths, as well as mixed infections of the dogs and cats was 100% in clinical studies. The efficacy in the cats with notoedric mange was 80%, and 83.4% in the dogs with sarcoptic mange. The advantage of four-component Insacar Total C Plus Drops for Dogs and Insacar Total K Plus Drops for Cats is the presence of several components, namely, imidacloprid, praziquantel, pyriproxyfen, and moxidectin. The unique combination of active ingredients ensures the efficacy of drugs against external and internal parasites including ixodid ticks, and preventive efficacy against entomosis and ixodid ticks for 30 days. The drops for dogs and cats are advisable against mixed infections.","PeriodicalId":34353,"journal":{"name":"Rossiiskii parazitologicheskii zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45843439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficiency of coccidiostat combined with probiotic for treatment of coccidiosis in rabbits","authors":"I. V. Petrova, A. N. Semikrasova, K. V. Zhilina","doi":"10.31016/1998-8435-2023-17-2-284-289","DOIUrl":"https://doi.org/10.31016/1998-8435-2023-17-2-284-289","url":null,"abstract":"The purpose of the research is to determine the efficiency of coccidiostat combined with probiotic for treatment coccidiosis in rabbits in a comparative aspect.Materials and methods. Rabbits suffering from eimeriosis were treated with coccidiostat and probiotic. The anticoccidial drug of the benzeneacetonitrile group, Diclacox 2.5%, the active ingredient of which is diclazuril, and probiotic Mucinolextra, which is a freeze-dehydrated biomass of Bifidobacterium globosum, Enterococcus faecium, B. subtilis, and B. licheniformis at a concentration of 1010 CFU/g were used as preparations. Feces from the rabbits were examined every 3 days by the Fülleborn method to identify coccidia oocysts and determine the infection intensity and prevalence. On the first and last experiment days, the rabbits were weighed to assess the dynamics of live weight. The experiment duration was 15 days.Results and discussion. Coccidiostat Diclacox 2.5% combined with probiotic Mucinol-extra proved to be highly effective against coccidiosis in rabbits.","PeriodicalId":34353,"journal":{"name":"Rossiiskii parazitologicheskii zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48405874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Organoleptic and physical and chemical parameters of Nubian goats’ milk at mixed infection with gastrointestinal nematodes from the suborder Strongylata","authors":"I. I. Tsepilova, A. Konovalov, S. A. Shemyakova","doi":"10.31016/1998-8435-2023-17-2-257-264","DOIUrl":"https://doi.org/10.31016/1998-8435-2023-17-2-257-264","url":null,"abstract":"The purpose of the research is to determine the species composition of nematodes from the suborder Strongylata and to study organoleptic and physical and chemical parameters of the Nubian goats’ milk at strongylatoses of the digestive tract. Materials and methods. The study subjects were lactating Nubian goats aged 3 to 5 years from private farms in the Moscow Region. A total of 37 animals were examined. Faeces were studied by flotation methods per Fülleborn and KotelnikovKhrenov. To determine the species composition, partial helminthological dissections per K. I. Skryabin were used. In the infected animals from the experimental and control groups, organoleptic and physical and chemical milk parameters were studied prior to and after therapeutic measures using an anthelmintic with the active ingredient fenbendazole at a dose of 5 mg/kg. The deworming effectiveness was determined by the control test. Physical and chemical milk parameters were determined using an automatic Klever-2 milk analyzer, and organoleptic parameters were determined according to common methods pursuant to the effective GOST.Results and discussion. The lactating Nubian goats infected with gastrointestinal strongylates on the Moscow Region private farms amounted to 100% in the Podolsk Urban Okrug, and 88.2% in the Voskresensk Urban Okrug. The species composition was represented by 8 species, namely, Haemonchus сontortus, Ostertagia ostertagi, Trichostrongylus axei, T. colubriformis, Nematodirus spathiger, N. filicollis, Cooperia оvina, and Bunostomum trigonocephalum. In the pre- and postdeworming milk studies, the organoleptic parameters corresponded to the effective GOST in appearance, texture, color and smell; the sweetish taste was only absent after deworming in the experimental goats. Gastrointestinal nematodes from the suborder Strongylata did not affect the organoleptic parameters of milk. However, the pre- and posttreatment weight fraction of fat changed from 2.90±0.30 to 5.40±0.22% in the experimental group.","PeriodicalId":34353,"journal":{"name":"Rossiiskii parazitologicheskii zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46777742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of experimental Trichinella spiralis larvae infection in rats and mice on hematological and biochemical parameters of the host at different infection stages","authors":"G. V. Konovalova, E. Koveshnikova","doi":"10.31016/1998-8435-2023-17-2-250-256","DOIUrl":"https://doi.org/10.31016/1998-8435-2023-17-2-250-256","url":null,"abstract":"The purpose of the research is the study of effects of experimental Trichinella spiralis infection in rats and mice on hematological and biochemical blood parameters of the host at different infection stages.Materials and methods. The experiment was performed on mature outbred male rats and male mice that were infected by T. spiralis larvae orally administered at the rate of 10 larvae/1 g of body weight. Blood samples were taken from the rats at 40 days and 3 months after infection; from the mice, on day 40 after infection. The main parameters of peripheral blood in the rats were determined by a MicroCC-20 Plus hematological analyzer (High Technology, Inc. (USA)) using reagents from Clinical Diagnostic Solutions, LLC (Russia). Biochemical blood parameters in the rats and mice were determined by a Clima MC-15 analyzer, RAL Technical el Laboratoria, S.A. (Spain) using reagents produced by Diakon-DS, CJSC (Russia).Results and discussion. At 40 days and 3 months after the rats were experimentally infected with T. spiralis, we observed a consistent increase in the hemoglobin concentration, erythrocytes and leukocytes, and hematocrit, and a decrease in the alkaline phosphatase activity and ALT, and an increase in total protein. On day 40 after infection in the mice, an increase in total protein was observed as in the rats, and a decrease in blood urea. The changes detected in hematological and biochemical parameters in the rats and mice were associated with the toxic effect of Trichinella infection and the response of the host organism. Such changes are dependent on the infection stage and animal species.","PeriodicalId":34353,"journal":{"name":"Rossiiskii parazitologicheskii zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47969327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vivo anthelmintic efficacy of some plant species of the family Compositae Cisece","authors":"L. Novruzova","doi":"10.31016/1998-8435-2023-17-2-276-283","DOIUrl":"https://doi.org/10.31016/1998-8435-2023-17-2-276-283","url":null,"abstract":"The purpose of the research is to study the anthelmintic efficacy of decoctions of various parts of plants, as well as granules and essential oils of plants of the species İnula helenium L., Cichorium intybus L., Arctium lappa L. and Helichrysum araxinium Taxt ex Kirp of the family Compositae Cisece in the Nakhichevan Autonomous Republic of Azerbaijan.Materials and methods. Herbal preparations were tested on sheep spontaneously infected with gastrointestinal Strongylates. Decoctions of various parts of plants, as well as prepared granules and herbal essential oils were administered to the experimental animals in different doses. Sheep of the control group did not receive the drug. After the administration of the drugs, the condition of the animals was recorded. The drug efficacy was recorded at 5 days based on coproovoscopy results.Results and discussion. The decoctions of the tested plant species were found to have a high anthelmintic effect against nematodes parasitizing in the digestive tract of sheep. The efficacy of the decoctions prepared from roots and aerial parts of plants of the species I. helenium was 72–78%, the decoction efficacy from roots and aerial parts of the species C. Intybus was 70–76%, the decoction efficacy from roots and aerial parts of the species A. lappa was 69–71%, and the decoction efficacy from the aerial parts part of plants of the species H. araxinium was 74.6%. The anthelmintic effect of essential oils in the experiment was higher and reached 86.7 % from I. helenium, 85.1% from C. intybus, 80.8 % from A. lappa, and 83.5% from H. araxinium. The anthelmintic efficacy of the decoction from I. helenium mixed with C. intybus prepared from the aerial parts of plants was 72.4%, the decoction efficacy from H. araxinium mixed with A. lappa was 65.1, and the efficacy of the flour mixture from the roots of I. helenium, A. lappa and C. intybus was 71.9%.","PeriodicalId":34353,"journal":{"name":"Rossiiskii parazitologicheskii zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47423270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"To the fauna of gastrointestinal nematodes of sheep in the European part of Russia","authors":"I. A. Pimenov, D. Kuznetsov, I. Odoevskaya, A. D. Afanasyev, A. I. Varlamova, I. Arkhipov","doi":"10.31016/1998-8435-2023-17-2-206-213","DOIUrl":"https://doi.org/10.31016/1998-8435-2023-17-2-206-213","url":null,"abstract":"The purpose of the research is to study the fauna of gastrointestinal nematodes of sheep in the European part of the Russian Federation.Materials and methods. The studies were carried out in 2022–2023. The objects for the study were the sets of the gastrointestinal tracts of sheep aged from one to 2.5 years, delivered to the slaughterhouse in the Moscow region from different regions of the Russian Federation, including the Oryol and the Astrakhan regions, the Republic of Dagestan and Stavropol Krai. After slaughter, 10 sets of gastrointestinal tracts were taken by the random sampling method from each batch of delivered sheep. Then, these sets of gastrointestinal tracts were subjected to helminthological necropsy according to the method of K. I. Skryabin (1928). The species of detected nematodes were identified according to K. I. Skryabin et al. (1952) and V. M. Ivashkin et al. (1989).Results and discussion. A different degree of gastrointestinal nematodes infection of sheep has been established in different regions of the European part of the Russian Federation. Thus, the rate of infection in the Oryol region was 80%, in the Astrakhan region – 100%, in the Republic of Dagestan – 100% and in Stavropol Krai – 50%. Sheep were infected with Trichostrongylus colubriformis and Teladorsagia circumcincta with an intensity of infection, on average, 251.86±25.2 and 99.25±9.9 ex./head respectively in the Oryol region; T. colubriformis (242.65±24.3 ex./head), T. circumcincta (76.6±7.7 ex./head.), Haemonchus contortus (6.5±0.7 ex./head) and Marshallagia marshalli (19±1.9 ex./head) in the Astrakhan region; T. colubriformis (89.7±9 ex./head), T. circumcincta (43.6±4.4 ex./head), H. contortus (6.8±0.7 ex./head) and M. marshalli (17.8±1.8 ex./head) in the Republic of Dagestan; T. colubriformis (20.2±2 ex./head) and T. circumcincta (11±1.1 ex./head) in Stavropol Krai. Thus, T. colubriformis and T. circumcincta were the most frequently found nematodes in sheep in all of the four studied regions, and these two species also showed the highest rates of infection. The noted low species diversity of nematodes is obviously associated with the mandatory use of anthelmintic drugs. The studied sheep were treated against parasites (according to the accompanying veterinary documentation). At the same time, the detection of nematodes in treated animals possibly indicates the presence of resistant strains.","PeriodicalId":34353,"journal":{"name":"Rossiiskii parazitologicheskii zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49269666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epizootic situation on bovine hypodermatosis in Russia in 2020–2021","authors":"Y. Faenova, S. A. Shemyakova, S. Kapustin","doi":"10.31016/1998-8435-2023-17-2-236-241","DOIUrl":"https://doi.org/10.31016/1998-8435-2023-17-2-236-241","url":null,"abstract":"The purpose of the research is the analysis of the epizootic situation on bovine hypodermatosis in the Russian Federation for 2020–2021.Materials and methods. Veterinary reporting data in the form 1-VET-G were processed and analyzed on the basis of the Center of Veterinary Medicine. The data processing took into account the following indicators: available cattle in the constituent entities of the Russian Federation at the beginning of the reporting period, the number and percentage of cattle examined for hypodermatosis, and the percentage ratio of animals affected by warble fly larvae to the total number of livestock.Results and discussion. The number of animals affected by warble fly larvae was 1299 in 2020, and 1184 in 2021, which was 0.008% for 2020 and 0.007% for 2021 as a percentage of the existing animal population.","PeriodicalId":34353,"journal":{"name":"Rossiiskii parazitologicheskii zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46650709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current situation on ectoparasitosis in dogs in Moscow","authors":"S. B. Devyatyarova","doi":"10.31016/1998-8435-2023-17-2-224-228","DOIUrl":"https://doi.org/10.31016/1998-8435-2023-17-2-224-228","url":null,"abstract":"The purpose of the research is the study of the current situation on ectoparasite infections in dogs in Moscow considering the season of the year.Materials and methods. The current situation on ectoparasitosis in dogs in Moscow was studied on the basis of the VNIIP – FSC VIEV and OOO GLOBALVET CLINIC (Moscow) in 2020–2022. Ninety-four dogs were examined in different seasons of the year. When examining the animals, attention was paid to pelage and skin damage. The history was taken with the animal sex, age, and pelage and skin state taken into account; the ears were examined; the pelage was combed out using a magnifying glass; ear contents were microscopically examined; and scrapings of the superficial and deep layers of the skin were made. The results were statistically processed using Microsoft Excel.Results and discussion. The infection of the dogs with Demodex canis was the highest possible in the autumn-winter period (7.4%), and in spring and summer it decreased to 5.3 and 4.2%, respectively. Ixodes ricinus ticks were only found on the skin and pelage of the dogs (18%) in the warm season. No significant difference was observed in the infection of the dogs with Otodectes cynotis, Sarcoptes canis and Cheyletiella jascuri in different seasons of the year. The seasonal dynamics of the infection of the dogs with different species of insects varied. Fleas were found in winter in 6.4% of the dogs, and in spring and summer in 8.5% and 10.6% of the dogs, respectively. The infection of the dogs with lice was 3.2% in winter, 4.2% in spring, 5.3% in summer and 6.4% in autumn. The maximum infection of dogs with lice was observed in summer (4.2%), and it decreased in winter to 2.1%.","PeriodicalId":34353,"journal":{"name":"Rossiiskii parazitologicheskii zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47274531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphological and molecular identification of Neomoliniella longicorpa gen. et sp. nov. (Digenea: Echinostomatidae) from the Eurasian coot Fulica atra (Aves: Rallidae): a taxonomic evaluation","authors":"K. Vainutis, A. Voronova, M. E. Andreev, M. Shchelkanov","doi":"10.31016/1998-8435-2023-17-2-181-197","DOIUrl":"https://doi.org/10.31016/1998-8435-2023-17-2-181-197","url":null,"abstract":"The purpose of the research is the morphological and molecular identification of trematodes found in the intestines of migratory waterfowl with subsequent taxonomic evaluation.Materials and methods. Mature specimens of trematodes were collected from the intestines of waterfowl (Fulica atra and Aythya ferina) shot during the ecological-faunistic monitoring in the southern part of the Primorsky krai. Preliminary morphological analyze revealed that trematodes belong to the Echinostomatidae family. The whole-mounts of worms from F. atra were prepared using standard methods with alum carmine. Divergent domains of 28S ribosomal RNA gene were sequenced and used to determine systematic position and relationships of discovered species of echinostome by reconstructing Bayesian and Maximum likelihood trees.Results and discussion. Trematodes found in the coots' intestine, should be described as Neomoliniella longicorpa in the new genus Neomoliniella gen. et sp. nov., which is reliably confirmed by morphological and genetics data. Another cryptic echinostomatid species sister to Neomoliniella gen. nov., and probably representing the separate unknown genus, was demonstrated only on the phylogenetic reconstructions and confirmed by large genetic distances. Currently, this taxon is indicated as Echinostomatidae gen. sp. and more evidence is needed for its validation. We also report about the first detection of Echinostoma paraulum from A. ferina in the south of the Russian Far East. The biology, morphology of each life cycle stage of newly described species of worms should be investigated to test not only their scientific but also medical significance. For the first time in the history of the group, dichotomous keys for eight families of the superfamilyEchinostomatoidea and, to date, the largest of all previously known for the family Echinostomatidae identification chart – dichotomous keys for the identification of 27 Palearctic genera were compiled.","PeriodicalId":34353,"journal":{"name":"Rossiiskii parazitologicheskii zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46288825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}