Hamdan Medical Journal最新文献_第9页

Hamdan Medical Journal Pub Date : 2022-07-01 DOI: 10.4103/hmj.hmj_9_22

G. Ano-Edward, Kehinde Aworinde-Olufemi, Enugwaronu Agbakwuru, Mathew E. Lasisi, B. Famoroti

引用次数: 0

Lactate dehydrogenase as marker for foetal outcome in pre-eclampsia 乳酸脱氢酶作为先兆子痫胎儿预后的标志物

Hamdan Medical Journal Pub Date : 2022-07-01 DOI: 10.4103/hmj.hmj_3_22

S. Salman, M. Rafiq

{"title":"Lactate dehydrogenase as marker for foetal outcome in pre-eclampsia","authors":"S. Salman, M. Rafiq","doi":"10.4103/hmj.hmj_3_22","DOIUrl":"https://doi.org/10.4103/hmj.hmj_3_22","url":null,"abstract":"Background: Studies have shown LDH is raised in Pre-eclampsia (PE) with levels increasing with increased severity of PE. Aims and Objectives: To study lactate dehydrogenase (LDH) as a marker for foetal outcome in mothers with pre-eclampsia (PE). Materials and Methods: A prospective cohort study was conducted at our facility from February 2019 to November 2021 on all admitted patients with PE. Two hundred and two patients were studied during this period. The inclusion criteria were mild and moderate PE. The exclusion criteria were severe PE, haemolysis, elevated liver enzymes and low platelets syndrome, eclampsia, any comorbid disease, and multiple gestations. Patients were divided into two groups. Group 0 had mothers with LDH <600 IU/L and Group 1 included mothers with LDH ≥ 600 IU/L. Both groups were documented and monitored until delivery to document foetal outcome as live birth or death in utero. Results: The mean maternal characteristics were as follows: age in years (26.45 ± 3.74), body mass index (30.04 ± 1.58), parity (2.39 ± 0.91), and age of gestation in weeks (33.27 ± 1.18). Group 1 had 61 (30.2%) previous history of PE, 84 (41.6%) live births, and 17 (8.4%) deaths in utero. Group 0 had 60 (29.7%) previous history of PE, 95 (47%) live births and 6 (3%) deaths in utero. The mean gestational age of Group 1 was shorter; 32.29 ± 1.17 weeks versus 33.23 ± 1.16 for Group 0. LDH as a marker for death in utero had a P = 0.01 which is significant. Conclusion: LDH can be used as a marker for foetal outcome in women with PE.","PeriodicalId":34280,"journal":{"name":"Hamdan Medical Journal","volume":"15 1","pages":"122 - 125"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41387168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of ramadan fasting on diabetic nephropathy in patients with type 2 diabetes 斋月禁食对2型糖尿病肾病的影响

Hamdan Medical Journal Pub Date : 2022-07-01 DOI: 10.4103/hmj.hmj_11_22

MagdaShukry Mohammad, Maram M. M. Aboromia, N. Ibrahim, N. Abdul Jalil

{"title":"Effects of ramadan fasting on diabetic nephropathy in patients with type 2 diabetes","authors":"MagdaShukry Mohammad, Maram M. M. Aboromia, N. Ibrahim, N. Abdul Jalil","doi":"10.4103/hmj.hmj_11_22","DOIUrl":"https://doi.org/10.4103/hmj.hmj_11_22","url":null,"abstract":"Background: Many patients with type 2 diabetes (T2D) insist to fast during the holy month of Ramadan against medical advice. Aims and Objectives: The study aimed to evaluate the effects of Ramadan fasting on diabetic nephropathy in patients with T2D. Materials and Methods: The present study was conducted on ninety patients with T2D who intended to fast Ramadan; they were divided into the following groups: Group 1: 30 patients with T2D, without albuminuria (normoalbuminuria); Group 2: 30 patients with T2D, with microalbuminuria; and Group 3: 30 patients with T2D, with macroalbuminuria. Laboratory tests including fasting plasma glucose, 2-h postprandial plasma glucose, haemoglobin A1c, serum creatinine, blood urea and urinary albumin/creatinine ratio (UACR) were measured 2 weeks before Ramadan fasting and then repeated within 2 weeks after Ramadan. Results: On comparing data before and after Ramadan, there was a significant increase in creatinine and urea levels, while there was a significant decrease in the estimated glomerular filtration rate (eGFR) and UACR in all the study groups. There was no significant difference between the study groups regarding the percentage of increase in creatinine (P = 0.204) and urea (P = 0.505), while the percentage of decrease in eGFR was significantly higher in the macroalbuminuria group (P = 0.038), and the percentage of decrease in UACR was significantly higher in the normoalbuminuria group (P = 0.001). Conclusion: Ramadan fasting adversely affects the renal function and causes a decrease in the eGFR in type 2 diabetic patients with diabetic nephropathy. Fasting should be under close medical supervision with strict attention to fluid intake and daily activity, as well as adjustment of drug regimens.","PeriodicalId":34280,"journal":{"name":"Hamdan Medical Journal","volume":"15 1","pages":"132 - 138"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42784263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MMTV-like Env sequences from human breast cancer patients cannot yet be considered as a separate species 来自人类乳腺癌症患者的MMTV-样Env序列还不能被视为一个单独的物种

Hamdan Medical Journal Pub Date : 2022-07-01 DOI: 10.4103/hmj.hmj_35_22

Waqar Ahmad, T. Khader, N. Panicker, Shaima Akhlaq, Jasmin Baby, Bushra Gull, F. Mustafa

{"title":"MMTV-like Env sequences from human breast cancer patients cannot yet be considered as a separate species","authors":"Waqar Ahmad, T. Khader, N. Panicker, Shaima Akhlaq, Jasmin Baby, Bushra Gull, F. Mustafa","doi":"10.4103/hmj.hmj_35_22","DOIUrl":"https://doi.org/10.4103/hmj.hmj_35_22","url":null,"abstract":"Background: Mouse mammary tumour virus (MMTV), a betaretrovirus, causes breast cancer in mice. Since its discovery, scores of studies have reported the detection of MMTV-like antigens and sequences primarily in human breast cancer, but not normal tissues. The presence of these sequences in humans has been hypothesised to be possibly due to zoonosis of MMTV into humans, named human mammary tumour virus (HMTV). However, many groups have not been able to repeat these findings, making these observations controversial. Over the years, an increasing number of HMTV env gene sequences from human breast cancer patients worldwide have been deposited in GenBank and other repositories. Aims and Objectives: The aim of this study was to use the current bioinformatic tools to analyse these highly homologous sequences to determine if any signature sequences could be associated specifically with HMTV. Materials and Methods: We first built an MMTV env gene consensus sequence (MMTV_CON) from the 41 MMTV sequences available in the database that was used to align the reported HMTV sequences (n = 333). Results: As expected, the MMTV envs showed 4-5% genetic variation within the mouse isolates. Alignment of MMTV_CON with those from HMTV revealed ten nucleotide variations that were like those observed within MMTV env, showing that the two viral strains could not be distinguished. Conclusion: Thus, we conclude that despite extensive data, inadequate env coverage, conservation of MMTV and HMTV envs and limitations in HMTV study design suggest that HMTV cannot be considered a separate species until the availability of more data covering full-length env or HMTV genome.","PeriodicalId":34280,"journal":{"name":"Hamdan Medical Journal","volume":"15 1","pages":"155 - 163"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41609152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Internal hernia in pregnancy after Roux-en-Y gastric bypass: A surgical diagnostic dilemma Roux-en-Y胃旁路手术后妊娠内疝:外科诊断困境

Hamdan Medical Journal Pub Date : 2022-07-01 DOI: 10.4103/hmj.hmj_74_21

Hadiel Kaiyasah, Maryam Saif Al Ali, L. Alhubaishi, Shiney Oliver, Faiza Badawi, A. Al Ani

{"title":"Internal hernia in pregnancy after Roux-en-Y gastric bypass: A surgical diagnostic dilemma","authors":"Hadiel Kaiyasah, Maryam Saif Al Ali, L. Alhubaishi, Shiney Oliver, Faiza Badawi, A. Al Ani","doi":"10.4103/hmj.hmj_74_21","DOIUrl":"https://doi.org/10.4103/hmj.hmj_74_21","url":null,"abstract":"Rationale: Internal hernia after Roux-en-Y gastric bypass (RYGB) is a lifelong risk. During pregnancy, this risk increases due to the rise in the intra-abdominal pressure. Early recognition and intervention are the keys to have a better outcome. The aim of this case report is to shed the light on the possibility of such occurrence. Patient Concerns: A 40-year-old woman presented to the emergency department at 36 weeks of gestation with acute abdominal pain. Diagnosis: She was in labor. In view of her past history of gastric bypass, a surgical consult was obtained. Patient developed episodes of hypotension with deceleration, so an emergency caesarean section was performed. Interventions: The abdomen was explored Intraoperatively. An internal hernia with small bowel volvulus was found. Outcomes: The hernia reduced and bowel revived. Postoperatively, the patient had a smooth recovery and a healthy baby. Lessons: Nowadays, due to the global obesity epidemic, lots of women of childbearing age are undergoing bariatric surgery all over the world. Having the knowledge about the possible complications of such procedures is of paramount importance. This is in order to be able to have an earlier operative intervention whenever indicated, hence, decreasing the maternofetal morbidity and mortality. Internal herniation after RYGB exemplifies a rare, high-risk complication that might occur in pregnancy. A high index of suspicion is required for early diagnosis and better outcome.","PeriodicalId":34280,"journal":{"name":"Hamdan Medical Journal","volume":"15 1","pages":"164 - 167"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44580997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Outcome of craniotomy and membranectomy in the management of chronic subdural haematoma recurrence: A series of 17 patients 开颅和膜切除术治疗慢性硬膜下血肿复发的结果:17例患者

Hamdan Medical Journal Pub Date : 2022-07-01 DOI: 10.4103/hmj.hmj_10_22

T. Bennafaa, Adel Khelifa, W. Bennabi, Y. Felissi, F. Aichaoui, A. Morsli

{"title":"Outcome of craniotomy and membranectomy in the management of chronic subdural haematoma recurrence: A series of 17 patients","authors":"T. Bennafaa, Adel Khelifa, W. Bennabi, Y. Felissi, F. Aichaoui, A. Morsli","doi":"10.4103/hmj.hmj_10_22","DOIUrl":"https://doi.org/10.4103/hmj.hmj_10_22","url":null,"abstract":"Background: Chronic subdural hematoma (CSDH) is a proportionally frequent neurosurgical pathology, and burr hole craniotomy is the most commonly used procedure in its treatment. However, currently, there is no real consensus on its management, especially recurrences. Many authors forwarded each management modality for the recurrence of CSDH; bone flap craniotomy was less frequently defended. Aims and Objectives: we aim to confirm the superiority of bone flap craniotomy with membranectomy over other techniques in the management of CSDH recurrences. Materials and Methods: We studied retrospectively 17 patients operated on at our department from February 2016 to February 2020, for particular situations of CSDH recurrence. Results: 17 patients with recurrent chronic subdural hematomas were operated on with bone flap craniotomy and membranectomy; with main age of 67 years old. Only one patient (5.8 %) presented recurrence of the hematoma after bone flap craniotomy. We have got one case (5.8%) of suspect osteitis on the bone flap managed successfully. Unfortunately, one patient in this series died. Conclusion: In careful surgical hands, the bone flap is not more harmful than other surgical procedures and it is found to be effective in CSDH recurrence management.","PeriodicalId":34280,"journal":{"name":"Hamdan Medical Journal","volume":"15 1","pages":"126 - 131"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45243768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Financial benefit of antidiabetic drugs available at jan aushadhi (people's drug) stores to geriatric pensioners: A pilot study from India jan aushadhi（人民药品）商店提供的抗糖尿病药物对老年养老金领取者的经济效益：来自印度的一项试点研究

Hamdan Medical Journal Pub Date : 2022-04-01 DOI: 10.4103/hmj.hmj_64_21

J. Mamatha, P. Palatty, Dhanya Sachendran, R. Vijendra, M. Baliga

{"title":"Financial benefit of antidiabetic drugs available at jan aushadhi (people's drug) stores to geriatric pensioners: A pilot study from India","authors":"J. Mamatha, P. Palatty, Dhanya Sachendran, R. Vijendra, M. Baliga","doi":"10.4103/hmj.hmj_64_21","DOIUrl":"https://doi.org/10.4103/hmj.hmj_64_21","url":null,"abstract":"Background: For the elderly, affected with Type II diabetes the costs for medications can be immense and forms a substantial part of their savings and pensions. Aims and Objectives: Diabetes mellitus is a major health issue in India and the treatment costs severely affect the elderly who are dependent on their family or on their pensions. In this study, we evaluated the economic cost of branded versus Jan Aushadhi drugs for geriatric pensioners. Materials and Methods: This was an observational, cross-sectional study and was conducted at the outpatient department of General medicine and Endocrinology at Amrita Institute of Medical Sciences, Ernakulam, Kerala, India. The prescriptions of patients attending the clinic for the care of type II diabetes and associated co-morbidities were analysed. The age, sex, and the number of medications were noted. The price of the costliest, cheapest, and most prescribed branded drugs were noted from the CIMS index 2020, while that for Jan Aushadhi drug was observed from the price catalogue. The financial cost burden on retired aged citizens was calculated by considering INR 8000 as the pension amount. Results: The average cost of the drugs when bought from the costliest brands amounted to 2592.52, of which 750.31 amounted for antidiabetics, while when purchased from Jan Aushadhi was 542.3 and 350.46, respectively. The percentages of the cost required for monthly treatment for an individual with 8000 INR pension for the branded drug was 32.4% and 6.77% for all medications and antidiabetic drugs, while when bought from Jan Aushadhi was 9.37 and 4.38, respectively. Conclusions: A significant difference between cost for Jan Aushadhi and branded drugs and this can be of benefit to the geriatric pensioners. As far as the authors are aware of this is the first study that addresses the beneficial effect of Jan Aushadhi antidiabetic drugs in the geriatric pensioners and has high relevance and use in public health.","PeriodicalId":34280,"journal":{"name":"Hamdan Medical Journal","volume":"15 1","pages":"66 - 70"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46670831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of microalbuminuria, creatinine, glomerular filtration rate and body mass index in predicting early nephropathy in patients with sickle cell disease 微量白蛋白尿、肌酐、肾小球滤过率和体重指数在预测镰状细胞病患者早期肾病中的作用

Hamdan Medical Journal Pub Date : 2022-04-01 DOI: 10.4103/hmj.hmj_60_21

Abazar Ismail, A. Abakar, M. Elkarsany, B. Almugadam

{"title":"Role of microalbuminuria, creatinine, glomerular filtration rate and body mass index in predicting early nephropathy in patients with sickle cell disease","authors":"Abazar Ismail, A. Abakar, M. Elkarsany, B. Almugadam","doi":"10.4103/hmj.hmj_60_21","DOIUrl":"https://doi.org/10.4103/hmj.hmj_60_21","url":null,"abstract":"Background: Notably, sickle cell disease (SCD) is a major risk for renal problems. Proteinuria is a feature of sickle cell nephropathy that can develop into end-stage renal disease. Objective: The main goal of this study was to assess the link between microalbuminuria, creatinine, glomerular filtration rate (GFR) and body mass index (BMI) with the predicting early nephropathy in sickle cell disease patients who were admitted to Kosti Teaching Hospital during the period from June to August 2018. Materials and Methods: A total of 156 SCD participants were enrolled in this study. Venous blood and fresh urine samples were collected from each participant using sterile containers. Serum creatinine and urine microalbuminuria were measured. Results: Out of 156 patients, 61.5% were underweight. Interestingly, a decline in creatinine level and GFR was observed in 21.1% and 64.7% of the SCD cases, respectively. Likewise, microalbuminuria was detected in 55.8% of participants. Notably, the duration of SCD (P < 0.05), creatinine level (P < 0.05), age (P < 0.05) and microalbuminuria (P < 0.05) was significantly positively correlated with BMI. SCD duration, GFR, microalbuminuria, weight and highest exhibited a significant positive correlation with creatinine. Furthermore, GFR has presented a positive correlation with weight and highest, P < 0.05. In addition, weight displayed a positive correlation (P < 0.000) with disease duration. Conclusion: Altogether, the study findings highlighted the link of BMI, creatinine, microalbuminuria and GFR with SCD, which is significant in the prediction and assessment of early nephropathy in SCD patients.","PeriodicalId":34280,"journal":{"name":"Hamdan Medical Journal","volume":"15 1","pages":"71 - 77"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42452992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Screening for aneuploidies in first trimester: Overview and patient management 妊娠早期非整倍体筛查：综述和患者管理

Hamdan Medical Journal Pub Date : 2022-04-01 DOI: 10.4103/hmj.hmj_41_22

Daria Pashkunova, A. Tammaa

引用次数: 0

Comparison of Foley's catheter and misoprostol versus misoprostol alone on labour induction Foley导管和米索前列醇与单独米索前列在引产中的比较

Hamdan Medical Journal Pub Date : 2022-04-01 DOI: 10.4103/hmj.hmj_7_22

M. Rafiq, S. Salman

{"title":"Comparison of Foley's catheter and misoprostol versus misoprostol alone on labour induction","authors":"M. Rafiq, S. Salman","doi":"10.4103/hmj.hmj_7_22","DOIUrl":"https://doi.org/10.4103/hmj.hmj_7_22","url":null,"abstract":"Background: Labour is traditionally induced with sub lingual (SL) misoprostol but researchers have proposed greater effectives and benefits if Foley's catheter is also used. Aims and Objectives: The aim was to study the effect of cervical Foley's catheter and misoprostol on labour induction in comparison to SL misoprostol alone. Materials and Methods: This randomised controlled trial was conducted from January 2020 to January 2021 on a study population of 96 female patients. They were distributed by lottery method into Groups 0; having been given SL misoprostol alone and Group 1; given the same in addition to cervical Foley's catheter. After randomisation, each group of 48 patients was noted for the method of delivery and time from induction to delivery in hours. Results: Groups 0 and 1 had 48 patients each with a total of 96 patients. Overall means for age in years and age of gestation in weeks were 25.80 ± 5.73 and 39.51 ± 1.13, respectively. Overall parity was 1.88 ± 0.83. Normal vaginal delivery (NVD) was seen in 25 (26%) patients in Group 0 and 34 (35.4%) in Group 1, P = 0.01. Meantime from induction to delivery for Group 0 was 17.89 ± 1.05 h and for Group 1 13.93 ± 1.47 h respectively, with a difference of 3.96 ± 0.42 h and P = 0.01. Conclusion: The combination of misoprostol and Foley's catheter in the cervix is associated with more vaginal deliveries characterised by shorter times of delivery.","PeriodicalId":34280,"journal":{"name":"Hamdan Medical Journal","volume":"15 1","pages":"93 - 96"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43736334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0