Hamdan Medical Journal最新文献

{"title":"Effect of Sharbat-i-Anar Sheerin (pomegranate juice) in nausea and vomiting in pregnancy: A pre- and post-interventional study","authors":"Ismath Shameem, None Meharunnisa, Vandana Rajak, Siddiqui Sumaiya, K Radhika","doi":"10.4103/hmj.hmj_10_23","DOIUrl":"https://doi.org/10.4103/hmj.hmj_10_23","url":null,"abstract":"Background: Qay’al-hamal (Nausea and vomiting in pregnancy) is the most common gastrointestinal symptom of pregnancy, occurring in 80-85% of all pregnancies during the first trimester. The severity of nausea and vomiting in pregnancy (NVP) affects both the mother and foetus. Aims and Objectives: The objective planned for the study was to evaluate the effect of Sharbat-i-Anar Sheerin (Pomegranate Juice) in NVP. Materials and Methods: An open observational study was carried out in the Dept. of Ilmul Qabalat wa Amraze Niswan, National Institute of Unani Medicine Hospital, Bengaluru. Pregnant women 18-35 years of age, having singleton pregnancy in 6-12 weeks of gestational age with NVP (n=30) were included based on mild to moderate Pregnancy Unique Quantification of Emesis (PUQE-24) score and patients with severe NVP, systemic diseases, multiple gestation, ectopic and molar pregnancy were excluded. Sharbat-i-Anar Sheerin (20 ml) twice daily was administered orally on empty stomach for four weeks. The main outcome measure was a reduction in PUQE score. Results: 96.7% of pregnant women achieved a reduction in PUQE score and only 3.3% had no reduction. Mean±SD of PUQE score before, during treatment (on 1st and 2nd follow up), and after treatment (on 1st and 2nd follow up) was 7.73±1.66, 6.03±1.83, 4.97±1.75, 4.13±1.25, 3.7±0.95 respectively (P <0.001). Conclusion: This trial provides evidence of improved effectiveness and safety of Sharbat-i-Anar Sheerin in women with NVP. Moreover, no adverse effect of the research drug was noted during the trial.","PeriodicalId":34280,"journal":{"name":"Hamdan Medical Journal","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135262785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intensive 360° (Capsule) versus conventional phototherapy in neonatal jaundice","authors":"AmmarMohammed Haidar Shehadeh, AamerKamel Sammak, Rikaz Bizzari","doi":"10.4103/hmj.hmj_59_23","DOIUrl":"https://doi.org/10.4103/hmj.hmj_59_23","url":null,"abstract":"Background: Neonatal jaundice is a common condition affecting a high percentage of neonates. In severe cases, if left untreated, it could lead to damaging neurologic complications. Capsule phototherapy is an innovative model of phototherapy that could be faster and more effective than conventional phototherapy. However, to date, only a few studies have compared its effect with conventional phototherapy. Methods: This article is a retrospective, non-randomised and observational study conducted in the neonatal unit at Hatta Hospital, Dubai. All infants above 35-week gestation who presented with neonatal jaundice above the threshold for intensive phototherapy were included in the study. Babies were exposed to conventional intensive phototherapy if the bilirubin level crossed the intensive phototherapy level and to capsule phototherapy once the bilirubin level reached 2.5 mg/dL below the exchange transfusion level. The rate of bilirubin decline and the time needed to reach below the intensive phototherapy level was compared between babies under either model of phototherapy. Results: The efficacy difference was significant, as the mean serum bilirubin decreased 1.29 ± 0.45 mg/dL/h and 0.31 ± 0.13 mg/dL/h in capsule and intensive phototherapy, respectively. The difference was about 0.98 ± 0.23 mg/dL/h, with a P = 0.0001. The duration of treatment in capsule phototherapy was much shorter at 6.45 ± 2.3 h in comparison to 22 ± 10.8 h in intensive phototherapy (difference of 15.5 ± 6.8 h, P = 0.0001). Conclusion: Capsule phototherapy resulted in a faster decline of serum bilirubin level, and therefore, a shorter treatment duration than intensive phototherapy. However, more robust clinical trials with a higher number of subjects are required before suggesting capsule phototherapy, as the standard treatment for severe neonatal jaundice.","PeriodicalId":34280,"journal":{"name":"Hamdan Medical Journal","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135262977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"N-Terminal pro-B-Type natriuretic peptide correlates with prevalence of microvascular complications in emirati adults with type 2 diabetes mellitus","authors":"PierreSamir Raoof, Alaaeldin Bashier, Marwan Zidan","doi":"10.4103/hmj.hmj_91_22","DOIUrl":"https://doi.org/10.4103/hmj.hmj_91_22","url":null,"abstract":"Background: Pro-B-type natriuretic peptide (BNP) is a well-known predictor of congestive heart failure. No published data, to our knowledge, are available on the correlation of NT-proBNP with microvascular complications of type 2 diabetes in the Emirati population. Aims and Objectives: We aimed to evaluate the correlation between N-terminal-proBNP (NT-proBNP) and microvascular complications in patients with type 2 diabetes and to evaluate the correlation between NT-proBNP and metabolic parameters in patients with type 2 diabetes. Materials and Methods: This was a cross-sectional study conducted from 1st January 2016 to 31st December 2016. Eligible participants with type 2 diabetes were assessed for the evidence of nephropathy, neuropathy and retinopathy as well as biochemical testing for metabolic parameters. They were divided into two groups based on NT-proBNP level (100 pg/mL). Results: The total number of patients recruited was 236; 39.5% (n = 93) had an NT-proBNP of ≥100 pg/mL (Group A), and 60.5% (n = 143) had an NT-proBNP of <100 pg/mL (Group B). The odds ratio (OR) for patients with NT-proBNP ≥100 (Group A) to develop retinopathy was 2.196 (95% confidence interval [CI] 1.307–3.689, P = 0.003), the OR for Group A to develop neuropathy was 1.607 (95% CI 1.046–2.469, P = 0.031), while the OR for Group A to develop microalbuminuria was 1.082 (95% CI 0.855–1.369, P = 0.515). Conclusion: NT-proBNP is related to the prevalence of microvascular complications in patients with type 2 diabetes mellitus. Using NT-proBNP as a marker can define the population of patients at risk who may benefit from the therapeutic interventions to delay microvascular complication.","PeriodicalId":34280,"journal":{"name":"Hamdan Medical Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135263518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A cross-sectional survey on knowledge, beliefs and attitude towards childhood COVID-19 vaccination amongst the parents attending a tertiary care hospital in Kolkata for child health services","authors":"M. Datta, Abhishek Reja, Pushpak Das","doi":"10.4103/hmj.hmj_86_22","DOIUrl":"https://doi.org/10.4103/hmj.hmj_86_22","url":null,"abstract":"Background: Before starting the coronavirus vaccination drive in children, it is necessary to know about the knowledge, attitude and perceptions of the parents regarding vaccinating their children. This study aimed to explore the knowledge of the parents of children aged <12 years on coronavirus infection and vaccine and to assess their beliefs and attitude about COVID vaccination amongst the 0–11 years of age group. It also aimed to find out the factors to prefer government facility for COVID vaccination. Materials and Methods: An observational, descriptive, hospital-based cross-sectional study was conducted by interviewing parents who attended Medical College, Kolkata, during November–December, 2021. The data were analysed with the Statistical Package for Social Sciences (SPSS). Results: A total of 106 respondents were interviewed (50.9% males and 49.1% females). All the respondents heard about coronavirus disease and vaccines, almost everybody knew how to prevent transmission of the virus. 56.6% respondents were aware of the correct age group for vaccination and 77.4% considered the vaccines to be safe. Regarding the factors amongst parents to prefer government facilities, significant associations were found with the level of education, employment status, number of children and vaccination status of the parents. Statistical significance level was at P< 0.05. Conclusion: Majority of parents considered existing vaccines as safe for children and almost everyone thought of vaccination as social responsibility. Most parents wanted the vaccines to be given from immunisation clinics or through schools. They also had a clear preference for government facilities.","PeriodicalId":34280,"journal":{"name":"Hamdan Medical Journal","volume":"16 1","pages":"47 - 52"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49201140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A prognostic hypoxia gene signature is associated with a dampened tumour immune microenvironment in cervical cancer","authors":"R. Khouzam, G. Venkatesh, S. Rao, S. Chouaib","doi":"10.4103/hmj.hmj_60_22","DOIUrl":"https://doi.org/10.4103/hmj.hmj_60_22","url":null,"abstract":"Background: Hypoxia, or low oxygen, is a condition that is characteristic of solid tumours, including cervical cancer. Hypoxia is associated with worse survival in this disease and supports tumorigenic characteristics of stemness, survival, metastasis and angiogenesis, as well as immune resistance. Aims: In this work, we aimed to determine the prognostic significance of a previously derived in vitro eight-gene hypoxia signature in cervical cancer, and to investigate the interplay between the hypoxic and immune features of the cervical tumour microenvironment (TME). Subjects and Methods: The 240 patients with cervical squamous cell carcinoma obtained from the Cancer Genome Atlas Pan-Cancer study were first given a hypoxia score and an immune score (IS) and subsequently subjected to survival analysis. CIBERSORTx was also applied to determine the fractions of immune cells residing in the hypoxia high versus hypoxia low patient groups. Results: We show that the eight-gene hypoxia signature is predictive of worse prognosis in patients with cervical cancer and is associated with a less immunogenic TME. Furthermore, by combining the hypoxia score with an IS to stratify patients based on both their hypoxic and immune status, we achieve an enhancement in survival prediction, with the hypoxia high/immune low subgroup of patients showing the worse probability of overall and disease-specific survival. Conclusions: It is clear from this work that the interplay between the hypoxic and immune microenvironment can contribute to cervical cancer patients' survival. Furthermore, patients with tumours that are both highly hypoxic and immune deprived should be considered for hypoxia-targeted therapy when planning treatment modalities to improve survival.","PeriodicalId":34280,"journal":{"name":"Hamdan Medical Journal","volume":"16 1","pages":"7 - 13"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48176996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perspectives of doctors and nurses about the implementation of respectful maternity care in a teaching hospital in India","authors":"Indrani Das, M. Datta, S. Samanta","doi":"10.4103/hmj.hmj_72_22","DOIUrl":"https://doi.org/10.4103/hmj.hmj_72_22","url":null,"abstract":"Background: An important component of the mother-and-baby-friendly birthing facility is respectful maternity care (RMC) during delivery. Aims and Objectives: The objectives of this study were to identify resident doctors' and staff nurses' opinions on the provision of RMC at their workplace, to explore the association between opinion on RMC and respondent's characteristics, and to explore the perceived barriers. Materials and Methods: A facility-based observational, descriptive study of the cross-sectional design was thus conducted among 78 resident doctors and staff nurses posted in the labour room of the study hospital. Data were collected by a predesigned, self-administered questionnaire. Variables included were demographic, service related and opinion on prevalent RMC practice at the respondents' workplace. SPSS version 17 was used for data analysis. Results: Providers' mean age was 30.5 years, and the mean work experience of 3.1 years. About two-thirds of the respondents were resident doctors and 83.3% were female. More than 60% of providers were trained on RMC. Providers reported desirable practices on most items related to RMC except in providers introducing themselves to women, allowing birthing companions and allowing women to assume the position of choice. Opinion about RMC was significantly associated with training status. Uncooperative women were considered the most important barrier to providing optimum RMC. Conclusion: It can be concluded from this study that training providers can reinforce good practices related to RMC and improve the quality of care at birth.","PeriodicalId":34280,"journal":{"name":"Hamdan Medical Journal","volume":"16 1","pages":"20 - 25"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45028943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibiotic consumption in a tertiary care hospital during the pre-COVID-19 and COVID-19 years: A pharmacy-based, retrospective study","authors":"Sarmila Nath, Tanmoy Gangopadhyay, Shritama Banerjee, Pragnadyuti Mandal, DilipKumar Khatua","doi":"10.4103/hmj.hmj_82_23","DOIUrl":"https://doi.org/10.4103/hmj.hmj_82_23","url":null,"abstract":"","PeriodicalId":34280,"journal":{"name":"Hamdan Medical Journal","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135311642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare presentation of psoas abscess causing necrotising fasciitis and meleney's gangrene extending to the perianal region","authors":"DoaaMohamad Hassan, AlaaAllam Ibrahim Ismail, HasanEbrahim Badawi, AbanobEshak Wanis, AbdullahiMohammed Haji Sufi, MashhourGhonaim Mohammed, AmirMounir Henry","doi":"10.4103/hmj.hmj_84_23","DOIUrl":"https://doi.org/10.4103/hmj.hmj_84_23","url":null,"abstract":"","PeriodicalId":34280,"journal":{"name":"Hamdan Medical Journal","volume":"78 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135313111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology of pica amongst pregnant women and its clinical, psychological, basic science, realities and myths in UAE","authors":"Hana Iqbal, Batool Khan, Sabila Siddiqui, Hafez Ahmed","doi":"10.4103/hmj.hmj_6_23","DOIUrl":"https://doi.org/10.4103/hmj.hmj_6_23","url":null,"abstract":"Background: Pica is an eating disorder that affects pregnant women which is manifested by craving for ingestion of non-food items that are unusual in kind or quantity e.g. soil, ice, dirt, hair, chalk. Although there is a rich literature describing this behavior from most parts of the world, there is a dearth of studies reporting this behavior in UAE. Aims and Objectives: This cross-sectional exploration study sought to determine the prevalence of pica, its various patterns of presentation, causes, related misconceptions and its impact on behavior and health of pregnant women and their infants in Dubai, UAE. Materials and Method: A random sample of pregnant women (n = 60) were interviewed using an online questionnaire during 2020. Results: The results showed that 57.9% of interviewed women practiced pica, with pagophagia having the highest prevalence (20.4%) followed by sapophagia (8.2%), amylophagia (2%), geophagia (2%), baking soda (2%), coffee ground (2%), roses (2%), paper (2%) and many other rare forms collectively adding up to 59.4%. Age and level of education were not significantly related to the practice of pica. Interestingly, 32.8% of the interviewed women reported that other family members also practiced many patterns of pica during their pregnancies. Effects, myths or misconceptions of pica are also addressed in the study. Conclusion: Several patterns of pica are highly prevalent among pregnant women in the UAE, with pagophagia and sapophagia being the most commonly encountered forms. More than half of the women showed symptoms of stress and anxiety which highlights the importance of studying the pica as a “stress mediator during pregnancy. Iron deficiency anemia and malnutrition are the biggest contributors to the development of pica following pregnancy. In this study, 25% of the respondents had both anaemia and pica. Majority of women were uncertain of the harmful effects of pica which clearly points at the lack of knowledge and understanding of pica. 17.5% of the respondents considered pica to be important for a healthy pregnancy. Given the results, there is no significant relation between the level of education and the practice of pica as 63.3% were graduates of college and University. Our study concluded that pica in pregnant women is associated with weight gain, anemia and polycythemia among their babies.","PeriodicalId":34280,"journal":{"name":"Hamdan Medical Journal","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135262569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary Papillary Thyroid Carcinoma Arising in a Branchial Cleft Cyst – Navigating a Hidden Malignancy on Histopathology","authors":"Swati Raj, Monika Singh, Mamta Gupta, Naveen Thapliyal","doi":"10.4103/hmj.hmj_26_23","DOIUrl":"https://doi.org/10.4103/hmj.hmj_26_23","url":null,"abstract":"Rationale: Papillary thyroid carcinoma arising from ectopic thyroid tissue within a branchial cleft cyst is extremely rare. To the best of our knowledge, only 17 cases have been reported as Papillary carcinoma in branchial cyst, being primary or secondary in the archives. Only 7 cases are reported as primary, with only 5 cases having regional lymph node metastasis. Patient Concerns: We present a case report of an Indian male in his 30s, presented with complaints of a progressively enlarging, non-tender swelling in the left cervical region for 1 year. Diagnosis: The Contrast - enhanced computed tomography & Fine needle aspiration performed in an outside laboratory showed findings suggestive of branchial cyst. A clinical diagnosis of “branchial cyst” was formed. Interventions: The Cyst excision was done and sent for histopathological examination(HPE) for confirmation. Outcomes: Microscopic examination revealed papillary carcinoma arising from branchial cleft cyst with three out of seven lymph nodes identified showing metastatic deposits. The remaining four lymph nodes showed marked fibrosis and sinus histiocytosis. Then the patient was subjected for total thyroidectomy, which showed no evidence of malignancy on HPE, followed by I-131 radioactive ablation. Lessons: Primary PTC arising in a branchial cleft cyst is an incidental, extremely rare entity and should be kept in mind while dealing with a lateral cervical cystic lesion. They bear a high risk of regional lymph node metastasis. FNAC and radiological investigations alone cannot warrant the diagnosis. Histopathological examination is the key to unlocking the diagnosis and is considered the “gold standard”. Complete cyst excision and regional lymph node removal, along with precautionary hemi- or total thyroidectomy, are highly suggested to reduce metastasis and increase survival rates.","PeriodicalId":34280,"journal":{"name":"Hamdan Medical Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135263311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}