The Medical Journal of Basrah University最新文献

{"title":"Association between apolipoprotein E polymorphism and lipid profile in patients of myocardial infarction","authors":"P. Kamble","doi":"10.33762/MJBU.2020.127936.1030","DOIUrl":"https://doi.org/10.33762/MJBU.2020.127936.1030","url":null,"abstract":"Objective: To determine the effect of apo E polymorphism on lipid profile in patients of myocardial infarction as well as normal healthy controls. Subjects and Method: Total 100 acute myocardial infarction patients with age and gender matched controls, within age ranging from 25 to 80 years were included. Lipid profile levels of MI patients and controls were estimated by standard methods. DNA’s were extracted by salting out method and Genotypes for Apo-E were determined by Multiplex Amplification Refractory Mutation System PCR. Results: The total cholesterol, LDL cholesterol, TC/HDL-C ratio, LDL-C/HDL-C ratio level was significantly increased (P < 0.01) in E4E4 allele than E3E3 allele. Analysis of variants has significant difference (P < 0.01) observed in total cholesterol and LDL cholesterol levels in all Apo E alleles of MI patients. Conclusion: Our results suggestive that the risk of myocardial infarction with Apo E4E4 alleles.","PeriodicalId":33859,"journal":{"name":"The Medical Journal of Basrah University","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78083172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early Mortality Risk in Patients with Multiple Myeloma","authors":"Diveen J Hussein","doi":"10.33762/MJBU.2020.127475.1022","DOIUrl":"https://doi.org/10.33762/MJBU.2020.127475.1022","url":null,"abstract":"Background: advances in treatment has improved greatly survival of multiple myeloma in the last two decades, and this improvement has been endorsed by wider use of novel drugs and tandem autologous stem cell transplantation. however, still there were cases died earlier post diagnosis Objectives: to study the risk factors of early mortality in patients with multiple myeloma in Kurdistan region of Iraq Patients and methods: a 176 cases that were diagnosed with symptomatic multiple myeloma between (January 2012 – July 2019) in cancer centers in Kurdistan region of Iraq. a total of 152 were continued within the study through their recorded sheet. their data were analysed to determine what are the main risk factors that have an impact on early mortality among our myeloma patients. Results: among the total of 152 studied patients nine of them (5.9%) died early. the highest proportion (32.2%) of the sample aged 60-69 years, more than half (57.2%) of the them were male. the majority of the patients (80.9%) have been diagnosed during 2016-2019. the incidence of early death was 8.7% among patients who didn’t take the cytotoxic treatment compared with 1.7% of patients who took that treatment, but the difference was not significant (P = 0.089). the early death rate was significantly high (22.2%) among patients who didn’t take the immunomodulatory drugs, versus 2.4% of patients who took the immunomodulatory drugs (P = 0.001). the incidence of early mortality was 9.6% among patients with lactate dehydrogenase of ≥ 250 U/L compared with 0% among patients with LDH of less than 250 (P = 0.013). Conclusion: LDH level is a high prediction in finding early mortality among patients with multiple myeloma, and intake of immunomodulatory drugs is highly preventive in early death occurrence. keywords: Multiple Myeloma, Kurdistan Region of Iraq Principle Investigator Full name: Diveen Jalal Hussein  Email: diveen.jelal@gmail.com Mobile phone number: 07504884399 Research Supervisor: Full name: Dr. Kawa Muhamedamin Hasan  Email: mah_kawa@yahoo.com Mobile phone number: 07504486240 Research CO_Supervisor: Full name: Dr. NawsherwanSadiq Mohammed  Email: naw_sadiq@yahoo.com","PeriodicalId":33859,"journal":{"name":"The Medical Journal of Basrah University","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78652631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Body Weight Changes in 210 Breast Cancer Patients after Finishing Chemotherapy; Cross Sectional Study","authors":"H. Ali, E. Al-Tawri","doi":"10.33762/MJBU.2020.128412.1037","DOIUrl":"https://doi.org/10.33762/MJBU.2020.128412.1037","url":null,"abstract":"Background and aim: Increasing body weight in breast cancer patients after finishing chemotherapy is a rising health problem among many countries; this study try to evaluate this health issue among breast cancer patients attended Basra Oncology Center. Patients and Methods: This cross sectional study carried out on 210 patients with breast cancer who received chemotherapy at Basra oncology center, from 2017 to 2019. The participant's personal data and the other clinical information were derived from patient file. Results: Weight changes after finishing chemotherapy occurred in about 95% of breast cancer patients, and measurement of body mass index of patients at the start and at the end of chemotherapy revealed more women occupied the obese strata after completing the chemotherapy. The study showed statistically significant differences in the weight changes among the age, weight at diagnosis, state of hormone receptor & marital status subgroups. The only significant predictors of body weight changes after completing chemotherapy were patient age and body mass index at time of diagnosis. Conclusion: There is a significant weight gain in breast cancer patients in Basra Oncology Center after finishing chemotherapy.","PeriodicalId":33859,"journal":{"name":"The Medical Journal of Basrah University","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76762261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Vitamin D in Female Pattern Hair Loss Among Iraqi Women: A Case- Control Study","authors":"S. Dhaher, Mehad H Alwan","doi":"10.33762/MJBU.2020.127206.1026","DOIUrl":"https://doi.org/10.33762/MJBU.2020.127206.1026","url":null,"abstract":"Background: Low serum level of Vitamin D may have a potential role in the pathogenesis of female pattern hair loss (FPHL). Aims: To evaluate serum vitamin D level in Iraqi women with female pattern hair loss and compare it with normal healthy control. Settings and Design: A case-control study was carried out on 190 women: 95 patients with FPHL aged ≥15 years and 95 healthy agematched control. Methods and Material: The diagnosis and severity of FPHL were based on clinical examination and using Ludwig classification. All participants were investigated for vitamin D level and alkaline phosphatase. Data were collected and statistically analyzed. Results: The mean ± SD level for vitamin D was significantly lower in the FPHL group than control (13.8 ± 2.6 ng/mL vs 37.6 ± 4.7ng/mL, p < 0.001). Eighty-two patients (86.1%) of the FPHL group and 35 (36.9%) of the control group had a low vitamin D level (p < 0.001). Alkaline phosphatase level was significantly elevated in 77of FPHL compared to the control group ((81% versus 19%, p < 0.001). Low vitamin D level was significantly correlated with the duration of hair loss, alkaline phosphatase elevation, and symptom of bone pain. Conclusions: Women with low serum vitamin D levels have a high potential for the development of FPHL suggesting that vitamin D may have a possible role in the etiopathogenesis of this pattern of hair loss.","PeriodicalId":33859,"journal":{"name":"The Medical Journal of Basrah University","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88750409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effectiveness of uterine packing combined with topical tranexamic acid for the management of primary postpartum hemorrhage","authors":"Maysara Mohammed Abdulrhidha, Jubran K Hassan, D. S. Alharoon","doi":"10.33762/MJBU.2020.127000.1010","DOIUrl":"https://doi.org/10.33762/MJBU.2020.127000.1010","url":null,"abstract":"Objectives: the aim of the study is to identify the effectiveness of adding topical tranexamic acid to uterine pack to control primary postpartum hemorrhage PPH compared to uterine packing alone. Methods: the study included 30 women with intractable primary PPH after vaginal deliveries due to uterine atony in whom the conventional local pathway of management of PPH had failed to control bleeding. In 15 women (the case group), uterine pack impregnated with 20 ml of tranexamic acid(1gm/10ml) was used to control bleeding and compared to 15 women (the control group) in whom uterine pack without tranexamic acid was used, outcome studied include the need for further surgical intervention and the need for blood product transfusion. Results: although uterine packing impregnated with TXA was successful in controlling bleeding in 13 women out of 15(86.7%) compared to 10 out of 15 cases (66.7%) in women who underwent uterine packing without TXA, however; the difference between effectiveness of each method is statistically insignificant. The requirement for blood product transfusion was less in TXA group. Conclusion: topical uterine TXA increase the efficiency of uterine tamponade to control PPH, and may decrease the need for more invasive surgical intervention as hysterectomy","PeriodicalId":33859,"journal":{"name":"The Medical Journal of Basrah University","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82415560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypopharyngeal Foreign Body in A 9-months-Old Male Baby","authors":"Raid M. Al-Ani","doi":"10.33762/MJBU.2020.127476.1023","DOIUrl":"https://doi.org/10.33762/MJBU.2020.127476.1023","url":null,"abstract":"Fishbone is the commonest pharyngeal foreign body in Asia. However, uncommon types also were reported in the literature. A 9-months-old male infant presented with crying, dysphagia and excessive salivation. Plain X-ray of the cervical spine lateral view confirmed the diagnosis of a metallic foreign body in the hypopharynx. The foreign body was extracted under general anesthesia without complications. A high index of suspicion from the caregiver and early intervention from the dealing doctor are crucial to avoid unwanted complications of pharyngeal foreign bodies' impaction. In conclusion, we reported a rare hypopharyngeal foreign body (Sim Card Slotter of an old fashion mobile phone) in a 9-months-old boy.","PeriodicalId":33859,"journal":{"name":"The Medical Journal of Basrah University","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77196352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Folate Status on Methotrexate Serum Level and Response in Children with Acute Lymphoblastic Leukemia","authors":"Dhuha Emad Omran, Nabeel Salih Ali, Jenan Ghalib","doi":"10.33762/mjbu.2020.126734.1006","DOIUrl":"https://doi.org/10.33762/mjbu.2020.126734.1006","url":null,"abstract":"","PeriodicalId":33859,"journal":{"name":"The Medical Journal of Basrah University","volume":"81 3‐4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72414371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tachycardia-induced cardiomyopathy, a diagnosis forgotten in the real world: Review of case series.","authors":"Amar Alhamdi","doi":"10.33762/mjbu.2020.165391","DOIUrl":"https://doi.org/10.33762/mjbu.2020.165391","url":null,"abstract":"Background: Left ventricular dysfunction induced by long-standing recurrent tachyarrhythmias, known as tachycardia-induced cardiomyopathy, is a reversible type of dilated cardiomyopathy and heart failure characterized by left ventricular failure that is usually recoverable once the tachyarrhythmia is well controlled by stabilizing the sinus rhythm or by heart rate control. Patients and methods: Twenty four patients with heart failure due to dilated cardiomyopathy and tachyarrhythmia were included. The arrhythmia and heart failure were both treated accordingly. The New York Heart Association’sfunctional class, left ventricular ejection fraction assessment and chest X-ray were done periodically to assess improvement. Results: Stabilization of the sinus rhythm was achieved in all patients. The NYHA class improved remarkably, from class III-IV to class I in all patients. The left ventricular ejection fraction rose remarkably from 20-30% to 4557%. The cardiac size remarkably improved radiologically. The symptoms of recurrent long-standing palpitation preceding the symptoms of dyspnea in heart failure are the first implication that arrhythmia is inducing the heart failure this was noticed in 20 patients. Conclusion: Tachycardia-induced cardiomyopathy is a reversible cause of heart failure. Controlling the arrhythmia recovers normal LV function.","PeriodicalId":33859,"journal":{"name":"The Medical Journal of Basrah University","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86075442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological Features of COVID-19 Epidemic in Basrah-Southern Iraq-First Report","authors":"O. Habib, Abbas K AlKanan, A. Abed, Nihad K Mohammed","doi":"10.33762/MJBU.2020.126943.1008","DOIUrl":"https://doi.org/10.33762/MJBU.2020.126943.1008","url":null,"abstract":"","PeriodicalId":33859,"journal":{"name":"The Medical Journal of Basrah University","volume":"139 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76573020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cisplatin & IV Etoposide combination in the treatment of advanced breast cancer pretreated with anthracyclines","authors":"A. Allami","doi":"10.33762/mjbu.2019.163352","DOIUrl":"https://doi.org/10.33762/mjbu.2019.163352","url":null,"abstract":"Background: Aims of this study was to determine the benefit of cisplatin and i.v etoposide combination in treatment of advanced breast cancer (ABC) patients who were pretreated with anthracyclines, as an alternative to the newer, more expensive, and unavailable anticancer drugs like Taxanes, carboplatin, and gemcitabine. Patients and methods: The study was performed in the period from March 2010 to June 2016, 235 patients were given cisplatin 50mg/m and etoposide 100mg /m for 6 cycles. The patients were divided into 4 groups according to the site of metastasis (vertebral metastases, liver metastases, loco-regional metastases, and pleuro-pulmonary metastases). Results: Evaluation of treatment was considered on two levels: Whole 235 patient level, and patient-group level. On whole patient level: Response to Treatment was 65.1%, which is higher than similar responses in many other studies. While on patient-group level: response to treatment was highest in patients with vertebral secondaries 75.3%. There was drug toxicity in all groups of patients. Some patients did not continue the treatment protocol because of bad performance status, toxicity and death. Conclusion: In comparison with other regimes of chemotherapy cisplatin and i.v etoposide are still useful anticancer drugs in the management of advanced breast cancer.","PeriodicalId":33859,"journal":{"name":"The Medical Journal of Basrah University","volume":"91 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77031026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}