Medical Theory and Hypothesis最新文献_第10页

A new explanation to homeopathy: observation of some phenomena and the nature of disease 顺势疗法的新解释:对某些现象和疾病本质的观察

Medical Theory and Hypothesis Pub Date : 1900-01-01 DOI: 10.53388/tmrth202004001

D. Deb

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Exploring the mechanisms of lipid regulation in metabolic syndrome: Recent developments 代谢综合征中脂质调节机制的探索:最新进展

Medical Theory and Hypothesis Pub Date : 1900-01-01 DOI: 10.53388/tmrth202306009

Guilou Wang, Qian Shen, Chuan-long Zhang

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Research on "Erchen" in Erchen decoction 二陈汤中“二陈”的研究

Medical Theory and Hypothesis Pub Date : 1900-01-01 DOI: 10.53388/tmrth202212019

Xie Yu-han, Liu Xiao-yi, Ruan Wen-Xiu

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Cyclic feeding regime stimulates chromatin condensation in the hepatocytes’ nuclei of old rats 循环喂养刺激老龄大鼠肝细胞核染色质凝聚

Medical Theory and Hypothesis Pub Date : 1900-01-01 DOI: 10.53388/tmrth202309017

C. Danladi, Bozhkov Anatolii Ivanovich

{"title":"Cyclic feeding regime stimulates chromatin condensation in the hepatocytes’ nuclei of old rats","authors":"C. Danladi, Bozhkov Anatolii Ivanovich","doi":"10.53388/tmrth202309017","DOIUrl":"https://doi.org/10.53388/tmrth202309017","url":null,"abstract":"Aging-related human malignancies and diseases are linked to flaws in chromatin condensation, which may be due to its significance in the segregation of chromosomes, regulation of genes and apoptosis. Investigations of Calorie Restriction (CR) have given significant information on the mechanisms that control cell reactions to metabolic variations and how these structures function in synergy toward ensuring a harmonized reaction. Chromatin plays a vital part in this process. Cyclic feeding regime (CFR) is more beneficial than CR in that it is easy to carry out. Therefore, the reason for this investigation was to investigate the effect of CFR on chromatin condensation in the hepatocytes’ nuclei of 20-month-old rats. DNA accessibility assay was used as a marker for chromatin condensation using Acridine Orange. DNA accessibility is the ability of Acridine Orange (AO) to intercalate and stain the DNA structure. Thus, from the DNA accessibility results, DNA condensation increased to 66% with 34% DNA accessibility after the first fasting, with a reduction to 41% with 59% DNA accessibility following refeeding. The second fasting–refeeding regime leads to a sharp 74% increase and 35% decrease in DNA condensation with 26% and 65% DNA accessibility, respectively. The results showed that old animals responded to CFR, with their consecutive fasting regime increasing the chromatin condensation.","PeriodicalId":338270,"journal":{"name":"Medical Theory and Hypothesis","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114104293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recombinant HIV to kill latent reservoir cells: a hypothetical therapeutic strategy 重组HIV杀死潜伏库细胞:一种假设的治疗策略

Medical Theory and Hypothesis Pub Date : 1900-01-01 DOI: 10.53388/tmrth202212024

U. C. Halder

引用次数: 0

Meta-analysis of therapeutic effect of Xiaoxuming decoction on stroke 小舒明汤治疗脑卒中疗效的meta分析

Medical Theory and Hypothesis Pub Date : 1900-01-01 DOI: 10.53388/tmrth202003004

Xin Wang, Zeying Wang

引用次数: 0

Natural gum: an option to prepare nanocarriers 天然口香糖:制备纳米载体的一种选择

Medical Theory and Hypothesis Pub Date : 1900-01-01 DOI: 10.53388/tmrth202309015

S. Rohilla, Gitika Gitika, D. Bhagwat, A. Rohilla

{"title":"Natural gum: an option to prepare nanocarriers","authors":"S. Rohilla, Gitika Gitika, D. Bhagwat, A. Rohilla","doi":"10.53388/tmrth202309015","DOIUrl":"https://doi.org/10.53388/tmrth202309015","url":null,"abstract":"The tree gum polysaccharide and their nanostructure are used eventually in various food and non-food industries. They attracted interest because of their makeup, non-toxicity and biological compatibility. They are currently being investigated as delivery systems for oral medicinal compounds. Natural gums have attracted more interest in the area of drug delivery systems due to their unique attributes. They are derived from bacteria, plants and algae. They are thought to be attractive prospective medication carriers as they have excellent biocompatibility and biodegradability. They swell in the intestine and are degraded by the colon microbiome. The original compounds are blended with other polymers to modify their properties as per requirements. Gums and gum-derived compounds can be used to prepare micro and nanoformulations that can deliver the drugs via different routes. In this review, We detailed and outlined the most recent studies on micro-and nanoparticles made from gums that have been extensively researched in pharmaceutical technology. This review focuses on the most crucial elements influencing the properties of micro-and nanoparticle systems and their applications as medication delivery systems.","PeriodicalId":338270,"journal":{"name":"Medical Theory and Hypothesis","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129640341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Discussion on reprogramming of tumor energy metabolism and intervention of traditional Chinese medicine based on the theory of “collateral qi stagnation” 基于“络气郁结”理论的肿瘤能量代谢重编程及中医干预探讨

Medical Theory and Hypothesis Pub Date : 1900-01-01 DOI: 10.53388/tmrth202303004

Yi Li, Guijie Wang, Chuan-long Zhang, Bo Pang

引用次数: 0

Application of data mining technology for inheriting medical experience of famous traditional Chinese medicine veterans in the diagnosis and treatment of diabetes mellitus 数据挖掘技术在传承著名中医老兵诊疗经验中的应用

Medical Theory and Hypothesis Pub Date : 1900-01-01 DOI: 10.53388/tmrth202309014

Yi Li, Guijie Wang, Bo Pang

{"title":"Application of data mining technology for inheriting medical experience of famous traditional Chinese medicine veterans in the diagnosis and treatment of diabetes mellitus","authors":"Yi Li, Guijie Wang, Bo Pang","doi":"10.53388/tmrth202309014","DOIUrl":"https://doi.org/10.53388/tmrth202309014","url":null,"abstract":"The inheritance of academic experience of famous traditional Chinese medicine (TCM) practitioners is the living soul of TCM. Applying systematic and scientific inheritance methods is an important means to continue the characteristic theory and unique experience of TCM. Data mining technology is a scientific research method based on the interdisciplinary content of statistics, informatics and other disciplines, and has played an important role in the inheritance of academic experience of famous TCM veterans in recent years. With the challenges of the information revolution and artificial intelligence era, TCM needs to use information technology’s unique advantages in inheriting essence and maintaining integrity and innovation to realize a high degree of integration of knowledge discovery and learning, experience, and inheritance. Taking diabetes mellitus, with high incidence in our country, as an example. This study commented on the research of data mining technology in the diagnosis and treatment inheritance of diabetes among famous traditional Chinese medicine veterans, systematically discussed the current situation, dilemma, prospect and outlook to provide new ideas for the inheritance of the diagnosis and treatment experience of famous TCM veterans with diabetes.","PeriodicalId":338270,"journal":{"name":"Medical Theory and Hypothesis","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126280927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thinking about traditional Chinese medicine treatment for COVID-19 对新冠肺炎中医药治疗的思考

Medical Theory and Hypothesis Pub Date : 1900-01-01 DOI: 10.53388/tmrth202001001

E. Group

引用次数: 0