Psikhiatriia nevrologiia ta medichna psikhologiia最新文献

{"title":"Enuresis: modern aspects of etiology, pathogenesis, psycho-, pharmaco-, physical therapy and phytotherapy (part 2)","authors":"","doi":"10.26565/2312-5675-2020-15-03","DOIUrl":"https://doi.org/10.26565/2312-5675-2020-15-03","url":null,"abstract":"In the second part of the review, the current state of the pharmacological, psycho-, physical therapy and phytotherapy of enuresis is analyzed in detail. An algorithm for the treatment of bedwetting, recommended by experts from the International Children's Continence Society, based primarily on behavioral therapy, alarm-therapy (“bedwetting alarm clock”), pharmacotherapy, is considered. Methods of psychotherapy are discussed in detail: behavioral therapy, in particular the token system, as well as the differentiated application of the method of suggestion (hypnotic, \"maternal suggestion\", the method of \"hypnosis-repose\", self-hypnosis). The using of play therapy, cognitive-behavioral, family-, art therapy, and a child variant of gestalt therapy in psychotherapy of neurotic disorders in case of enuresis is substantiated. The date showing the effectiveness of alarm therapy (a lower rate of subsequent relapses and a lower risk of side effects compared with the widespread treatment with desmopressin) are given. The main targets of pharmacotherapy and the corresponding drugs are analyzed in accordance with the etiology and pathogenesis of the disease. The use of psychostimulants, tricyclic antidepressants for normalization of the sleep depth, nootropic drugs (especially calcium hopantenate) in neurosis-like enuresis, and anxiolytics and sedatives in the relatively rare neurotic form is substantiated. New approaches to pharmacotherapy are discussed, including the use of uroselective antagonists of M3-cholinergic receptors (tolterodine, solifenacin), α1-adrenoblockers, non-steroidal anti-inflammatory drugs in the off label format. A critical analysis of treatment with desmopressin is given. The features of differentiated physical therapy of enuresis (high frequency current, electrophoresis with antispasmodics, magnetic therapy, thermal procedures, electric sleep, reflex therapy, exercise therapy, biofeedback method) are considered. The analysis of traditional approaches to herbal medicine as an auxiliary method of enuresis treatment using neurotropic, anticholinergic, antispasmodic properties of plants is presented. Strategies for increasing compliance and creating a therapeutic alliance are discussed. The researches supporting the benefits of early treatment of bedwetting are analyzed.","PeriodicalId":33688,"journal":{"name":"Psikhiatriia nevrologiia ta medichna psikhologiia","volume":"46 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69006742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimization of correction of sleep, speech and cognitive development in children as a result of perinatal injury of the central nervous system","authors":"","doi":"10.26565/2312-5675-2020-15-07","DOIUrl":"https://doi.org/10.26565/2312-5675-2020-15-07","url":null,"abstract":"The article presents the results of a clinical study on the efficacy and tolerability of the Anantavati® Kids dietary supplement (Ananta Medicare, UK) in children with speech, cognitive and sleep disorders as a result of perinatal lesions of the central nervous system (CNS). The peculiarities of the effect of Bacopa Monier and Vitania sleeping pills on functional changes in the brain in the main group of children receiving Anantavati® Kids and the comparison group are shown. During the study of the results of the use of the phytocomplex Anantavati® Kids (a fixed combination of Bacopa Monier - 150 mg and Vitania sleeping pills - 300 mg), 38 children aged 4 to 12 years were examined who received Anantavati® Kids in addition to rehabilitation psychological and speech therapy measures. For comparison, 20 children were examined who had similar syndromes and received only rehabilitation psychological and speech therapy measures, the groups were comparable in terms of gender and age. The efficacy, tolerability and safety of the dietary supplement \"Anantavati® Kids\" for behavioral disorders, impaired speech cognitive development and sleep disturbances due to perinatal CNS damage in children were assessed using neurophysiological methods and neuropsychological indicators, statistical methods. Children of the main group received Anantavati® Kids syrup for 30 days, and underwent two clinical-neurological, neuropsychological, speech therapy and neurophysiological examinations: immediately before the start of the course and 1 month after taking Anantavati® Kids. A positive effect, according to an individual assessment of the clinical state in dynamics after 1 month of using Anantavati® Kids, was registered in most children. In the main group, the prevalence of complaints of sleep disorders decreased by 71%, speech impairment – by 47.37%, hyperactivity – by 55.26%, memory impairment - by 42.11%, attention impairment - by 65.79%, emotional disorders spheres by 63.16%. Positive dynamics of speech therapy indicators, in the form of an increase and active use of vocabulary, an increase in the structure of the word and the volume of coherent speech, was observed in 18 (47.37%) children. After the end of the course Anantavati® Kids in 28 (73.68%) children of the main group, a pronounced positive dynamics of EEG indicators was determined. A good safety profile was noted with the use of Anantavati® Kids, which is manifested by good tolerance during the study. Thus, the analysis of the data obtained after the use of Anantavati® Kids in children with the consequences of perinatal CNS lesions demonstrate the profound effect of the Anantavati® Kids phytocomplex on sleep disturbances, symptoms of cognitive and speech and psychoemotional disorders against the background of a course intake.","PeriodicalId":33688,"journal":{"name":"Psikhiatriia nevrologiia ta medichna psikhologiia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69006809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The structure of cognitive and non-cognitive impairment in patients with hallucinatory-paranoid disorders in mixed dementia","authors":"","doi":"10.26565/2312-5675-2020-13-05","DOIUrl":"https://doi.org/10.26565/2312-5675-2020-13-05","url":null,"abstract":"The aim of the study was to determine the specifics of cognitive impairment and clinic-psychopathological characteristics in patients with hallucinatory-paranoid disorders in mixed dementia. In study involved 72 patients with hallucinatory-paranoid disorders in mixed dementia (main group) and 61 patients with mixed dementia without psychotic disorders (control group). To achieve the goals and objectives of the study a comprehensive approach was used, which was implemented using the following research methods: the clinic-psychopathological method (a structured interview conducted as part of the clinical, phenomenological and psychopathological approaches in psychiatry), elementary neuropsychological studies of the main cognitive functions of patients (compilation of pictures, understanding of stories and plot pictures, establishing a sequence of events, classification, elimination of excess, highlight significant features, search for analogies, definition and comparison of concepts, formation of artificial concepts, selection antonyms words), held in a structured interview; Mini-Mental State Examination (MMSE) short mental state assessment scale; Montreal Cognitive Assessment Scale (MoCa); Behavioral Disorders Scale (BEHAVE-AD) and non-cognitive sections of the Alzheimer's Disease Rating Scale (ADAS-Non Cog). As a result of the study, features of cognitive impairment in mixed dementia with hallucinatory-paranoid disorders, which included: decreased concentration, impaired praxis, gnosis, delayed reproduction, counting skills, thinking (motivational, operational components of thinking and criticality) and orientation in one's own personality. The psychopathological features of hallucinatory-paranoid disorders in the structure of mixed dementia were determined, which included: delusions about dishonesty of others, hallucinations, disorders of the depressive spectrum, vagrancy, aimless activity (cognitive bulimia), inappropriate behavior, circadian rhythm disturbance, fear of being left alone. The distinguished features must be taken into account in the process of diagnosis and treatment of patients with hallucinatory-paranoid disorders in mixed dementia.","PeriodicalId":33688,"journal":{"name":"Psikhiatriia nevrologiia ta medichna psikhologiia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69006467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamics of morbidity indicators of neurotic, stress-related and somatoform disorders in the rural population of Ukraine","authors":"","doi":"10.26565/2312-5675-2020-13-06","DOIUrl":"https://doi.org/10.26565/2312-5675-2020-13-06","url":null,"abstract":"In order to study the dynamics of indicators of the incidence of neurotic, stress-related and somatoform disorders in the rural population of Ukraine, an analysis of statistical data of reporting forms No. 10 “Report on diseases of persons with mental and behavioral disorders” reflecting the objectively taken into account the incidence of neurotic, stress-related and somatoform disorders for 2000 - 2017 years. The analysis revealed the main features of neurotic morbidity associated with stress and somatoform disorders in the rural population of Ukraine for the period from 2000 to 2017. Thus, the primary incidence rate of neurotic, stress-related and somatoform disorders in the rural population of Ukraine for the period from 2000 to 2017 decreased by 9.11% (from 45.0 per 100 thousand of the rural population in 2000 to 40, 9 per 100 thousand urban population in 2017). The overall incidence rate of neurotic, stress-related and somatoform disorders in the rural population of Ukraine tended to gradually increase, from 259.0 in 2000 to 313.3 per 100 thousand rural population in 2017. A significant proportion of neurotic, stress-related and somatoform disorders in the structure of the incidence of non-psychotic mental disorders and the identified regional features of the dynamics of the primary and general morbidity of neurotic, stress-related and somatoform disorders in the rural population of Ukraine should be taken into account when developing organizational measures to optimize the system of assistance and prevention rural mental health disorders.","PeriodicalId":33688,"journal":{"name":"Psikhiatriia nevrologiia ta medichna psikhologiia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69006537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Objective assessment of the therapy effectiveness for patients with depression based on the analysis of their involuntary reactions during a combined psychodiagnostic and psychophysiological study","authors":"","doi":"10.26565/2312-5675-2020-15-02","DOIUrl":"https://doi.org/10.26565/2312-5675-2020-15-02","url":null,"abstract":"The aim of this work was the development a method for objective assessment of therapy effectiveness for patients with depression based on measurements of reaction time and other parameters of involuntary response to audiovisual stimuli in the process of combined psychodiagnostic and psychophysiological investidation. 97 patients with depression (main group) were examined, at an average age of 40.94 ± 1.25 years (among them 51 persons diagnosed with “depressive episode” (F32 by ICD-10) and 46 persons with “recurrent depressive disorder” (F33 by ICD-10), as well as 64 almost healthy individuals (control group), at age 41.21 ± 1.21 years. Clinical-psychopathological, psychometric (computer versions of: Zung’s scales, HADS, Spielberger tests in Khanina modification, AUDIT and SCL-90R), and psychophysiological methods were used, the latter method involved the use of software and hardware complex \"Reocom-stress\" (manufacturer: \" XAI-MEDICA\", Kharkiv, Ukraine) in the \"Attitude to the topic\" mode with registration of psychophysiological response to groups of questions (thematic groups) from the above-mentioned psychometric methods. The described procedure was used twice during the study: with an interval of 17-19 days. It was shown that the response time and other parameters of involuntary response to audiovisual stimuli are valuable sources of information for quality control of the therapy effectiveness for patients with depression. And three channels of information (scale scores, and response time to questions in psychodiagnostic investigation and attitude to the topics (the questions of the mentioned scales), and assessed by the results of psychophysiological research) are relatively independent of each other and carry additional information about the mental status of the respondents. We found out that the channel of mental chronometry is the most sensitive to residual depressive symptoms. It has been proven that the best choice for objective assessment of therapy effectiveness for patients with depression is a computer version of the Zung’s scale with registration of the response time to each questions of this scale. This approach has the highest diagnostic properties (sensitivity — 86.60%, specificity — 96.88% and accuracy — 90.68%), which, together with the simplicity of implementation, makes it quite suitable for practical use.","PeriodicalId":33688,"journal":{"name":"Psikhiatriia nevrologiia ta medichna psikhologiia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69006730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychopathological peculiarities of vascular dementia with different localization of pathological focuses","authors":"","doi":"10.26565/2312-5675-2020-14-04","DOIUrl":"https://doi.org/10.26565/2312-5675-2020-14-04","url":null,"abstract":"Relevance. Vascular dementia, caused by various organic lesions, volume and location of organic damage to brain tissue, manifests itself in a wide range of concomitant neuropsychiatric symptoms. However, despite the obvious link between the location of vascular lesions and the patient's psychopathological symptoms, the effects of the physical characteristics of the brain damage that caused the vascular dementia and the corresponding neuropsychiatric symptoms remain poorly understood. The aim of the study was to investigate psychopathological features of cognitive impairment in patients with vascular dementia depending on the location of the lesion. Contingents and methods. 157 people with a diagnosis of vascular dementia were examined, divided into five groups: group 1 — 22 people with localization of the pathological process in the frontal lobe; group 2 — 18 patients with temporal lobe lesions; group 3 — 17 patients with parietal lobe lesions; group 4 — 15 patients with occipital lobe lesions and group 5 — 68 people with total lesions. Results: It was found that the lesion of the frontal lobes is characterized by a high frequency of euphoria and hallucinatory phenomena, as well as minor manifestations of apathy and anxiety; lesion of the temporal lobe — the highest frequency and severity of apathy; parietal lesions — low frequency of anxiety combined with its high intensity; occipital lesions — intense depressive experiences (in cases where they occurred), total brain damage — the lowest prevalence and intensity of delusional feelings, irritability and agitation. Conclusions. A comprehensive study of patients with vascular dementia identified specific to each localization of brain lesions spectra of neuropsychiatric symptoms, which creates the necessary conditions for early application of differentiated therapeutic and rehabilitation measures and, accordingly, to improve the quality of patients life in this category.","PeriodicalId":33688,"journal":{"name":"Psikhiatriia nevrologiia ta medichna psikhologiia","volume":"88 1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69007054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroplasticity in a range of induced effects of transcranial electrical stimulation","authors":"П. Волошина, Е. Черненко, Академіка Павлова, пл. Свободы","doi":"10.26565/2312-5675-2020-13-08","DOIUrl":"https://doi.org/10.26565/2312-5675-2020-13-08","url":null,"abstract":"This article presents the results of an analysis of modern scientific data on the induction of neuroplasticity using transcranial electrical stimulation. Three types of effects arising from the use of transcranial electrical stimulation are considered: central, peripheral and mixed. The central effects are analgesia, stabilization of hemodynamics, relief of pain. Peripheral effects include slowing the growth of tumors, modulating the dynamics of the acute phase response during inflammation, accelerating the healing of skin wounds, ulcerative defects of the gastric mucosa, and the focus of necrosis in myocardial infarction. Of the mixed effects are antistress, antipruritic, antitoxic effects. All of the above effects are based on the release of beta-endorphins. Potentiation of the effects of transcranial electrical stimulation is caused by enkephalinase inhibitors, 5-HT precursors, monoamine oxidase and tryptophanpyrrolase inhibitors. The features of the therapeutic effects of transcranial electrical stimulation are highlighted: they have a homeostatic character and are manifested both comprehensively and systemically. The effect on neuroplasticity by transcranial direct current stimulation (tDCS) was examined. tDCS is presented as a modulator of global neural activity. It was shown that tDCS leads to the activation of neurons and astrocytes through neurovascular conjugation, directly affects the cells of the vascular endothelium, and helps increase the speed of blood flow in the capillaries. It was shown that transcranial electrical stimulation has a corrective effect on clinical electrophysiological parameters in patients with neurogenic bladder dysfunction and nocturnal enuresis, has a stimulating effect on glial cells, diversifies the brain neurochemical status, modifies the synaptic microenvironment, regulates various neurotransmitters, and increases BDNF secretion. Studies show that tDCS led to a significant decrease in glutamate and glutamine in the anterior cingulate gyrus, a tendency to decrease glutamate and glutamine in the thalamus, and a tendency to increase GABA in the anterior part of the islet. Thus, transcranial electrical stimulation is a method capable of providing long-term therapeutic effects of stimulation and affect the processes of neuroplasticity.","PeriodicalId":33688,"journal":{"name":"Psikhiatriia nevrologiia ta medichna psikhologiia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69006641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of multiple sclerosis patients with sleep disorders associated with anxiety","authors":"","doi":"10.26565/2312-5675-2020-13-09","DOIUrl":"https://doi.org/10.26565/2312-5675-2020-13-09","url":null,"abstract":"","PeriodicalId":33688,"journal":{"name":"Psikhiatriia nevrologiia ta medichna psikhologiia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69006656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Remission structure in schizoaffective disorder","authors":"Ірина Олексіївна Сєрікова, О. В. Скринник, Академіка Павлова","doi":"10.26565/2312-5675-2020-14-01","DOIUrl":"https://doi.org/10.26565/2312-5675-2020-14-01","url":null,"abstract":"The article describes the comparative study of clinical and dynamic structure of remission in schizoaffective disorder (SAD), depending on its type. With the help of the clinical-psychopathological method with an analytical study of tavailable medical documentation and the method of follow-up examination, remissions were analyzed in 78 patients with SAD. In parallel, during the year, the severity of clinical manifestations of the disease was determined using psychometric scales (Young Mania Rating Scale – YMRS, Hamilton Depression Rating Scale – HDRS, Positive and Negative Symptoms Scale – PANSS). Several degrees of remission were identified – partial, complete clinical and complete functional remission. By partial remission, we understood a state when there was a pronounced reduction in clinical manifestations, but residual productive symptoms, poor insight and social maladjustment were observed. Complete clinical remission indicated the absence of any clinically significant signs, but social functioning was reduced. Full functional remission was characterized by the absence of any clinical signs and patient’s good social adaptation. All patients went through the stage of partial remission, however, about half of them (40 observations – 51.3%) went into complete clinical remission. Persistent partial remission which later did not transform into clinical remission was observed in 38 patients with SAD (48.7%). It was represented by the following syndromes — asthenic (28.9%), hypersthenic (23.8%), psychopathic (34.2%), residual delusional syndrome (13.1%). Complete functional remission was found in 19 patients (24.4%). The data obtained indicate that the longest and most complete remissions were observed in manic and depressive types of SAD compared with mixed ones. In the manic type of SAD complete functional remission was more common (12 cases – 38.7%), with the depressive type - complete clinical remission (8 patients – 32.0%), with the mixed type - partial remission (10 patients – 38.5%). Depending on the type of SAD remission there is a different risk of disease recurrence, therefore, the treatment and rehabilitation measures, the appointment of maintenance therapy should be differentiated.","PeriodicalId":33688,"journal":{"name":"Psikhiatriia nevrologiia ta medichna psikhologiia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69006327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modern view of the pathogenetic mechanisms of the limbic system role in the forming of pain syndromes in pharmacoresistant facial sympathalgia","authors":"","doi":"10.26565/2312-5675-2019-11-05","DOIUrl":"https://doi.org/10.26565/2312-5675-2019-11-05","url":null,"abstract":"The present work was devoted to pharmacoresistant facial sympathalgia which held one of the frequent places among other neuropatic acute and chronic pain syndromes; they usually characterized by long-term clinical course and severe pain which is resistant to conducted conservative therapy by several pharmaceutical drugs. In this paper the general modern data about the etiopathogenetic mechanisms and the role of limbic system, its other anatomical and physiological parts in the genesis and forming of pain paroxysms in facial sympathalgia were presented. Pharmacoresistant facial sympathalgia differs from the other pain syndromes with more similar and typical localization, the severity of clinical manifestations, the presence of neurological deficit, long-recurrent clinical course, resistance to various treatment methods, both therapeutic and neurosurgical, and different somatic complications. At the autonomic response disturbances, epileptic or paroxysmal focus plays the leading disorganizing role, located mainly in the medial structures of the limbic-reticular complex. It has been established, that the limited convulsive activity in various structures of the limbic-reticular complex is the pathogenesis basis of non-epileptic or painful paroxysms, which does not reach of the formation of morpho-functional epileptic system because of influence of various stabilizing factors. Also it was discussed that in the pathogenetic mechanisms any changes in the functional state of the pain-sensing nociceptive and antinociceptive systems and leading neurotransmitters have played the certain role in pharmacologically resistant facial sympathalgia where glutamate and aspartate are being modulators of the convulsive and neuroplastic brain activity, directly and indirectly participating in the formation of processes of excitation and pain threshold, different neurotoxic processes.","PeriodicalId":33688,"journal":{"name":"Psikhiatriia nevrologiia ta medichna psikhologiia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69005828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}