Jing Liu, Yao Xie, Xian-Mei Li, Min Xu, Chun-Xue Fan, Nian Xin, Yulin Deng
{"title":"Suppression of NF-κB signaling by Ganoderma-Rhodiola compound preparation alleviates immune dysregulation in a rat model of simulated microgravity","authors":"Jing Liu, Yao Xie, Xian-Mei Li, Min Xu, Chun-Xue Fan, Nian Xin, Yulin Deng","doi":"10.1016/j.mores.2026.100022","DOIUrl":"https://doi.org/10.1016/j.mores.2026.100022","url":null,"abstract":"Background The extreme environment of spaceflight facilitates the increased pathogenicity of microorganisms while simultaneously compromising the immune systems of astronauts, thereby escalating the risk of infections and threatening mission safety. Effective countermeasures to bolster immune defenses in space are therefore imperative. Objective: This study investigated the immunomodulatory effects and underlying mechanisms of a Ganoderma-Rhodiola Compound Preparation (GRCP) using a rat model subjected to dual stressors (simulated microgravity and microbial challenge). Methods Fifty-four male SD rats were randomized into six groups: Normal Control (NC), Model Control (MC), Positive Control (PC), and three GRCP dosage groups (Low, Medium, and High). To simulate the space environment, the MC, PC, and GRCP groups underwent 4 weeks of tail suspension (hindlimb unloading) and were orally challenged with high-risk space-associated microorganisms to induce immune dysregulation. Post-intervention, we assessed growth trajectories, delayed-type hypersensitivity (DTH), immune organ indices, splenic histopathology, and a panel of serum and jejunal biomarkers, with a specific focus on inflammatory mediators and the NF-κB subunit (RelA) Results GRCP administration significantly improved the physiological status of the rats, including enhanced appetite and weight gain, with the high-dose group (GRCPH) demonstrating the most pronounced efficacy (P < 0.01 vs. MC). Biochemically, GRCP treatment normalized blood indices and modulated both the DTH response and serum hemolysin levels. Notably, GRCPH restored the splenic microarchitecture and elevated serum albumin levels. Furthermore, GRCPH significantly suppressed the overproduction of serum IgG and IgA, pro-inflammatory cytokines, and jejunal inflammatory factors (IL-6, TNF-α, IL-1β, and RelA). Conclusion These findings suggest that the Ganoderma-Rhodiola formulation can effectively restore immune homeostasis and suppress systemic and mucosal inflammation in simulated spaceflight conditions, likely via the inhibition of the NF-κB/RelA pathway. This study provides a scientific rationale for utilizing traditional herbal compounds as protective strategies for long-duration manned space missions.","PeriodicalId":33617,"journal":{"name":"Journal of Applied Structural Equation Modeling","volume":"1 2","pages":"100022-100022"},"PeriodicalIF":0.0,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148861183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"MODELING THE EFFECT OF HIGHER-ORDER THINKING SKILLS AND TECHNOLOGICAL PEDAGOGICAL CONTENT KNOWLEDGE ON STUDENTS’ DIGITAL LITERACY","authors":"","doi":"10.47263/jasem.7(2)06","DOIUrl":"https://doi.org/10.47263/jasem.7(2)06","url":null,"abstract":"","PeriodicalId":33617,"journal":{"name":"Journal of Applied Structural Equation Modeling","volume":"79 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139359242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"ANTECEDENTS OF PERCEIVED USEFULNESS OF NEGATIVE REVIEWS AND PURCHASE INTENTION BASED ON THE SEM AND FSQCA APPROACHES","authors":"","doi":"10.47263/jasem.7(2)05","DOIUrl":"https://doi.org/10.47263/jasem.7(2)05","url":null,"abstract":"","PeriodicalId":33617,"journal":{"name":"Journal of Applied Structural Equation Modeling","volume":"78 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139358950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"INSTITUTIONAL PRESSURES AND GREEN INNOVATION: A CASE OF CHINESE CHEMICAL COMPANIES","authors":"","doi":"10.47263/jasem.7(2)04","DOIUrl":"https://doi.org/10.47263/jasem.7(2)04","url":null,"abstract":"","PeriodicalId":33617,"journal":{"name":"Journal of Applied Structural Equation Modeling","volume":"75 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139359246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"COMPLEX ADAPTIVE BEHAVIOR OF INVESTORS TO MARKET DYNAMICS: A PLS-SEM ANALYSIS","authors":"","doi":"10.47263/jasem.7(2)03","DOIUrl":"https://doi.org/10.47263/jasem.7(2)03","url":null,"abstract":"","PeriodicalId":33617,"journal":{"name":"Journal of Applied Structural Equation Modeling","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139359294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Memon, R. Thurasamy, J. Cheah, H. Ting, Francis Chuah, T. Cham
{"title":"ADDRESSING COMMON METHOD BIAS, OPERATIONALIZATION, SAMPLING, AND DATA COLLECTION ISSUES IN QUANTITATIVE RESEARCH: REVIEW AND RECOMMENDATIONS","authors":"M. Memon, R. Thurasamy, J. Cheah, H. Ting, Francis Chuah, T. Cham","doi":"10.47263/jasem.7(2)01","DOIUrl":"https://doi.org/10.47263/jasem.7(2)01","url":null,"abstract":"When editing regular and special issues of numerous journals, we have observed several recurring shortcomings in the manuscripts, particularly in relation to methodology. Many of these manuscripts are often found lacking in providing critical methodological information or justifying the use of the selected methods, thus resulting in desk rejection at the preliminary stage or major revision in the review process. Although the theoretical and managerial aspects of manuscripts are essential to publication consideration, methodological flaws can be detrimental. It is therefore of no surprise that failures to address methodological concerns are some of the common reasons for a manuscript to be rejected from publication, even after going through several rounds of revision. The purpose of this editorial is to provide clear guidelines on effectively reporting the methodological section in a quantitative manuscript in the fields of business and social sciences. Specifically, we present a set of recommendations on implementing and reporting operationalization, instrument validation, sampling techniques, questionnaire administration, and common method bias. Researchers, whether students or academics, should consider these guidelines to ensure methodological rigor in their research projects.","PeriodicalId":33617,"journal":{"name":"Journal of Applied Structural Equation Modeling","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41522979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"DO SOCIAL AND COMMERCIAL DESIRES INFLUENCE THE PURCHASING INTENTIONS OF GENERATION Z IN ONLINE SOCIAL SHOPPING?","authors":"","doi":"10.47263//jasem.7(1)05","DOIUrl":"https://doi.org/10.47263//jasem.7(1)05","url":null,"abstract":"","PeriodicalId":33617,"journal":{"name":"Journal of Applied Structural Equation Modeling","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42671360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rachelle Ann, A. Beninsig, Hersheys V. Calumpang, Ma. Olivia, B. Espedion, Leandro R. De Luna
{"title":"THE MEDIATING ROLE OF DRINKING MOTIVES ON THE LINK BETWEEN ALCOHOL USE AND PERSONALITY FACTORS","authors":"Rachelle Ann, A. Beninsig, Hersheys V. Calumpang, Ma. Olivia, B. Espedion, Leandro R. De Luna","doi":"10.47263/jasem.7(1)01","DOIUrl":"https://doi.org/10.47263/jasem.7(1)01","url":null,"abstract":"Culture, purpose, motive, or even the person itself has an essential part on how an individual treats a substance. Drinking motives have been known to affect the alcohol use of people and how personality factors influence alcohol consumption. However, this study investigated the mediating effect of drinking motives between the two variables. This association was investigated based on perspectives of college students from different colleges and universities within Calamba City, Philippines through Partial Least Square-Structural Equation Modeling (PLS-SEM). The findings uncovered that extraversion and alcohol use have a positive significant relationship, whereas neuroticism and alcohol use are inversely related. Meanwhile, extraversion and neuroticism are directly related to drinking motives like the relationship between drinking motives and alcohol use. Conscientiousness, on the other hand, has no significant effect on alcohol use and drinking motives. Given that each variable has a direct effect towards one another, this may imply that different drinking motives, distinguished personality traits, and alcohol use are interrelated. The study also revealed that drinking motives have no intervening effects on the link between identified personality traits and alcohol use. The reason why further investigation on other factors that might lead to mediation between personality factors and alcohol use is recommended.","PeriodicalId":33617,"journal":{"name":"Journal of Applied Structural Equation Modeling","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46653027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"AUTHENTICITY AND WORK ENGAGEMENT IN TEACHERS: A MULTIGROUP ANALYSIS BASED ON GENDER","authors":"","doi":"10.47263//jasem.7(1)04","DOIUrl":"https://doi.org/10.47263//jasem.7(1)04","url":null,"abstract":"","PeriodicalId":33617,"journal":{"name":"Journal of Applied Structural Equation Modeling","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43651240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}