{"title":"Dupilumab for Atopic Dermatitis-From Clinical Trials to Molecular and Cellular Mechanisms.","authors":"Beatriz Cabanillas","doi":"10.1097/DER.0000000000000905","DOIUrl":"10.1097/DER.0000000000000905","url":null,"abstract":"<p><p>Dupilumab is a monoclonal antibody that represents the first approved targeted biological therapy for adults, adolescents, and children older than 6 years with moderate-to-severe atopic dermatitis (AD). Dupilumab binds the shared chain of the interleukin-4 and interleukin-13 receptor blocking the downstream signaling of these cytokines. The clinical improvements induced by dupilumab were associated with remission of the dysregulated immune mechanisms linked with AD. Dupilumab reversed the epidermal barrier defects and improved the global molecular signature of AD. This review seeks to provide an overview on the development of dupilumab as the first target-specific biological treatment for AD, with a description of the clinical trials that have been performed in different age groups, their outcomes, and reported adverse effects. Novel aspects of dupilumab treatment, as well as the current knowledge on the molecular and cellular mechanisms underlying the treatment of AD with dupilumab, are summarized and discussed.</p>","PeriodicalId":33604,"journal":{"name":"Vestnik Moskovskogo gosudarstvennogo oblastnogo universiteta Seriia Psikhologicheskie nauki","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89959482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Soсial representation of counceling among orthodox respondents with different religious identity intensity","authors":"M. Chibisova, A. Belaia","doi":"10.18384/2310-7235-2022-3-133-145","DOIUrl":"https://doi.org/10.18384/2310-7235-2022-3-133-145","url":null,"abstract":"","PeriodicalId":33604,"journal":{"name":"Vestnik Moskovskogo gosudarstvennogo oblastnogo universiteta Seriia Psikhologicheskie nauki","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67941321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. M. Borisova, T. Kubrak, V. Latynov, A. V. Makhnach
{"title":"INTERDEPENDENCE OF PSYCHOLOGICAL CHARACTERISTICS AND PERCEPTIONS OF COVID-19 WITH THE ADAPTIVE PANDEMIC RESPONSE","authors":"A. M. Borisova, T. Kubrak, V. Latynov, A. V. Makhnach","doi":"10.18384/2310-7235-2022-2-47-59","DOIUrl":"https://doi.org/10.18384/2310-7235-2022-2-47-59","url":null,"abstract":"","PeriodicalId":33604,"journal":{"name":"Vestnik Moskovskogo gosudarstvennogo oblastnogo universiteta Seriia Psikhologicheskie nauki","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67941121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Luchinkina, L. V. Zhihareva, I. S. Liuchinkina, A. Grebenyuk, T. V. Yudeeva, R. Zekeriaev, N. M. Davidyuk
{"title":"Features of network aggression of Internet-active youth","authors":"A. Luchinkina, L. V. Zhihareva, I. S. Liuchinkina, A. Grebenyuk, T. V. Yudeeva, R. Zekeriaev, N. M. Davidyuk","doi":"10.18384/2310-7235-2022-3-21-35","DOIUrl":"https://doi.org/10.18384/2310-7235-2022-3-21-35","url":null,"abstract":"","PeriodicalId":33604,"journal":{"name":"Vestnik Moskovskogo gosudarstvennogo oblastnogo universiteta Seriia Psikhologicheskie nauki","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67941364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"WISE HUMANITY IN ORGANIZATIONS OF VARIOUS TYPES: METHODOLOGY AND RESEARCH METHODOLOGY","authors":"A. V. Bulgakov, N. Andreeva, M. N. Berezhnaya","doi":"10.18384/2310-7235-2022-2-135-155","DOIUrl":"https://doi.org/10.18384/2310-7235-2022-2-135-155","url":null,"abstract":"","PeriodicalId":33604,"journal":{"name":"Vestnik Moskovskogo gosudarstvennogo oblastnogo universiteta Seriia Psikhologicheskie nauki","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67941378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"PERSONAL REFLECTION AS A MECHANISM OF SELF-DECEPTION AWARENESS BY THE CLIENT IN EXISTENTIAL-ORIENTED COUNSELING","authors":"O. Kayasheva","doi":"10.18384/2310-7235-2022-2-20-35","DOIUrl":"https://doi.org/10.18384/2310-7235-2022-2-20-35","url":null,"abstract":"","PeriodicalId":33604,"journal":{"name":"Vestnik Moskovskogo gosudarstvennogo oblastnogo universiteta Seriia Psikhologicheskie nauki","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67941400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Foreign research of climate in the organization: main trends","authors":"K. A. Lukasheva, E. G. Chirkovskaya","doi":"10.18384/2310-7235-2022-3-52-63","DOIUrl":"https://doi.org/10.18384/2310-7235-2022-3-52-63","url":null,"abstract":"","PeriodicalId":33604,"journal":{"name":"Vestnik Moskovskogo gosudarstvennogo oblastnogo universiteta Seriia Psikhologicheskie nauki","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67942555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The range of equivalence as an emotional and stylistic component of decision making","authors":"E. Kryukova","doi":"10.18384/2310-7235-2022-4-18-28","DOIUrl":"https://doi.org/10.18384/2310-7235-2022-4-18-28","url":null,"abstract":"","PeriodicalId":33604,"journal":{"name":"Vestnik Moskovskogo gosudarstvennogo oblastnogo universiteta Seriia Psikhologicheskie nauki","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67943428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Y. Maksudov, A. V. Bulgakov, E. Bulgakova, V. N. Seleznev, L. I. Chistokhodova
{"title":"Psychotechnics of emotional stability development among specialists of socionomic professions","authors":"M. Y. Maksudov, A. V. Bulgakov, E. Bulgakova, V. N. Seleznev, L. I. Chistokhodova","doi":"10.18384/2310-7235-2022-4-29-40","DOIUrl":"https://doi.org/10.18384/2310-7235-2022-4-29-40","url":null,"abstract":"","PeriodicalId":33604,"journal":{"name":"Vestnik Moskovskogo gosudarstvennogo oblastnogo universiteta Seriia Psikhologicheskie nauki","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67943525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Features of experiencing psychological well-being by cadets of a departmental university with different levels of emotional stability","authors":"T. A. Basina","doi":"10.18384/2310-7235-2022-3-109-119","DOIUrl":"https://doi.org/10.18384/2310-7235-2022-3-109-119","url":null,"abstract":"","PeriodicalId":33604,"journal":{"name":"Vestnik Moskovskogo gosudarstvennogo oblastnogo universiteta Seriia Psikhologicheskie nauki","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67941250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}