P. Kolo, Y. Jibrin, E. Sanya, M. Alkali, A. Salami, A. Omotoso, A. Tahir
{"title":"Outcome of cholera admissions in Bauchi, Nigeria","authors":"P. Kolo, Y. Jibrin, E. Sanya, M. Alkali, A. Salami, A. Omotoso, A. Tahir","doi":"10.1080/10158782.2013.11441536","DOIUrl":"https://doi.org/10.1080/10158782.2013.11441536","url":null,"abstract":"In 2007, the World Health Organization Regional Committee for Africa officially noted the resurgence of cholera in the Africa subregion, and called for strengthening of policies on water supply and sanitation. We study the mortality profile of patients admitted for cholera and factors associated with adverse outcomes. Records of patients admitted with cholera between 1 November 2010 and 31 October 2011 were studied. Patients' age, sex, duration of symptoms before hospitalisation, duration of hospitalisation, and outcome after hospitalisation, were noted. One thousand, two hundred and twenty cholera cases were admitted during the study period, accounting for 39.3% of 3 108 admissions to the medical wards. Of the 1 220 managed cases of cholera, 38 died, providing a case fatality of 3.1%. The mean age of the non-survivors (42.3 ± 16.2) was higher (p-value = 0.01) than that of the survivors (34.9 ± 15.1). Similarly, the mean duration of symptoms before hospitalisation, and duration of hospitalisation, was hig...","PeriodicalId":335691,"journal":{"name":"The Southern African Journal of Epidemiology and infection","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130789285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Maasdorp, C. Snyman, M. Prins, Fc Van Rooyen, M. Struwig
{"title":"Clinical profile of patients diagnosed with primary lung cancer at the Pulmonology Division, Universitas Academic Hospital, Bloemfontein, 2010-2011","authors":"S. Maasdorp, C. Snyman, M. Prins, Fc Van Rooyen, M. Struwig","doi":"10.1080/10158782.2013.11441556","DOIUrl":"https://doi.org/10.1080/10158782.2013.11441556","url":null,"abstract":"Lung cancer is regarded by the World Health Organization as a leading cause of death globally. Limited data are available on lung cancer epidemiology in South Africa. This study aimed to determine the profile of patients with lung cancer who were seen at a local pulmonology clinic. A retrospective audit was conducted on patients ≥ 18 years of age who were diagnosed with primary lung cancer at the Universitas Academic Hospital (Pulmonology Division) between 1 January 2010 and 31 December 2011. Information was collected with regard to demographic variables, smoking status, performance status, histological subtype and stage of disease. Ninety-two patients’ records were included in the study. The median age was 61.2 years (a range of 44-86 years). 57.6% of patients were black, 33.7% white and 8.7% coloured. The male to female ratio was 3:1. The largest group of patients was black men (46.7%). Most patients were current or previous smokers. 45.2% of white patients had a history of ≥ 30 smoking pack years (one pack year of smoking was defined as 20 cigarettes smoked every day for a year), compared to 26.4% of black and 37.5% of coloured patients. Squamous cell carcinoma (SCC) and adenocarcinoma were diagnosed in 34.8% and 32.6% of patients, respectively. Adenocarcinoma occurred more commonly in white patients (38.7%), while SCC was diagnosed more frequently in black patients (34%). The majority of patients presented with advanced stage of disease. Thorough recordkeeping on the epidemiology of lung cancer in South Africa is necessary to enable the planning and implementation of a national strategy with regard to treatment options and prevention.","PeriodicalId":335691,"journal":{"name":"The Southern African Journal of Epidemiology and infection","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133395249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Gonorrhoea resistance among men who have sex with men: what’s oral sex got to do with it?","authors":"D. Lewis","doi":"10.1080/10158782.2013.11441523","DOIUrl":"https://doi.org/10.1080/10158782.2013.11441523","url":null,"abstract":"The term “men who have sex with men” (MSM) refers to men who engage in sexual activity with other men, but who may also have sex with women. Relevant to healthcare delivery and sexual historytaking, many MSM do not consider themselves to be “homosexual” or “gay”, so it is important that appropriate language is used during clinical consultations. MSM are an important group of individuals from the public health perspective as they may act as a bridging population for sexually transmitted infections (STIs), including human immunodeficiency virus, to pass from high-risk MSM sexual networks into the general population, and vice versa. Research conducted on 1783 men in the Eastern Cape and KwaZulu-Natal provinces showed that more than one in 20 South African men engage in consensual sexual activity with other men. 1","PeriodicalId":335691,"journal":{"name":"The Southern African Journal of Epidemiology and infection","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124387092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Health-seeking behaviour of people with sexually transmitted infections in the community of Nkomazi East, Mpumalanga","authors":"I. Govender, M. Eche","doi":"10.1080/10158782.2012.11441508","DOIUrl":"https://doi.org/10.1080/10158782.2012.11441508","url":null,"abstract":"The control of sexually transmitted infections (STIs) is a priority for the World Health Organization. It is estimated that there are 11 million cases of STIs per year in South Africa. Health-seeking and sexual behaviours are important in the management of STIs. The aim was to assess the health-seeking behaviour of people who had STIs in the community of Nkomazi East, Mpumalanga. The study design was a descriptive cross-sectional survey. Participants included patients who presented with confirmed signs or symptoms of an STI, were 16 years or older, voluntarily agreed to participate in the study and were residents of the community. A total of 332 questionnaires were collected. The majority of the participants were single, literate, unemployed black patients aged from 16-23 years (43.7%). Participants were very knowledgeable about STIs. Urethral discharge, painful micturition, vaginal discharge and lower abdominal pain were the most commonly recognised STI symptoms. All the participants (100%) sought help when they thought that they had an STI. Their preferred source of help was the public healthcare sector. Traditional healers were also consulted frequently. While compliance to treatment was satisfactory, ongoing unsafe sexual practices were common among participants who had active STIs. The respondents had a good knowledge of STI symptoms and signs and sought help early, usually from public healthcare facilities. STI health-seeking behaviour was influenced by multiple factors. This study suggests that STI control programmes should be designed around public healthcare facilities. However, adequate knowledge of STIs did not deter many respondents from engaging in unprotected sexual activity, sometimes with multiple partners.","PeriodicalId":335691,"journal":{"name":"The Southern African Journal of Epidemiology and infection","volume":"99 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132767202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Book Review: Mabey’s Principles of Medicine in Africa","authors":"H. Koornhof","doi":"10.1080/10158782.2013.11441544","DOIUrl":"https://doi.org/10.1080/10158782.2013.11441544","url":null,"abstract":"This medical textbook is written for medical doctors, medical students and other health professionals working in sub-Saharan Africa by authors with many years of experience of medical practice in different parts of Africa.","PeriodicalId":335691,"journal":{"name":"The Southern African Journal of Epidemiology and infection","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129918516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Aspinall, B. Pretorius, T. Vally, Boitumelo Sebopa, Caroline Turner-Babb
{"title":"An observational study of influenza A(H1N1)pdm09 viral shedding and resistance under standard-duration oseltamivir treatment","authors":"S. Aspinall, B. Pretorius, T. Vally, Boitumelo Sebopa, Caroline Turner-Babb","doi":"10.1080/10158782.2013.11441531","DOIUrl":"https://doi.org/10.1080/10158782.2013.11441531","url":null,"abstract":"An observational study was established in South Africa in 2009, early in the influenza A(H1N1)pdm09 outbreak, to provide information on the virological response of the new virus to oseltamivir and the potential for resistance. Patients (n = 54) aged 1-64 years who were treated with standard five-day courses of oseltamivir, starting within two days of onset of the symptoms, showed rapid reductions in viral load or shedding and clinical signs and symptoms. Oseltamivir was well tolerated, with no serious adverse events. Signs of treatment-emergent phenotypic and genotypic resistance were noted in one patient.","PeriodicalId":335691,"journal":{"name":"The Southern African Journal of Epidemiology and infection","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134178456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Detection of multidrug-resistant gonorrhoea in the Gauteng province","authors":"D. Lewis, C. Sriruttan, J. Coetzee","doi":"10.1080/10158782.2012.11441509","DOIUrl":"https://doi.org/10.1080/10158782.2012.11441509","url":null,"abstract":"Two cefpodoxime-resistant Neisseria gonorrhoeae isolates were identifed with high minimum inhibitory concentrations (MIC) for oral cephalosporins. The ceftriaxone MICs for both isolates were still in the susceptible range, although raised at 0.064 mg/l. Both isolates were cultured from urethral specimens that were collected from male patients who had presented to their general practitioners with urethral discharge. Patient 1 was treated empirically with azithromycin. Patient 2, who reported having had sex with other men, was given intravenous ceftriaxone as he had recently failed two courses of oral cefxime. Both isolates were also highly resistant to ciprofoxacin, resistant to penicillin (s-lactamase negative) and resistant to tetracycline (and thus doxycycline), and exhibited decreased susceptibility to both azithromycin and gentamicin. On molecular testing, both isolates were found to have mosaic penA genes, which encode for penicillin-binding protein 2. Mosaic penA gene formation is the most common ge...","PeriodicalId":335691,"journal":{"name":"The Southern African Journal of Epidemiology and infection","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124773137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hepatitis C virus infection in 2012 and beyond","authors":"W. Abuelhassan","doi":"10.1080/10158782.2012.11441492","DOIUrl":"https://doi.org/10.1080/10158782.2012.11441492","url":null,"abstract":"Hepatitis C virus infection is estimated to affect 150 million people worldwide. A large number of individuals are chronically infected and are at risk of developing chronic liver disease, cirrhosis and hepatocellular carcinoma. Chronic hepatitis C infection causes significant morbidity and mortality. It is the leading indication for liver transplantation in the USA and Europe, and accounts for 30-50% of liver transplants in those countries. The introduction of blood and blood product screening protocols in 1992 led to a decline in new infections, but intravenous drug abuse still remains a major risk factor for acquiring the disease. Since no vaccine is available to prevent infection with this virus, research has been ongoing to find a cure. Treatment of hepatitis C has continuously evolved since the introduction of interferon monotherapy in the early 1990s, with very low response rates. In 2002, the use of pegylated interferon and ribavirin significantly improved sustained virological response rates to 50-80%. The management of patients who do not respond to standard care remains challenging. The US FDA approved directly acting antivirals in May 2011. This introduced a new era with regard to management of this condition.","PeriodicalId":335691,"journal":{"name":"The Southern African Journal of Epidemiology and infection","volume":"54 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121642360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Centre for Tuberculosis : from reference laboratory to public health institution","authors":"N. Ismail, C. Ihekweazu, H. Koornhof, S. Madhi","doi":"10.1080/10158782.2012.11441491","DOIUrl":"https://doi.org/10.1080/10158782.2012.11441491","url":null,"abstract":"Tuberculosis (TB) continues to be one of the biggest public health challenges of our time, and as epidemiology of the disease evolves in an era of high HIV prevalence in South Africa, so must the response. With exciting developments in diagnostics, treatment options and vaccine candidates at various stages of development, South Africa needs a centre that can synthesise all these options and advise government on preventing TB transmission and caring for those infected. The new Centre for Tuberculosis (CTB) of the National Institute for Communicable Diseases (NICD) is well placed to provide this service for the South African government and people.","PeriodicalId":335691,"journal":{"name":"The Southern African Journal of Epidemiology and infection","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121439830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hepatitis C virus infection: an evolving field of medicine","authors":"W. Abuelhassan","doi":"10.1080/10158782.2012.11441481","DOIUrl":"https://doi.org/10.1080/10158782.2012.11441481","url":null,"abstract":"Hepatitis C infection is a leading cause of chronic hepatitis, cirrhosis and hepatocellular carcinoma. It is also an important indication for liver transplantation in the USA and Europe, yet it is potentially curable. It is estimated that 3% of the world population (170 million people) are infected with hepatitis C. The highest prevalence is in North Africa and the Eastern Mediterranean. The prevalence in South Africa is not known, but is estimated to be in the range of 0.1-1.7%. 1-3","PeriodicalId":335691,"journal":{"name":"The Southern African Journal of Epidemiology and infection","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134175270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}