Practica Farmaceutica最新文献_第2页

Determination of the total content of polyphenols, flavonoids and the antioxidant capacity of extracts from viola x wittrockiana flowers 薇花提取物中多酚、黄酮类化合物总含量及抗氧化能力的测定

Practica Farmaceutica Pub Date : 2022-03-31 DOI: 10.37897/rjphp.2022.1.3

E. Marian, C. Morgovan, L. Vicaș, T. Jurca, A. Pallag, M. Mureşan, O. Frent

引用次数: 1

Adverse effects due to changes in the composition of the intestinal microbiota as result of the administration of antibiotics during the perinatal period 围产期服用抗生素引起的肠道微生物群组成变化引起的不良反应

Practica Farmaceutica Pub Date : 2022-03-31 DOI: 10.37897/rjphp.2022.1.1

C. Ghiciuc, Ionela-Alina Grosu-Creangă, D. Petrescu, A. Vicovan, Ioana Maria Onofrei, I. Roșca

{"title":"Adverse effects due to changes in the composition of the intestinal microbiota as result of the administration of antibiotics during the perinatal period","authors":"C. Ghiciuc, Ionela-Alina Grosu-Creangă, D. Petrescu, A. Vicovan, Ioana Maria Onofrei, I. Roșca","doi":"10.37897/rjphp.2022.1.1","DOIUrl":"https://doi.org/10.37897/rjphp.2022.1.1","url":null,"abstract":"Antibiotic administration commonly induces allergic reactions, dysmicrobism and microbial resistance, but long-term effects due to changes in gut microbiota composition are difficult to assess. This paper aims to identify in the literature adverse effects induced by changes in gut microbiota composition after perinatal administration of antibiotics. Antibiotic administration during pregnancy is a predisposing factor for the development of bronchial asthma, eczema, or allergic rhinitis in children, but does not support the hypothesis as being a risk factor for childhood obesity/overweight. The effect on the newborn’s microbiota of prophylactic administration of antibiotics during caesarean section is controversial. Postnatal treatments with antibiotics frequently causes intestinal dysmicrobism, the most severe form being necrotizing enterocolitis, especially among premature infants, but effects on the changes in body weight are controversial. Early administration of broad-spectrum antibiotics, particularly macrolides and cephalosporins, is strongly associated with the development of bronchial asthma at age 5 years. Recently, altered auditory processing and changes in recognition memory were described in newborn exposed to antibiotics in the absence of infection. More studies are needed to clarify the association between the type of antibiotic, the frequency, respectively period (both prenatal and intrapartum) of administration and long-term effects.","PeriodicalId":33513,"journal":{"name":"Practica Farmaceutica","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46707953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Conventional and modern therapeutic approaches in topical medication of onicosis onicosis的常规和现代治疗方法

Practica Farmaceutica Pub Date : 2021-12-31 DOI: 10.37897/rjphp.2021.4.2

L. Ochiuz, E. G. Popa, C. Ghiciuc, Alexandra Bujor, S. Mousa, C. Gafitanu

引用次数: 0

Evaluation of the clinical efficiency of COVID drug treatment of clinical-paraclinical parameters in a critical case of COVID-19 with severe pulmonary dysfunction after cesarean section 1例危重病例剖宫产术后合并严重肺功能障碍的COVID-19药物治疗临床-临床旁参数临床疗效评价

Practica Farmaceutica Pub Date : 2021-12-31 DOI: 10.37897/rjphp.2021.4.1

Bianca Laura Sugac, T. Pop, Monica Boros, A. Huniadi, L. Vicaș, T. Jurca, E. Marian, A. Pallag, Florina Miere (Groza), Liana Ștefan, M. Mureşan

{"title":"Evaluation of the clinical efficiency of COVID drug treatment of clinical-paraclinical parameters in a critical case of COVID-19 with severe pulmonary dysfunction after cesarean section","authors":"Bianca Laura Sugac, T. Pop, Monica Boros, A. Huniadi, L. Vicaș, T. Jurca, E. Marian, A. Pallag, Florina Miere (Groza), Liana Ștefan, M. Mureşan","doi":"10.37897/rjphp.2021.4.1","DOIUrl":"https://doi.org/10.37897/rjphp.2021.4.1","url":null,"abstract":"On 11 March 2020 World Health Organization declared the Coronavirus disease 2019 (COVID-19) caused by a novel coronavirus (SARS–CoV–2, 2019 – nCoV) a global pandemic. After a year, there are still many unknowns about peripartum women suffering from COVID – 19. In some pregnant women, respiratory failure can rapidly progress to acute respiratory distress syndrome (ARDS) which is requiring extracorporeal membrane oxygenation (ECMO) as a life – saving therapy. This motivated our team to report the case of a 22-year-old pregnant woman suffering from obesity, gestational hypertension with a severe COVID – 19 forms associated with ARDS. We want to highlight the potential benefits of therapeutic management, after an analysis of clinical and paraclinical parameters, especially because the patient was discharge after 40 days with no major complications. The urgent delivery, early initiation of ECMO and the complex pharmacological therapy (including Remdesivir) resulted in favorable maternal– fetal outcomes.","PeriodicalId":33513,"journal":{"name":"Practica Farmaceutica","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47353468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The patient, the OTC drug, and the pharmacist – an (in)separable triad? A critical analysis of self-medication 病人、非处方药和药剂师是可分离的三位一体吗?自我用药的批判性分析

Practica Farmaceutica Pub Date : 2021-09-30 DOI: 10.37897/rjphp.2021.3.2

C. Vari, B. Ösz, George Jîtcă, Alexandra Groșan, M. Stoica

引用次数: 0

Direct virucidal effect of a throat lozenge with fixed combination of cetylpyridinium chloride and benzydamine hydrochloride on SARS-CoV-2 – in vitro study 氯化十六烷基吡啶鎓和盐酸苄脒固定组合咽喉含片对严重急性呼吸系统综合征冠状病毒2型的直接杀毒作用——体外研究

Practica Farmaceutica Pub Date : 2021-09-30 DOI: 10.37897/rjphp.2021.3.3

C. Sarafoleanu, R. Enache

引用次数: 0

Chemical analysis of some Ocimum basilicum medicinal teas 几种罗勒药用茶的化学分析

Practica Farmaceutica Pub Date : 2021-09-30 DOI: 10.37897/rjphp.2021.3.6

D. Benedec, Diana ROZSA (RUS), D. Hanganu, I. Oniga

引用次数: 0

NIR spectroscopy coupled with multivariate data analysis in the prediction of the characteristics of mannitol lyophilized cakes 近红外光谱结合多元数据分析预测甘露醇冻干蛋糕的特性

Practica Farmaceutica Pub Date : 2021-09-30 DOI: 10.37897/rjphp.2021.3.4

Alexandru Gâvan, Cătălina Bogdan, L. Rus, Paula Râșteiu, Ioana Toma, M. Achim, Sonia Iurian

{"title":"NIR spectroscopy coupled with multivariate data analysis in the prediction of the characteristics of mannitol lyophilized cakes","authors":"Alexandru Gâvan, Cătălina Bogdan, L. Rus, Paula Râșteiu, Ioana Toma, M. Achim, Sonia Iurian","doi":"10.37897/rjphp.2021.3.4","DOIUrl":"https://doi.org/10.37897/rjphp.2021.3.4","url":null,"abstract":"Mannitol is used in freeze-dried products as a bulking agent, consistency enhancer, or stabilizer, having the lowest hygroscopicity among the excipients commonly used as consistency agents, therefore it can be used in the formulation of unstable preparations. Lyophilization is a complex method of drying a solution at low temperature and low-pressure that addresses especially thermolabile substances, such as proteins. The end-product is a lyophilized powder, which can be administered parenterally after reconstitution with suitable solvents. The objective of this study was to evaluate freeze-dried products obtained from mannitol solutions of different concentrations. Mannitol solutions of increasing concentrations of 2.5%, 5%, 7.5%, and 10% were prepared by dissolving mannitol in distilled water. The prepared solutions were freeze-dried after a preliminary DSC analysis, in which the thermal phenomena that occurred during lyophilization were identified. Freeze-dried preparations were analyzed by different methods: macroscopic analysis by visual assessment and comparison with data from the literature, texture analysis by which several properties of these preparations were studied (hardness, deformation, mechanical work, adhesive strength, fracture resistance, and the number of fractures), evaluation of reconstitution time and porosity. The mannitol used in the lyophilization process, being partially amorphous, required differential calorimetric analysis to establish its glass transition and to avoid the collapse of the preparations during lyophilization. Finally, NIR spectroscopy was used to predict the characteristics of the freeze-dried powders in a non-invasive manner, without prior sample preparation.","PeriodicalId":33513,"journal":{"name":"Practica Farmaceutica","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42834813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antirid peptides in cosmeceutical formula 药妆配方中的抗氧化肽

Practica Farmaceutica Pub Date : 2021-09-30 DOI: 10.37897/rjphp.2021.3.1

Gabriela Tătărîngă, A. Zbancioc

引用次数: 0

Evaluating the activity of dispensing opioid analgesic medication 评价配药阿片类镇痛药物的活性

Practica Farmaceutica Pub Date : 2021-09-30 DOI: 10.37897/rjphp.2021.3.5

E. Dinte, Radu Borza, Oana MOCAN GURKA

{"title":"Evaluating the activity of dispensing opioid analgesic medication","authors":"E. Dinte, Radu Borza, Oana MOCAN GURKA","doi":"10.37897/rjphp.2021.3.5","DOIUrl":"https://doi.org/10.37897/rjphp.2021.3.5","url":null,"abstract":"Objectives. The purpose of this paper was to evaluate the drug dispensing activity of analgesic opioids in pharmacies. Materials and methods. The study was conducted in an observational and retrospective manner, based on a questionnaire distributed in different pharmacies across Romania. Results. The dispensing activity of opioid analgesics is conducted in 71 out of the 100 pharmacies that have received the questionnaire. These pharmacies are located in 12 out of the 41 counties, mostly in the urban area and 96% of them are community pharmacies. The most prescribed and dispensed pharmaceutical forms are solid forms, the injectable products and transdermic systems being dispensed in a high percentage, up to 40% respectively, only in 25% of the questioned pharmacies. The average time spent by a pharmacist for the entire activity of dispensing an opioid analgesic prescribed by a doctor was estimated at 17.82± 0.58 minutes. Conclusions. The activity regarding opioid analgesics in the community pharmacy is limited by the low rentability, high costs and time consumption. The results of the study impose a further analysis on the impact that this service has upon public health, in order to this activity be sustained by the national health insurance system. Measures must be implemented to ensure that patients from rural or unprivileged areas are able to get their analgesics from the nearest community pharmacy constantly.","PeriodicalId":33513,"journal":{"name":"Practica Farmaceutica","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43726068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0