Scripta Medica最新文献

{"title":"Association of cardiovascular and metabolic diseases with risk of dementia in the urban population of North India","authors":"Ram B Singh, A. Wilczynska, J. Fedacko, Rie Horiuchi, Toru Takahashi, G. Fatima, M. Ismail, A. Magomedova, Arsha Moshiri, M. Moshiri","doi":"10.5937/scriptamed54-42576","DOIUrl":"https://doi.org/10.5937/scriptamed54-42576","url":null,"abstract":"Background/Aim: Dementia has become a public health problem due to its association with biological risk factors; obesity, diabetes, hypertension and hypercholesterolaemia. Most of these risk factors, appear to be associated with dementia as well as with risk of coronary artery diseases (CADs) and stroke. This study aimed to find out the association of biological risk factors with cognitive impairment and dementia. Methods: Cross-sectional survey in a hospital was performed. After written informed consent and approval from hospital ethic committee, all subjects (n = 2002) above 25 years of age (1016 males and 986 females) were randomly selected and recruited from urban population of Moradabad, North India. Clinical data and risk factors were recorded with the help of case record form and validated questionnaires. Assessment of cognitive decline and dementia was made by Singh's memory function rating scale and biological risk factors by physical examination, sphygmomanometer and electrocardiography. The association of biological risk factors with dementia was calculated by multivariate logistic regression analysis after adjustment of age and sex. Results: Obesity, diabetes, hypertension, CAD and hypercholesterolemia were highly prevalent independent risk factors among patients with dementia. Multivariate logistic regression analysis showed that regardless of age and body mass index, diabetes mellitus and CAD were highly significant (p < 0.001) risk factors of dementia. Hypertension and family history of dementia were weakly but significantly(p < 0.05) associated with dementia. Conclusion: It is possible that increased frequency of obesity, diabetes, hypertension and CAD may increase the risk of dementia in an ageing population. Prevention and control of these biological risk factors may cause decline in the risk of dementia.","PeriodicalId":33497,"journal":{"name":"Scripta Medica","volume":"66 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85032356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antioxidative potential of pomegranate peel extract: In vitro and in vivo studies","authors":"Nebojša Mandić-Kovačević, Zoran Kukrić, Staniša Latinović, Tanja Cvjetković, Tanja Sobot, Zorislava Bajic, Uglješa Maličević, Sonja T Marinković, Đorđe Đukanović, Snežana Uletilović, Relja Suručić","doi":"10.5937/scriptamed54-43453","DOIUrl":"https://doi.org/10.5937/scriptamed54-43453","url":null,"abstract":"Background/Aim: Due to the numerous beneficial effects of pomegranate that can be explained through its antioxidative effects, the aim of this study was to determine the antioxidant potential of pomegranate peel extract (PoPEx) prepared from pomegranate that was harvested in the southeast region of Herze-govina (Bosnia and Herzegovina), through in vitro and in vivo studies. Methods: In PoPEx total phenols, flavonoids, flavonols, flavan-3-ols and antho-cyanins content was determined, as well as several antioxidative assays, including 2,2 diphenyl-1-picrylhydrazyl assay (DPPH), 2,2'-azino bis(3-ethylbenzothi-azoline-6-sulphonic acid) assay (ABTS), iron (III)-2,4,6-tripyridyl-S-triazine complex assay (FRAP), reduction of copper(II) ions (CUPRAC) assay, Briggs-Rauscher oscillatory reactions, neutralisation of OH radicals and lipid peroxidation assay. In vivo studies were performed by administrating 100 mg/ kg of body weight of PoPEx to the rats by gavage for 7 days, after which the rats were euthanised and prooxidative parameters (thiobabrituric acid reactive substances-TBARS as an index of lipid peroxidation, nitrites-NO 2 , hydrogen peroxide-H 2 O 2 and superoxide anion radical O 2-) were determined in plasma, as well as antioxidative parameters (superoxide dismutase-SOD, reduced gluta-thione-GSH and catalase-CAT) in erythrocyte lysates. Results: High content of phenolic compounds was found in PoPEx, which resulted in high antioxidative potential in all in vitro tests performed. In vivo study showed that PoPEx administration caused a significant decrease in TBARS, NO 2-, as well as an increase in reduced glutathione (p < 0.05) in comparison to the control group, while H 2 O 2 and O 2 * showed a lowering trend and SOD and CAT showed an increasing trend in PoPEx group, but without statistical significance. Conclusion: PoPEx demonstrated high antioxidative capacity measured in vitro and in vivo and can be potentially used as a supplement treatment in the prevention of various inflammatory conditions.","PeriodicalId":33497,"journal":{"name":"Scripta Medica","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80467704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The correlation between aminotransferase enzyme levels, neutrophil-to-lymphocyte ratio, absolute lymphocyte count and the severity of Covid-19","authors":"Sas Al, Budi Santosa, Lisyani Suromo, Satriya Pranata","doi":"10.5937/scriptamed54-44627","DOIUrl":"https://doi.org/10.5937/scriptamed54-44627","url":null,"abstract":"Background/Aim: Aspartate aminotransferase (AST), alanine aminotransferase (ALT), neutrophil-to-lymphocyte ratio (NLR) and absolute lymphocyte count (ALC) are indicators that are widely used as a determinant of the prognosis of patients with viral pneumonia. Thus, the study aim was to prove the correlation between AST/ALT, NLR and ALC levels with the severity of COVID-19. Methods: The research method was carried out by collecting medical record data of positive COVID-19 patients who were hospitalised at the Indramayu Hospital in the period September 2020 - January 2021. Results: The results showed normal AST levels in 63 and elevated AST levels in 57 patients. Normal and elevated ALT levels were in 68 and 52 patients, respectively. The normal NLR was in 102 patients and the high NLR was in 18 patients. The low and normal ALC was in 19 and 101 patients, respectively. AST levels correlated with the severity of COVID-19 (p = 0.045). Other parameters were without statistical significance (p &gt; 0.05). Conclusion: AST enzyme levels had a weak positive correlation with the severity of COVID-19. On the other hand, ALT, NLR and ALC had not correlated with the severity of COVID-19.","PeriodicalId":33497,"journal":{"name":"Scripta Medica","volume":"82 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135845125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thanatological perspectives in geriatrics and gerontopsychiatry","authors":"Alen Greš, Dijana Staver, Branislav Šakić, Ljubomir Radovančević","doi":"10.5937/scriptamed54-45477","DOIUrl":"https://doi.org/10.5937/scriptamed54-45477","url":null,"abstract":"Thanatology is the science of death in relation to aging and old age. The concept of death and dying is presented in many works and is the subject of many scientific and professional research. Death and dying do not have their proper place in social understanding and are increasingly being ignored and suppressed. Despite modern medical discoveries and achievements, death still eludes human control. People often avoid talking about death, thinking that death happens to someone else. They consider it as an inevitable reality for some upcoming future.","PeriodicalId":33497,"journal":{"name":"Scripta Medica","volume":"72 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135845128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A quadricuspid aortic valve combined with coronary artery disease","authors":"Ž. Jonjev, Novica Kalinić","doi":"10.5937/scriptamed54-44041","DOIUrl":"https://doi.org/10.5937/scriptamed54-44041","url":null,"abstract":"","PeriodicalId":33497,"journal":{"name":"Scripta Medica","volume":"52 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82522258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occupational diseases in the Republic of Srpska from 2011-2020","authors":"N. Marić, Sonja Peričević-Medić, M. Španović","doi":"10.5937/scriptamed54-41569","DOIUrl":"https://doi.org/10.5937/scriptamed54-41569","url":null,"abstract":"Background/Aim: The importance of occupational diseases is due to their influence on workers' quality of life and significant socioeconomic problems for the health sector, employers and the state. Occupational diseases are generally not curable but are preventable diseases, so it is extremely important to develop a good system of detection, registration and prevention. Therefore, special attention should be paid to the occupational incidence analysis. Aim of this study was to assess the incidence of occupational diseases in the Republic of Srpska. Methods: The research was conducted as a cross-sectional study based on the obtained data on occupational diseases in the Republic of Srpska for ten years (from 2011 to 2021). Results: In the observed period, 12 cases of occupational diseases were registered in the Republic of Srpska and the incidence was less than 1/100,000 per year. Occupational diseases were diagnosed in: - agriculture, forestry and fishing; - construction and - healthcare and social welfare. Conclusion: The study showed a low incidence of occupational disease and it was observed that certain industrial sectors were particularly undervalued. The current situation regarding occupational diseases in the Republic of Srpska requires an urgent response from the occupational medicine services and the state. It is necessary to initiate procedures as soon as possible to ensure uniformity in the criteria of diagnosis and records of occupational diseases and revision of the list of occupational diseases by the International Labour Organisation. In the future, it is necessary to conduct additional and more detailed research in the field of occupational diseases.","PeriodicalId":33497,"journal":{"name":"Scripta Medica","volume":"77 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74828104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical features and management of human monkeypox","authors":"D. Moĭsova, Vladislav Daguf, Maria Grebennikova, Y. Tretyakova, Georgy Oflidi, A. Filonov","doi":"10.5937/scriptamed54-43494","DOIUrl":"https://doi.org/10.5937/scriptamed54-43494","url":null,"abstract":"The COVID-19 pandemic is abating, but the threat of a new epidemic is growing due to the spread of monkeypox in non-endemic regions of the world. In 2022, there were the monkeypox outbreaks throughout Europe, in the Western Hemisphere. With the cessation of the vaccine, due to the global eradication of smallpox, outbreaks of monkeypox have become more common. Currently, there are no exact recommendations for complex treatment and alleviation of the monkeypox symptoms for infected people. Under these conditions, it is especially important to know the pathogenetic mechanisms and epidemiology of the virus for the most effective containment of its spread, especially in view of the negative experience gained in combating the COVID-19 epidemic. The purpose of this study was to summarise the known data on the epidemiology, clinical course and treatment of monkeypox, as well as an attempt to assess the possibility of a new world-spanning pandemic. A targeted search was performed on the keywords \"monkeypox\", \"virology\", \"Tecovirimat\", \"Cidofovir\", \"Brincidofovir\" in PubMed, in the period up to July 2022. 661 articles were reviewed, among them as reviews, original research and clinical trials. Preference was given to articles in English that dealt in most detail with cases of monkeypox infection outside the Africa and included comments on the therapy. Seventeen articles were selected and analysed, as well as links within them for additional information on the case. It was revealed that monkeypox is mainly treated with maintenance therapy and the treatment of more complex cases is based on the use of specific antiviral drugs: Tecovirimat, Cidofovir, Brincidofovir. However, there is no widespread therapeutic practice for these drugs. Little is currently known about the monkeypox virus; the transmission of infection, the animal reservoirs, the host range and the prospects for specific treatment are not fully understood. Sharing resources and data with outbreak tracking around the world will greatly facilitate the process of learning about the virus and how to deal with it effectively","PeriodicalId":33497,"journal":{"name":"Scripta Medica","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78880916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging non-pharmacological refractory intervention for pain relief in fibromyalgia: A case report","authors":"Saif Al-Zoubi, Alameen Alsabbah, Maggie Wassouf, A. Al-Mnayyis","doi":"10.5937/scriptamed54-43092","DOIUrl":"https://doi.org/10.5937/scriptamed54-43092","url":null,"abstract":"Fibromyalgia (FM) is a common disorder characterised by widespread musculoskeletal pain often associated with fatigue, sleep, memory and mood disturbances. Females are more likely to suffer from FM and experience a reduced quality of life. This is a case report of a 21-year-old female patient diagnosed with FM whose pain was managed by a non-pharmacological method, weightlifting exercises. The patient suffered from chronic generalised muscular pain, muscle stiffness, fatigue, depression and anxiety. She was started on a tight progressive weight-lifting program to increase muscle mass. The program led to a resolution of symptoms after 3 months of gradual improvement, in addition to stopping taking analgesics for the pain. Notably, a relapse occurred after halting the exercise program suggesting that the weight-lifting regime was correlated to reducing symptom severity and better quality of life. Exercises involving weight-lifting could potentially provide an affordable treatment option for patients with FM.","PeriodicalId":33497,"journal":{"name":"Scripta Medica","volume":"40 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90222220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of nutraceutical use in younger population of North India and the association between gender and community in its usage: Cross-sectional study","authors":"Divyam Saran, A. Bansal, A. Agrawal, L. Sharma, Smita Jain, Punam Jakhar","doi":"10.5937/scriptamed54-42072","DOIUrl":"https://doi.org/10.5937/scriptamed54-42072","url":null,"abstract":"Background/Aim: Nutraceuticals or dietary supplements have been recognised as a fundamental part of the holistic approach to achieve complete wellness and health. Their usage is continuously increasing due to lifestyle and sport-style requirements. The present study was designed to estimate the use of nutraceuticals in the younger population and find the association between gender and community in their usage. Methods: An observational cross-sectional study was carried out on the younger population (between 15 and 30 years of age) of North India over a period of two weeks in October 2022. The data regarding the demographic profile and nutraceutical use among participants was collected per predesigned and pre-validated questionnaire. The collected data were analysed to determine the outcomes. Results: The study included 575 participants, with 272 males and 303 females. Out of them, 321 were from the urban background. It was found in the study that a total of 275 (47.82 %) study subjects were using nutraceuticals, with 163 (59.27 %) and 112 (40.73 %) from the urban and rural dwellings, respectively. Among the users, 122 (44.36 %) were men and 153 (55.64 %) were women. Thus, overall, 153 (50.49 %) of females and 122 (44.85 %) of males in survey were consuming dietary supplements. The study further added that 189 (68.72 %) users believed that nutraceuticals improved their health, two-thirds of participants were using nutraceuticals for lifestyle reasons and 239 (86.90 %) of consumers were using single nutraceuticals. There was no association between gender and community in nutraceuticals usage (Chi-square test, p > 0.05). Conclusion: Almost half of the younger population was using nutraceuticals and there was no association between gender and community while using them.","PeriodicalId":33497,"journal":{"name":"Scripta Medica","volume":"126 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87867645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obesity: An important predictor of metabolic syndrome","authors":"B. Kumar, S. Kumari, Neelam Khandelwal, D. Kumar, S. Dhaked, R. Bhatt","doi":"10.5937/scriptamed54-40389","DOIUrl":"https://doi.org/10.5937/scriptamed54-40389","url":null,"abstract":"Background/Aim: The leading avoidable cause of mortality in the world is obesity. It modifies how the body reacts to insulin, which might result in insulin resistance and an elevated risk of type 2 diabetes. Recent investigations have revealed a link between obesity and the metabolic syndrome. Therefore, it was intended for the current study to look at the prevalence of obesity and how it relates to the metabolic syndrome. Methods: 120 healthy males between 30-50 years of age were chosen from the general population of Kota District, Rajasthan, India and screened for obesity and divided in three groups: normal, overweight and obese. Each group comprised of forty subject. Serum was separated and run in department of biochemistry , GMC Kota. Anthropometric parameters were taken. The completely automated analyser ERBA EM 360 performed lipid profile and blood sugar analyses on serum. Result: Obesity increased metabolic syndrome prevalence. In comparison to overweight and normal weight people, obese subjects exhibited considerably lower levels of high-density lipoprotein (HDL) cholesterol and significantly higher levels of blood glucose, triglycerides, total cholesterol and low-density lipoprotein (LDL) cholesterol. Additional coronary artery disease (CAD) risk prediction ratios, such as total cholesterol/HDL, LDL/HDL and triglycerides/ HDL ratios that have gradually increased from the normal to obese group, show that obese subjects have a relatively higher risk of developing cardiovascular diseases (CVD) than do those in the overweight and normal groups. Conclusion: One of the key elements of metabolic syndrome, which is a collection of clinical and metabolic anomalies including abdominal obesity, insulin resistance, hypertension and dyslipidaemia, is obesity. Each of these conditions raises the risk of CVD and diabetes mellitus type 2 directly. The progression towards diabetes and CVD can be prevented by lifestyle modification programmes and regular health checks (to explore the risk factors of metabolic syndrome).","PeriodicalId":33497,"journal":{"name":"Scripta Medica","volume":"49 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79849782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}