Jurnal Ilmu Dasar最新文献_第7页

The Binding Prediction of 6-Paradol and its Derivatives on TRPV1 Agonist as a New Compound for Treating Painful Diabetic Neuropathy 6-对羟基苯酚及其衍生物与TRPV1激动剂的结合预测

Jurnal Ilmu Dasar Pub Date : 2020-07-03 DOI: 10.19184/jid.v21i2.15501

F. Fajrin, Fina Rahmayanti, D. K. Pratoko

{"title":"The Binding Prediction of 6-Paradol and its Derivatives on TRPV1 Agonist as a New Compound for Treating Painful Diabetic Neuropathy","authors":"F. Fajrin, Fina Rahmayanti, D. K. Pratoko","doi":"10.19184/jid.v21i2.15501","DOIUrl":"https://doi.org/10.19184/jid.v21i2.15501","url":null,"abstract":"Ginger was reported to have a suppressive effect on pain in patients with Painful Diabetic Neuropathy (PDN). Our latest study revealed that 6-shogaol, one of the ginger components, had the best affinity in the Transient Receptor Potential Vanilloid 1 (TRPV1), a key receptor in PDN). Paradol, which obtained from gingerol and shogaol metabolism, also had potent activities in several diseases, compared to the other derivatives of gingerol and shogaol. However, shogaol and paradol is very similar in chemical structure with only different in one double bond in 4-5 position. Until now there is no explanation about paradol mechanism in TRPV1. Based on this, our study was designed to predict the activity of 6-paradol and its derivatives to TRPV1 as target receptor in PDN using in-silico model. 2-paradol, 4-paradol, 6-paradol, 8-paradol and 10-paradol were used as ligands. Capsaisin, the agonist of TRPV1, was used as a native ligand in this study. TRPV1 was obtained from protein data bank (PDB). Ligand bond prediction and affinity was performed using Molegro Virtual Docker. The results showed 2-paradol, 4-paradol, 6-paradol, 8-paradol and 10- paradol had good affinity against TRPV1. These result indicated that 6-paradol and the derivatives had potential as a drug compound for PDN therapy.Keywords: ginger, 6-paradol, painful diabetic neuropathy, trpv1.","PeriodicalId":33444,"journal":{"name":"Jurnal Ilmu Dasar","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49431078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Environmental Isotope of Radon-222 for Ciliwung River and Shallow Deep Water Interaction Study 慈溪翁河氡-222环境同位素与浅水-深水相互作用研究

Jurnal Ilmu Dasar Pub Date : 2020-07-03 DOI: 10.19184/jid.v21i2.11940

E. R. Pujiindiyati, B. Pratikno

{"title":"Environmental Isotope of Radon-222 for Ciliwung River and Shallow Deep Water Interaction Study","authors":"E. R. Pujiindiyati, B. Pratikno","doi":"10.19184/jid.v21i2.11940","DOIUrl":"https://doi.org/10.19184/jid.v21i2.11940","url":null,"abstract":"Aquifer in river bank area is mostly susceptive toward pollution occurring in river. One of parameters to determine the interaction process between groundwater and river is a natural isotope of 222Rn. The significant difference of radon concentration in groundwater and river water can be utilized as a scientific basis for investigating groundwater infiltration in river bank. Those studied parameters are residence time and infiltration rate. The research using 222Rn had been conducted in shallow groundwater of Ciliwung river bank - South Jakarta during rainy and dry season. The range of 222Rn concentration in shallow groundwater monitored in dry season was between 666 - 2590 Bq/m3 which was higher than that of rainy season ranging at 440 to 1546 Bq/m3. Otherwise, concentration of 222Rn in river water could not be detected (its 222Rn concentration = 0 Bq/m3) due to its much lower concentration either rainy or dry season. During dry season monitoring, equilibration between groundwater and river water was reached at the distance approximately 98 - 140 m away from river side. Estimating residence time based on 222Rn concentration at nearest site from the river and at equlibration area was 4.2 days such that the infiltration rate from river water into aquifer might be 7.8 m/day.Keywords: 222Rn, groundwater, residence time, infiltration rate.","PeriodicalId":33444,"journal":{"name":"Jurnal Ilmu Dasar","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41669348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Adaptation and Production of Three Selected Cassava (Manihot esculenta Crantz) in Peat Land Area of Central Kalimantan 三种精选木薯在加里曼丹中部泥炭地的适应性和生产评价

Jurnal Ilmu Dasar Pub Date : 2019-07-16 DOI: 10.19184/JID.V20I2.7449

H. Fitriani, N. Hartati, E. Sudarmonowati

{"title":"Evaluation of Adaptation and Production of Three Selected Cassava (Manihot esculenta Crantz) in Peat Land Area of Central Kalimantan","authors":"H. Fitriani, N. Hartati, E. Sudarmonowati","doi":"10.19184/JID.V20I2.7449","DOIUrl":"https://doi.org/10.19184/JID.V20I2.7449","url":null,"abstract":"Along with the increasing the of the land-use change of the fertile agricultural land in Java, the better awareness has been subjected to the importance of function peat land for agricultural development. Cassava (Manihot esculenta Crantz) is a tuber plant that potentially developed as important carbohydrate source. The objective of this research was to identify superior cassava variety candidate of selected cassava developed by of Research Centre Biotechnology, LIPI which has high adaptation capability and yield in Central Kalimantan peat land area. This research was conducted from July 2010 through May 2011 in Central Kalimantan Province (Kalampangan dan Pulang Pisau in total of area 1.5 and 2.25 ha respectively). There were three genotypes of cassava tested, i.e. Iding (high amylose), Gebang (low amylose), and Menti (high starch) compared to Adira 4 (35 ton/ha) and Darul Hidayah (102.1 ton/ha). The variables observed were plant height (cm) and tuber weight (grams). Observations were conducted at the age of 10 months. Data was analyzed using SPSS version 16.0. The results showed that the plant height and yield were higher in Pulang Pisau than Kalampangan even though the difference is not significant (P ≤ 0,05). Darul Hidayah has highest plant height and yield, 229.8 cm and 2271 g respectively among other genotypes/varieties grown at Pulang Pisau even though the value was not significant, whereas in Kalampangan, Darul Hidayah showed the lowest yield (670 g). Based on the data obtained, the Darul Hidayah variety can be cultivated by farmers in Pulang Pisau peat land to fulfill the availability of superior cassava seedlings for food, feed and industry. Keywords: Peat, tuber yield, plant height, liquid organic fertilizer, yam wood.","PeriodicalId":33444,"journal":{"name":"Jurnal Ilmu Dasar","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44118093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The Effect of Nonwoven Microfiber Substrate Polypropylene Thickness to Air Filtration Performance of Polyacrilonitrille Nanofiber 非织造微纤维基体聚丙烯厚度对聚丙烯腈纳米纤维空气过滤性能的影响

Jurnal Ilmu Dasar Pub Date : 2019-07-16 DOI: 10.19184/JID.V20I2.9658

A. Rajak, T. S. Syahputra, M. Munir, K. Khairurrijal

{"title":"The Effect of Nonwoven Microfiber Substrate Polypropylene Thickness to Air Filtration Performance of Polyacrilonitrille Nanofiber","authors":"A. Rajak, T. S. Syahputra, M. Munir, K. Khairurrijal","doi":"10.19184/JID.V20I2.9658","DOIUrl":"https://doi.org/10.19184/JID.V20I2.9658","url":null,"abstract":"Since a nanofiber medium on itself is soft and fragile and cannot be used alone as air filters. Coating nanofiber on a rigid substrate to form a composite that can be handled readily is necessary. Beside can improve the filtration efficiency, adding the substrate will also save the use of nanofibers mat itself. The aim of this study is to evaluate the effect of substrate thickness on the performance of nanofibers mat in aerosol filtration in order to find the optimum thickness of substrate that can increase the quality of nanofiber filter. The substrate used was a low cost microfiber non-woven fabric made from polypropylene (PP). The nanofibers mat was composed of electrospun polyacrylonitrile (PAN) with concentration of 9 wt.% which dissolved at N,N dimethylformamide (DMF). Five variations of PP different in thickness was used as substrate. From the SEM image, it was found that there is increasing fiber diameter of PAN after electrospun into PP substrate. From the porosity estimation of each nanofiber, it was found that the porosity decreased with increasing the substrate thickness. For test the performance of nanofiber filter, the particles of polystyrene latex (PSL) which generated by atomizer was used as the aerosol particle. In addition, to evaluate the performance filter in PM2.5 filtration, the experiment was carried out with generate the smoke from burning incense. Air filtration performance of all variations is obtained by comparison the results of measurement including: pressure drop, efficiency and quality factor. From the results, there is limitation on the substrates thickness based on the value of the quality factor obtained. Overall, PP nonwoven as the substrates gives the great contribution on the efficiency of PAN nanofiber. Keywords: substrate, polypropylene, thickness, nanofiber, air filtration.","PeriodicalId":33444,"journal":{"name":"Jurnal Ilmu Dasar","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44298743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Essential Oil Composition of Rose Flowers from Karangpring Village Jember District Extracted by Distillation and Enfleurage 詹伯区卡朗斯普林村玫瑰精油的蒸馏和发酵提取

Jurnal Ilmu Dasar Pub Date : 2019-07-16 DOI: 10.19184/JID.V20I2.8995

I. Oktavianawati, Nanda Letisya, Priscillia Citra, D. Utari, I. Winata, Wuryanti Handayani, A. S. Nugraha

{"title":"Essential Oil Composition of Rose Flowers from Karangpring Village Jember District Extracted by Distillation and Enfleurage","authors":"I. Oktavianawati, Nanda Letisya, Priscillia Citra, D. Utari, I. Winata, Wuryanti Handayani, A. S. Nugraha","doi":"10.19184/JID.V20I2.8995","DOIUrl":"https://doi.org/10.19184/JID.V20I2.8995","url":null,"abstract":"Karangpring is one tourist destination villages in Jember district which is popular with beautiful large rose field areas. Therefore, this area grows to be a leading producer of rose flowers in Jember district. However, the bulky presence of these flowers made its price becomes lower in regular days. Local community only uses and sells these fresh flowers as the flower for funeral. The rose flower has a great potency to be explored as a source of rose essential oil production. To date, there is no previous research on studying rose flowers from Karangpring village for its potency on the essential oil production. In this research, rose flowers were subjected to be extracted of its essential oil using two extraction methods, distillation, and enfleurage. Hydrodistillation resulted two phases of distillates, above part formed a cloudy white phase as a normal essential oil extracted from plants, and the lower phase was an aqueous phase containing rose hydrosols. Both phases of these condensates were analyzed using GCMS. Data explained that above phase, with a yield oil of 0.07%, only contains long-chain hydrocarbons such as n-nonadecane, n-heptadecane, 9-nonadecene, and eicosane, while the lower phase only contains 2-phenylethyl alcohol. On the other hand, enfleurage of fresh rose flowers resulted in 0.06% oil yield. GCMS analysis of this oil shows that 2-phenylethyl alcohol, eugenol, and phenylacetic acid are three major compounds which take more than 85% of total rose absolute. The results show that enfleurage is a better method for extracting rose oil in better quality than using the distillation method, in term of the variety of volatile components. Meanwhile, hydrodistillation is still benefiting from producing rose water that is qualified as an industrial additive agent for food and cosmetic productions or even a new potent of agromedicine products. Keywords: rose, rose oil, rose water, rose absolute, distillation, enfleurage.","PeriodicalId":33444,"journal":{"name":"Jurnal Ilmu Dasar","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44904343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Halal Identification for Meatballs in Pasar Tambun, Bekasi, West Java By Acrylamide Gels 丙烯酰胺凝胶对西爪哇省贝卡西Pasar Tambun肉丸的清真鉴定

Jurnal Ilmu Dasar Pub Date : 2019-07-16 DOI: 10.19184/JID.V20I2.9062

W. Hidayati, Meta Apriaji, Almawati Situmorang, Ifany Agustian, Miftahul Janah

引用次数: 0

Discriminant AnalysisFor Cluster Validation In A Case Study of District Grouping In Jember Regency Based On Poverty 基于贫困因素的重庆市县域分组聚类验证的判别分析

Jurnal Ilmu Dasar Pub Date : 2019-07-16 DOI: 10.19184/JID.V20I2.9862

Fikriana Nur Istiqomah, Made Tirta, Dian Anggareni

{"title":"Discriminant AnalysisFor Cluster Validation In A Case Study of District Grouping In Jember Regency Based On Poverty","authors":"Fikriana Nur Istiqomah, Made Tirta, Dian Anggareni","doi":"10.19184/JID.V20I2.9862","DOIUrl":"https://doi.org/10.19184/JID.V20I2.9862","url":null,"abstract":"Cluster validation is a procedure to evaluate the results of cluster analysis quantitively and objectively on a data. The validation process is very important to get the results of a good and appropriate grouping. In the validation process, the author uses internal validation, stability, and discriminant analysis test. This study aims to obtain validation results from the hierarchy and kmeans method. This data grouping uses “iris” simulation data, which results from the grouping method used can be applied to the original data to see which vaidation method is used for all data and produce an optimal grouping. The result of the study show that in the “iris” data, a single linkage link is an appropriate grouping method because the result of the grouping are optimal for all validations and classification of group members whose groups are significant. In District poverty data in Jember Regency with a single linkage link optimal grouping was obtained and complete linkage links were also used as a method that resulted in optimal groupig for all validation. Cluster validation discriminant analysis test is appropriate for various types of data in general annd shows that single linkage methods are better than other methods for grouping and validation methods for “iris” data and District data in Jember Regency based on variabels of poverty status. Keywords: Cluster Analysis, Diskriminant Analysis, Multivariate Analysis, Validation Cluster.","PeriodicalId":33444,"journal":{"name":"Jurnal Ilmu Dasar","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43672898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Catalytic Conversion From Plastic Waste by Silica-Alumina-Ceramic Catalyst to Produce an Alternative Fuel Hydrocarbon Fraction 硅铝陶瓷催化剂从塑料废料中催化转化制备替代燃料烃馏分

Jurnal Ilmu Dasar Pub Date : 2019-07-16 DOI: 10.19184/JID.V20I2.8829

H. Juwono, M. Arif Tri Sujadmiko, Laily Fauziah, Ismi Qurrota Ayyun

引用次数: 2

The The Correlation Between Type of Land Use and Water Quality in the Rembangan River, Jember Regency 詹伯县Rembangan河土地利用类型与水质的相关性

Jurnal Ilmu Dasar Pub Date : 2019-07-16 DOI: 10.19184/JID.V20I2.8939

Fefi Eka Wardiani, Retno Wimbaningrum, R. Setiawan

{"title":"The The Correlation Between Type of Land Use and Water Quality in the Rembangan River, Jember Regency","authors":"Fefi Eka Wardiani, Retno Wimbaningrum, R. Setiawan","doi":"10.19184/JID.V20I2.8939","DOIUrl":"https://doi.org/10.19184/JID.V20I2.8939","url":null,"abstract":"The river is one of the important water sources and at this time the river water quality has decreased.The type of land use around the river is thought to have a significant contribution to river water quality. This research was conducted to determine of correlation between the type of land use and water quality in Rembangan River, Jember Regency.The study was carried out at four stations that passed through secondary forests, coffee plantations, rice fields and residential housing. The data of biodiversity and density of plants and physical-chemical parameters of river water were noted, and benthic macroinvertebratessamples were collected at each station. Data of biodiversity and density plants were used to determine of environmental services index (ESI) values. Benthic macroinvertebrates samples were identifiedat the family level, and after that the tolerance score and the abundance of each family was determined. The last two data were analyzed to determine of Family Biotic Index (FBI) values.The value of ESI, physico-chemical parameters of river waterand FBI were analyzedto determine the relationship between these variables by using Pearson correlation analysis (α < 0.05).The research result revealed that the type of land use (ESI) was significantly related to the biological quality of river water (FBI) as indicated by the p value > 0.05. The correlation characteristic is negative and very strong (R = 0.886). High ESI values indicate that the diversity and carbon sequestration of plant community around the river are in good condition and vice versa. Low HBI values indicate good river water quality and vice versa. Based on this research, each land use type must provide space for the natural growth of the plant communityto maintain the quality of river water to remain good. Keywords: river, benthic macroinvertebrates, land use, water quality, ESI, HBI.","PeriodicalId":33444,"journal":{"name":"Jurnal Ilmu Dasar","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42206379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Determination of Sucrose Content in Sugarcane Liquids Through Angular Dispersion Angle Measurement 角分散角法测定甘蔗液中蔗糖含量

Jurnal Ilmu Dasar Pub Date : 2019-07-16 DOI: 10.19184/JID.V20I2.8497

M. Misto, T. Mulyono, B. E. Cahyono

引用次数: 0