{"title":"Evaluation of in vitro drug release and in vivo tolerance of porous biodegradable reservoir device","authors":"D. Yang, G. Peyman, K. Fillacier, B. Khoobehi","doi":"10.1109/SBEC.1995.514418","DOIUrl":"https://doi.org/10.1109/SBEC.1995.514418","url":null,"abstract":"The biodegradable polymer polycaprolactone was tested in vitro and in vivo as an intraocular drug delivery device loaded with 5-carboxyfluorescein dye. Zero-order release of carboxyfluorescein was obtained in vitro. The device was tolerated well after implantation in the rabbit eye. Further studies are necessary to determine the efficacy of this form of drug delivery.","PeriodicalId":332563,"journal":{"name":"Proceedings of the 1995 Fourteenth Southern Biomedical Engineering Conference","volume":"72 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1995-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127366086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Water and filler content of hybrid glass ionomers","authors":"B. Roberts, A. Puckett, B. Bennett","doi":"10.1109/SBEC.1995.514444","DOIUrl":"https://doi.org/10.1109/SBEC.1995.514444","url":null,"abstract":"Summary form only given. The objective of this study was to determine the water and filler content of five different hybrid glass ionomers (GI) after aging in distilled water at 37 /spl deg/C for 7 days. The materials were A.) Encapsulated and B.) hand mixed Variglass (Caulk Dentsply, Milford, DE) C.) Photacfil Aplicaps (ESPE Premier, Norristown, PA) D.) Fuji II capsules (GC corp., Tokyo, Japan) and E.) Vitremer (3M, St. Paul, MN). Based upon the mass loss with increasing temperature and the residual mass, the percent water and filler content of the materials were determined. Comparison of the results using ANOVA and the Tukey test (p <.05) reveals that the water content is significantly different for every material and the filler contents are different for every material except C and D.","PeriodicalId":332563,"journal":{"name":"Proceedings of the 1995 Fourteenth Southern Biomedical Engineering Conference","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1995-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131441326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Wavelet transformation of chaotic biological signals","authors":"Bai-lian Li, Hsin-i Wu","doi":"10.1109/SBEC.1995.514474","DOIUrl":"https://doi.org/10.1109/SBEC.1995.514474","url":null,"abstract":"Wavelet analysis is a recently developed mathematical theory and computational method for decomposing a nonstationary signal into components that have good localization properties both in time and frequency and hierarchical structures. Wavelet transform provides local information and multiresolution decomposition on a signal that cannot be obtained using traditional methods such as Fourier transforms and statistical estimation theory. Hence the change in complex biological signals can be detected. We use wavelet analysis as an innovative method for identifying and characterizing chaotic biological signals in this paper. We usually do not know the underlying mechanism that determine the behavior of a biosystem. We are instead presented with nothing more than a phenomenological time series signal of the behavior, and must infer the mechanism from simple measurements of that time series. Data we used are simulated chaotic signals from the logistic equation. Using wavelet transformation we extract instantaneous frequencies of the signal varying in time across scales. The results under different parameters and initial conditions show that the phase maps of their wavelet transforms are different between period doubling bifurcation and chaos. This information could be used as a diagnostic for detecting different nonlinear dynamic responses. This may lead to a better understanding of the system, that may allow us to predict the onset of lethal arrhythmias and to intervene prior to the development of catastrophic clinical events.","PeriodicalId":332563,"journal":{"name":"Proceedings of the 1995 Fourteenth Southern Biomedical Engineering Conference","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1995-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124938736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A model-based reasoning system for the management of respiratory weaning process","authors":"Qian Tan, S. Napper","doi":"10.1109/SBEC.1995.514417","DOIUrl":"https://doi.org/10.1109/SBEC.1995.514417","url":null,"abstract":"Summary form only given. The progressive withdrawal of mechanical ventilation is called weaning. A computerized decision support system (off-line or on-line) would help the medical staff to wean patients more efficiently and can potentially reduce treatment duration and mortality rates. The aim of this research is to design a model-based reasoning system to provide on-line guidance in respiratory weaning process management. In this approach, the semi-quantitative reasoning method is applied to regulate and control the weaning process by adjusting the ventilator settings. A semi-quantitative method provides a level of description that is intermediate between abstract qualitative models and precise numerical models. It combines both qualitative and quantitative knowledge within a single semi-quantitative qualitative differential equation (SQDE) representation. It is a set of qualitative constraints which are augmented with envelopes for all monotonic functions and numeric ranges for all model variables and initial conditions. The model is then simulated to compute the variables in ventilator setting. The control system is tested under different physiological conditions, using a detailed simulation model of the human respiratory system.","PeriodicalId":332563,"journal":{"name":"Proceedings of the 1995 Fourteenth Southern Biomedical Engineering Conference","volume":"48 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1995-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123866973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pathologic processes associated with the use of scleral buckling in humans","authors":"R. Misra","doi":"10.1109/SBEC.1995.514463","DOIUrl":"https://doi.org/10.1109/SBEC.1995.514463","url":null,"abstract":"Scleral buckling or indentation over a retinal tear or detachment was popularized by Ernst Custodis in 1953. Since then it has become one of the most popular and effective retinal reattachment surgical procedures. Although a few biologic materials such as fascia lata, lyophilized sclera and gelatin are used sometimes as scleral buckles, the most common material for buckles currently used is derivatives of medical grade silicone rubber or MAI. When the scleral buckling material is of foreign origin, the body reacts with acute and chronic inflammation, extrusion, and intrusion. The author has studied five eneucleated globes, with scleral buckles in place for periods of 3 to 48 months. The globes were removed for \"painful blind eyes\". The author's studies consisted of histomorphological analyses. The author observed foreign body granulomatous reaction and extensive fibrosis of Tenon's capsule and the sclera. The precise mechanism by which scleral buckling works remain uncertain at this time.","PeriodicalId":332563,"journal":{"name":"Proceedings of the 1995 Fourteenth Southern Biomedical Engineering Conference","volume":"66 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1995-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125424546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The acoustic sweep method for monitoring osteoporosis","authors":"S. Panteliou, H. Abbasi-Jahromi, A. Dimarogonas","doi":"10.1109/SBEC.1995.514491","DOIUrl":"https://doi.org/10.1109/SBEC.1995.514491","url":null,"abstract":"A non-invasive method to measure bone integrity has been developed which has potential for monitoring osteoporosis. It is based on a patented process of obtaining the dynamic characteristics of the bone using dynamic excitation in the range of acoustic frequencies (a sound source). The Modal Damping Factor has been used as an indicator of the tendency of the bone to fracture. Results of numerous animal studies have supported this hypothesis.","PeriodicalId":332563,"journal":{"name":"Proceedings of the 1995 Fourteenth Southern Biomedical Engineering Conference","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1995-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117057341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Aging characteristics of four hybrid glass ionomers","authors":"B. Bennett, A. Puckett, J. Fitchie","doi":"10.1109/SBEC.1995.514439","DOIUrl":"https://doi.org/10.1109/SBEC.1995.514439","url":null,"abstract":"Summary form only given. The objective of this study was to evaluate the change in Barcol hardness of five different hybrid glass ionomers (GI) after storage in distilled H/sub 2/O at 37/spl deg/C. The materials were (A) Encapsulated and (B) Handmixed Variglass (Caulk Dentsply, Milford, DE), (C) Vitremer (3M, St. Paul, MN), (D) Fuji II (GC Corp., Tokyo, Japan) and (E) Photacfil (ESPE Premier, Norristown, PA). Barcol hardness measurements were taken on all the samples after twenty-four hours, 1 week and 1 month of aging. Comparison of the initial hardness using ANOVA (p<0.05) revealed no significant differences. However, materials A and B showed a decrease in hardness after 1 week of storage. In contrast, materials C, D and E showed a significant increase (p<0.05) in hardness after storage. Based upon these results, it may be concluded that materials C, D and E continue to react during aging resulting in a harder material. In contrast, the materials A and B do not continue to react but actually become softer due to plasticization by absorbed water. The additional reaction of materials C, D and E is most probably the result of further ionic crosslinking which may be facilitated by water absorption.","PeriodicalId":332563,"journal":{"name":"Proceedings of the 1995 Fourteenth Southern Biomedical Engineering Conference","volume":"100 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1995-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129400461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cell adhesion strength to bioceramics and morphology","authors":"T. Tateishi, T. Ushida","doi":"10.1109/SBEC.1995.514501","DOIUrl":"https://doi.org/10.1109/SBEC.1995.514501","url":null,"abstract":"The aim of this study is to measure adhesion strength of cultured cells to bioceramics such as alumina, and to adapt a mathematical model of defect growth kinetics to the cell adhesion phenomena. Fibroblasts from mouse (L-929) were cultured on alumina plates and fibronectin-coated alumina plates. The adhesion strength was measured by loading adhered cells with centrifugal force vertical to the material's surface. At the same time, we measured adhered areas and morphology of cells on the 2 types of surfaces by using an image analyzing method. The results show that the cells adhered more tightly to fibronectin coated alumina than to alumina. (50% of the cells were peeled off from the fibronectin-coated alumina under the load of 500 G, while 50% of the cells were peeled off from the alumina under the load of 100 G.) The image processed data show that the average of adhered areas of cells to fibronectin coated alumina was 3 times as large as to alumina 6 hours after seeding. The results show influence of fibronectin-receptor bonds on the cell's adhesion strength and the cell's adhesion phenomena. Considering the influence of fibronectin-receptor bonds, a mathematical model of defect growth kinetics was adapted to the cells adhesion phenomena, where we assumed that the rate of condensation of vacancies or the rate of rupture of fibronectin-receptor bonds at the tip of the crack was proportional to the radius of the crack.","PeriodicalId":332563,"journal":{"name":"Proceedings of the 1995 Fourteenth Southern Biomedical Engineering Conference","volume":"83 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1995-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126280255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Efficiency of muscular contractions in mouse is different from that in frog","authors":"C. Yin, R. Woledge","doi":"10.1109/SBEC.1995.514475","DOIUrl":"https://doi.org/10.1109/SBEC.1995.514475","url":null,"abstract":"Traditionally, muscle efficiency studies were performed on frog muscles. Muscles of other animal species are assumed to have efficiency values similar to that in frog muscles. This assumption has not been vigorously tested. Our goal was to test this assumption by determining efficiencies of mouse and frog muscles and comparing them. Mouse soleus and frog semitendinosus muscles were isolated and stimulated electrically to produce shortening against external load. The force, muscle length and temperature change associated with these contractions were recorded simultaneously. Efficiency values were worked out from these signals. Our results showed that mouse soleus muscle had a significantly lower efficiency than frog semitendinosus.","PeriodicalId":332563,"journal":{"name":"Proceedings of the 1995 Fourteenth Southern Biomedical Engineering Conference","volume":"103 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1995-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123713620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Model of the behavior of a Kirschner-Ehmer style external fixator clamp","authors":"G. Pijanowski, J. W. Phillips, M. Swindeman","doi":"10.1109/SBEC.1995.514486","DOIUrl":"https://doi.org/10.1109/SBEC.1995.514486","url":null,"abstract":"Several Kirschner-Ehmer style clamps used in external fixation of fractures were loaded in various configurations. The clamp was found to be characterized mechanically as a torsional spring, rather than a rigid connector between a sidebar and a bone pin. Also, the center of rotation is offset from the center of the bolt. Proper modeling of planar unilateral and bilateral fixator frames should be possible by treating the KE-style clamp as a torsional spring with a center of rotation displaced slightly toward the sidebar.","PeriodicalId":332563,"journal":{"name":"Proceedings of the 1995 Fourteenth Southern Biomedical Engineering Conference","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1995-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129854222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}