Revista de la Facultad de Medicina Humana最新文献_第7页

EFFECT OF TROPAEOLUM TUBEROSUM "MASHUA" (TROPAEOLACEAE) ON GENE EXPRESSION RELATED TO SPERMATOGENESIS IN MOUSE tropaeolum tuberosum“mashua”对小鼠精子发生相关基因表达的影响

Revista de la Facultad de Medicina Humana Pub Date : 2023-09-30 DOI: 10.25176/rfmh.v23i3.5907

José Gonzales Daga, José L. Pino Gaviño, Rafael Alvis Dávila, Juan C. Francia Quiroz, Carlos Bell Cortez, Pilar V. Pino Velásquez, Betty E. Shiga Oshige

{"title":"EFFECT OF TROPAEOLUM TUBEROSUM \"MASHUA\" (TROPAEOLACEAE) ON GENE EXPRESSION RELATED TO SPERMATOGENESIS IN MOUSE","authors":"José Gonzales Daga, José L. Pino Gaviño, Rafael Alvis Dávila, Juan C. Francia Quiroz, Carlos Bell Cortez, Pilar V. Pino Velásquez, Betty E. Shiga Oshige","doi":"10.25176/rfmh.v23i3.5907","DOIUrl":"https://doi.org/10.25176/rfmh.v23i3.5907","url":null,"abstract":"Introduction: Tropaeolum tuberosum, known as \"mashua\" is an Andean tuber that has both economic and nutritional value for low-income populations. It is believed that it affects male fertility because Andean men associate it with impotence and decreased fertilizing capacity. Studies done on rats fed mashua showed that there was a 45% decrease in the testosterone/dihydrotestosterone ratio. The effect of this plant on reproduction is related to its content of isothiocyanates, compounds that bind covalently to proteins, which may be directly or indirectly involved in the spermatogenic process. The purpose of this research was to evaluate the effect of the aqueous extract of \"mashua\" on spermatogenesis and reproductive physiology of mice. Methodology: tThe in vivo morphofunctional parameters of mouse sperm (spermatogram) were evaluated and the expression of: Cytochrome P450 17α-hydroxylase/17,20-lyase, protein that regulates acute steroidogenesis, Cyclin cyclin and Pprotamine, related to spermatogenesis, was quantified. Results: The results indicated that Aat 7, 14 and 21 days of dosing, the sperm count is affected, as well as their progressive motility (PM);, on the other hand, a delay in their maturation was observed. Regarding gene expression, no significant differences were found between the expression of the two genes studied (cCytochrome P450 17α-hydroxylase/17,20-lyase, cCyclin), Conclusion: Tthe effect of \"mashua \" does not occur at the level of the expression of the genes involved in spermatogenesis, but at the level of its functions as a protein.","PeriodicalId":33139,"journal":{"name":"Revista de la Facultad de Medicina Humana","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136277182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sperm DNA integrity and reproductive toxicity of lead nitrate in adult male mice 硝酸铅对成年雄性小鼠精子DNA完整性和生殖毒性的影响

Revista de la Facultad de Medicina Humana Pub Date : 2023-04-18 DOI: 10.25176/rfmh.v23i2.5637

José Gonzáles Daga, J. V. Vásquez Cavero, Rosmary Y. López Sam, P. P. Pino Velásquez, J. L. Pino Gaviño, Betty E. Shiga Oshige

{"title":"Sperm DNA integrity and reproductive toxicity of lead nitrate in adult male mice","authors":"José Gonzáles Daga, J. V. Vásquez Cavero, Rosmary Y. López Sam, P. P. Pino Velásquez, J. L. Pino Gaviño, Betty E. Shiga Oshige","doi":"10.25176/rfmh.v23i2.5637","DOIUrl":"https://doi.org/10.25176/rfmh.v23i2.5637","url":null,"abstract":"Introduction: Lead toxicity has been linked to different diseases in humans and several evidences suggest a strong relationship with the observed damage on reproductive function in humans and rodents. Methods: we provide to mice a single dose of lead nitrate (LN) of 50mg/kg body weight. Mice were euthanized seven days post-injection with the aim of evaluating sperm to come out from the seminiferous tubules and are in transit through the epididymis. Also the TUNEL test was done to evaluate the sperm DNA fragmentation. Results: The decrease in body weight in mice treated with LN (p <0.05), suggest a toxic systemic effect. However, we didn´t find an effect on the reproductive system because the weights of the testes, epididymis, prostate and seminal vesicles were not altered (p>0.05), in the same way physiological values such as sperm concentration and motility didn´t decrease with the treatment (p> 0.05). Transit and sperm maturation in the epididymis would not be affected by the LN, and because we did not observe increased sperm DNA fragmentation in the treated group (p>0.05), sperm protamination would be fulfilling its protective role on murine genetic material avoiding genotoxic damage by LN. Conclusion: The intraperitoneal administration of 50mg/kg/pc of lead nitrate (LN) for seven days does not cause systemic toxicity or effect on spermatogenesis in mice.","PeriodicalId":33139,"journal":{"name":"Revista de la Facultad de Medicina Humana","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43146145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Raptor and the importance of traffic accidents 猛禽和交通事故的重要性

Revista de la Facultad de Medicina Humana Pub Date : 2023-04-18 DOI: 10.25176/rfmh.v23i2.5710

Lucia Victoria Ulloa-Ordoñez, José M. Vela-Ruiz

引用次数: 0

Nuevas indexaciones de la Revista de la Facultad de Medicina Humana: Harvard Library y DRJI 人类医学院杂志的新索引:哈佛图书馆和DRJI

Revista de la Facultad de Medicina Humana Pub Date : 2023-04-18 DOI: 10.25176/rfmh.v23i2.5741

J. A. De la Cruz-Vargas, Gianella Zulema Zeñas-Trujillo, D. M. Quiñones-Laveriano

引用次数: 0

Knowledge about non-adherence to contraceptive methods Could it decrease mortality? 关于不坚持避孕方法的知识它能降低死亡率吗？

Revista de la Facultad de Medicina Humana Pub Date : 2023-04-18 DOI: 10.25176/rfmh.v23i2.5651

Luis Facundo Gramajo Cortez

{"title":"Knowledge about non-adherence to contraceptive methods Could it decrease mortality?","authors":"Luis Facundo Gramajo Cortez","doi":"10.25176/rfmh.v23i2.5651","DOIUrl":"https://doi.org/10.25176/rfmh.v23i2.5651","url":null,"abstract":"ntroduction: In Peru, 78.1% of women between the ages of 15 and 49 use a contraceptive method, which is diminished by various factors associated with non-adherence to the contraceptive method, thus producing unwanted pregnancies and the spread of sexually transmitted diseases. Objective: To determine the factors associated with non-adherence to contraceptive methods in women of childbearing age in Peru according to ENDES 2021. Methods: Observational, analytical and cross-sectional study. The information used is found in the ENDES 2021 public database. The population of this research is made up of Peruvian women between the ages of 15 and 49. Statistical analysis was performed with the statistical program SPSS version 26.0. The qualitative variables were represented in a univariate table with frequencies and coefficients of variation. The approved statistical significance value was p <0.05 with 95% confidence intervals. Results: 43.7% of women did not adhere to the contraceptive method. There was a significant association for the variables: area of rural residence (Rpa 1.05 IC 1 – 1.1), separated marital status (Rpa 1.1, IC 1 – 1.1), widow marital status (Rpa 1.3, IC 1.1 – 1.5), cohabiting marital status ( Rpa 1.1, IC 1.1 – 1.2) , poor wealth index (Rpa 1.03, IC 0.9 – 1.0) Conclusions: The factors associated with non-adherence to contraceptive methods in women of childbearing age in Peru, which are significantly associated are: Rural area of residence, separate marital status, widow and cohabitant and have a poor wealth index.","PeriodicalId":33139,"journal":{"name":"Revista de la Facultad de Medicina Humana","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46066654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risky eating behaviors in young adults from two communes in the Ñuble region, Chile in the COVID-19 pandemic 2019冠状病毒病大流行期间智利Ñuble地区两个社区年轻人的危险饮食行为

Revista de la Facultad de Medicina Humana Pub Date : 2023-04-18 DOI: 10.25176/rfmh.v23i2.5648

Javiera Saéz-Opazo, Valeria Quiroga-Salom, Monserrat Torres-Landeros, Ismael Morales-Ojeda, M. López-Espinoza, Pía Rojas-Cárdenas

引用次数: 0

University social responsibility in Latin America: Systematic review 拉丁美洲大学社会责任:系统回顾

Revista de la Facultad de Medicina Humana Pub Date : 2023-04-18 DOI: 10.25176/rfmh.v23i2.5653

Juana Matilde Cuba Sancho, Rosa María Contreras Gómez, Heddy Liliana Colca García, Alicia Lourdes Merino Lozano

{"title":"University social responsibility in Latin America: Systematic review","authors":"Juana Matilde Cuba Sancho, Rosa María Contreras Gómez, Heddy Liliana Colca García, Alicia Lourdes Merino Lozano","doi":"10.25176/rfmh.v23i2.5653","DOIUrl":"https://doi.org/10.25176/rfmh.v23i2.5653","url":null,"abstract":"Introduction: University social responsibility is present in the discourses of academics, but it fails to permeate the actions that lead to the transformation of the university, requiring a paradigm shift. At present there are conceptual confusions that make its promotion and transformative practice very difficult, in many universities it is confused with social projection, which reduces its transversal dimension. Objective: To analyze the scientific evidence related to university social responsibility in Latin America. Methods: Systematic review of the literature, between the months of August to December 2021; the search for articles was carried out in the databases: Scopus, Scielo, Doaj, Lilacs and Redalyc; the use of Descriptors in Health Sciences (DeCS) and the combination of the Boolean operators OR and AND were applied. Full texts in Spanish between the years 2015 and 2021 were considered. Results: 508 articles were obtained, which were submitted to the PRISMA methodology, selecting 20 articles, grouped into four categories according to the Social Responsibility Manual of the Úrsula Model: management, training, cognitive, and social participation. Conclusion: USR is an inalienable moral commitment, it is important in university management to promote sustainable development, with ethics and respect for human rights, the participation of committed actors is necessary, considering that it currently has a welfare and reductionist approach, scarce support, socialization and implementation and there is a need to unify criteria.","PeriodicalId":33139,"journal":{"name":"Revista de la Facultad de Medicina Humana","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47643514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Fe de erratas 勘误表的信仰

Revista de la Facultad de Medicina Humana Pub Date : 2023-04-18 DOI: 10.25176/rfmh.v23i2.5735

J. A. De la Cruz-Vargas

引用次数: 0

UNIVERSIDAD RICARDO PALMA IN THE SCIMAGO INSTITUTIONS RANKINGS 2023 里卡多·帕尔马大学在2023年Scimago机构排名中

Revista de la Facultad de Medicina Humana Pub Date : 2023-04-18 DOI: 10.25176/rfmh.v23i2.5734

J. A. De La Cruz-Vargas, I. Hernández-Patiño, V. Vera-Ponce, L. Correa-López, R. Pichardo-Rodríguez, Willy Ramos

引用次数: 0

Socio-cultural factors that influence 50-year-old users for papanicolau taking from a nasca hospital 影响50岁用户从美国国家医疗服务体系医院服用木瓜蛋白酶的社会文化因素

Revista de la Facultad de Medicina Humana Pub Date : 2023-04-18 DOI: 10.25176/rfmh.v23i2.5645

Ashli Rosa Parra Zambrano, Jesús E. Talavera, Andrea P. Ramirez-Ortega, Catherine A. Suárez Egoávil

{"title":"Socio-cultural factors that influence 50-year-old users for papanicolau taking from a nasca hospital","authors":"Ashli Rosa Parra Zambrano, Jesús E. Talavera, Andrea P. Ramirez-Ortega, Catherine A. Suárez Egoávil","doi":"10.25176/rfmh.v23i2.5645","DOIUrl":"https://doi.org/10.25176/rfmh.v23i2.5645","url":null,"abstract":"Objective: The objective of this study was to determine the sociocultural factors in 50-year-old users for Pap smears at the Ricardo Cruzado Rivarola de Nasca hospital during the period December 2021 - February 2022. Material and Methods: Observational, analytical, and prospective study. The study population is made up of 80 50-year-old users who attend the Ricardo Cruzado Rivarola hospital for Pap tests at the gynecology-obstetrics office and the sample is 67 users, selected by non-probabilistic sampling for convenience. Results: For the first analysis, in simple and multiple regression, it was found that women with high levels of knowledge had a 384% and 382% higher frequency of having ever undergone a PAP test compared to those with low levels of knowledge. Conclusions: The level of knowledge about the PAP has a relevant influence on having carried out a PAP; but also the women who had a high level were the ones who had the highest frequency of having done it. This added to the number of children; possibly because in the circles of women with children one of the topics to be discussed is about maternal health and within them the PAP.","PeriodicalId":33139,"journal":{"name":"Revista de la Facultad de Medicina Humana","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43512657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0