The Open Physiology Journal最新文献_第2页

Effects of Light With Reduced Short Wavelength Components on Parameters of Circadian Rhythm and Performance in an Experimental Night Shift Model 减少短波分量的光对实验夜班模型中昼夜节律参数和性能的影响

The Open Physiology Journal Pub Date : 1900-01-01 DOI: 10.2174/1874360900801010034

G. Hoffmann, V. Leichtfried, A. Griesmacher, C. Bartenbach, M. Canazei, S. Staggl, W. Schobersberger

引用次数: 5

Androgen Receptor Expression and Function in Osteoclasts 雄激素受体在破骨细胞中的表达和功能

The Open Physiology Journal Pub Date : 1900-01-01 DOI: 10.2174/1874360900901010028

R. Davey, A. Notini, W. Chiu, J. Hodge, G. Nicholson, J. Zajac, A. Turner

引用次数: 7

Radiobiological Study of Retinal Microvessel Proliferation in Diabetic-like Rat Model 糖尿病样大鼠视网膜微血管增殖的放射生物学研究

The Open Physiology Journal Pub Date : 1900-01-01 DOI: 10.2174/1874360900801010044

X. Mao, P. Archambeau, Waheed Baqai, S. Larsen, J. Archambeau

{"title":"Radiobiological Study of Retinal Microvessel Proliferation in Diabetic-like Rat Model","authors":"X. Mao, P. Archambeau, Waheed Baqai, S. Larsen, J. Archambeau","doi":"10.2174/1874360900801010044","DOIUrl":"https://doi.org/10.2174/1874360900801010044","url":null,"abstract":"Progressive evolution of retinal vascular in diabetic retinopathy leads to blindness in up to 8,000 patients yearly. The major purpose of this investigation was to determine proton radiation dose response of the eye's retinal vascu- lature in the hypergalactosemia induced rat model of diabetic-like retinopathy and gain insight of possible role of proton radiotherapy in controlling diabetic retinopathy. A single dose range of proton radiation (8, 14, and 20 Gy) was delivered to one eye of each rat at 4 months following induction of hypergalactosemia. The opposite eye of each rat, which was not irradiated, showed normal progression of retinopathy. Stereologic techniques were used to quantify tissue parameters in situ in a retinal digest preparation that allowed unobstructed access to the vasculature. 15 months following 50% galactose diet, characteristic histopathological lesions of retinopathy such as capillary endothelial cell proliferation, capillary clo- sure, capillary microaneurysms, pericyte loss developed in non-irradiated eyes. The endothelial cell densities for rat re- ceiving 50% galactose diet were significantly higher than that of control (p<0.05). Proton irradiation inhibited significant endothelial cell proliferation at dose from 14Gy to 20Gy (p<0.05), yet not diminished pericyte loss at current dose sched- ule. These findings indicated beneficial effects of proton radiation on hypergalactosemia induced diabetic-like retinopa- thy. Our study should have an impact on further studies to optimize radiation treatment strategies for diabetic retinopathy.","PeriodicalId":331207,"journal":{"name":"The Open Physiology Journal","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127760818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuroprotective Effect of Melatonin on Glucocorticoid Toxicity in the Rat Hippocampus 褪黑素对大鼠海马糖皮质激素毒性的神经保护作用

The Open Physiology Journal Pub Date : 1900-01-01 DOI: 10.2174/1874360900801010023

Analía M. Furio, Ramiro Fontão, N. Falco, J. Ruiz, R. Caccuri, D. Cardinali

引用次数: 16

Melatonin Beyond Its Classical Functions 褪黑素超越其经典功能

The Open Physiology Journal Pub Date : 1900-01-01 DOI: 10.2174/1874360900801010001

R. Hardeland, B. Poeggeler

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引用次数: 58