雄激素受体在破骨细胞中的表达和功能

The Open Physiology Journal Pub Date : 1900-01-01 DOI:10.2174/1874360900901010028

R. Davey, A. Notini, W. Chiu, J. Hodge, G. Nicholson, J. Zajac, A. Turner

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引用次数: 7

摘要

我们评估了雄激素受体(AR)在体外和原位破骨细胞中的表达。大鼠多核破骨细胞原位表达可检测到AR蛋白，体外在小鼠和人源性破骨细胞样细胞中检测到AR mRNA。双氢睾酮治疗不影响体外人破骨细胞样细胞的形成或吸收。

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Androgen Receptor Expression and Function in Osteoclasts

We assessed androgen receptor (AR) expression in osteoclasts in vitro and in situ. Rat multinucleated osteo- clasts expressed detectable AR protein in situ, and AR mRNA was detected in mouse and human derived osteoclast-like cells in vitro. Dihydrotestosterone treatment did not affect human osteoclast-like cell formation or resorption in vitro.

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The Open Physiology Journal

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