IJS Short Reports最新文献

{"title":"Perspectives on stercoral perforation","authors":"E. Weledji, T. Nana","doi":"10.4103/ijssr.ijssr_7_17","DOIUrl":"https://doi.org/10.4103/ijssr.ijssr_7_17","url":null,"abstract":"Stercoral perforation results from ischemic necrosis of the colonic wall by a fecaloma. The cause is multifactorial and the diagnosis is usually made only at laparotomy. There is high mortality from fecal peritonitis and Hartmann's procedure in the ill and toxic elderly patient carries the lowest mortality.","PeriodicalId":331041,"journal":{"name":"IJS Short Reports","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123769640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Weledji's clinicopathological classification of perianal paget's disease","authors":"E. Weledji","doi":"10.4103/IJSSR.IJSSR_8_17","DOIUrl":"https://doi.org/10.4103/IJSSR.IJSSR_8_17","url":null,"abstract":"P erianal Paget’s disease is a heterogeneous entity which may fall into four clinicopathological groups (Weledji’s classification). In the first group (Type 1), there is a high frequency of an associated distant malignancy with similar immunoprofile (lysozyme/ leu1–M1), requiring an aggressive search for the primary. This is akin to a paraneoplastic syndrome and has the worse prognosis. In the second group (Type 2), perianal Paget’s disease represents a cutaneous manifestation through the intraepithelial spread of an underlying anorectal or vulvar adenocarcinoma (i.e., secondary). The third group (Type 3) represents true primary intraepithelial cutaneous apocrine adenocarcinoma. The fourth group (Type 4) represents a primary perianal Paget’s disease with an associated malignancy but with discordant immunoprofile. Perianal Paget’s disease is exceedingly rare. First discovered by Paget in 1874 as a breast lesion, similar findings in the perianal area were reported 20 years later.[1,2] It is important to distinguish true Paget’s disease (a primary lesion of the apocrine glands) from the pagetoid spread of signet ring cells from a nearby carcinoma (a secondary lesion) by immunohistochemical studies. As perianal Paget’s disease is a heterogeneous entity, the author attempted to simplify the conundrum by proposing a clinicopathological classification system of perianal Paget’s disease (Weledji’s classification). The author classifies perianal Paget’s disease into four clinicopathological groups [Table 1].[3] In the first group (Type 1), there is a high frequency of associated malignancies with similar immunoprofile (lysozyme/leu1–M1) and resultant poor outcome highlighting the importance of an aggressive search for a second malignancy. This is akin to a paraneoplastic syndrome.[4] Regression of perianal Paget’s disease (Type 1) has been observed following removal of an associated sigmoid colon carcinoma.[5] In the second group (Type 2), perianal Paget’s disease merely represents a cutaneous manifestation through intraepithelial spread of an underlying anorectal or vulvar adenocarcinoma (i.e., secondary).[6‐9] This type may be made latent by neoadjuvant and adjuvant chemotherapy to slowly re‐emerge as the evidence of local rectal recurrence after anterior resection [Figure 1].[3] The third group (Type 3) represents the true primary intraepithelial cutaneous apocrine adenocarcinoma.[10‐12] The fourth group may represent primary Paget’s disease IJS Publishing Group Ltd www.ijsshortreports.com INTERNATIONAL JOURNAL OF SURGERY SHORT REPORTS","PeriodicalId":331041,"journal":{"name":"IJS Short Reports","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130004494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MicroRNAs in hepatocellular carcinoma – therapeutics and beyond: A systematic review","authors":"Gaurav Roy, Papai Roy","doi":"10.4103/ijssr.ijssr_6_17","DOIUrl":"https://doi.org/10.4103/ijssr.ijssr_6_17","url":null,"abstract":"Hepatocellular carcinoma (HCC) causes major cancer-related deaths worldwide. The current therapeutic strategies pitted against early HCC are woefully inadequate with surgical interventions, radiation therapy, and chemotherapy to suffice for. Therefore, the quest for novel, effective, and decisive screening tools is paramount. In context, microRNAs (miRNAs) have emerged as useful biomarkers in HCC. Accordingly, PubMed, Medline, Embase, and Cochrane databases were explored for relevant literature in English with combination of keywords “microRNA and hepatocellular carcinoma,” “microRNA and diagnosis and hepatocellular carcinoma,” “microRNA and prognosis and hepatocellular carcinoma,” “microRNA and survival and hepatocellular carcinoma,” and “microRNA and therapy and hepatocellular carcinoma” that were extracted till January 2017. Manuscripts relating to long noncoding RNAs and other concomitant small molecules involved in HCC were excluded from the review. Studies revealed a plethora of miRNAs and their altered expression profiles being significantly implicated in the diagnosis, prognosis, recurrence, and overall survival in HCC. Several miRNAs are currently being tested in different phases of clinical trials. Efforts should aim at a better validation and establishment of miRNAs as powerful diagnostic and prognostic investigating aid for HCC. However, despite extensive research, a consensus on the universal set of miRNAs to be used as diagnostic, prognostic, or recurrence markers for HCC is yet to be achieved. In addition, various targeted approaches should focus to reduce the possibility of deleterious off-target effects of miRNAs. On this background, this systematic review discusses latest developments on miRNAs as a marker of diagnosis, prognosis, recurrence, overall survival as well as a therapeutic target in HCC (REVIEW registry216).","PeriodicalId":331041,"journal":{"name":"IJS Short Reports","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115269735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Roux limb volvulus and perforation as a rare complication of Roux-en-Y hepaticojejunostomy","authors":"K. Parasar, S. Govind, S. Saluja, P. Mishra","doi":"10.4103/2468-7332.188049","DOIUrl":"https://doi.org/10.4103/2468-7332.188049","url":null,"abstract":"Roux-en-Y hepaticojejunostomy (RYHJ) is a versatile surgical procedure for various hepatobiliary disorders with success rate as high as 90 %. Complications such as cholangitis, biliary calculi, pancreatitis, liver failure, reflux induced peptic ulcer disease have been described in the literature. We describe a rare complication of RYHJ which we recently encountered which to our knowledge has not been reported previously.","PeriodicalId":331041,"journal":{"name":"IJS Short Reports","volume":"114 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121016074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The value of publishing negative studies: Introducing IJS Short Reports","authors":"R. Agha","doi":"10.4103/2468-7332.186170","DOIUrl":"https://doi.org/10.4103/2468-7332.186170","url":null,"abstract":"© 2016 International Journal of Surgery Short Reports | Published by Wolters Kluwer Medknow in the correct direction, aid collaboration, and prevent duplication and wasted resources. Other issues our community grapples with are underpowered studies, poor statistical methods, poor reproducibility and external validity, and poor methodology and reporting of studies. Publishing negative results bring the focus away from the results themselves to the research questions, the hypothesis and the robustness of the methodology used to investigate it. Such studies are all too often rejected by journals due to the direction of their results, rather than the quality of the methodology and the data and the contextual significance of the research questions they answer.","PeriodicalId":331041,"journal":{"name":"IJS Short Reports","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131618820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical prevention and management of radiation-induced xerostomia in head-and-neck cancer patients","authors":"R. Sukhia, H. Sukhia, D. Ghandhi","doi":"10.4103/ijssr.ijssr_5_18","DOIUrl":"https://doi.org/10.4103/ijssr.ijssr_5_18","url":null,"abstract":"Head-and-neck cancer is the sixth most commonly diagnosed cancer in the world and amounts to nearly 3% of all malignancies. Therapeutic irradiation is a common mode of treatment either alone or in conjunction with surgery for treatment of head-and-neck cancers which leads to irradiation-induced xerostomia which may in turn lead to disturbances in taste, speech, and prosthesis wear, etc. Xerostomia may also lead to infections in the oral cavity and rampant carious lesion in teeth. Salivary gland transfer is a surgical procedure done to prevent the gland from radiation exposure during radiotherapy of the head-and-neck region. Management of xerostomia is usually done with systemic or topical pilocarpine or cevimeline, artificial saliva compounds, herbal compounds, acupuncture and acupuncture-like transcutaneous nerve stimulation, low-level laser therapy, etc. with varying effectiveness.","PeriodicalId":331041,"journal":{"name":"IJS Short Reports","volume":"78 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129620131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extent of thyroidectomy for well-differentiated thyroid cancers","authors":"S. Akhtar, H. Iftikhar","doi":"10.4103/ijssr.ijssr_1_18","DOIUrl":"https://doi.org/10.4103/ijssr.ijssr_1_18","url":null,"abstract":"In patients with well-differentiated thyroid carcinoma (WDTC), the extent of thyroid surgery is controversial. There are proponents of both total thyroidectomy (TT) and thyroid lobectomy (TL). A review of literature was performed. We included studies investigating the extent of thyroid surgery, TT versus TL, for WDTC. Multiple studies have failed to show any significant difference in posttreatment recurrence between TT and lobectomy. In properly selected low-to-intermediate risk patients, the extent of initial thyroid surgery probably has little impact on disease-specific survival.","PeriodicalId":331041,"journal":{"name":"IJS Short Reports","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124454116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Liver transplantation for cholangiocarcinoma: Past, present, and the future","authors":"S. Begum, M. Khan, Stephen K. Y. Chang","doi":"10.4103/ijssr.ijssr_3_18","DOIUrl":"https://doi.org/10.4103/ijssr.ijssr_3_18","url":null,"abstract":"Management of hilar cholangiocarcinoma (CCA) remains a major challenge incorporating complex diagnostic and therapeutic modalities. The management has evolved over the decades in pursuit of optimal therapeutic outcome for this challenging pathology. The only curative therapeutic option for CCA is complete (R0) surgical resection with negative margins. Curative resection for hilar CCA (HCCA) remains a surgical challenge due to its high propensity for invasion into liver parenchyma, encasement of portal vessels, and metastasis to regional lymph nodes. Liver transplantation (LT) was proposed as an alternative therapeutic option, but the initial results were extremely disappointing due to high rate of recurrence. The management has evolved over decades with introduction of neoadjuvant treatment options followed by LT resulting in optimal outcomes for an otherwise lethal disease. The current review outlines the changing trends in the management of HCCA over the years.","PeriodicalId":331041,"journal":{"name":"IJS Short Reports","volume":"70 3-4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120892973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evidence-based advances in glioma management","authors":"M. A. Samad, K. Nathani, U. K. Choudry, M. Waqas, S. Khan, S. Enam","doi":"10.4103/ijssr.ijssr_2_18","DOIUrl":"https://doi.org/10.4103/ijssr.ijssr_2_18","url":null,"abstract":"Glioma is primary brain tumors of the glial origin. Glioblastoma multiforme traditionally classified as Grade IV glial tumor carries the worst prognosis. Over the past decades, focus of the diagnosis and management has gradually shifted toward molecular and genetic profiling. This has been accompanied by advancement in radiology, radiation, and medical oncology. Despite significant progress in the individual disciplines, the overall prognosis has not increased significantly. There is consensus on the need of maximum safe resection for most of these tumors. Details of anatomy and white matter tracts obtained through preoperative imaging. These detailed radiological modalities allow the surgeons to plan a safe trajectory to the lesion, avoiding neurological complications. Five aminolevulinic acid and fluorescein guidance help increasing the extent of resection. Awake craniotomy with brain mapping has regained popularity for the safe resection of low-grade glioma, especially those located in eloquent areas. In this review article, we have discussed various aspect of glioma management including diagnosis and surgical resection.","PeriodicalId":331041,"journal":{"name":"IJS Short Reports","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122991478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cone-beam computed tomography analysis of centering ability and transportation of curved root canals prepared with three rotary nickel-titanium systems (In Vitro-Study)","authors":"Hanan Y Fallatah, Samia M El Sherief","doi":"10.4103/ijssr.ijssr_21_17","DOIUrl":"https://doi.org/10.4103/ijssr.ijssr_21_17","url":null,"abstract":"Objective: The aim of this study is to compare the degree of transportation, centering ability, and dentin thickness after mechanical preparation using three different nickel-titanium rotary instrumentation systems, ProTaper Next (PTN), twisted file (TF), and K3 Endo in curved root canals analyzed using cone-beam computed tomography (CBCT). Materials and Methods: Thirty moderately curved roots of extracted human maxillary and mandibular molars were divided into three groups with 10 root canals each. Group I, the root canals were prepared with PTN rotary system; Group II, the root canals were prepared with TF rotary system; and Group III, were prepared with K3 rotary file system. Preinstrumentation and postinstrumentation three-dimensional CBCT images were obtained from root cross sections in three levels; coronal, middle, and apical third. Results: It was observed that there were no significant differences in the degree of canal transportation at apical level and the remaining dentin thickness between the rotary instruments (P > 0.05). There were no statistical significant differences in centering ability between buccolingual centering ratio after using the three systems at coronal and middle levels (P > 0.05) except for apical level is significantly difference (P = 0.047). In addition, there were no statically significant differences between centering ratio after using the three systems at cervical, middle, and apical levels (P > 0.05). Conclusions: Under the conditions of this study, CBCT analysis showed that the TF has the ability to produce centered preparation maintaining the original root canal anatomy in the apical one-third of the root canal while PTN showed some degree of canal deviation and K3 showed the highest canal deviation.","PeriodicalId":331041,"journal":{"name":"IJS Short Reports","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128614365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}