Journal of Vaccines and Immunology最新文献_第2页

Nano-chemistry and Bio-conjugation with perspectives on the design of Nano-Immune platforms, vaccines and new combinatorial treatments 纳米化学和生物偶联与纳米免疫平台，疫苗和新的组合治疗设计的观点

Journal of Vaccines and Immunology Pub Date : 2021-12-13 DOI: 10.17352/jvi.000047

Gomez Palacios Luna R, Martinez Sofia, Tettamanti Cecilia, Quinteros Daniela, Bracamonte A Guillermo

{"title":"Nano-chemistry and Bio-conjugation with perspectives on the design of Nano-Immune platforms, vaccines and new combinatorial treatments","authors":"Gomez Palacios Luna R, Martinez Sofia, Tettamanti Cecilia, Quinteros Daniela, Bracamonte A Guillermo","doi":"10.17352/jvi.000047","DOIUrl":"https://doi.org/10.17352/jvi.000047","url":null,"abstract":"This Mini-Review and Opinion letter, it was addressed different themes and topics implicated in the development of new treatments and vaccines applied to pathologies developed in humans such as by Virus and related pathogens. In this context, it was presented and discussed different strategies used, which were contemplated from the design of small molecules, towards higher sized chemical structures and new Nanoarchitectures. In particular, it was discussed varied studies developed for the Corona Virus treatment; which afforded to the main mechanisms of action of pharmacophores and targeted functional Nanoparticles. In this direction, it was highlighted the importance of Bioconjugation of molecules and variable Nanoarchitectures for their incorporation within cells as well as for the development of Nano-vaccines. Moreover, it was discussed about the development of combinatory treatments based on different strategies recently reported. Similarly, it was presented different studies and developments actually in progress related to the design of functional and Multifunctional Nano-platforms with potential perspectives on Lab-On particles and Nano-vaccines for precision Nanomedicine and new treatments.","PeriodicalId":330981,"journal":{"name":"Journal of Vaccines and Immunology","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126126259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Immunogenicity and safety of inactivated Influenza Split-Virion vaccine administered via a transdermal micro needle system 经透皮微针系统给药的流感分裂病毒灭活疫苗的免疫原性和安全性

Journal of Vaccines and Immunology Pub Date : 2021-11-26 DOI: 10.17352/jvi.000046

Ameri Mahmoud, Lewis Hayley, Nguyen Joe

{"title":"Immunogenicity and safety of inactivated Influenza Split-Virion vaccine administered via a transdermal micro needle system","authors":"Ameri Mahmoud, Lewis Hayley, Nguyen Joe","doi":"10.17352/jvi.000046","DOIUrl":"https://doi.org/10.17352/jvi.000046","url":null,"abstract":"The purpose of the study was to evaluate the immunogenicity and safety of an inactivated influenza split virion vaccine administered via a transdermal microneedle system. In this Phase 1, single-center, randomized, controlled study, 90 subjects aged 18 to 40 years received influenza vaccine (strains (A/H1N1, A/H3N2, and B) either via a transdermal microneedle system (“patch”; 10 µg) for 5 or 15 minutes or by Intramuscular (IM) injection (15g). Influenza antibody titers were measured by the hemagglutinin inhibition method and compared to EMEA guidelines for influenza vaccines (seroconversion rate, mean increase in hemagglutinin inhibition titer, and percentage of seroprotected subjects). Safety was assessed through local and systemic adverse events, and specific application site events in the transdermal groups. At Day 21, the EMEA criteria were met in all treatment groups for all three influenza strains. The immunogenicity response was similar between all three groups and increased antibody levels persisted to Month 6. The transdermal microneedle system was generally well tolerated, although pinpoint red spots, edema, and erythema were noted after patch removal in most subjects. Influenza vaccination administered via a novel transdermal microneedle system was generally well tolerated and provided similar antibody response using a lower dose than IM injection.","PeriodicalId":330981,"journal":{"name":"Journal of Vaccines and Immunology","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124851171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Japanese Encephalitis (JE): A curse for people living in Uttar Pradesh, India 日本脑炎(乙脑):印度北方邦人民的诅咒

Journal of Vaccines and Immunology Pub Date : 2021-10-04 DOI: 10.17352/jvi.000045

P. Prakash, V. Kusum, Singh Vijeta

{"title":"Japanese Encephalitis (JE): A curse for people living in Uttar Pradesh, India","authors":"P. Prakash, V. Kusum, Singh Vijeta","doi":"10.17352/jvi.000045","DOIUrl":"https://doi.org/10.17352/jvi.000045","url":null,"abstract":"Japanese Encephalitis (JE) follows due to viral infection that directly affects brain leading to coma and finally death. JE which finally leads to Acute Encephalitis Syndrome (AES) have been creating devastation in eastern Uttar Pradesh for decades. The Gorakhpur in Uttar Pradesh is the epicenter of encephalitis induced deaths and the disease mostly affect its rural areas. However, Maharajgang, Sant Kabir Nagar, Basti, Kushinagar, Siddharth Nagar, Deoria and Mau are the most affected districts in the state. Independent figures put the toll around 50,000 as many kids die without reaching hospital. Every year, in rainy season the condition is worst for children in Uttar Pradesh. The Japanese Encephalitis Virus (JEV) is generally spread by mosquitoes, specifically those of the genus Culex. Pigs and wild birds serve as reservoir for the JEV. Encephalitis can be air or water borne, the result of a mosquito bite or spread by ticks. The initial symptoms are fever, cold or headache. However, it becomes life threatening only when it crosses the blood and brain barrier. There is no full cure of the disease; however, it can only be treated by vaccination to some extent. Prevention includes control of the vector mosquitoes of JEV by fogging with ultra-low levels of insecticides and by raising the immunity in children by vaccination. There are three types of vaccines has been used in large scale. In India, the JE vaccination was launched during 2006. Recently Shri Yogi Adityanath (Chief Minister, Uttar Pradesh) government has launched a massive encephalitis vaccination program during 2017-18 which is a positive hopeful step towards saving the lives of several innocent people of our country.","PeriodicalId":330981,"journal":{"name":"Journal of Vaccines and Immunology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116152729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

COVID-19, nursing publication and the future of nursing research infection COVID-19，护理出版物与护理研究感染的未来

Journal of Vaccines and Immunology Pub Date : 2021-07-24 DOI: 10.17352/jvi.000044

Salam Banihani

引用次数: 0

COVID-19 IGG better than PCR for the green pass COVID-19 IGG的绿通率优于PCR

Journal of Vaccines and Immunology Pub Date : 2021-07-20 DOI: 10.17352/JVI.000043

Damsa Cristian, Damsa Tomas

引用次数: 1

Avian infl uenza 禽流感

Journal of Vaccines and Immunology Pub Date : 2019-11-07 DOI: 10.17352/jvi.000026

E. El-Kady, H. El-Shafei, S. Saleh

引用次数: 2

A review on natural way of vaccination: Plant derived edible vaccines 天然疫苗接种方法综述:植物源性食用疫苗

Journal of Vaccines and Immunology Pub Date : 2019-11-02 DOI: 10.17352/jvi.000025

A. Khan, Asad U. Khan, I. Khan, M. Shehzad, Waqar Ali, A. Muhammad, M. Akif

引用次数: 3

Mapping the evidence-base of adolescent and adult vaccination in Africa: A slow but growing trend 绘制非洲青少年和成人疫苗接种的证据基础:缓慢但不断增长的趋势

Journal of Vaccines and Immunology Pub Date : 2019-09-06 DOI: 10.17352/jvi.000024

E. Haddison, S. Machingaidze, C. Wiysonge, G. Hussey, B. Kagina

引用次数: 2

Ability of TLR agonists to upregulate Brucella abortus strain RB51 mediated protection in a murine respiratory model TLR激动剂在小鼠呼吸模型中上调流产布鲁氏菌RB51介导的保护能力

Journal of Vaccines and Immunology Pub Date : 2019-04-24 DOI: 10.17352/JVI.000023

Michelle Walker

{"title":"Ability of TLR agonists to upregulate Brucella abortus strain RB51 mediated protection in a murine respiratory model","authors":"Michelle Walker","doi":"10.17352/JVI.000023","DOIUrl":"https://doi.org/10.17352/JVI.000023","url":null,"abstract":"Brucella abortus is a Gram-negative intracellular zoonotic bacterium that causes infertility and abortion in cattle, and undulant fever in humans. Its low dose of infectivity, ability to be aerosolized, and ease of genetic modification, makes it a bioterror concern. The overall goal is to generate a safe and effective vaccine for humans. One candidate vaccine is Brucella abortus strain RB51, which was approved for use in cattle, and provides protection by initiating a strong T-helper 1 (CD4 Th1) response. Based on a model for aerosol exposure, mice were vaccinated intranasally (IN) with strain RB51 and challenged IN with B. abortus strain 2308. However, strain RB51 did not protect. Protection against Brucella is mediated through Toll Like Receptors (TLRs) 2, 4 and 9. The addition of TLR 2 or TLR 4, and a trend with TLR9 agonists, when combined with IN strain RB51 vaccination, significantly increased bacterial clearance in the lung after strain 2308 challenge. Therefore, for this study, we hypothesized that combining TLR agonists 2, 4, and 9 with strain RB51 IN would enhance protection and clearance in the lung against strain 2308 challenge (IN), by activating the DC1 and CD4 Th1 and CD8 immune response. This study showed that protection was not enhanced by combining all TLR agonists. The group with non-significantly greater clearance was strain RB51 and TLR 2 and 4 agonists. Additional studies are warranted to further define the differential mechanisms and endpoints of protection and chronic infection.","PeriodicalId":330981,"journal":{"name":"Journal of Vaccines and Immunology","volume":"115 3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132052546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0