Journal of Phytomolecules and Pharmacology最新文献

Evaluation of analgesic, anti-inflammatory and antipyretic properties of the Flacourtia indica extract in laboratory animal 黄花提取物的镇痛、抗炎和解热作用的实验动物评价

Journal of Phytomolecules and Pharmacology Pub Date : 1900-01-01 DOI: 10.56717/jpp.2022.v01i02.009

Md Al Foyjul Islam, Runa Masuma, R. Rahman, Md Shohel Hossain, M. Hasan, Arafath Jubayer

引用次数: 0

Antifungal, antiradical, anti-inflammatory and antineoplastic activities of essential oils of some medicinal plants of the Annonaceae family of Chad and Cameroon 乍得和喀麦隆番荔枝科药用植物精油的抗真菌、抗自由基、抗炎和抗肿瘤活性

Journal of Phytomolecules and Pharmacology Pub Date : 1900-01-01 DOI: 10.56717/jpp.2022.v01i02.010

I. Bakarnga-Via, N. Bessimbaye, Patrick Valere Tsouh Fokou, L. R. Y. Tchokouaha, J. H. Fokou, Kemzeu Raoul, M. Gary‐Bobo, A. Gallud, Marcel Garcia, P. M. J. Dongmo, F. Boyom, T. Abdelsalam, C. Menut

引用次数: 0

An in silico ADME/T and molecular docking studies of phytochemicals derived from Holigarna caustica (Dennst.) for the management of pain 从Holigarna caustica (denst .)中提取的植物化学物质用于疼痛管理的计算机ADME/T和分子对接研究

Journal of Phytomolecules and Pharmacology Pub Date : 1900-01-01 DOI: 10.56717/jpp.2022.v01i01.005

T. Enam, R. Agarwala, Md. Helal Uddin Chowdhury, Md. Nazim Uddin Chy, Md. Adnan

引用次数: 2

Impact of Achillea moschata Wulfen on germination and growth of weed species Echinochloa oryzoides (Ard.) Fritsch and Lolium multiflorum Lam 毛茛伍芬对禾草类紫锥藻萌发和生长的影响何首乌

Journal of Phytomolecules and Pharmacology Pub Date : 1900-01-01 DOI: 10.56717/jpp.2022.v01i02.007

S. Vitalini, S. Garzoli, Valentina Vaglia, M. Iriti

{"title":"Impact of Achillea moschata Wulfen on germination and growth of weed species Echinochloa oryzoides (Ard.) Fritsch and Lolium multiflorum Lam","authors":"S. Vitalini, S. Garzoli, Valentina Vaglia, M. Iriti","doi":"10.56717/jpp.2022.v01i02.007","DOIUrl":"https://doi.org/10.56717/jpp.2022.v01i02.007","url":null,"abstract":"Weeding is a practice of primary importance both in conventional agriculture where the intensive use of herbicides can represent a significant environmental risk and in organic farming where this practice is prohibited. Therefore, the need to identify alternative means of controlling weeds is evident. In this respect, allelopathy proves to be a useful tool to be integrated with conventional agronomic techniques for the management of infesting flora. In this work, we investigated the phytotoxic potential of Achillea moschata Wulfen (Asteraceae) against Echinochloa oryzoides (Ard.) Fritsch and Lolium multiflorum Lam., two noxious plants for crops such as rice and wheat. Preliminary anti-germination assays were carried out in controlled conditions by testing both the powder (0.25 g) and the aqueous extract (1%, 10% and 20%) from the A. moschata aerial parts. The obtained results showed that the powder was more effective than the extract in inhibiting seed germination (up to –81.6% vs –48.8% at 20% concentration) and seedling development (up to –99.4% vs –75.9% at 20% concentration) of both target species, although L. multiflorum was more susceptible than E. oryzoides to treatments. Furthermore, the chemical composition of the two used matrices was characterized by Solid-Phase Microextraction (SPME) sampling technique and Gas Chromatograph/Mass spectrometer (GC/MS) analyses. Camphor (25.8% and 49.9%) and 1,8 cineole (25.9% and 20.7%) were the main constituents in the samples, followed by bornyl acetate (6.7%) in the powder and fragranol (10.5%) in the aqueous extract.","PeriodicalId":330664,"journal":{"name":"Journal of Phytomolecules and Pharmacology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128473862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular interaction between xanthorrhizol with ghrelin-o-acyl transferase (goat) and growth hormone SECRETAGOG3UE receptor (GHS-R): a docking analysis 黄菌根醇与ghrelin-o-酰基转移酶(山羊)和生长激素SECRETAGOG3UE受体(GHS-R)的分子相互作用:对接分析

Journal of Phytomolecules and Pharmacology Pub Date : 1900-01-01 DOI: 10.56717/jpp.2023.v02i01.014

A. Limanto, A. Simamora, K. Timotius

{"title":"Molecular interaction between xanthorrhizol with ghrelin-o-acyl transferase (goat) and growth hormone SECRETAGOG3UE receptor (GHS-R): a docking analysis","authors":"A. Limanto, A. Simamora, K. Timotius","doi":"10.56717/jpp.2023.v02i01.014","DOIUrl":"https://doi.org/10.56717/jpp.2023.v02i01.014","url":null,"abstract":"After curcuminoids, xanthorrhizol is the second primary bioactive compound from Curcuma xanthorrhiza. Traditionally, the rhizome of Curcuma xanthorriza is well-known for its appetite stimulation. However, the mechanism of appetite stimulation is still unclear, particularly its interaction with the appetite-related ghrelin system. Therefore, understanding interactive molecular modulations of xanthorrhizol with ghrelin, GOAT (ghrelin-O-acyl transferase), and ghrelin receptor (GHS-R: growth hormone secretagogue receptor is essential. Xanthorrhizol, an appetite stimulant, may interact with ghrelin, GOAT, and GHS-R. Herein, this study aimed to do in silico analysis to hypothetically predict the molecular interaction of xanthorrhizol with ghrelin, ghrelin-O-acyl transferase (GOAT), and growth hormone secretagogue receptor (GHS-R). Docking analysis was conducted to understand the interactive molecular patterns of xanthorrhizol, ghrelin, GOAT, and GHS-R. The docking studies showed that the molecular interaction of xanthorrhizol is with Arg10 of ghrelin and not with Ser2, which is essential for the linkage of octanoic acid. The molecular interaction of xanthorrhizol with GOAT is in the active sites of either deacylated ghrelin or octanoic acid. Therefore, xanthorrhizol is a competitive inhibitor of GOAT. It inhibits GOAT activity. Xanthorrhizol interacts with GHS-R in its small cavity II. Itnis still unclear whether this interaction is agonist or antagonist. This in silico analysis showed that xanthorrhizol is probably not a stimulating appetite natural drug via stimulating GHS-R signaling.","PeriodicalId":330664,"journal":{"name":"Journal of Phytomolecules and Pharmacology","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126913390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In-silico structural insights of Dengue 4 NS3 protease: homology modeling and structural validation 登革4型NS3蛋白酶的硅结构分析:同源性建模和结构验证

Journal of Phytomolecules and Pharmacology Pub Date : 1900-01-01 DOI: 10.56717/jpp.2023.v02i01.013

Md. Helal Uddin Chowdhury, T. Das, Suranjan Sikdar

引用次数: 0

Phytomolecules-drug interactions: clinical and nutritional implications 植物分子-药物相互作用:临床和营养意义

Journal of Phytomolecules and Pharmacology Pub Date : 1900-01-01 DOI: 10.56717/jpp.2022.v01i02.008

I. Peluso

引用次数: 1

Journal of Phytomoleculs & Pharmacology: ‘Why a new journal? 《植物分子与药理学杂志》:为什么是一本新杂志?

Journal of Phytomolecules and Pharmacology Pub Date : 1900-01-01 DOI: 10.56717/jpp.2022.v01i01.001

M. Iriti

引用次数: 1

Botany and phytochemistry of Adenanthera pavonina L (Rakta Kambal) - A mini review 腺花菜(Adenanthera pavonina L (Rakta Kambal))的植物学和植物化学综述

Journal of Phytomolecules and Pharmacology Pub Date : 1900-01-01 DOI: 10.56717/jpp.2022.v01i01.002

M. Saleh‐e‐In, Pallab Kar, A. Ara, A. Roy, M. Iriti

引用次数: 0

In vitro anti-oxidant and anti-adhesin assays of n-hexane and methanolic extracts of Caryota no seeds 山核桃种子正己烷和甲醇提取物的体外抗氧化和抗黏附试验

Journal of Phytomolecules and Pharmacology Pub Date : 1900-01-01 DOI: 10.56717/jpp.2023.v02i01.015

Chinonye Anuli Maduagwuna , M. Dapar, B. Ubani

{"title":"In vitro anti-oxidant and anti-adhesin assays of n-hexane and methanolic extracts of Caryota no seeds","authors":"Chinonye Anuli Maduagwuna , M. Dapar, B. Ubani","doi":"10.56717/jpp.2023.v02i01.015","DOIUrl":"https://doi.org/10.56717/jpp.2023.v02i01.015","url":null,"abstract":"To determine the anti-oxidant and anti-adhesin activities of the n-hexane and methanolic extracts of Caryota no (CN) seeds. For anti-adhesin properties, the wells of a sterile flat-bottomed tissue culture plate were filled with 200µL of each extract in several concentrations, incubated and washed twice. 200µL of bacterial suspension was added, incubated and washed thrice with PBS. Adherent bacteria were fixed with methanol, plates emptied, left to dry and stained with crystal violet. Excess stain was rinsed under running water, air dried, bound dye resolubilized with glacial acetic acid, and the absorbance measured using a microplate reader to calculate the percentage inhibition. For antioxidant properties, three different concentrations of the DPPH solution were prepared. 2 mg of each extract was weighed out and dissolved in 10 mL of their corresponding solvent. 1 mL of DPPH solution was added to 2 ml solution of the extracts and ascorbic acid. The reaction mixture was vortexed and left in the dark for 30 minutes then absorbance was measured against blank solution to calculate the percentage scavenging radical inhibition. Statistical difference was presumed at P < 0.05. The extracts showed significant (P < 0.05) adhesin inhibition activities, n-hexane (64%) and methanolic (46%) at 200µg/mL concentrations. The fractions of the extracts also showed various remarkable results. The anti-adhesin activity increased with increasing extract concentration in both extracts. Antioxidant assays revealed that at 200 mg/mL, both extracts were significantly (P<0.05) lower than the control. Both the n-hexane and methanolic extracts showed remarkable adhesin inhibition activities at concentration of 200 µg/mL and antioxidant effects, with the methanolic extract demonstrating comparable levels as the standard, ascorbic acid. This implies that both extracts may serve as veritable natural sources of anti-adhesins, antioxidants and thus adjunct anti-infective agents or immune enhancers.","PeriodicalId":330664,"journal":{"name":"Journal of Phytomolecules and Pharmacology","volume":"37 12","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131992126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0