ExRNA最新文献

{"title":"Serum microRNAs as novel biomarkers for early prediction of disease severity in patients with acute pancreatitis","authors":"Yu-ping Zhang, Lei Ye, Na Yu, Cheng Wang, Lin Wu, Chun-ni Zhang, Chenyu Zhang, Fang-yu Wang","doi":"10.1186/s41544-020-00048-z","DOIUrl":"https://doi.org/10.1186/s41544-020-00048-z","url":null,"abstract":"","PeriodicalId":33060,"journal":{"name":"ExRNA","volume":"2 1","pages":"1-12"},"PeriodicalIF":0.0,"publicationDate":"2020-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46023822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MicroRNA’s in cancer as biomarkers and therapeutic keys","authors":"S. Sreedharam, Vinayaga Moorthi Puthamohan, Sona Valiya Parambil","doi":"10.1186/s41544-020-00051-4","DOIUrl":"https://doi.org/10.1186/s41544-020-00051-4","url":null,"abstract":"","PeriodicalId":33060,"journal":{"name":"ExRNA","volume":" ","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2020-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s41544-020-00051-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46043415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of ncRNAs in modulation of liver fibrosis by extracellular vesicles","authors":"Giulia Chiabotto, G. Camussi, S. Bruno","doi":"10.1186/s41544-020-00050-5","DOIUrl":"https://doi.org/10.1186/s41544-020-00050-5","url":null,"abstract":"","PeriodicalId":33060,"journal":{"name":"ExRNA","volume":" ","pages":"1-14"},"PeriodicalIF":0.0,"publicationDate":"2020-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s41544-020-00050-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47408066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential exosome miRNA expression in oral cancer stem cells","authors":"M. Shoff, T. Booker, B. Leavitt, D. Harmon, K. Kingsley, K. Howard","doi":"10.1186/s41544-019-0045-6","DOIUrl":"https://doi.org/10.1186/s41544-019-0045-6","url":null,"abstract":"","PeriodicalId":33060,"journal":{"name":"ExRNA","volume":" ","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2020-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s41544-019-0045-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47621945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implications of microRNA in kidney metabolic disorders","authors":"Yang Zhou, Junwei Yang","doi":"10.1186/s41544-019-0042-9","DOIUrl":"https://doi.org/10.1186/s41544-019-0042-9","url":null,"abstract":"","PeriodicalId":33060,"journal":{"name":"ExRNA","volume":"2 1","pages":"1-14"},"PeriodicalIF":0.0,"publicationDate":"2020-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s41544-019-0042-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42692617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction and experimental confirmation of banana bract mosaic virus encoding miRNAs and their targets","authors":"Ramamoorthy Sankaranarayanan, Sankara Naynar Palani, Abhishek Kumar, P. Selvakumar A. S., J. Tennyson","doi":"10.1186/s41544-019-0044-7","DOIUrl":"https://doi.org/10.1186/s41544-019-0044-7","url":null,"abstract":"","PeriodicalId":33060,"journal":{"name":"ExRNA","volume":"2 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2020-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s41544-019-0044-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47043018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MicroRNAs in bovine milk exosomes are bioavailable in humans but do not elicit a robust pro-inflammatory cytokine response","authors":"E. Mutai, A. Ramer-Tait, J. Zempleni","doi":"10.1186/s41544-019-0041-x","DOIUrl":"https://doi.org/10.1186/s41544-019-0041-x","url":null,"abstract":"","PeriodicalId":33060,"journal":{"name":"ExRNA","volume":"2 1","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2020-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s41544-019-0041-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42085102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary impact of a plant-derived microRNA on the gut microbiome.","authors":"Jennifer K Spinler,&nbsp;Numan Oezguen,&nbsp;Jessica K Runge,&nbsp;Ruth Ann Luna,&nbsp;Vivekanudeep Karri,&nbsp;Jian Yang,&nbsp;Kendal D Hirschi","doi":"10.1186/s41544-020-00053-2","DOIUrl":"https://doi.org/10.1186/s41544-020-00053-2","url":null,"abstract":"<p><strong>Background: </strong>Global estimations of 4 billion people living on plant-based diets signify tremendous diversity in plant consumption and their assorted miRNAs, which presents a challenging model to experimentally address how plant-based miRNAs impact the microbiome. Here we establish baseline gut microbiome composition for a mouse model deficient in the specific mammalian miR-146a shown to alter gut microbiomes. We then asses the effect on the gut microbiome when miR-146a-deficient mice are fed a transgenic plant-based diet expressing the murine-derived miR-146a. Mice deficient in miR-146a were maintained either on a baseline diet until 7 weeks of age (day 0) and then fed either vector or miR-146a-expressing plant-based diets for 21 days. The gut microbiomes of mice were examined by comparing the V4 region of 16S rRNA gene sequences of DNA isolated from fecal samples at days 0 (baseline diet) and 21 (vector or miR-146a expressing plant-based diets).</p><p><strong>Results: </strong>Beta-diversity analysis demonstrated that the transition from baseline chow to a plant-based diet resulted in significant longitudinal shifts in microbial community structure attributable to increased fiber intake. Bipartite network analysis suggests that miR-146a-deficient mice fed a plant diet rich in miR-146a have a microbiome population modestly different than mice fed an isogenic control plant diet deficient in miR-146a.</p><p><strong>Conclusion: </strong>A mouse diet composed of a transgenic plant expressing a mouse miR-146a may fine tune microbial communities but does not appear to have global effects on microbiome structure and composition.</p>","PeriodicalId":33060,"journal":{"name":"ExRNA","volume":"2 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s41544-020-00053-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25333649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RNA virus-encoded microRNAs: biogenesis, functions and perspectives on application.","authors":"Shoubin Zhan,&nbsp;Yanbo Wang,&nbsp;Xi Chen","doi":"10.1186/s41544-020-00056-z","DOIUrl":"https://doi.org/10.1186/s41544-020-00056-z","url":null,"abstract":"<p><p>MicroRNAs (miRNAs) are small, noncoding RNAs that regulate gene expression at the posttranscriptional level and play a crucial role in development and many diseases. The discovery of miRNAs has greatly expanded our understanding of the intricate scenario of genome-wide regulation. Over the last two decades, hundreds of virus-encoded miRNAs have been identified, most of which are from DNA viruses. Although the number of reported RNA virus-derived miRNAs is increasing, current knowledge of their roles in physiological and pathological processes has remained lacking. In this review, we discuss the biogenesis and biological functions of RNA virus- encoded miRNAs and their proposed roles in virus-host interactions and further underscore their potential value in the diagnosis and treatment of viral diseases.</p>","PeriodicalId":33060,"journal":{"name":"ExRNA","volume":"2 1","pages":"15"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s41544-020-00056-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38620222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"nSARS-Cov-2, pulmonary edema and thrombosis: possible molecular insights using miRNA-gene circuits in regulatory networks.","authors":"P Khurana,&nbsp;A Gupta,&nbsp;R Sugadev,&nbsp;Y K Sharma,&nbsp;R Varshney,&nbsp;L Ganju,&nbsp;B Kumar","doi":"10.1186/s41544-020-00057-y","DOIUrl":"https://doi.org/10.1186/s41544-020-00057-y","url":null,"abstract":"<p><strong>Background: </strong>Given the worldwide spread of the novel Severe Acute Respiratory Syndrome Coronavirus 2 (nSARS-CoV-2) infection pandemic situation, research to repurpose drugs, identify novel drug targets, vaccine candidates have created a new race to curb the disease. While the molecular signature of nSARS-CoV-2 is still under investigation, growing literature shows similarity among nSARS-CoV-2, pulmonary edema, and thromboembolic disorders due to common symptomatic features. A network medicine approach is used to to explore the molecular complexity of the disease and to uncover common molecular trajectories of edema and thrombosis with nSARS-CoV-2.</p><p><strong>Results and conclusion: </strong>A comprehensive nSARS-CoV-2 responsive miRNA: Transcription Factor (TF): gene co-regulatory network was built using host-responsive miRNAs and it's associated tripartite, Feed-Forward Loops (FFLs) regulatory circuits were identified. These regulatory circuits regulate signaling pathways like virus endocytosis, viral replication, inflammatory response, pulmonary vascularization, cell cycle control, virus spike protein stabilization, antigen presentation, etc. A unique miRNA-gene regulatory circuit containing a consortium of four hub FFL motifs is proposed to regulate the virus-endocytosis and antigen-presentation signaling pathways. These regulatory circuits also suggest potential correlations/similarity in the molecular mechanisms during nSARS-CoV-2 infection, pulmonary diseases and thromboembolic disorders and thus could pave way for repurposing of drugs. Some important miRNAs and genes have also been proposed as potential candidate markers. A detailed molecular snapshot of TGF signaling as the common pathway, that could play an important role in controlling common pathophysiologies among diseases, is also put forth.</p><p><strong>Supplementary information: </strong><b>Supplementary information</b> accompanies this paper at 10.1186/s41544-020-00057-y.</p>","PeriodicalId":33060,"journal":{"name":"ExRNA","volume":"2 1","pages":"16"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s41544-020-00057-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38620223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}