ExRNA最新文献 - Book学术

In silico analysis of maize and wheat miRNAs as potential regulators of human gene expression 玉米和小麦mirna作为人类基因表达潜在调控因子的计算机分析

ExRNA Pub Date : 2023-09-01 DOI: 10.21037/exrna-23-4

Aizhan Rakhmetullina, Anatoliy Ivashchenko, Anna Pyrkova, Kairat Uteulin, Piotr Zielenkiewicz

引用次数: 0

Extracellular miRNAs for predicting risk following acute myocardial infarction: a narrative review 预测急性心肌梗死风险的细胞外mirna:一项叙述性综述

ExRNA Pub Date : 2023-09-01 DOI: 10.21037/exrna-22-21

Morgane M. Brunton-O’Sullivan, Kirsty M. Danielson

引用次数: 0

The extracellular RNA and drug resistance in cancer: a narrative review 细胞外RNA与肿瘤耐药:综述

ExRNA Pub Date : 2023-01-01 DOI: 10.21037/exrna-22-19

Minghui Cao

引用次数: 2

The potential role of exosomal microRNAs as biomarkers source for solid and hematological cancers: a narrative review 外泌体microRNAs作为实体癌和血液病生物标志物来源的潜在作用:一篇叙述性综述

ExRNA Pub Date : 2023-01-01 DOI: 10.55092/exrna20230006

Anna Maria Zimbo, Nancy Nisticò, Domenico Maisano, Rossella Russo, Massimo Gentile, Enrica Antonia Martino, Ernesto Vigna, Antonella Bruzzese, Annamaria Aloisio, Giuseppe Fiume, Ileana Quinto, Selena Mimmi, Enrico Iaccino

{"title":"The potential role of exosomal microRNAs as biomarkers source for solid and hematological cancers: a narrative review","authors":"Anna Maria Zimbo, Nancy Nisticò, Domenico Maisano, Rossella Russo, Massimo Gentile, Enrica Antonia Martino, Ernesto Vigna, Antonella Bruzzese, Annamaria Aloisio, Giuseppe Fiume, Ileana Quinto, Selena Mimmi, Enrico Iaccino","doi":"10.55092/exrna20230006","DOIUrl":"https://doi.org/10.55092/exrna20230006","url":null,"abstract":"Background and Objective: Exosomes are extracellular vesicles that regulate communication between cells and participate in various physiological and pathological processes. These nanovesicles transport proteins, lipids, and nucleic acids, including microRNAs (miRNAs). miRNAs are small non-coding RNA molecules that regulate gene expression. Exosomal miRNAs (exo-miRNAs) modulate many pathways involved in tumor progression, growth, metastasis, and angiogenesis. Therefore, in this review we investigated the role of exosomal miRNAs in both solid and hematological tumors, with the purpose of highlighting their potential role as disease biomarkers. Methods: Published peer-reviewed papers used as references for this narrative review were selected from the PubMed database using “exosomes”, “microRNA” and “cancers” as keywords. The time frame adopted in the bibliographic research covers an 11-year period, from January 2012 to January 2023. Key Content and Findings: This review explores the role of exosomal miRNAs as disease biomarkers. An excursus on exosomes and miRNAs is initially made to then illustrate the mechanisms of miRNAs sorting in exosomes. Exo-miRNAs can communicate with cells and can modulate their actions. Their half-life is extended thanks to the protection provided by exosomes. The role of exosomal miRNAs in different types of solid and hematological tumors is summarized highlighting the potential of disease staging and progression. Conclusions: All manuscripts studied suggest that exosomal miRNAs can be used as diagnostic and prognostic biomarkers iwn cancer. The lack of appropriate and usable biomarkers for cancer diagnosis and prognosis makes exosomal miRNAs good candidates to provide non-invasive information to guide disease management in different types of cancer.","PeriodicalId":33060,"journal":{"name":"ExRNA","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135447216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extracellular tRNA-derived RNAs as emerging activators of endosomal Toll-like receptors: a narrative review 细胞外tRNA衍生的RNA作为内体Toll样受体的新兴激活剂：叙述性综述

ExRNA Pub Date : 2023-01-01 DOI: 10.21037/exrna-22-22

J. Gumas, Y. Kirino

引用次数: 0

Extracellular vesicles from cancer cells are key players of metastatic cell phenotype induction 来自癌细胞的细胞外囊泡是转移细胞表型诱导的关键参与者

ExRNA Pub Date : 2023-01-01 DOI: 10.55092/exrna20230005

Ana Luísa Teixeira, Francisca Dias

引用次数: 0

Exploration of neuroblastoma xenograft models for tumor extracellular RNA profiling in murine blood plasma 神经母细胞瘤异种移植模型用于小鼠血浆肿瘤细胞外RNA谱分析的探索

ExRNA Pub Date : 2023-01-01 DOI: 10.55092/exrna20230007

Jill Deleu, Hanne Van Droogenbroeck, Jasper Anckaert, Anneleen Decock, Jilke De Wilde, Kaat Durinck, Liselot M. Mus, Justine Nuytens, Muhammad Rishfi, Kathleen Schoofs, Frank Speleman, Maaike Van Trimpont, Kimberly Verniers, Nurten Yigit, Jo Vandesompele, Bram De Wilde, Tom Van Maerken

{"title":"Exploration of neuroblastoma xenograft models for tumor extracellular RNA profiling in murine blood plasma","authors":"Jill Deleu, Hanne Van Droogenbroeck, Jasper Anckaert, Anneleen Decock, Jilke De Wilde, Kaat Durinck, Liselot M. Mus, Justine Nuytens, Muhammad Rishfi, Kathleen Schoofs, Frank Speleman, Maaike Van Trimpont, Kimberly Verniers, Nurten Yigit, Jo Vandesompele, Bram De Wilde, Tom Van Maerken","doi":"10.55092/exrna20230007","DOIUrl":"https://doi.org/10.55092/exrna20230007","url":null,"abstract":"Background: Minimally invasive liquid biopsies are becoming increasingly important in the diagnosis and treatment follow-up of cancer patients, including children with neuroblastoma. Such biopsies contain various biomarker analytes, including extracellular RNA (exRNA) with the potential to reflect dynamic changes in the tumor. However, it is challenging to distinguish tumor-derived exRNA from normal RNA. To overcome this limitation, xenograft models serve as a practical tool. In a mouse engrafted with human tumor cells, human exRNA is by definition originating from the tumor, whereas murine exRNA is host-derived. To study treatment response by monitoring tumor-derived exRNA, xenograft models with a high release of tumor exRNA into the circulation are desirable. Methods: The aim of this study was to evaluate whether and to what extent the cell line, its engraftment site, or the tumor size influence the amount of tumoral exRNA detected in blood plasma. To that end, four different neuroblastoma cell lines were engrafted in nude mice, either subcutaneously in the flank or orthotopically in the adrenal gland. Tumor sizes were monitored by caliper measurements (subcutaneous grafts) or MRI scans (orthotopic grafts) and blood was collected via terminal cardiac puncture to evaluate the tumoral exRNA fraction. Results: We demonstrate that the tumoral exRNA levels are correlated with the size of the subcutaneous tumor grafts. These levels are also highly dependent on the engrafted cell line. Furthermore, orthotopic engraftment potentially results in superior levels of tumoral exRNA, likely because of higher vascularity of the tumor tissue. Conclusions: Factors as cell line, tumor size and injections site should carefully be considered when performing experiments to study circulating RNA biomarkers.","PeriodicalId":33060,"journal":{"name":"ExRNA","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135447208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

miRNAs provide mechanisms for integrated control of endocrine pancreas homeostasis and metabolic disease pathogenesis: a narrative review miRNAs提供综合控制内分泌、胰腺稳态和代谢性疾病发病机制的机制:叙述性综述

ExRNA Pub Date : 2022-11-01 DOI: 10.21037/exrna-22-17

Ruo-Qi Du, A. Vidal-Puig, S. Rodriguez-Cuenca

引用次数: 0

Extracellular RNAs from immune cells under obesity-a narrative review. 肥胖免疫细胞的细胞外rna综述

ExRNA Pub Date : 2022-08-30 DOI: 10.21037/exrna-22-15

Keaton Karlinsey, Alyssa Matz, Lili Qu, Beiyan Zhou

{"title":"Extracellular RNAs from immune cells under obesity-a narrative review.","authors":"Keaton Karlinsey, Alyssa Matz, Lili Qu, Beiyan Zhou","doi":"10.21037/exrna-22-15","DOIUrl":"10.21037/exrna-22-15","url":null,"abstract":"Background and objective: Obesity affects hundreds of millions of people worldwide and is characterized by chronic inflammation and insulin resistance, leading to Type II diabetes and atherosclerotic cardiovascular disease. Extracellular RNAs (exRNAs) are among the components which effect immune actions under obese conditions, and technological advances in recent years have rapidly increased our understanding of their roles and functions. Here we review essential background information on exRNAs and vesicles as well as the impact of immune-derived exRNAs in obesity-related disease. We also offer perspectives on clinical applications of exRNAs and future research directions.Methods: We searched PubMed for articles relevant to immune-derived exRNAs in obesity. Articles written in English and published prior to May 25, 2022 were included.Key content and findings: We report findings on the roles of immune-derived exRNAs which are important in obesity-related disease. We also highlight several exRNAs derived from other cell lineages which act on immune cells in metabolic disease.Conclusions: ExRNAs produced by immune cells have profound local and systemic effects under obese conditions and can impact metabolic disease phenotypes. Immune-derived exRNAs represent an important target for future research and therapy.","PeriodicalId":33060,"journal":{"name":"ExRNA","volume":"4 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ae/92/nihms-1832741.PMC9977143.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9136260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adipogenesis-related microRNAs in obesity 肥胖中与脂肪形成相关的microRNAs

ExRNA Pub Date : 2022-07-01 DOI: 10.21037/exrna-22-4

A. Engin, A. Engin

引用次数: 2