ExRNA Pub Date : 2022-01-01 DOI: 10.21037/exrna-22-12

Katarina T. Chang, Julia A Ju, M. Vitolo

引用次数: 1

Outer membrane vesicles are the powerful cell-to-cell communication vehicles that allow bacteria to monitor extracellular milieu 外膜囊泡是强大的细胞间通讯载体，允许细菌监测细胞外环境

ExRNA Pub Date : 2022-01-01 DOI: 10.21037/exrna-22-18

M. Sarshar, Daniela Scribano, P. Behzadi, A. Masotti, C. Ambrosi

引用次数: 3

Milk exosomal microRNAs: friend of foe?—a narrative review 乳外泌体microrna:敌是友?-叙述回顾

ExRNA Pub Date : 2022-01-01 DOI: 10.21037/exrna-22-5

B. Melnik, R. Weiskirchen, Gert Schmitz

引用次数: 3

DodecaRNAs (doRNAs) are abundant in cow’s milk and differentially enriched in milk ultracentrifugation fractions DodecaRNA（doRNA）在牛奶中含量丰富，在牛奶超速离心组分中差异富集

ExRNA Pub Date : 2022-01-01 DOI: 10.21037/exrna-22-6

A. Benmoussa, Z. Husseini, Jeffrey Ho, Sara Guellal, Marine Lambert, C. Gilbert, P. Provost

引用次数: 0

Liquid biopsies in lung cancer—a narrative review 肺癌的液体活检:综述

ExRNA Pub Date : 2022-01-01 DOI: 10.21037/exrna-22-16

P. Gahan, H. Schwarzenbach

引用次数: 0

Urine-based liquid biopsy: a new avenue for the management of renal cell cancer 尿基液体活检:肾细胞癌治疗的新途径

ExRNA Pub Date : 2022-01-01 DOI: 10.21037/exrna-22-14

Guorong Li, N. Mallouk, P. Cornillon

引用次数: 0

Metabolically stressed adipocytes: mediators of cardioprotection via extracellular vesicle-mediated transport of oxidatively damaged mitochondria. 代谢应激脂肪细胞:通过细胞外囊泡介导的氧化损伤线粒体运输的心脏保护介质。

ExRNA Pub Date : 2022-01-01 Epub Date: 2022-01-25 DOI: 10.21037/exrna-21-31

Sarah R Anthony, Michael Tranter

{"title":"Metabolically stressed adipocytes: mediators of cardioprotection via extracellular vesicle-mediated transport of oxidatively damaged mitochondria.","authors":"Sarah R Anthony, Michael Tranter","doi":"10.21037/exrna-21-31","DOIUrl":"https://doi.org/10.21037/exrna-21-31","url":null,"abstract":"Obesity is a known risk factor for cardiovascular disease (CVD), including heart failure and ischemia. However, although the incidence of CVD is higher in obese humans, numerous studies have found that obese individuals with CVD have a better prognosis than lean individuals, a phenomenon known as the “obesity paradox” (1). Adipose tissue has a well-defined role as an endocrine organ that differs by anatomical location [e.g., inguinal white adipose tissue (WAT), perigonadal WAT, interscapular brown adipose tissue (BAT), etc.] as well as adipocyte cell content (white vs. brown vs. beige), and recent work has focused on the adipose-cardiac signaling axis to decipher the endocrine mechanisms of adipocytes. We and others have recently reviewed adipose tissue-derived signals that are known to directly impact the myocardium (2–4). Some of these adipose-derived endocrine signals are mediated by small extracellular vesicles (sEVs) that can deliver diverse cargo, including RNA, protein, and lipids (4). However, the cardiac effect of adipose-derived sEVs is not always consistent. Multiple recent studies describe EV-mediated delivery of specific microRNA (miRNA) from adipose-derived stem cells that impact mouse models of cardiac ischemic injury (5–9). BAT-derived EVs blunt obesity-induced declines in cardiac function, but their delivered EVs were shown to accumulate mainly in the liver, spleen, and lungs, and the direct effects on the myocardium were not investigated (10). Conversely, EVs secreted from WAT in response to PPARγ activation induce hypertrophic signaling in neonatal cardiac myocytes via transport of miRNA (11). sEVs isolated from epicardial adipose tissue were associated with atrial fibrillation in humans, were sufficient to induce cardiac fibrosis when injected into rats, and implicated sEV-mediated delivery of pro-fibrotic miRNAs as a potential mechanism (12).","PeriodicalId":33060,"journal":{"name":"ExRNA","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/47/e4/nihms-1774408.PMC8865429.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39959237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Extracellular RNA biology in plants: controversial or just unexplored? 植物的细胞外RNA生物学:有争议还是未被探索?

ExRNA Pub Date : 2022-01-01 DOI: 10.21037/exrna-22-20

Meenu Singla-Rastogi, R. Innes

引用次数: 1

Backhanded complement: circulating exosomes in aged animals add insult to injury after stroke. 反讽的补充:老年动物体内循环的外泌体对中风后的损伤是一种侮辱。

ExRNA Pub Date : 2021-12-01 Epub Date: 2021-12-30 DOI: 10.21037/exrna-21-21

Haobo Li, Cedric Sheffield, J Sawalla Guseh, Anthony Rosenzweig

{"title":"Backhanded complement: circulating exosomes in aged animals add insult to injury after stroke.","authors":"Haobo Li, Cedric Sheffield, J Sawalla Guseh, Anthony Rosenzweig","doi":"10.21037/exrna-21-21","DOIUrl":"https://doi.org/10.21037/exrna-21-21","url":null,"abstract":"It has long been recognized that many diseases are due to the two deadly “C’s” of either the clotting or complement systems (1) and stroke is a prime example. Stroke remains one of the leading causes of disability and death worldwide (2) and is predominantly due to thromboembolic occlusion of a major artery feeding the brain. While the initial management of stroke has understandably focused on clotting as manifest in the 1996 FDA approval of tissue plasminogen activator (tPA), often known as a “clot-busting” agent, there has been increasing recognition that other factors including inflammation are important determinants of outcome. In the new issue of Circulation Research (3), we learn that the complement system activated through exosomal signaling may also play a critical role after ischemic stroke. Age-associated increases in circulating inflammatory mediators have been suggested as contributors to the development of stroke and other neurological disorders (4). This notion has been supported by data showing that exposing young mice to plasma from aged mice led to cognitive functional decline (5). In contrast, heterochronic parabiosis experiments, in which the circulations of mice of different ages are connected, demonstrate that neurogenesis in aged mice can be restored by exposure to youthful circulation (6). However, the mechanism by which age-associated inflammatory mediators influence stroke remains elusive.","PeriodicalId":33060,"journal":{"name":"ExRNA","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/24/f7/nihms-1769490.PMC9585525.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40581453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Novel extracellular RNA biomarkers for early stage hepatocellular cancer. 早期肝细胞癌的新型细胞外RNA生物标志物

ExRNA Pub Date : 2021-12-01 Epub Date: 2021-12-30 DOI: 10.21037/exrna-21-23

Piyush Gondaliya, Tushar Patel

引用次数: 0

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