Jurnal Manajemen dan Pelayanan Farmasi最新文献

{"title":"Adaptation and Validation of the Beliefs about Medicines Questionnaire (BMQ) in HIV Out-patients in Indonesia","authors":"E. Sianturi, E. Gunawan, D. Perwitasari","doi":"10.22146/JMPF.65032","DOIUrl":"https://doi.org/10.22146/JMPF.65032","url":null,"abstract":"This study aimed to translate and cross-cultural adapt the version of the Beliefs about Medicines Questionnaire (BMQ) into Indonesia language, and explored its psychometric properties, and establish preliminary norms. We followed the guideline for forward-backward translation and 201 HIV out-patients were recruited. They all completed BMQ-general and BMQ-specific scales that were previously culturally adapted and translated into the Indonesian language. All participants were patients visiting a referral hospital in Papua Province, Indonesia. One-third of participants were indigenous Papuans, and the majority were female. The overall Cronbach's alpha of BMQ was acceptable (0.80) however each domain of BMQ was lower than the original study. The Cronbach alpha value for each section of BMQ-Indonesian version was as follows: BMQ Specific-Necessity 0.56; BMQ Specific-Concerns 0.50; BMQ General-Overuse 0.65; and BMQ General-Harm 0.53. The reasons for the distinction between this study to original may be complex and HIV associates with the problem in neurological and cognitive symptoms at a later stage. Since the Cronbach alpha in this study was within the range of the original study the BMQ-Indonesian version is applicable to be used in Indonesia, especially among HIV patients but caution is still needed in this questionnaire.","PeriodicalId":33008,"journal":{"name":"Jurnal Manajemen dan Pelayanan Farmasi","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43474097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pengaruh Intervensi Apoteker terhadap Tingkat Bahaya Drug-Related Problems pada Pasien Geriatrik Rawat Inap","authors":"M. K. Setiawati, Nanang Munif Yasin, I. Pramantara","doi":"10.22146/JMPF.66776","DOIUrl":"https://doi.org/10.22146/JMPF.66776","url":null,"abstract":"Geriatric patients are at high risk of Drug-Related Problems (DRPs) associated with multimorbidity, physiologic changes, and pharmacologic alterations, that caused by the aging process. The pharmacist plays an important role in optimizing the effectiveness and safety of the patient’s drug therapies. This study aims to know the effect of pharmacist intervention in reducing the harmful levels of DRPs and to know the factors associated with the reduction of DRPs harm level in hospitalized geriatric patients. This research uses quasi-experimental study with a one-group pretest and posttest design. This research was conducted in Panti Rapih Hospital between March-April 2021, with patients’ inclusion criteria of ≥ 60 years old, with internal diseases cases, and identified DRPs in the therapy. The exclusion patient criteria are hospitalized in the intensive unit and Covid-19 ward. A pharmacist reviewed patient drug therapy, identified and solved DRPs. The harm level of DRPs was compared before and after pharmacist interventions. The harm level of DRPs was determined through professional adjustment according to The Harm Associated with Medication Error Classification tools, then analyzed using Wilcoxon test with a level of confidence 95%. Factors of age, the number of drugs received by the patient, comorbidities, and acceptance of the intervention were investigated for their effect on reducing the harm level of DRPs using a multivariate logistic regression test. A total of the research subject were 28 inpatients, with 47 DRPs identified. The most frequent DRPs were adverse drug reactions  (27,66%). Among all interventions, 77,36% of them were accepted with full implementation. The pharmacist intervention resulted in a significant reduction in the harm level of both potential and actual DRPs (p < 0,05). A factor of the number of drugs received by patients and acceptance of pharmacist intervention was associated with the reduction of the harm level of DRPs (p < 0,05). This study shows that multidisciplinary collaboration is needed in the care of geriatric patients.","PeriodicalId":33008,"journal":{"name":"Jurnal Manajemen dan Pelayanan Farmasi","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47191345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pengaruh Komorbid dan Jenis Terapi terhadap Outcome Kolesterol Total Pasien Dislipidemia","authors":"Fitri Apriliany, Z. Ikawati, I. Pramantara","doi":"10.22146/JMPF.64328","DOIUrl":"https://doi.org/10.22146/JMPF.64328","url":null,"abstract":"Dislipidemia is one of the main risk factors of cardiovascular diseases that contributed more than 25% of death in this world. Hypertension and DM are associated with comorbidity in chronic disease, include of dislipidemia. This study aimed to determine the effect of comorbid and type of therapy on clinical outcomes in the outpatient installation at Puskesmas Jetis, Yogyakarta. This research is descriptive observational analytic with a cross-sectional. Data derived from primary data and secondary data. The inclusion criteria were patients dyslipidemia, received antidyslipidemia at least 3 months before the study, completed medical record, willing to able respondents, and can communicate well. Those who were pregnant or breastfeeding were excluded from the study. Data analysis used the Wilcoxon test. Most of respondents were majority dominated by women (86,14%), hypertension is the most comorbid (42,46%), most of patients used simvastatin (76,24%), gemfibrozil (16,83%), and combination of simvastatin+gemfibrozil (6,93%). The analysis showed that there was a significant effect on patients with comorbid diabetes and used simvastatin value before and after therapy for 3 months (p<0,05). This result showed that there was an effect of diabetes comorbidities and simvastatin therapy on the total cholesterol of patients, So this study implies that in providing statin therapy need to consider comorbid because they will affect to total cholesterol which one comorbid management that good need to achieve optimal therapeutic and type of therapy must be correct to improve outcome.","PeriodicalId":33008,"journal":{"name":"Jurnal Manajemen dan Pelayanan Farmasi","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44792560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antidiabetic Regimen and Factors Associated with Glycemic Control in Patients with Type 2 Diabetes mellitus in Public Health Centers in Jakarta: A Cross-Sectional Study","authors":"N. Wulandari, Maifitrianti Maifitrianti, Fadilla Muthi’ah, Nava Nur Disya","doi":"10.22146/JMPF.64431","DOIUrl":"https://doi.org/10.22146/JMPF.64431","url":null,"abstract":"Background:The glycemic control of diabetes mellitus patients is affected by many factors, including its antidiabetic regimen. Objectives: This study aimed to describe the antidiabetic regimen used in patients with T2DM in the public health centres in Jakarta and to evaluate the association of the regimens and other factors with glycemic control. Methods:This was a cross-sectional study conducted in thirteen public health centres in Jakarta with HbA1C of ≤ 7% indicating good glycemic control and > 7% poor glycemic control. The univariate analysis tests were used to analyze factors that potentially associate with glycemic control. Association between antidiabetic regimen and glycemic control were done by Pearson chi-square test and Fisher exact test.Results:Combination of sulfonylureas and biguanides was the most frequent antidiabetic regimen prescribed to the patients. Univariate analysis showed that age, duration of T2DM, route of administration, number of antidiabetics, and number of other daily regular drugs significantly (P<0.05) related to glycemic control.Sulfonylurea and biguanides as monotherapy were significantly (P<0.05) associated with good glycemic control. Conclusion:Sulfonylurea and biguanide as monotherapy were found to be associated with good glycemic control. In contrast, the combination of and with the two did not show the same.","PeriodicalId":33008,"journal":{"name":"Jurnal Manajemen dan Pelayanan Farmasi","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43843469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hubungan Drug Related Problems (DRPs) dan Outcome Pengobatan Pada Pasien Tuberkulosis Dengan Diabetes Melitus","authors":"Fita Rahmawati, Tista Ayu Fortuna, Nanang Munif Yasin","doi":"10.22146/JMPF.62602","DOIUrl":"https://doi.org/10.22146/JMPF.62602","url":null,"abstract":"Tuberkulosis dan Diabetes adalah kondisi penyakit yang saling berkaitan sehingga diperlukan terapi agresif untuk mengatasinya. Adanya Drug Related Problems (DRPs) yang terjadi dapat mempengaruhi outcome pengobatan pasien Tuberkulosis-Diabetes Mellitus (TB-DM). Penelitian bertujuan untuk menganalisis hubungan terjadinya DRPs dan outcome pengobatan pasien TB-DM. Penelitian menggunakan rancangan kohort retrospektif. Pengambilan sampel dilakukan menggunakan consecutive sampling  melalui catatan rekam medik pasien TB-DM pada 9 Puskesmas di Kota Malang. Sejumlah 100 kasus pasien TB-DM yang menjalani pengobatan  tahun 2017 hingga 2020 yang memenuhi kriteria inklusi selanjutnya  dibagi menjadi dua kelompok, yaitu kelompok yang mengalami DRPs dan kelompok pasien yang tidak mengalami DRPs sejumlah masing-masing 48 pasien dan 52 pasien. Jenis DRPs mengikuti klasifikasi Cipolle 2004. Outcome pengobatan dinilai berdasarkan hasil tes BTA (Bakteri Tahan Asam) pada akhir masa pengobatan bulan kedua. Analisis data menggunakan statistik Chis-quare dilanjutkan analisis multivariat untuk menganalisis adanya variabel perancu yang diprediksikan dapat mempengaruhi outcome pengobatan pada penelitian ini. Hasil penelitian menunjukkan terdapat hubungan antara kejadian DRPs dan outcome pengobatan pasien (p-value <0,05). Pasien dengan DRPs 5,41 kali lebih beresiko mengalami kegagalan terapi dibandingkan dengan pasien yang tidak mengalami DRPs (RR 5,417; 95% CI, 1,994-14,713). Keterlibatan farmasi klinis sangat diperlukan untuk mencegah dan menyelesaikan masalah terkait obat serta monitoring pengobatan pada pasien TB-DM yang ada di Puskesmas sehingga luaran pengobatan menjadi optimal","PeriodicalId":33008,"journal":{"name":"Jurnal Manajemen dan Pelayanan Farmasi","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42068440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pengaruh Pemberian Leaflet Terhadap Pengetahuan Masyarakat tentang Obat Tradisional","authors":"Ratna Sari Dewi, Fina Aryani, Yelly Hidayani","doi":"10.22146/JMPF.60889","DOIUrl":"https://doi.org/10.22146/JMPF.60889","url":null,"abstract":"Obat tradisional yang mengandung Bahan Kimia Obat (BKO) saat ini masih banyak ditemukan sehingga masyarakat harus waspada dengan meningkatkan pengetahuan tentang obat tradisional seperti informasi minimal yang perlu diketahui ketika membeli sediaan obat tradisional dan cara membedakan sediaan obat tradisional yang legal ataupun ilegal. Penelitian ini bertujuan untuk mengetahui efek pemberian media edukasi leaflet terhadap pengetahuan masyarakat tentang obat tradisional di wilayah Simpang Tiga Kota Pekanbaru. Pengaruh media leaflet dinilai berdasarkan perubahan skor pengetahuan. Metode penelitian yang digunakan adalah quasi experiment dengan rancangan non randomized control group pretest and posttest design yang dilakukan terhadap 70 responden kelompok kontrol (tanpa pemberian leaflet) dan 70 responden kelompok perlakuan (dengan pemberian leaflet). Sampel penelitian adalah masyarakat Simpang Tiga yang dipilih menggunakan teknik convenience sampling sesuai kriteria inklusi dan eksklusi. Instrumen yang digunakan berupa kuesioner untuk mengukur pengetahuan yang telah diuji validitas (diperoleh 17 pertanyaan yang valid) dan reliabilitasnya (r=0,929). Analisis data menggunakan uji Wilcoxon dan Mann-Whitney. Hasil penelitian menunjukkan bahwa terdapat perbedaan yang signifikan pada perubahan skor pengetahuan responden kelompok kontrol dan kelompok perlakuan dengan p value = 0,000. Dapat disimpulkan bahwa pemberian media leaflet sangat berpengaruh terhadap pengetahuan masyarakat tentang obat tradisional di wilayah Simpang Tiga Kota Pekanbaru. Tenaga Kefarmasian harus aktif dalam memberikan edukasi kepada masyarakat tentang obat tradisional dan sebaiknya menggunakan media seperti leaflet.","PeriodicalId":33008,"journal":{"name":"Jurnal Manajemen dan Pelayanan Farmasi","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41680473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kontrol Glikemik dan Profil Serum Kreatinin Pada Pasien DM Tipe 2 Dengan Gagal Ginjal Kronik","authors":"Emy Oktaviani","doi":"10.22146/JMPF.60323","DOIUrl":"https://doi.org/10.22146/JMPF.60323","url":null,"abstract":"Diabetes mellitus adalah kelainan metabolik yang ditandai dengan hiperglikemia yang jumlahnya terus meningkat sehingga meningkatkan jumlah pengunaan obat antidiabetik dan berisiko menimbulkan efek samping obat terutama pada fungsi ginjal. Penelitian ini bertujuan untuk mengetahui pola penggunaan antidiabetik dan hubungannya dengan kontrol glikemik dan serum kreatinin, serta hubungan kontrol glikemik dengan serum kreatinin pada pasien DM tipe 2 dengan gagal ginjal kronik rawat jalan. Rancangan penelitian ini adalah cross sectional secara retrospektif menggunakan data rekam medik pasien. Kontrol glikemik dilihat dari gula darah puasa (GDP) dan gula darah 2 jam post prandial (GD2JPP). Hasil analisis statistik menunjukkan bahwa dari 83 data rekam medik yang memenuhi kriteria inklusi mengindikasikan bahwa tidak terdapat hubungan yang signifikan antara pola pengunaan antidiabetik oral dengan GDP (p-value=0,546), namun menunjukkan hubungan yang signifikan antara pola pengunaan antidiabetik oral dengan GD2JPP (p-value=0,008) dan serum kreatinin (p-value=0,000). Hasil penelitian juga menunjukan terdapat hubungan yang signifikan antara GD2JPP dengan serum kreatinin (p-value=0,009).Kata Kunci: Diabetes, Kontrol Glikemik, Serum Kreatinin","PeriodicalId":33008,"journal":{"name":"Jurnal Manajemen dan Pelayanan Farmasi","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44189229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pengaruh Medication Therapy Management terhadap Persepsi Sakit dan Outcome Klinik Pasien Diabetes Melitus di Puskesmas Kota Yogyakarta","authors":"Nanang Munif Yasin, T. Andayani, Yanverty Idda Listyana","doi":"10.22146/JMPF.63876","DOIUrl":"https://doi.org/10.22146/JMPF.63876","url":null,"abstract":"Diabetes Melitus (DM) merupakan penyakit kronis yang komplek membutuhkan perawatan medis berkelanjutan dengan strategi pengurangan risiko multifaktorial di luar kendali glikemik. Penyakit DM memerlukan managemen terapi yang tepat, salah satu upaya yang diberikan adalah Medication Therapy Management (MTM). Pasien yang mendapatkan MTM memiliki persepsi sakit terhadap penyakitnya menjadi lebih baik dan akan berpengaruh pada hasil terapi. Penelitian ini bertujuan untuk mengetahui pengaruh pelayanan farmasi berbasis MTM terhadap persepsi sakit dan outcome klinik pada pasien diabetes melitus di Puskesmas Kota Yogyakarta pada periode Maret-April 2020. Jenis penelitian yang digunakan adalah quasi experimental one group with pretest and posttest design. Analisa menggunakan uji paired sample t-test dengan signifikansi yang digunakan P<0,05. Responden berjumlah 20 orang, merupakan pasien diabetes melitus tipe 2 yang memenuhi kriteria inklusi dan mendapatkan pelayanan farmasi berbasis MTM oleh apoteker berupa asesmen, edukasi, dan konseling. Hasil penelitian diperoleh skor persepsi sakit pasien terhadap penyakitnya yang diukur menggunalan brief illness perception questionnaire (BPI-Q), sebelum mendapatkan pelayanan MTM 49,95±10,41 menjadi 50,45± 10,06 (P=0.780). Outcome klinik berupa kadar glukosa darah puasa semula 128,66±43,99 mg/dL menjadi 129,96±23,46 mg/dL (P=0,876) setelah mendapatkan pelayanan berbasis MTM. MTM pada penelitian ini bisa meningkatkan skor persepsi sakit pasien terhadap penyakitnya meskipun belum berbeda bermakna, sedangkan hasil pemeriksaan kadar glukosa darah puasa pasien belum memberikan perbaikan outcome klinik pasien. Diperlukan penelitian dengan periode waktu yang lebih lama dan jumlah responden yang lebih banyak.  ","PeriodicalId":33008,"journal":{"name":"Jurnal Manajemen dan Pelayanan Farmasi","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45440555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analisis Biaya dan Luaran Klinis Sindrom Koroner Akut Berbasis Clinical Pathway","authors":"S. Candradewi, D. A. Perwitasari, Nabilah Nabilah","doi":"10.22146/JMPF.51176","DOIUrl":"https://doi.org/10.22146/JMPF.51176","url":null,"abstract":"Health clinicians often show different variations in the choice of therapy they prescribe for patients depending on their expertise, knowledge, and even their art. This is likely to affect several things, including the cost that patients have to pay. Such a difference in costs is avoidable by applying scientific evidence-based medical service standards and having measurable outcomes known as Clinical Pathways. A clinical pathway serves as a tool to measure the quality of health services based on the standardization of the treatment process. This research was designed to determine the cost analysis of treatments received by patients with acute coronary syndrome (ACS) according to the clinical pathway. This non-experimental research employed a retrospective cohort study design. The data were gathered from the medical records of ACS patients who were treated at the ICCU of PKU Muhammadiyah Hospital in Yogyakarta, and the costs incurred were compared between treatments that matched and did not match the clinical pathways. The inclusion criteria were ACS patients treated during 2016 who were between ≥ 18 and <75 years old and had complete data. Meanwhile, the exclusion criteria were ACS patients who had incomplete data, tumor malignancy, and a creatinine level of > 3 mg/dL. Here, therapies given to patients are concluded to fit the clinical pathway if they are precisely the same (100%) as the Clinical Practice Guide used by this hospital. The clinical outcome was measured from the patient’s length of stay (LOS). During the data analysis, the costs of ACS patient treatments that were compliant and non-compliant with the clinical pathway were compared based on the level of severity using the Mann-Whitney test in the SPSS program. The results showed that of the 63 patients, 31 received treatments according to the clinical pathway, while the other 32 did not. The average LOS of the former and the latter were, respectively, 4.45 and 5.53 (p= 0.043), with the total costs of treatments up to IDR5,474,001,73 and IDR6,728,153.13 (p= 0,154). Conformity to a clinical pathway significantly influences the length of stay but does not affect the cost of care for acute coronary syndrome patients.","PeriodicalId":33008,"journal":{"name":"Jurnal Manajemen dan Pelayanan Farmasi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41481903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adverse Drug Events on the Use of Sertraline in Clinical Studies: A Review","authors":"Syahrul Hidayat, I. Puspitasari","doi":"10.22146/JMPF.56558","DOIUrl":"https://doi.org/10.22146/JMPF.56558","url":null,"abstract":"Major depressive disorder (MDD) and anxiety are known as a widespread public health problem treated with sertraline, a class of Selective Serotonin Reuptake Inhibitor (SSRI) drugs as first-line therapy. However, clinical evidence showed that MDD and anxiety therapy with sertraline has not been optimal due to patient non-compliance associated with adverse drug events (ADE) occurring. A literature search on sertraline clinical study was conducted on the PubMed and Science Direct electronic database in April 2020. A total of 12 articles from 5.664 articles have been selected at the initial screening. A total of 6 articles used sertraline as a testing drug in MDD patients, 2 articles used sertraline as testing drug in anxiety patients, 2 articles with sertraline as a comparative drug, 1 article with sertraline as a positive control, and 1 article with sertraline as an adjuvant in MDD patients. Studies on these articles were carried out worldwide from 2010 to 2019. ADEs that occur due to the use of sertraline were: gastrointestinal disorders, nutritional and metabolic disorders, central nervous system disorders, sweating, sleep disorders, irritability, eye disorders, as well as disorders of the skin and subcutaneous tissues. Nausea is the most common ADE of sertraline. ADEs are affected by several factors such as, age, the sertraline combination therapy, and alcohol consumption.","PeriodicalId":33008,"journal":{"name":"Jurnal Manajemen dan Pelayanan Farmasi","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48855070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}