Farmatsevtichnii zhurnal最新文献

{"title":"Marketing research of the range of medicinal products based on salts of natural origin","authors":"О. О. Салій, О. П. Баула, К. Ю. Мелеш, Г. І. Кузьміна","doi":"10.32352/0367-3057.5.22.03","DOIUrl":"https://doi.org/10.32352/0367-3057.5.22.03","url":null,"abstract":"As a source of supply of a balanced complex of salts in pharmaceutical practice, sea water (MW), sea salt (MS), obtained by the method of ordinary evaporation, or salt solutions made from standardized raw materials are used. Deep seawater (SW), typically pumped from depths greater than 200 m, contains a wealth of trace elements, including magnesium, calcium, potassium, chromium, selenium, zinc, and vanadium. Due to this, SW has the potential of a source and raw material for the creation of medicinal products for human health. \u0000The purpose of the work was to research the assortment of preparations based on salts of natural origin and analyze the segment of such products on the pharmaceutical market of Ukraine as of June 2022. \u0000The research was conducted on the basis of data from the State Register of Medicinal Products of Ukraine, the Morion information search program, and the classification system of the ATS electronic resource Compendium.online. Methods of structural, statistical and graphic analysis were applied in the work, and their generalization and systematization was carried out. \u0000It was established that on the pharmaceutical market of Ukraine, the segment of medicines, medical products and cosmetics, the source of active substances of which is SW and/or SS, is represented by 150 trade names. It was determined that by type of registration, the most common are medical products (51%) and cosmetics (42%), only 7% of registered drugs are registered. Manufacturers use sea water obtained from the deep water basins of the Adriatic, Aegean, Mediterranean Seas, Atlantic Ocean, Kankal Bay, sea water of Gullmarsfjorden. Domestically produced drugs of the investigated market segment occupy a share of 57%. Among the importing countries, the leaders are Croatia (9%) and Poland (5%). The analysis of the nomenclature established that the most common medicinal form of the drugs are nasal sprays (78%). \u0000The obtained data show that as the active substance of saline solutions, manufacturers declare SS (56% of the nomenclature) and SW (53%), however, not all products contain information about the source of origin of SS/SW. It was determined that there are no products on the pharmaceutical market of Ukraine based on the SW and SS of the Black and Azov seas, which is the basis for research and the creation of new drugs of domestic production.","PeriodicalId":32942,"journal":{"name":"Farmatsevtichnii zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46987928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modern ways of doxicycline delivery and prospects of application in pharmacy","authors":"О. О. Салій, Є. В. Саченко, Т. А. Пальчевська, В. В. Страшний","doi":"10.32352/0367-3057.4.22.06","DOIUrl":"https://doi.org/10.32352/0367-3057.4.22.06","url":null,"abstract":"Currently, the global increase in resistance of pathogens to widely used antibiotics requires a return to the practice of using some classic drugs with preserved activity, finding new ways and directions of delivery of antibiotics to the locations of pathogenic microorganisms and the use of antimicrobial drugs that are not yet resistant. Doxycycline refers to antimicrobial drugs that do not yet have widespread resistance. Numerous studies of doxycycline have now been described as enhancing therapeutic effects, including COVID-19-related diseases, and finding new delivery routes to limit systemic side effects associated with high doses and avoid antibiotic resistance. \u0000The aim of the work was to analyze modern ways of doxycycline delivery, to determine the prospects for use in pharmacy, to summarize and systematize data on its functional purpose in the development of drugs with specified pharmaco-technological parameters. \u0000It is established that in the Ukrainian pharmaceutical market the range of drugs based on doxycycline hyclate is represented only by solid oral dosage forms - tablets and capsules for immediate release, but in the global pharmaceutical market there are additional dosage forms that provide parenteral delivery of doxycycline and oral forms. suspensions, syrups, dispersed tablets and delayed-release dosage forms – tablets, capsules and granules, which are the basis for the development of domestic drugs based on doxycycline. \u0000Development of new dosage forms with modified DH, such as implants, aerosols, lyophilisate for solution for injection, development of new manufacturing technologies, selection of excipients and delivery systems can improve the pharmacological action of antibiotics by reducing the dose and frequency of administration, prolonged or controlled programming. , and expanding the range of therapeutic action. \u0000Doxycycline is promising in pharmaceutical practice for the treatment of COVID-19, both due to its ability to inhibit matrix metalloproteinases (MMPs) and antiviral activity, especially against Mycoplasma pneumoniae, which is a secondary bacterial cause of pneumonia during the COVID-19 pandemic.","PeriodicalId":32942,"journal":{"name":"Farmatsevtichnii zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47407750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elements of good pharmaceutical practice in the implementation of pharmaceutical care for patients with diabetes during the martial law","authors":"І. О. Власенко, О. О. Комаріда, Л. Л. Давтян","doi":"10.32352/0367-3057.4.22.03","DOIUrl":"https://doi.org/10.32352/0367-3057.4.22.03","url":null,"abstract":"During the martial law, the role of pharmacists increases, but they must be educated for such activities. It will ensure pharmaceutical care according to Good Pharmacy Practice. Currently, there are no developed standards for the provision of pharmaceutical care to patients with diabetes mellitus (DM) during the martial law. \u0000The purpose of the work is to analyze the legislative changes that took place in the pharmaceutical provision for diabetes patients during the martial law. Recommendations for pharmacists to provide pharmaceutical care to diabetes patients in humanitarian disasters have been developed. \u0000The regulatory framework of Ukraine for the provision of diabetes patients and international recommendations for the provision of pharmaceutical assistance to diabetes patients during humanitarian disasters. Content analysis, bibliosemantic, analytical, generalizing analyzes were used. \u0000To prevent the consequences of humanitarian disasters for people with diabetes, there must be universal access to insulin, other essential drugs and diagnostics for monitoring of blood glucose level and blood pressure in the conditions of humanitatian crises. The peculiarities of the pharmaceutical supply of patients with diabetes during the martial law have been established. Patients with diabetes in Ukraine can receive insulin and other tableted sugar-reducing drugs in pharmacies, which are reimbursed by medical guarantee program (free of charge or with copayment by the patient), or patients can receive insulin free of charge in regional centers (hospitals) wich were received as humanitarian aid from other countries. \u0000The importance to use international gidiline recommendations when receiving drugs as humanitarian aid was underlined. The information about insulin, which are reimbursed now according to the ATC classification, taking into account the duration of action of insulin, has been analyzed and summarized. This information is important for practical use by pharmacists who dispenses insulin according to the newly introduced order (by classification of duration of action of insulin). \u0000During the martial law, the role of pharmaceutical workers increases. Recommendations for pharmacists have been developed on the basis of international recommendations and the results of scientific research. These recommendations are appropriate for pharmaceutical care to diabetes patients according to Good Pharmacy Practice during the martial law.","PeriodicalId":32942,"journal":{"name":"Farmatsevtichnii zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44355995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the domestic list of otc medicines and development of approaches to its improvement","authors":"Л. О. Гала, А. О. Чубай","doi":"10.32352/0367-3057.4.22.02","DOIUrl":"https://doi.org/10.32352/0367-3057.4.22.02","url":null,"abstract":"In recent decades, every citizen tries for an active position regarding his own health. Such factors as improving the general level of medical literacy and quality of life of the population, developing of pharmaceutical market contribute to the spread of self-medication. The formation of the concept of responsible self-medication, which includes the free use by consumers of effective and safe over-the-counter (OTC) medicines has been the solution to the specified needs of society. \u0000The purpose of the study was to develop modern organizational approaches to the formation of the List of OTC medicines in Ukraine to ensure the proper level of pharmaceutical care. \u0000The objects of the study were the Lists of OTC medicines approved by orders of the Ministry of Health of Ukraine during 2010–2019; the register of medicines allowed to be dispensed without a prescription (according to the State Register of Medicines of Ukraine, as of February 2022); protocols of the pharmacist. The methods of marketing analysis, analytical-comparative, systematic, graphic and method of generalization were used. \u0000Based on the analysis of the Lists of OTC medicines valid in Ukraine in the relevant years (2010–2022), it was established that the number of OTC medicines and the specific weight of it in the registered drugs on the pharmaceutical market decrease annually (from 26.0% to 21.2%). \u0000According to the results of the comparative marketing analysis of the current List of OTC medicines (order of the Ministry of Health of Ukraine dated April 18, 2019 N 876) and the register of OTC medicines (according to the State Register of Drugs of Ukraine, as of February 2022), only insignificant differences were found in the distribution of assortment items by composition, ATC classification, countries of origin, dosage forms. \u0000Deficiencies of the current List of OTC medicines were identified, such as the presence of medicines with expired registration in 2019–2022; duplication of positions; the presence of trade names of the prescription group. \u0000According to the results of the research, organizational approaches that will contribute to the proper formation of the next edition of the domestic List of OTC medicines and its rational use by pharmacists and consumers to realize the possibilities of responsible self-medication are proposed. The results of the research can be used in the formation of a legal framework in Ukraine, which regulates the circulation of OTC medicines on the pharmaceutical market.","PeriodicalId":32942,"journal":{"name":"Farmatsevtichnii zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48058281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of public administration of the health care system and pharmacy in Ukraine","authors":"М. М. Бабенко","doi":"10.32352/0367-3057.4.22.01","DOIUrl":"https://doi.org/10.32352/0367-3057.4.22.01","url":null,"abstract":"The study of public administration in the field of health care system of Ukraine is a very promising direction due to the problems of public administration in the field. \u0000Healthcare scientists, in particular pharmacy, have presented quite a few works where public administration of the medical industry is considered as a subject of research. There are no comprehensive studies on this topic that would take into account the current trends in its development. \u0000The purpose of the study is to highlight the essence of public administration, analyze its stages and the history of its emergence and further development in the field of health care of Ukraine. The object of the study is information from relevant legal acts regulating the basic principles of public health care management. The information sources were data from online resources about the formation of state policy in the field of protection in Ukraine, informational materials about the essence, theoretical, scientific and social basis of the emergence of public administration. Documentary, informative, empirical research methods (generalization, comparison), document study were used for the research. \u0000The theoretical, methodological and scientific and practical principles of public administration in health care of Ukraine are considered. Normative legal acts have been developed that regulate the basic principles of public administration in health care, determine the goals of public administration bodies and establish their legal status. \u0000It was determined that the need to improve the policy in the field of health care system, in accordance with modern needs, which is carried out by public administration bodies, is extremely relevant and important for Ukraine. \u0000To improve public administration in accordance with updated public expectations, modern training programs for health care workers in the post-graduate education system are needed, as well as the training of specialists at the second (master's) level of higher pharmaceutical education, in particular, the educational and professional program «Health Technology Assessment».","PeriodicalId":32942,"journal":{"name":"Farmatsevtichnii zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42020341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis of dichloroacetamides and study of their anti-tumor activity","authors":"ТА Синтез, Аналіз Біологічно, Активних Сполук, L. Havryshchuk","doi":"10.32352/0367-3057.4.22.05","DOIUrl":"https://doi.org/10.32352/0367-3057.4.22.05","url":null,"abstract":"Dichloroacetic acid and its derivatives exhibit the properties of metabolic cytoprotectors and apoptosis inducers. Nowadays evaluation of these derivatives is being conducted regarding the induction of immunogenic cell death. Therefore, the search for new derivatives of dichloroacetic acid as potential antitumor agents has a certain perspective and may be successful for the molecular design of «drug-like» structures. \u0000The aim of the work was the development of synthetic approaches to the obtaining of dichloroacetic acid amides and the primary screening of the antitumor activity of the synthesized compounds. \u0000Synthetic studies were conducted using reagents from the companies «Merck» (Darmstadt, Germany) and «Sigma-Aldrich» (Missouri, USA). 1H NMR spectra were measured on a Varian VXR-400 instrument, and LC-MS spectra on an Agilent 1100 Series LCMS instrument. The anticancer activity of the synthesized compounds was studied according to the international scientific program of the US National Cancer Institute – DTP (Developmental Therapeutic Program). \u0000Amides were synthesized based on acylation reactions of the corresponding substituted ethylamines and aminobenzoic acids with methyldichloroacetate and dichloroacetyl chloride. The use of two methods of acylation of amines allows obtaining the target compounds with sufficient purity and satisfactory yields (44–98%). The structure and purity of the synthesized compounds were confirmed by the methods of elemental analysis, LCMS spectrometry and 1H NMR spectroscopy. \u0000It was shown that dichloroacetyl chloride and methyl dichloroacetate are effective acylating agents, which was confirmed by the synthesis of a series of amides based on substituted ethylamines and aromatic amino acids. Moderate antitumor activity of dichloroacetamides was established on some melanoma, leukemia, and renal cancer cell lines. The highest activity was observed for 4-(2,2-dichloroacetylamino)-2-hydroxybenzoic acid, against which the mitotic activity of the LOX IMV melanoma line was 45.83%. Preliminary data on the antitumor activity indicate certain prospects for the search for anticancer agents in the group of dichloroarylacetamides in comparison with alkyl amides.","PeriodicalId":32942,"journal":{"name":"Farmatsevtichnii zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44286859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study of some pharmacotechnological, physico-chemical and pharmacognostic properties of common fennel (Foeniculum vulgare) fruit","authors":"О. М. Филипюк, Л. І. Вишневська","doi":"10.32352/0367-3057.4.22.09","DOIUrl":"https://doi.org/10.32352/0367-3057.4.22.09","url":null,"abstract":"The search for new drugs from medicinal plant raw materials is relevant for the practical medicine and pharmacy of our country. For their development, it is advisable to use plant sources that are widely spread in the territory of Ukraine, have a sufficient raw material base and low toxicity. \u0000Information about the powerful multifaceted pharmacotherapeutic effect of Foeniculum vulgare, its sufficient raw material base, in Ukraine, and prompted us to study the fruits of this medicinal plant (determination of technological characteristics that would optimize the production process of obtaining medicines based on it). \u0000The aim of the work is to study the technological indicators of medicinal plant raw materials – Foeniculum vulgare fruits, whole and crushed, for creating drug based on them, which would improve digestion processes, motor-evacuation function, and the functional state of the gastrointestinal tract. \u0000During the research, bibliosemantic, pharmaco-therapeutic, physico-chemical, pharmacognostic and statistical research methods were used. \u0000The objects of the research were model samples of Foeniculum vulgare fruits, extractive substances of whole and crushed fruits, degree of grinding, fractional composition, moisture content, coefficients of absorption and swelling in purified water and ethanol 95%, bulk volume and bulk density before and after medicinal plant raw materials shrinkage, total ash, fluidity, angle of natural slope. Considering several technological factors, the optimal ratio of raw materials:extractant (1:4) was studied and calculated to ensure the process of extracting common fennel fruits. \u0000The technological properties of the medicinal plant raw material – common fennel fruit were experimentally investigated. The established pharmaco-technological indicators are qualitative parameters of the technology and allow to control and evaluate the technological parameters of medicinal plant raw materials of Foeniculum vulgare fruit, necessary for the process of manufacturing substances (extracts, infusions) and, based on them, medicinal preparations in various dosage forms.","PeriodicalId":32942,"journal":{"name":"Farmatsevtichnii zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43215790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacoeconomic justification of the choice of specific therapy schemes for the treatment of adult patients with pulmonary arterial hypertension","authors":"Нами було, здійснено фармакоекономічне, дослідження щодо, фармакотерапії паці, єнтів із, Лаг, що, перебувають у, певному функціональному, ФК класі, Визначено ФК як, клінічно значущий, результат ефективності, лікування пацієнтів, із Лаг","doi":"10.32352/0367-3057.4.22.04","DOIUrl":"https://doi.org/10.32352/0367-3057.4.22.04","url":null,"abstract":"Pulmonary arterial hypertension (PAH) is a progressive and debilitating disease that causes the blood vessels in the lungs to thicken and narrow, forcing the heart to pump blood through the lungs at high pressure. \u0000In recent years, a significant number of therapies have become available for the treatment of PAH. Pharmacoeconomic justification of the choice of specific pharmacotherapy requires weighing the effectiveness and cost of treatment of this disease and is extremely relevant. \u0000Given the limited budget for health care, the choice of drugs (drugs) should be based not only on the comparative clinical effectiveness of treatment, but also on the comparative cost-effectiveness, which ensures the maximum effectiveness of providing pharmaceutical care to patients with PAH. \u0000PAH is a life-threatening orphan disease with a poor prognosis, and in many cases a combination of specific drugs may be required regardless of their cost. Like patient survival, quality of life is the main factor in the pharmacoeconomic justification of the choice of specific drugs for the treatment of PAH. \u0000The objective of the paper – pharmacoeconomic research of specific therapy for the treatment of PAH and determination of «cost–utility», «quality of life», «QALY» indicators in various approaches to pharmacotherapy of PAH. \u0000The object of the study was the results of the analysis of pharmacotherapy schemes of patients with PAH in accordance with a certain functional class. Analytical, documentary, informational, graphic and mathematical research methods were used during the research. \u0000Our pharmacoeconomic analysis of the pharmacotherapy of patients with PAH who were in a certain functional class (FC) showed that for patients with FC II and FC III PAH, endothelin receptor antagonists (APE) or the combination of APE with prostaglandins was the least expensive treatment strategy and gave the largest average QALYs. \u0000At the same time, the obtained research results are the basis for the development of differential financing of PAH therapy for patients with different FCs. \u0000It should be noted that the study conducted by us is the first in Ukraine and can be the basis for further studies, strengthened by additional information and direct measurement of the impact of specific treatment on the quality of life of patients with the help of specially developed Ukrainian questionnaires, which can be used to estimate the increase in the QALY indicator during treatment, which will give a better idea about the effectiveness of these treatment methods.","PeriodicalId":32942,"journal":{"name":"Farmatsevtichnii zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48294091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antiseptics: analysis of assortment, technologies of compounding and using","authors":"О. Ю. Тозюк, О. В. Кривов’яз, Ю. О. Томашевська, А. С. Воронкіна, Г. І. Крамар, В. В. Кудря, М. Т. Лесько","doi":"10.32352/0367-3057.4.22.07","DOIUrl":"https://doi.org/10.32352/0367-3057.4.22.07","url":null,"abstract":"Proper hand hygiene disrupts the spread of a numerous infections and is therefore a guarantee of good human health. Wide use of antiseptics by the public raises questions about their effectiveness, safety and availability. At the same time, the culture of hand hygiene is a priority for all spheres of society. \u0000The aim of the work is to study the range of antiseptics on the pharmaceutical market of Ukraine and assess the peculiarities of their use, to compound the antiseptic for hands of optimal composition and provide its quality control. \u0000The study used information retrieval, pharmacological, organoleptic, physical and chemical, graphic and statistical methods. \u0000Based on the analysis of information sources, the active ingredients and their optimal concentrations in the composition of antiseptics of industrial and extemporaneous production have been established. According to the results of this stage of work, four prescriptions of antisepticswith different compositions were selected for further compounding.It was found that positive results of quality control according to the organoleptic and physical and chemical parameters were received for the solution compounded using 96%ethanol and paying attention to key technological features that are decisive in the compounding of non-aqueous solutions and affect the quality of the product. \u0000The problematic issues of registration and circulation of antiseptics in Ukraine were identified as a result of the development of normative documents. Its consequence is the spread of unscrupulous practices of selling products that do not have a proven disinfection effect. The active components of industrial and extemporaneous antiseptic agents were determined based on the analysis of literary sources. It was established that most of the products recommended for home production did not meet the requirements of regulatory documents in terms of composition and concentration of active substances. This is a sign of the spread of unreliable information among the population, which can harm health. The need to comply with the rules for dosing ingredients and the technological features of manufacturing of non-aqueous solutions is substantiated. It was established that the required concentration of ethanol in the finished product is achieved when preparing solutions according to prescription N 3, which included 96% ethanol according to the results of the physical and chemical control. The presence of disinfection corners at National Pirogov Memorial Medical University, Vinnytsya certainly popularizes hand hygiene among students of higher education. This is indicated by the high frequency of students' use of the products that were placed in the appropriate places. At the same time, it was established the need to conduct educational work among students, which will contribute to increasing the level of awareness of the regulatory framework of registered disinfectants, their proper composition, labeling and method of use.","PeriodicalId":32942,"journal":{"name":"Farmatsevtichnii zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42493010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analytical studies of scientific publications of the Pharmaceutical journal for 1959–2022 regarding the development of the composition and technology of medicinal products for the treatment of the wound process","authors":"Т. М. Остащенко, А. В. Луцька","doi":"10.32352/0367-3057.4.22.08","DOIUrl":"https://doi.org/10.32352/0367-3057.4.22.08","url":null,"abstract":"An actual direction of scientific research is the problem of diagnosis and treatment of infected wounds. An important place in the general structure of diseases of general surgical profile is occupied by patients with purulent-inflammatory diseases of soft tissues, the frequency of which sometimes reaches indicators of 35–40%. \u0000With the development of medical science, ideas about wounds and methods of influencing the purulent-inflammatory process are constantly changing. Based on clinical criteria, three consecutive stages (phases) of the development of the wound process with different pathogenesis can be distinguished: purulent-necrotic (inflammatory) - characterized by the presence of necrotic tissues and purulent content in the wound; stage of granulation (regenerative) – manifested by cleaning the wound from purulent-necrotic sequestration and the formation of granulation tissue in it, which gradually fills the wound cavity; stage of epithelization (healing) – epithelization of the wound surface and formation of a scar. \u0000The purpose of the work was the analysis of scientific publications of the Pharmaceutical Journal on the development of the composition and technology of drugs for the treatment of the wound process for 1959–2022. \u0000The research materials were scientific publications of the scientific and practical edition of the Pharmaceutical Journal for the past 63 years (1959–2022), which used the methods of systematic and structural-logical analysis. \u0000The analysis of the scientific publications of the Pharmaceutical Journal over the past 63 years showed that soft drugs for local use do not lose their relevance for a long time. The appearance of new auxiliary substances, scientific knowledge of the wound process creates the basis for the development of new soft drugs and forms for the treatment of the wound process. The following factors are becoming relevant in drug technology: the basis for soft drugs, the correspondence of the phase of the wound process to soft drugs. The medical and biological requirements for the development of soft drugs are also evolving. \u0000The analysis of literature data showed that the use of multicomponent ointments on hydrophilic and emulsion bases, which have dehydrating and wound-healing effects, is technologically justified for the local treatment of the wound process. \u0000Soft drugs have a leading role in the local treatment of purulent wounds, as they ensure the achievement of the optimal concentration of active pharmaceutical ingredients in the affected area, ensuring high therapeutic efficiency and prolonged effect. Natural components that are part of wound-healing ointments have a significant breadth of pharmacological action, low toxicity and rarely cause side reactions, unlike synthetic agents.","PeriodicalId":32942,"journal":{"name":"Farmatsevtichnii zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43650535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}