Journal of Medical and Scientific Research最新文献

{"title":"Notes on quantitative susceptibility mapping reconstruction accuracy under challenging conditions: Phantom measurements and simulations","authors":"Lundberg A, L. E., K. L., Wirestam R","doi":"10.17727/jmsr.2022/10-21","DOIUrl":"https://doi.org/10.17727/jmsr.2022/10-21","url":null,"abstract":"Magnetic susceptibility can be assessed by quantitative susceptibility mapping (QSM), based on measured magnetic resonance imaging (MRI) phase data. The QSM reconstruction process is, however, mathematically challenging and still not fully robust. A signal-generating holmium [Ho(III)] aqueous solution with air-equivalent magnetic susceptibility was prepared, and used as a surrounding medium in a water phantom with tubes filled with a solution of gadolinium contrast agent at various concentrations. Extended analyses under controlled conditions were accomplished by simulations of the phantom construction. Without surrounding holmium solution, a gadolinium tube positioned centrally, parallel with B0, showed a susceptibility difference that agreed well with theoretical values, whereas a peripheral parallel tube position showed larger deviation. Orientation perpendicular to B0 resulted in less variation between the internal tube positions. Air-equivalent magnetic susceptibility corresponded to 16.5 mM Ho(III) solution. With surrounding holmium solution, several post-processing steps became challenging. Simulations indicated higher degree of underestimation when the theoretical susceptibility difference increased. Details in the mathematical implementation, for example, background field removal can strongly influence the result. Simulated results were, in part, unexpected, and provided awareness of limitations in the reconstruction technique, mainly related to conditions with large susceptibility differences between compartments.","PeriodicalId":32890,"journal":{"name":"Journal of Medical and Scientific Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67450546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospective study to compare the dose distribution and acute toxicity of three-dimentional conformal radiation therapy with intensity-modulated radiation therapy for post-mastectomy radiotherapy in carcinoma breast","authors":"Chakrabarty S, S. S, Maji A, Biswas L, Mandal S","doi":"10.17727/jmsr.2022/10-25","DOIUrl":"https://doi.org/10.17727/jmsr.2022/10-25","url":null,"abstract":"Though adjuvant radiotherapy has an established role in the treatment of carcinoma breast, there is concern regarding irradiation to heart and lung, more on left sided disease. Intensity Modulated Radiation Therapy (IMRT) modulates the intensity of the radiation beams with better accuracy, sparing surrounding normal organs. But it increases integral dose to normal healthy tissues compared to 3-Dimensional Conformal Radiation Therapy (3DCRT). So, our study was aimed at comparing the dosimetry and acute toxicity profile of 3DCRT and IMRT in post-mastectomy patients. In study arm patients received radiotherapy with IMRT and in control arm with 3DCRT, radiation dose being 50 Gy in 25 fractions for 5 weeks for both the arms. We compared the dosimetric data for Planning Target Volume (PTV) and Organ At-risk (OAR) by both techniques along with acute toxicity profile. Dosimetric parameter of PTV coverage V95 and V107 were significantly better in IMRT than 3DCRT (p-value <0.0001). IMRT showed better homogeneity index (0.14 Gy vs 0.26 Gy) and conformity index was also better for IMRT (0.94 Gy vs 0.74 Gy, p-value 0.0028). The mean value of heart V25 in left sided disease was significantly lower in IMRT than 3DCRT (22.59 and 25.64, p value 0.01). V20 of ipsilateral lung was numerically less in IMRT though not significant (31.44 vs 35.3). But low dose volume was significantly more in IMRT, as seen by higher V5 of heart and ipsilateral lung. To conclude, IMRT has better PTV coverage and better sparing of organs at risk with more homogenous and conformal plans than 3DCRT.","PeriodicalId":32890,"journal":{"name":"Journal of Medical and Scientific Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41947413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Etiological spectrum of cardioembolic strokes in a tertiary care hospital of India: Analysis of one year data","authors":"K. M, S. S., Patil A, M. J., Yadav Pk, Jayalakshmi S, Varalakshmi Ea, Kaul S, S. M.","doi":"10.17727/jmsr.2022/10-22","DOIUrl":"https://doi.org/10.17727/jmsr.2022/10-22","url":null,"abstract":"Background: Traditionally rheumatic heart disease with mitral stenosis and atrial fibrillation has been the common mechanism of cardioembolic strokes in India. However, with the increase in life span and higher detection and development of cardiac diseases, the frequency and etiologic spectrum of cardioembolic stroke in an Indian hospital may be changing. Methods: The case records of patients admitted in the year 2020 were analyzed for the presence of risk factors and identified stroke mechanisms. Results: Among 538 patients of ischemic strokes, cardioembolic source was identified in 156 (29.8%) patients. Five major cardiac sources of embolism were identified: Coronary artery disease (with acute or remote myocardial infarction) 56/156 (35.89%), non valvular atrial fibrillation, 34/156(21.79%), post cardiac intervention 28/156 (17.94%), left atrial cardiomyopathy 20/156 (12.8%), and rheumatic heart disease 13/156 (8.3%). Conclusion: Coronary artery disease, non valvular atrial fibrillation, post intervention stroke and left atrial cardiomyopathy are emerging as common causes of cardioembolic strokes. Rheumatic heart disease continues to be an important but less frequent cause of cardioembolic strokes.","PeriodicalId":32890,"journal":{"name":"Journal of Medical and Scientific Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44544305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical outcomes after alcohol assisted photorefractive keratectomy versus excimer laser assisted epithelial removal photorefractive keratectomy","authors":"Srinivasa Kh, Maganty V, Kumar Kk, Babu Gs","doi":"10.17727/jmsr.2022/10-27","DOIUrl":"https://doi.org/10.17727/jmsr.2022/10-27","url":null,"abstract":"Background: Surface ablation methods as a method of refractive surgery is making a comeback considering its safety, efficacy and the ease of doing the surgery. Various techniques of epithelial debridement in photorefractive keratectomy were described, like mechanical debridement, using 20% alcohol, using excimer laser or using a rotating brush. This study compares two methods of epithelial removal, namely alcohol assisted and excimer laser assisted in patients undergoing photorefractive keratectomy. Material and methods: A prospective, randomized, interventional study in a tertiary care centre. A total of 50 patients were enrolled, after subjecting them to various test including a detailed history, ocular examination and pentacam. The patients selected were then divided into 2 groups using a randomization software, and the surgery was performed on the de novo eyes. Analysis was done using descriptive statistics namely mean, standard deviation, percentage. Student t test and chi square test was used for the analysis of the data, wherever applicable. Results: The baseline best corrected visual acuity was 0.03 ± 0.0 in the alcohol assisted photorefractive keratectomy group and 0.03 ± 0.08 in the excimer laser assisted epithelial removal photorefractive keratectomy group. At the end of 6 months, all the patients had a visual acuity of 0.00 on logmar scale. Corneal haze noticed on post-operative day one was 0.98 ± 0.09 in the alcohol assisted photorefractive keratectomy group and 0.94 ± 0.1 in the excimer laser assisted group. No corneal haze was found at the end of one week. Pain scale analysis showed that it was 3.08 ± 0.80 in the alcohol assisted photorefractive keratectomy group and 2.9 ± 0.1 in the excimer laser assisted epithelial removal photorefractive keratectomy group which was not statistically significant. There was no pain at the end of one week. Conclusion: Various modes of epithelium removal have evolved over time. The two methods of epithelial removal here have similar outcomes in visual outcome, corneal haze and pain, with a good safety margin.","PeriodicalId":32890,"journal":{"name":"Journal of Medical and Scientific Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41856324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pyogenic granuloma of eyelid: A literature review and case report","authors":"Dasari G, Rao Vvln, Satyanarayana Kvv, V. B","doi":"10.17727/jmsr.2022/10-31","DOIUrl":"https://doi.org/10.17727/jmsr.2022/10-31","url":null,"abstract":"Pyogenic granuloma is an acquired vascular proliferative lesion with associated inflammation, affecting the skin and mucous membranes more frequently. Ocular pyogenic granulomas are rare, involving adnexa, conjunctiva, and cornea. Eyelid pyogenic granuloma is uncommon, associated with chalazion, lid surgeries, lacrimal sac procedures, trauma, predisposing cutaneous lesions, congenital capillary malformations, and idiopathic. We report a case of a 40-year-old male patient who attended our outpatient department with right eye upper lid painless growth, gradually increasing in size in the last two months. The differential diagnosis was burst chalazion, capillary haemangioma, molluscum contagiosum, pilomatricoma, basal cell carcinoma, squamous cell carcinoma, and Kaposi's sarcoma. The lesion was surgically excised, and histopathological examination confirmed the diagnosis. There was no recurrence. This present case illustrates the importance of considering benign inflammatory causes in the differential diagnosis of eyelid mass lesions to avoid unnecessarily aggressive intervention.","PeriodicalId":32890,"journal":{"name":"Journal of Medical and Scientific Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42260315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cisplatin-induced ototoxicity in patients receiving concurrent chemoradiation in carcinoma cervix","authors":"Hanan M, Kutty Ckk, S. P, J. Mb","doi":"10.17727/jmsr.2022/10-26","DOIUrl":"https://doi.org/10.17727/jmsr.2022/10-26","url":null,"abstract":"Background: Weekly cisplatin at 40mg/m2 is the most common regimen followed in our institution. However, patients receiving cisplatin can experience high-frequency hearing loss due to its expansive toxicity profile, a side effect known as ototoxicity. The dearth of information on the extent and severity of cisplatin-associated ototoxicity prevents implementing a context-specific audiological monitoring program. The study aimed to determine the extent and severity of cisplatin ototoxicity in patients receiving concurrent chemoradiation in carcinoma cervix. Methods: Otoscopic examinations and audiological investigations were undertaken at regular intervals in patients undergoing concurrent chemoradiation for carcinoma cervix with single-agent cisplatin in the Department of Radiation Oncology, with the aid of the Department of ENT. All the audiological investigations were provided free of cost. Sixty-six patients who met the inclusion criteria were sent for audiological evaluation before the start of chemotherapy, immediately after chemotherapy completion and after one month following chemotherapy. Results: The study found that cisplatin was associated with high frequency, predominantly bilateral sensorineural hearing loss. Among 66 patients, seven patients (11%) developed cisplatin-induced hearing loss. However, most of the patients developed mild and minimal hearing loss. Conclusion: The study concluded that patients receiving concurrent chemoradiation for carcinoma cervix with cisplatin developed predominantly bilateral, high-frequency sensorineural hearing loss. However, most patients developed minimal or mild hearing loss.","PeriodicalId":32890,"journal":{"name":"Journal of Medical and Scientific Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47545215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A prospective randomised trial comparing the analgesic efficacy of postoperative infusion of epidural bupivacaine and ropivacaine in orthopaedic surgeries","authors":"Jisha M, Kannan D, Koti S, Polavarapu R, Arunpandiyan V","doi":"10.17727/jmsr.2022/10-28","DOIUrl":"https://doi.org/10.17727/jmsr.2022/10-28","url":null,"abstract":"Background: Epidural administration of local anaesthetic provides effective pain relief. Commonly used epidural local anaesthetics are bupivacaine and ropivacaine. Most studies compared these drugs along with an opioid or any other adjuvants like clonidine, dexmedetomidine etc. Our aim was to compare the analgesic efficacy and safety of continuous infusion of epidural ropivacaine and bupivacaine without any adjuvants in postoperative patients. Materials and methods: A prospective randomized clinical study was conducted in a tertiary care hospital in 60 patients between the age groups of 20-years and 60-years undergoing elective lower limb orthopaedic procedures. Total patients were divided into two groups (A and B) of 30 each. Continuous epidural infusion was started with 6ml per hour of 0.125% bupivacaine in Group A and 6ml per hour of 0.2% ropivacaine in Group B postoperatively. After the commencement of epidural infusions, heart rate, blood pressure, Visual Analogue Score (VAS) and supplementary analgesic requirement were monitored postoperatively for 48 hrs. Results: Our observations showed no significant difference in haemodynamic parameters like heart rate and blood pressure. VAS showed a statistically significant difference with higher mean VAS score in Group B patients at one hour (p value = 0.0126), 12 hrs (p value = 0.031) and 24 hrs (p value = 0.0421) as compared to Group A. Add on analgesic requirement was also higher for Group B patients. Conclusions: Both bupivacaine and ropivacaine can be used effectively for postoperative analgesia but bupivacaine has a superior analgesic efficacy than ropivacaine with similar safety profile.","PeriodicalId":32890,"journal":{"name":"Journal of Medical and Scientific Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49464325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of rapid shallow breathing index versus ultrasonographic guided diaphragmatic thickness fraction as weaning indices on mechanically ventilated patients","authors":"Manjunath Hg, Nisha Ba, Greeshma Nm, H. Kv","doi":"10.17727/jmsr.2022/10-23","DOIUrl":"https://doi.org/10.17727/jmsr.2022/10-23","url":null,"abstract":"Background: The discontinuation or weaning from mechanical ventilation is an important clinical issue which is associated with lot of complications and patient discomfort. So we need a reliable and feasible method for early, safe and effective liberation of patients from mechanical ventilation. The objectives of our study are to determine sensitivity and specificity of rapid sequence breathing index (RSBI) and ultrasonography (USG) guided diaphragmatic thickness fraction (DFT) as weaning indices and to compare their effectiveness. Methods: The study was carried out on mechanical ventilated patients, when they were considered ready for weaning and the underlying disease is stable or resolving. The measurements of RSBI and DFT using USG were carried out. Weaning was taken as successful if the patients could maintain spontaneous breathing at least 48hrs after extubating, otherwise weaning was classified as failed. Results: RSBI and DTF group showed no statistically significant difference in extubation of mechanically ventilated patients in the intensive care unit (ICU). RSBI showed sensitivity of 96%, specificity of 74.4%, positive predictive value of 88.2%, negative predictive value of 80.5%, and accuracy of 87.2%, and DTF showed sensitivity of 96%, specificity of 69.7%, positive predictive value of 82.4%, negative predictive value of 78.9% and accuracy of 81.9%. Conclusion: In our study since there was only one reintubation in each of the groups, that is failure of weaning of one case each in RSBI and DTF groups, both RSBI and DTF has the same sensitivity of 96%, RSBI has better specificity of 74.4% than DTF of 69.7%, RSBI having a better accuracy of 87.2% than DRF which has an accuracy of 81.9%. We conclude that both the methods are equally effective when used as weaning indices for extubation of mechanically ventilated patients.","PeriodicalId":32890,"journal":{"name":"Journal of Medical and Scientific Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44942420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of retinopathy in newly diagnosed type 2 diabetes mellitus patients and its association with microalbuminuria and HbA1c: A cross sectional study from Rajasthan","authors":"P. T, K. A, Arya Rk","doi":"10.17727/jmsr.2022/10-30","DOIUrl":"https://doi.org/10.17727/jmsr.2022/10-30","url":null,"abstract":"Background: Diabetes mellitus is a major public health problem with multiple medical complications. Microvascular complications of diabetes including diabetic retinopathy, depend on the duration and severity of hyperglycemia. There is a paucity of data about the relationship among diabetic retinopathy, microalbuminuria and HbA1c in newly diagnosed type 2 diabetes mellitus (T2DM) patients. The study was conducted on the prevalence of diabetic retinopathy and its association with microalbuminuria and HbA1c among newly diagnosed T2DM patients. Material and method: It was a hospital-based, cross-sectional study conducted at a tertiary care hospital in Rajasthan. After obtaining written informed consent, data were collected from 150 newly diagnosed T2DM patients. Data were analysed using SPSS 20.0. Categorical variables were presented as proportion and continuous variables were presented as mean (SD). Chi square test and one way ANOVA tests were used for bivariate analysis. Results: The mean (SD) age of patients was 50.43 (12.73) years. About 52.7% (n=79) patients were male. About 30% (n=45) of newly diagnosed T2DM patients had microalbuminuria. Thirty patients (20%) had diabetic retinopathy (DR). About 8% (n=12) participants had mild DR, 10.7% (n=16) had moderate to severe DR and 1.3 (n=2) % had proliferative DR. Microalbuminuria was found significantly associated with HbA1c (P<0.01). Diabetic retinopathy and its severity were also found significantly associated with HbA1c (P<0.01). Conclusion: In newly diagnosed T2DM patients, HbA1c and microalbuminuria are associated with the presence of retinopathy. If follow up studies support these results, periodic ophthalmologic monitoring may be beneficial for those newly diagnosed with T2DM.","PeriodicalId":32890,"journal":{"name":"Journal of Medical and Scientific Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42954702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship of mean platelet volume in predicting severity in hypertensive retinopathy – A cross sectional study","authors":"Mali Nh, A. K, Rakshitha Hb, S. M","doi":"10.17727/jmsr.2022/10-29","DOIUrl":"https://doi.org/10.17727/jmsr.2022/10-29","url":null,"abstract":"Background: Hypertension is a major health issue in India and it has led to increasing incidences of target organ damage including hypertensive retinopathy (HR). Many factors like platelet activation show influence in levels of HR. Mean platelet volume (MPV) being an indicator of platelet activation can help in predicting the severity of HR. The present study was planned to find a correlation of levels of MPV with the severity of HR. Methodology: Data of 100 cases of hypertensive retinopathy aged 31 to 80 years diagnosed by direct and indirect ophthalmoscopic examination in the outpatient department of ophthalmology was recorded and reviewed. Complete clinical and demographic data (age, gender, weight, body mass index and socioeconomic status) was noted. Mean platelet volume was obtained from fully automated haematology analyser Horiba medical Yumizen H550. Results: The mean age (years ± standard deviation) of cases with grade 1 HR was 59.448±11.642, grade 2 HR was 56.166±10.0377 and grade 3 HR was 58±19.37. The mean value of MPV in the study population for grade 1 HR was 8.55±0.576, for grade 2 HR was 9.17±0.8224, for grade 3 was 9.6±1.5594. The comparison between grades of HR and levels of MPV was done by one way analysis of variance. Conclusion: We established a significant relationship between mean platelet volume and severity grades of hypertensive retinopathy. MPV a cheap and easily available biomarker can be used for predicting severity in hypertensive retinopathy.","PeriodicalId":32890,"journal":{"name":"Journal of Medical and Scientific Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46341652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}