新诊断的2型糖尿病患者视网膜病变的患病率及其与微量白蛋白尿和HbA1c的关系:来自拉贾斯坦邦的横断面研究

P. T, K. A, Arya Rk
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摘要

背景:糖尿病是一种具有多种医学并发症的重大公共卫生问题。糖尿病的微血管并发症包括糖尿病视网膜病变,取决于高血糖的持续时间和严重程度。关于新诊断的2型糖尿病(T2DM)患者糖尿病视网膜病变、微量白蛋白尿和HbA1c之间关系的数据缺乏。研究新诊断T2DM患者糖尿病视网膜病变的患病率及其与微量白蛋白尿和HbA1c的关系。材料和方法:这是一项以医院为基础的横断面研究,在拉贾斯坦邦的一家三级保健医院进行。在获得书面知情同意后,收集了150名新诊断的T2DM患者的数据。数据采用SPSS 20.0进行分析。分类变量用比例表示,连续变量用均值(SD)表示。双变量分析采用卡方检验和单因素方差分析。结果:患者平均(SD)年龄为50.43(12.73)岁。男性约占52.7% (n=79)。约30% (n=45)的新诊断T2DM患者有微量白蛋白尿。30例(20%)患者有糖尿病视网膜病变(DR)。约8% (n=12)的参与者患有轻度DR, 10.7% (n=16)患有中度至重度DR, 1.3% (n=2) %患有增殖性DR。微量白蛋白尿与HbA1c显著相关(P<0.01)。糖尿病视网膜病变及其严重程度与HbA1c也有显著相关性(P<0.01)。结论:在新诊断的T2DM患者中,HbA1c和微量白蛋白尿与视网膜病变的存在相关。如果后续研究支持这些结果,定期眼科监测可能对新诊断为2型糖尿病的患者有益。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Prevalence of retinopathy in newly diagnosed type 2 diabetes mellitus patients and its association with microalbuminuria and HbA1c: A cross sectional study from Rajasthan
Background: Diabetes mellitus is a major public health problem with multiple medical complications. Microvascular complications of diabetes including diabetic retinopathy, depend on the duration and severity of hyperglycemia. There is a paucity of data about the relationship among diabetic retinopathy, microalbuminuria and HbA1c in newly diagnosed type 2 diabetes mellitus (T2DM) patients. The study was conducted on the prevalence of diabetic retinopathy and its association with microalbuminuria and HbA1c among newly diagnosed T2DM patients. Material and method: It was a hospital-based, cross-sectional study conducted at a tertiary care hospital in Rajasthan. After obtaining written informed consent, data were collected from 150 newly diagnosed T2DM patients. Data were analysed using SPSS 20.0. Categorical variables were presented as proportion and continuous variables were presented as mean (SD). Chi square test and one way ANOVA tests were used for bivariate analysis. Results: The mean (SD) age of patients was 50.43 (12.73) years. About 52.7% (n=79) patients were male. About 30% (n=45) of newly diagnosed T2DM patients had microalbuminuria. Thirty patients (20%) had diabetic retinopathy (DR). About 8% (n=12) participants had mild DR, 10.7% (n=16) had moderate to severe DR and 1.3 (n=2) % had proliferative DR. Microalbuminuria was found significantly associated with HbA1c (P<0.01). Diabetic retinopathy and its severity were also found significantly associated with HbA1c (P<0.01). Conclusion: In newly diagnosed T2DM patients, HbA1c and microalbuminuria are associated with the presence of retinopathy. If follow up studies support these results, periodic ophthalmologic monitoring may be beneficial for those newly diagnosed with T2DM.
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