Journal of Medical and Scientific Research最新文献_第4页

A model for upstream signalling in the control of capillary blood flow 控制毛细血管血流的上游信号模型

Journal of Medical and Scientific Research Pub Date : 2023-07-01 DOI: 10.17727/jmsr.2023/11-46

Townsend D

引用次数: 0

Assessment of cardiac biochemical markers cystatin C and lipoprotein(a) and their relationship with glycemic control in type 2 diabetes mellitus patients 2型糖尿病患者心脏生化指标胱抑素C和脂蛋白(a)的测定及其与血糖控制的关系

Journal of Medical and Scientific Research Pub Date : 2023-07-01 DOI: 10.17727/jmsr.2023/11-31

Aghade S, Argade S, Chandekar B, Bavikar J

{"title":"Assessment of cardiac biochemical markers cystatin C and lipoprotein(a) and their relationship with glycemic control in type 2 diabetes mellitus patients","authors":"Aghade S, Argade S, Chandekar B, Bavikar J","doi":"10.17727/jmsr.2023/11-31","DOIUrl":"https://doi.org/10.17727/jmsr.2023/11-31","url":null,"abstract":"Introduction: Type 2 diabetes mellitus, is one of the predominant health emergencies of this century. Cardiovascular diseases are associated with raised morbidity and mortality in diabetes, contributing to substantial share of community health expenditure. This study was taken up to determine level of cardiac biomarkers cystatin C (CysC) and lipoprotein(a) (Lp(a)) & their association with glycemic control & lipid profile parameters to assess cardiovascular risk profile in type 2 diabetes mellitus. Materials and methods: This study included 100 type 2 diabetes mellitus patients and 100 apparently healthy controls. Diabetic patients were categorised as good glycemic control (50) - HbA1c ≤ 7.5% and poor glycemic control (50) - HbA1c > 7.5% groups. Biochemical parameters CysC, Lp(a), HbA1c and lipid profile were analysed in all participants. Results: Lp(a) and CysC were significantly increased in diabetic patients than in controls. CysC, total cholesterol (TC), low density lipoprotein (LDL), TC/HDL, LDL/ high density lipoprotein (HDL) ratio were significantly increased and HDL was decreased in poor glycemic control group than good glycemic control. CysC correlated positively with HbA1c, Lp(a), TC and LDL while negatively with HDL which was statistically significant. Correlation observed between Lp(a) and HbA1c was not significant. Conclusion: Our study denotes increased cardiovascular disease risk in diabetic patients particularly in those with poor glycemic control. Evaluation of CysC and Lp(a) together, would ameliorate cardiovascular disease (CVD) risk prediction and facilitate appropriate interventions. This study aids in stratification of high-risk diabetic persons for cardiovascular diseases at early asymptomatic phases which will prevent or delay disease advancement and improve clinical outcomes in diabetic patients.","PeriodicalId":32890,"journal":{"name":"Journal of Medical and Scientific Research","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135813040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinicopathological spectrum of renal biopsies in children – A single center experience from Eastern India 儿童肾活检的临床病理谱-来自印度东部的单中心经验

Journal of Medical and Scientific Research Pub Date : 2023-07-01 DOI: 10.17727/jmsr.2023/11-33

Kanjilal S, Hui P, Roy SM, Das MK, Basu S, Sinha MK

{"title":"Clinicopathological spectrum of renal biopsies in children – A single center experience from Eastern India","authors":"Kanjilal S, Hui P, Roy SM, Das MK, Basu S, Sinha MK","doi":"10.17727/jmsr.2023/11-33","DOIUrl":"https://doi.org/10.17727/jmsr.2023/11-33","url":null,"abstract":"Background: Renal diseases are common in childhood and they often present with diagnostic challenges. Renal biopsy is of major importance in diagnosing many renal diseases in children. The aim of this study was to evaluate the clinicopathological aspect of renal diseases underwent biopsy in children in a tertiary care teaching institute in Eastern India. Materials and methods: This cross sectional study was conducted on children (≤12 year) admitted with difficult to treat renal disorders in Pediatric ward and thorough evaluations confirmed the requirement of renal biopsy. Sixty one (61) children satisfying the inclusion and exclusion criteria were enrolled in our study. Period of study was from February 2021 to July 2022. Results: In this study, males were 31 and females were 30 in numbers. The mean age was 6.77± 3.42 years. The indications for renal biopsy were steroid resistant nephrotic syndrome (SRNS) (49.18%), systemic lupus erythematosus (SLE) (29.51%), acute glomerulonephritis (AGN) (16.39%), and others. The major bulks of histopathological findings revealed focal segmental glomerulosclerosis (FSGS), membranoproliferative glomerulonephritis (MPGN) and minimal change disease (MCD) in 45.9%, 32.8% and 13.1% respectively. Hypertension was present in 58.1% and hematuria in 64.5% of cases (p value 0.001). Conclusion: SRNS (49.18%) was the most common indication of renal biopsy and FSGS (45.9%) was the most common histopathological finding in our study. This study provides data on biopsy proven childhood renal disorders from this region.","PeriodicalId":32890,"journal":{"name":"Journal of Medical and Scientific Research","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135812064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum gamma glutamyl transferase levels in metabolic syndrome in obese south Indian population 南印度肥胖人群代谢综合征血清γ -谷氨酰转移酶水平

Journal of Medical and Scientific Research Pub Date : 2023-07-01 DOI: 10.17727/jmsr.2023/11-30

Fernando ML, Babu SV, Silambanan S

{"title":"Serum gamma glutamyl transferase levels in metabolic syndrome in obese south Indian population","authors":"Fernando ML, Babu SV, Silambanan S","doi":"10.17727/jmsr.2023/11-30","DOIUrl":"https://doi.org/10.17727/jmsr.2023/11-30","url":null,"abstract":"Background: Increased waist circumference in metabolic syndrome (MS), which reflects central obesity is associated with an increased risk of type 2 diabetes, dyslipidemia, hypertension and coronary vascular disease. Generation of free radicals in central obesity depletes intracellular glutathione, thereby induces release of gamma glutamyl transferase (GGT) into circulation. Elevated GGT levels could be a marker of high oxidative stress which is known to be associated with central obesity and metabolic syndrome. Hence the aim of this study was to determine the association of GGT levels with components of metabolic syndrome in obese South Indian population. Materials and methods: In this case control study conducted at Master Health Check (MHC) Department, Sri Ramachandra Medical College, study population included 60 obese subjects with metabolic syndrome (cases) and 60 non obese subjects (controls) of South Indian population who were non-smokers and non-alcoholics, between the ages of 30-50 years. Components of metabolic syndrome such as waist circumference, blood pressure, fasting plasma glucose, lipid profiles and GGT measured in both the groups. Data between cases and controls compared with unpaired student t-test. Pearson’s correlation was performed to find the association of GGT levels with other variables in Metabolic syndrome. Results: Serum GGT levels were significantly higher in metabolic syndrome patients (cases) than controls with p < 0.0001. High levels of serum GGT were also associated with increase in BP and atherogenic lipid levels and ratios. Conclusion: Elevated serum GGT levels were significantly associated with components of metabolic syndrome in obese South Indian population.","PeriodicalId":32890,"journal":{"name":"Journal of Medical and Scientific Research","volume":"149 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135812067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Understanding disease pathogenesis and host response of endemic malaria in previously exposed individuals compared to naïve individuals 了解地方性疟疾的发病机制和宿主反应在以前暴露个体与naïve个体的比较

Journal of Medical and Scientific Research Pub Date : 2023-07-01 DOI: 10.17727/jmsr.2023/11-43

Carnemolla AR, Benton AH

{"title":"Understanding disease pathogenesis and host response of endemic malaria in previously exposed individuals compared to naïve individuals","authors":"Carnemolla AR, Benton AH","doi":"10.17727/jmsr.2023/11-43","DOIUrl":"https://doi.org/10.17727/jmsr.2023/11-43","url":null,"abstract":"Plasmodium falciparum and Plasmodium vivax are two major species of malaria that can establish a focus of infection in millions of individuals per year. Principally, this occurs in the tropical and subtropical regions of the world where malaria is endemic due to the ubiquity of the disease vector, the Anopheles mosquitos. Malaria takes the lives of thousands of infected individuals as the progression of disease symptoms having fatal consequences. This disease mainly affects children and pregnant women which poses a great public health concern. It is also a global economic burden from the millions of international dollars are aliquoted for research yearly. This review looks to discuss the pathogenesis of malaria, various host immune responses, the development of clinical immunity in reinfected individuals, and the effects that the presence of one species may have on the pathogenesis and disease outcome of another malarial species in co-infected individuals. Overall, this manuscript aims to provide an understanding of malarial infection and the differing host immune mechanisms of previously exposed individuals compared to those of naïve individuals in environments where malaria is of high prevalence. These highlights indicate a need for further research in order to better understand host-species and species-species interactions so that proper therapeutics and vaccinations may be developed as to not inhibit the beneficial effects species may have on one another in mixed species interactions as well as to aid in the development of clinical immunity.","PeriodicalId":32890,"journal":{"name":"Journal of Medical and Scientific Research","volume":"120 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135812201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of COVID-19 on neonatal hearing in a tertiary care hospital 某三级医院新冠肺炎对新生儿听力的影响

Journal of Medical and Scientific Research Pub Date : 2023-04-01 DOI: 10.17727/jmsr.2023/11-15

Thomas N, Pragathi Bs, Kanimozhi Ks, Seema Gb, Blesson Cs, Chaithra Kc

{"title":"The impact of COVID-19 on neonatal hearing in a tertiary care hospital","authors":"Thomas N, Pragathi Bs, Kanimozhi Ks, Seema Gb, Blesson Cs, Chaithra Kc","doi":"10.17727/jmsr.2023/11-15","DOIUrl":"https://doi.org/10.17727/jmsr.2023/11-15","url":null,"abstract":"Introduction: Coronavirus disease 2019 (COVID-19) outbreak in China has had far reaching repercussions on mankind. Its effects on pregnant women and neonates have been intricate. The aim of the study was to assess the impact of gestational COVID-19 on neonatal hearing with the objectives of determining the factors affecting hearing and to estimate the prevalence of hearing loss in neonates whose mothers had gestational COVID-19. Materials and methods: The hospital-based cross-sectional study included 60 neonates whose mothers had gestational COVID-19 infection and 60 neonates of healthy mothers as controls in a rural tertiary care hospital for a duration of 1 year from September 2020 to August 2021. The study and control groups were compared in terms of continuous and non continuous variables. Maternal age, birth week and birth weight were categorized as continuous variables. Trimester of RT-PCR positivity, parity, mode of delivery, gender and results of transient evoked otoacoustic emissions (TEOAE) were categorized as non continuous variables. All neonates were screened with TEOAE within the first 5 days of birth. Results: The demographic and clinical characteristics of the study and control groups on comparison did not reveal any statistically significant differences. All neonates passed the screening test in the first attempt. Conclusion: Otologic manifestations in COVID-19 has been diverse and is a cause of concern. Neonatal hearing loss was not observed in the study. A better understanding of this entity calls for further research as early detection can help to mitigate the aftermath of the infection if any. Keywords: COVID-19; neonates; hearing loss; pregnancy; TEOAE; congenital infections; vertical transmission","PeriodicalId":32890,"journal":{"name":"Journal of Medical and Scientific Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47888212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A prospective study on correlation of cord blood bilirubin with occurrence of neonatal hyperbilirubinemia 脐带血胆红素与新生儿高胆红素血症发生相关性的前瞻性研究

Journal of Medical and Scientific Research Pub Date : 2023-04-01 DOI: 10.17727/jmsr.2023/11-20

Anjanappa S, Ansari Tf, Unki P, Krishnegowda M

{"title":"A prospective study on correlation of cord blood bilirubin with occurrence of neonatal hyperbilirubinemia","authors":"Anjanappa S, Ansari Tf, Unki P, Krishnegowda M","doi":"10.17727/jmsr.2023/11-20","DOIUrl":"https://doi.org/10.17727/jmsr.2023/11-20","url":null,"abstract":"Background: Neonatal hyperbilirubinemia is one of the most common problems that can occur in a healthy new-born. This physiological rise in indirect component of bilirubin resolves gradually without any intervention in majority of cases. But few babies require intervention in the form of phototherapy and exchange transfusion when the bilirubin levels exceed the normal physiological range for gestational age. The study was aimed to evaluate the predictive value of cord blood bilirubin level for identifying newborn for development of significant hyperbilirubinemia. Methods: It was a prospective observational study carried out in Adichunchanagiri Institute of Medical Sciences, B.G. Nagara, Karnataka. The cord blood bilirubin at birth and 48 hrs serum bilirubin levels were measured. Also, blood group, Rh status and DCT (direct coomb’s test) were tested to estimate the risk in development of hyperbilirubinemia. Results: A total of 210 were included in the study, out of which 52 babies required phototherapy, with a sensitivity of 94.23% and specificity of 3.97%, with the mean cord blood bilirubin level of 2.6mg/dl, having sensitivity of 63.46% and specificity of 90.50%. The multivariate analysis showed ABO and Rh incompatibility, cord blood bilirubin level and lower gestational age had an increased the risk of hyperbilirubinemia requiring phototherapy. Conclusions: Cord blood bilirubin may be used as a potential tool to determine hyperbilirubinemia in newborns. And initiation of phototherapy early in at-risk neonates may decrease the hyperbilirubinemia related morbidity and mortality. Keywords: hyperbilirubinemia; cord blood bilirubin; phototherapy; newborn","PeriodicalId":32890,"journal":{"name":"Journal of Medical and Scientific Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44480772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Thrombocytosis in relation to severity of lower respiratory tract infection in children aged 2 months to 5 years 血小板增多与2个月至5岁儿童下呼吸道感染严重程度的关系

Journal of Medical and Scientific Research Pub Date : 2023-04-01 DOI: 10.17727/jmsr.2023/11-17

B. R, S. S., D. I., D. A.

{"title":"Thrombocytosis in relation to severity of lower respiratory tract infection in children aged 2 months to 5 years","authors":"B. R, S. S., D. I., D. A.","doi":"10.17727/jmsr.2023/11-17","DOIUrl":"https://doi.org/10.17727/jmsr.2023/11-17","url":null,"abstract":"Background: Primary or essential thrombocytosis in children is very rare but reactive thrombocytosis occurs in children and respiratory tract infection is the commonest cause. The study aimed to determine the association of thrombocytosis with severity of lower respiratory tract infection; and the association of degree of thrombocytosis with severity of pneumonia. Materials and methods: This observational study was conducted in the Department of Paediatrics of Fakhruddin Ali Ahmed Medical College & Hospital, Barpeta in Assam. This study was done on 120 children aged between 2 months and 5 years who were admitted with lower respiratory tract infection and classified according to WHO guidelines. Complete general physical examination and systemic examination with special orientation towards respiratory system was done. Complete blood count was performed with automated system sysmex xs800i cell counter. Thrombocytosis was noted and severity of thrombocytosis was classified. Results: Among 120 cases of lower respiratory tract infections, 48 children had thrombocytosis. 13 (48.1%) children with very severe disease, 29 (46.1%) children with severe pneumonia and 6(20%) children with pneumonia had thrombocytosis. Thus it was seen that there was significant association between platelet count and severity of pneumonia (p value=0.018). Two children had severe thrombocytosis (9.01-10.00L/mm3) and both of them had very severe disease. It indicates that degree of thrombocytosis increases as severity of pneumonia increases. Conclusion: There is a significant relationship between thrombocytosis and severity of pneumonia. Also degree of thrombocytosis increases as severity of pneumonia increases. Keywords: thrombocytosis; lower respiratory tract infection; pneumonia; severe pneumonia","PeriodicalId":32890,"journal":{"name":"Journal of Medical and Scientific Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41773492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between depression and diabetes in the South-Eastern zone of the state of Uttar Pradesh-India: A cross-sectional study 印度北方邦东南部地区抑郁症和糖尿病之间的关系:一项横断面研究

Journal of Medical and Scientific Research Pub Date : 2023-04-01 DOI: 10.17727/jmsr.2023/11-19

S. A., S. J., Sachan N, Kumari R, Dubeya Gp

{"title":"Association between depression and diabetes in the South-Eastern zone of the state of Uttar Pradesh-India: A cross-sectional study","authors":"S. A., S. J., Sachan N, Kumari R, Dubeya Gp","doi":"10.17727/jmsr.2023/11-19","DOIUrl":"https://doi.org/10.17727/jmsr.2023/11-19","url":null,"abstract":"Background: Depression is among the most common mental health problems among people with chronic complications like type 2 diabetes mellitus is brought on by flaws in insulin secretion and activity; however, genetic factors also play a role in both insulin resistance and beta-cell failure, but environmental factors also play a role in aggravating both problems. The presence of depression in patients with type 2 diabetes may interfere with treatment and efficacy. This study aimed to determine the prevalence of depression in this metabolic variant clinical condition, type 2 diabetes mellitus, in major tertiary care hospitals in the South-Eastern Uttar Pradesh cities of Allahabad and Varanasi. Subjects and methods: For this study, 206 subjects with type 2 diabetes mellitus from rural and urban areas were recruited. Demographic, clinical, and diabetes-related data were collected using a semi-structured questionnaire. Depression was assessed using the Patient Health Questionnaire 9 (PHQ9), a standardized questionnaire developed in the United States and validated in the Indian population. Results: The prevalence of depression in diabetics in the community was 43.2%. The most common type of depression was mild (29.3%, 26), and the least common was severe depression (3, 3.37%). Several factors were associated with depression in the female gender: living in a rural area, unemployment, and being single. The complications of diabetes and other chronic conditions, such as hypertension and obesity, are also associated with depression. Conclusion: Depression was found to be particularly high in the study population. Because depression can significantly impede patient adherence to treatment, there is an urgent need for early diagnosis and treatment. This requires integrating mental health care for diabetes patients. Keywords: prevalence; diabetes; depression; community; higher rate","PeriodicalId":32890,"journal":{"name":"Journal of Medical and Scientific Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47493783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brucellosis with multisystemic manifestations: Case report and literature review 布鲁氏菌病多系统表现病例报告及文献复习

Journal of Medical and Scientific Research Pub Date : 2023-04-01 DOI: 10.17727/jmsr.2023/11-28

Miguel A, Domínguez Nh, Moreno Lg

引用次数: 0