Meditsina boliu最新文献

{"title":"Assesment of Postoperative Analgesic Effects of Intramuscular Tramadol Administration and Intraperitoneal Bupivacaine following Laparoscopic Cholecystectomy","authors":"Deepthi Griddaluru S, Brinda Kuraparthy, Dwarakanath Reddy Vembuluru, Swapna Vankadara, Krishna Chaitanya Kandukuru","doi":"10.31636/pmjua.v8i1-2.4","DOIUrl":"https://doi.org/10.31636/pmjua.v8i1-2.4","url":null,"abstract":"Background: For postoperative pain relief after laparoscopic surgeries, intramuscular or intravenous non-steroidal anti-inflammatory drugs and opioids, infiltration at the incision site with local anesthetics, intraperitoneal infiltration of local anesthetics with adjuvants, epidurals and nerve blocks were in use. The study was aimed to assess the efficacy of intramuscular Tramadol and intraperitoneal instillation of bupivacaine on postoperative analgesia, postoperative nausea, and vomiting following laparoscopic cholecystectomy.&#x0D; Methods: This study included 60 American Society of Anesthesiologists (ASA) I and ASA II patients of aged 18-60 years who were scheduled for laparoscopic cholecystectomy under general anesthesia. 60 patients were classified randomly into two groups equally: Group T received 100 Mg of intramuscular tramadol and Group B received intraperitoneal instillation of 30 ml of plain bupivacaine. Time duration, postoperative pain, haemodynamics, nausea, vomiting, and time taken to rescue analgesia were noted.&#x0D; Results: The time for onset of analgesia was 6.51 ± 2.41min in group T and 7.61 ± 2.19 min in group B (p=0.039). The duration of analgesia was 2.37 ± 0.67 hours in group T and 3.65 ± 0.79 hours in group B (p=0.002). VAS Score was significantly lower in Group T than Group B at 1hr, 2hr, 4hr and 6hr (p <0.05). Intraperitoneal bupivacaine showed a significant reduction in postoperative pain for the first 6 hours postoperatively (P<0.05), and time taken to rescue analgesia requirement was prolonged (P<0.05). The rescue analgesia consumption of Paracetamol was 1.5 grams in group-B and 2.5 grams in group T (P<0.05) in 24 hr post-surgery. Nausea and vomiting were observed in 2 cases, and shoulder pain in one case in group T.&#x0D; Conclusion: Bupivacaine is effective in reducing postoperative pain, and it prolongs the requirement time for rescue analgesia after LC surgery. It also required less consumption of rescue analgesic without fluctuations in hemodynamics","PeriodicalId":32866,"journal":{"name":"Meditsina boliu","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135591420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metoxifluran, an inhalation analgesic that opens up new possibilities in anesthesia","authors":"Dmytro Dmytriev, Oleksandr Nazarchuk, Yuliana Babina","doi":"10.31636/pmjua.v8i1-2.2","DOIUrl":"https://doi.org/10.31636/pmjua.v8i1-2.2","url":null,"abstract":"Although numerous clinical guidelines for pain management have been published over the past decade, inadequate pain relief remains a major public health problem. Currently, several methods of analgesia are available for the treatment of acute pain, including intravenous analgesia, epidural anesthesia, and oral administration of medications. However, the existing methods of analgesia still do not cover all the needs of proper analgesia, the search for new forms of release, methods of administration and methods of analgesia continues. Currently, non-invasive methods of analgesia are being actively implemented, which include a transdermal delivery system of analgesics (in particular, fentanyl hydrochloride), intranasal and inhalational analgesia, in which the delivery of analgesics is controlled by both the doctor and the patient. The purpose of this article is to review the inhaled analgesic methoxyflurane, which is administered by means of an individual inhaler and is used for the treatment of acute pain.","PeriodicalId":32866,"journal":{"name":"Meditsina boliu","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135644358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pregabalin for Postoperative pain in patients undergoing spinal surgery: A Dose ranging randomized clinical study","authors":"Palak Goel, Anshu S.S. Kotia, Anil Kumar, Mona Bana, Reena Meena, Tarun Singh","doi":"10.31636/pmjua.v8i1-2.3","DOIUrl":"https://doi.org/10.31636/pmjua.v8i1-2.3","url":null,"abstract":"Background: The efficacy of pregabalin in acute post-surgical pain management is well demonstrated. As, the use of pregabalin is officially not approved and hence, there is no dosing guideline as well. Aim: To determine whether single preoperative administration of different doses of pregabalin (150 mg to 300mg) could decrease postoperative pain intensity following spinal surgery. Materials and Method: In this prospective, randomized double-blinded study, a total 60 patients undergoing spinal surgery were selected and randomly assigned any of these four groups of 15 each; group A (received placebo drug), group B (received pregabalin 150mg), group C (received pregabalin 200mg) and group D (received pregabalin 300mg). All the groups received the said drugs (coded as it was double-blinded study) in the same manner and two hours prior to operation. The patients were followed for pain scores on visual analogue scale (VAS), time to rescue analgesia and side effects as secondary outcomes. Results: Patients in pregabalin dose ranging group had lower pain in the initial hour of recovery. However, the pain scores subsequently decreased and became similar in all groups. Time for the requirement for analgesic was longer in pregabalin 300mg group when compared with other study groups. Conclusion: A single dose of 300 mg pregabalin given 1–2 hours prior to surgery is superior to placebo after spinal surgery.","PeriodicalId":32866,"journal":{"name":"Meditsina boliu","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135591114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishment of A Mouse Model of Stellate Ganglion Block and Subsequent Biphasic Effects on Bilateral Cerebral Cortical Blood Flow","authors":"Jiahua Wang, Wei Zhou, Xiaohong Wang, Shiting Yan, Shunping Yan, Ying Wang, Yanlong Yu, Hu Li, Dongsheng Zhang, Zhuan Zhang","doi":"10.31636/pmjua.v8i1-2.5","DOIUrl":"https://doi.org/10.31636/pmjua.v8i1-2.5","url":null,"abstract":"Background and objectives: Stellate ganglion block (SGB) has significant therapeutic efficacy in various clinical practices and further exploration of SGB is needed. The mouse model of SGB had not been reported and the effect on cerebral cortical blood flow (CCBF) was controversial. We aimed to establish an stellate ganglion block (SGB) mouse model and explore how SGB influences CCBF.&#x0D; Methods: Male C57BL/6 mice were randomly divided into five groups (n = 6): groups L (left SGB) and R (right SGB) received an injection of 0.25% ropivacaine hydrochloride (0.08 mL) on the respective stellate ganglion; similarly, groups SL (left saline control) and SR (right saline control) received an injection of normal saline (0.08 mL) instead. Group C received no intervention. CCBF was assessed before SGB (T0) and 10 (T1), 30 (T2), 60 (T3), 90 (T4), and 120 min (T5) after SGB using laser speckle contrast imaging system.&#x0D; Results: The SGB mouse model was successfully established in groups L and R. Compared with baseline, CCBF on the blocked side decreased at T1, increased at T2–T5, and peaked at T3 in groups L and R (all, P < 0.01). Compared with groups C and SL, the CCBF on the left side decreased at T1 and increased at T2–T5 in group L (all, P < 0.05). A similar trend was noted in groups C and SR relative to group R. The CCBF on the unblocked side decreased at T1, increased at T2–T5, and peaked at T3 in groups L and R (all, P < 0.01).&#x0D; Conclusions: The SGB mouse model was established successfully. Unilateral SGB can affect bilateral cerebral cortical blood flow, which shows a transitory decrease followed by a significant increase for at least 2 h.","PeriodicalId":32866,"journal":{"name":"Meditsina boliu","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135597444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glossary of key concepts and terms provided by the Іnternational association for the study of pain","authors":"M Golovenko, N Voloshchuk","doi":"10.31636/pmjua.v8i1-2.1","DOIUrl":"https://doi.org/10.31636/pmjua.v8i1-2.1","url":null,"abstract":"The publication collects and systematizes the main definitions and concepts related to pain sensations of various genesis and their changes in pathological conditions. The work includes terminology with appropriate changes and notes, which was prepared by the working group of the International Association for the Study of Pain (IASP) and is used in numerous reports and scientific publications. The glossary deals mainly with terms and does not contain the classification of pain, which is sufficiently presented in other modern scientific publications. The presented terms and their interpretation will be useful not only to scientists, but also to clinicians and students of medical universities of Ukraine.","PeriodicalId":32866,"journal":{"name":"Meditsina boliu","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135597613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}