MEDS Clinical Medicine最新文献

{"title":"Meta-analysis of the Role of Mercury Exposure in Autoimmune Diseases: Pathogenic or Therapeutic","authors":"Yihang Yang, Xinran Bao","doi":"10.23977/medsc.2023.040419","DOIUrl":"https://doi.org/10.23977/medsc.2023.040419","url":null,"abstract":": Researchers have long disagreed on whether mercury is pathogenic for autoimmune diseases such as psoriasis and rheumatoid arthritis, and it has also been used to treat autoimmune diseases. Exploring whether mercury is a risk factor for autoimmune diseases is important for disease treatment. In this paper, we searched Medline, Embase, and Cochrane Library databases, and collected the published literature on risk factors of autoimmune diseases from these databases to 2023-2, and performed Meta-analysis using RevMan 5.4 and Stata/SE 17.0 software. Meta-analysis results showed that exposure to mercury may be a risk factor for autoimmune diseases (OR=1.49, 95% CI: 0.30-7.29), but the risk factor for mercury correlated with the proportion of women included in the literature.","PeriodicalId":328259,"journal":{"name":"MEDS Clinical Medicine","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123579016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The predictive effect of serum HBV-RNA and HBcrAg on the disease changes in patients with chronic hepatitis B","authors":"","doi":"10.23977/medsc.2023.040108","DOIUrl":"https://doi.org/10.23977/medsc.2023.040108","url":null,"abstract":"","PeriodicalId":328259,"journal":{"name":"MEDS Clinical Medicine","volume":" 810","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120829205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review of neuroprotective mechanisms of dexmedetomidine","authors":"Wenxian An, Yaying Xie","doi":"10.23977/medsc.2023.040113","DOIUrl":"https://doi.org/10.23977/medsc.2023.040113","url":null,"abstract":": Dexmedetomidine (DEX) is a highly specific and effective α2-adrenergic receptor agonist. Due to its high protein binding rate, intravenous pumping can play a good role in sedation and hypnosis, analgesia, anti-anxiety, reducing inflammation, and so on, so it has been widely used in clinical anesthesia and basic research. In recent years, with the further study of dexmedetomidine, it has been found that it has a certain protective effect on nerve injury caused by various causes.","PeriodicalId":328259,"journal":{"name":"MEDS Clinical Medicine","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132269841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Matrix Stiffness Regulation of Macrophage Function","authors":"Yan Wang, Huiqin Wang, Li Jing, Liqiang Song","doi":"10.23977/medsc.2023.040312","DOIUrl":"https://doi.org/10.23977/medsc.2023.040312","url":null,"abstract":": Macrophages are found throughout the body, engulfing microorganisms and cell debris, while coordinating inflammatory responses to maintain tissue homeostasis. As macrophages patrol within different organs and tissues, they are exposed not only to a variety of biochemical cues, but also to mechanical cues, such as tissue stiffness. More and more studies have shown that macrophages can sense changes in microenvironment stiffness, but little is known about the molecular mechanism of how stiffness regulates macrophage function. The 2020 Nobel Prize-winning mechanically-sensitive ion channels the transient receptor potential channel subfamily V member 4 (TRPV4) and Piezo1 are of widespread interest. Research suggests that Piezo1 and TRPV4 on macrophages can sense matrix stiffness in the microenvironment and convert it into biochemical signals to activate specific cellular effector functions. These findings help us better understand how microenvironment stiffness affects macrophage behavior, which may be associated with diseases in which tissue stiffness is altered, and may enhance our understanding of disease mechanisms.","PeriodicalId":328259,"journal":{"name":"MEDS Clinical Medicine","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131718835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on the Effectiveness of Burdock Root in Weight Loss and Fat Reduction","authors":"G. Min, Wanzhu Yang","doi":"10.23977/medsc.2023.040418","DOIUrl":"https://doi.org/10.23977/medsc.2023.040418","url":null,"abstract":": In order to explore the effect of Burdock roots on fat reduction in obese mice, it was randomly to allote the meal 45 mice C57BL/6J into 5 groups, 9 in each group; The intragastric dose of each group was 16g/(kg·d), 8g/(kg·d, 4g/(kg·d). There were basal feed and fat feed for normal contral group and other 4 groups. Established fat model and used Burdock root for 6 weeks and recorded the weight of the mice weekly. After the sixty weeks, extracted mouse fat, emeasured related experimental indicator. The results manifested that the weight, Lee's index and fat coefficient of the model group were more higher than normal control group. The fat mold was created successfully. Triglyceride (TG), cholesterol (TC), low density lipoprotein cholesterol (LDL-C), Alanine transaminase (ALT)and free fatty acid (FFA) levels of serum had the varying degree to decline. Nevertheless, the high density lipoprotein cholesterol (HDL-C) hasn’t increased, Aspartate aminotransferase (AST) and lipase (LPS) were not decline, compared with model group. compared with normal control group, adipocytes’ diameter of model group were increased fat cells’ diameter of administration groups were decreased at different level microscopically. It revealed that Burdock roots had certainly effect on lessen weight and lipid lowering effect.","PeriodicalId":328259,"journal":{"name":"MEDS Clinical Medicine","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122213757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parapelvic cyst causing ureteropelvic junction stricture: a case report","authors":"","doi":"10.23977/medsc.2023.040210","DOIUrl":"https://doi.org/10.23977/medsc.2023.040210","url":null,"abstract":": Parapelvic cyst is a special type of cystic lesion of the kidney. Due to the characteristics of its anatomical relationship, parapelvic cyst can compress the collecting system or the blood vessels at the pedicle of the kidney in the early stage of the disease. Compared with other cystic diseases of the kidney, aggressive treatment should be taken earlier. Here, we report a patient with hydronephrosis secondary to renal pelvis and parapelvic cyst compression at the ureteropelvic junction was admitted to our hospital. Laparoscopic left pyeloureteroplasty was performed after condications were ruled out. During the operation, a cystic mass was observed between the two renal pelvis. There was no stenosis or dilatation in the upper part of the left ureter. In conclusion, considering the long-term compression of cysts between the renal pelvis of the two branches of the UPJO system in the patient, laparoscopic parapelvic cysts of the left side were performed.","PeriodicalId":328259,"journal":{"name":"MEDS Clinical Medicine","volume":"139 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124872163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Teriparatide and Bisphosphonates in Advanced Patients with Osteoporosis","authors":"","doi":"10.23977/medsc.2023.040317","DOIUrl":"https://doi.org/10.23977/medsc.2023.040317","url":null,"abstract":"","PeriodicalId":328259,"journal":{"name":"MEDS Clinical Medicine","volume":"60 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133916805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research progress of right unilateral electroconvulsive therapy for major depressive disorder","authors":"","doi":"10.23977/medsc.2023.040117","DOIUrl":"https://doi.org/10.23977/medsc.2023.040117","url":null,"abstract":"","PeriodicalId":328259,"journal":{"name":"MEDS Clinical Medicine","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125579183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the Clinical Effect of Teriparatide and Zoledronic Acid in Postmenopausal Osteoporosis","authors":"","doi":"10.23977/medsc.2023.040316","DOIUrl":"https://doi.org/10.23977/medsc.2023.040316","url":null,"abstract":"","PeriodicalId":328259,"journal":{"name":"MEDS Clinical Medicine","volume":"519 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134286759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy Analysis of Levofloxacin Combined with Cefoperazone/Sulbactam Sodium in the Treatment of Adult Bronchiectasis Complicated with Infection","authors":"Yingjie Jiang, Jie Ren","doi":"10.23977/medsc.2022.030413","DOIUrl":"https://doi.org/10.23977/medsc.2022.030413","url":null,"abstract":": Objective: To investigate the efficacy of levofloxacin combined with cefoperazone/ sulbactam sodium in the treatment of bronchiectasis complicated with infection in adults and its effect on lung function. Methods About 200 patients with bronchiectasis and infection from May 2019 to July 2022 in Jintan First People's Hospital of Changzhou City, Jiangsu Province were selected and divided into 2 groups (100 cases in each group) according to the treatment plan. The control group received cefoperazone /sulbactam sodium treatment, the observation group was treated with levofloxacin on the basis of the above. The evaluation was conducted by comparing the time of improvement of clinical symptoms, the decrease of inflammatory indicators, and the improvement of lung function indicators. Results After treatment, the overall effectiveness rate of the observation group was 93%, and the control group was 78%, which was significantly different (P<0.05), cough and sputum production, body temperature recovery and hemoptysis stop time were all earlier than those in the control group (P<0.05). Prior to treatment, there was no significant difference in neutrophil values (GRAN), white blood cell count (WBC), and hypersensitive C-reactive protein (CRP) between the two groups (P>0.05). After treatment, the GRAN, WBC and CRP of the control group were significantly higher than those in the observation group (P<0.05); there was no significant difference in forced expiratory volume (FVC), forced expiratory volume in 1 second (FEV1), FEV1/FVC between the two groups before treatment (P>0.05), After treatment, the FVC, FEV1, FEV1/FVC values in the observation group were significantly higher than those in the control group (P<0.05). Conclusion The application of levofloxacin combined with cefoperazone/sulbactam sodium can effectively improve the clinical symptoms, inflammation level and pulmonary function indexes of adult bronchiectasis complicated with infection. this study showed that after treatment, the FVC, FEV 1 , and FEV 1 /FVC of the two groups were significantly improved. The results confirmed that controlling and reducing the inflammatory response in patients with bronchiectasis can significantly improve the symptoms of airflow limitation and help improve lung function. The results also found that the improvement of lung function indexes in the observation group after treatment was better than that in the control group. The results show that the combined use of levofloxacin has a stronger effect on improving the lung function of patients with bronchiectasis than the non-combination use. The possible reason is that levofloxacin combined with cefoperazone/sulbactam sodium can significantly improve the antibacterial effect, and its mechanism of action needs to be further studied.","PeriodicalId":328259,"journal":{"name":"MEDS Clinical Medicine","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128359351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}