MEDS Clinical Medicine最新文献

Circulating MicroRNAs as Potential Biomarkers for the Diagnosis of Thyroid Carcinoma：A Systematic Review and Meta-analysis 循环microrna作为甲状腺癌诊断的潜在生物标志物:系统综述和荟萃分析

MEDS Clinical Medicine Pub Date : 2023-06-16 DOI: 10.37766/inplasy2023.6.0048

L. Kong, Yue Li, Li Yang, Jiamin Fan, X. Zhai, Xiaojuan Zhao, S. Wen

{"title":"Circulating MicroRNAs as Potential Biomarkers for the Diagnosis of Thyroid Carcinoma：A Systematic Review and Meta-analysis","authors":"L. Kong, Yue Li, Li Yang, Jiamin Fan, X. Zhai, Xiaojuan Zhao, S. Wen","doi":"10.37766/inplasy2023.6.0048","DOIUrl":"https://doi.org/10.37766/inplasy2023.6.0048","url":null,"abstract":": Thyroid cancer (TC) ranks as the most prevalent malignant endocrine neoplasm worldwide, holding 9th place in terms of occurrence and ranking 24th for fatality among all diagnosed malignant tumors. Thus, discovering efficient biomarkers for timely identification and diagnosis of TC is pivotal. A meta-analysis was conducted to evaluate the diagnostic capability of circulating microRNAs (miRNAs) in detecting TC, registered under INPLASY202360048 on the INPLASY website. A systematic search of four databases (PubMed, Embase, Web of Science, and Cochrane Library) was performed to identify relevant articles published from inception until December 22, 2022. Stata 14.0 software was used to calculate the pooled sensitivity, speciﬁcity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic ratio (DOR), and area under the summary receiver operating characteristic (ROC) curve to assess the accuracy of miRNAs in the diagnosis of TC. Study heterogeneity was quantitatively evaluated using the Cochran-Q test and I2 statistic. Given the significant variability among studies, we opted for a random-effect model. Subgroup analysis and regression analysis were conducted in an effort to identify any possible factors contributing to heterogeneity","PeriodicalId":328259,"journal":{"name":"MEDS Clinical Medicine","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128512526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Purification and Characteristics of a NAD(P)-Dependent Gluconate 5-Dehydrogenase from Thermotoga maritima MSB8 海洋热藻MSB8中NAD(P)依赖性葡萄糖酸5-脱氢酶的纯化及特性研究

MEDS Clinical Medicine Pub Date : 1900-01-01 DOI: 10.23977/medsc.2022.030503

Xiao He, M. Yan

{"title":"Purification and Characteristics of a NAD(P)-Dependent Gluconate 5-Dehydrogenase from Thermotoga maritima MSB8","authors":"Xiao He, M. Yan","doi":"10.23977/medsc.2022.030503","DOIUrl":"https://doi.org/10.23977/medsc.2022.030503","url":null,"abstract":": NADP-dependent gluconate 5-dehydrogenase catalyzes the reversible oxidoreduction reaction between D-gluconate and 5-keto-D-gluconate. NADP-dependent gluconate 5-dehydrogenase from bacteria and fungi has been reported. The reported enzyme showed activity only for NADP as the cofactor. This study purified and characterized a NAD(P)-dependent gluconate 5-dehydrogenase (TmGNDH) from the archaea Thermotoga maritima MSB8. TmGNDH is composed of two identical subunits, and a single subunit has 255 amino acids with molecular mass of 28 kDa. TmGNDH is affiliated with the short-chain dehydrogenase/reductase family. Purified TmGNDH has a specific activity of 102.8 U/mg. The enzyme preferred NADP to NAD as its cofactor. TmGNDH exhibited a Km value of 121.3 ± 3.0 mM and 𝑘 𝑐𝑎𝑡 value of 3181 ± 34.1 𝑠 −1 toward D-gluconate as a substrate. TmGNDH had lower activity with D-sorbitol, D-xylitol, D-glucose and D-xylose as substrates. The optimal pH and temperature of TmGNDH were observed at pH 9.0 and 60℃ with NADP as the cofactor . The thermostability of the enzyme suggests that it can be used as an industrially effective tool for synthesizing 5-keto-D-gluconate. gluconate 5-dehydrogenase has not been reported. In this study, we purified and characterized a thermostable NAD(P)-dependent gluconate 5-dehydrogenase (TmGNDH) from the archaea Thermotoga maritima MSB8. The crystal structure (PDB ID: 1VL8) of the enzyme has been resolved, but its biochemical properties have not been reported.","PeriodicalId":328259,"journal":{"name":"MEDS Clinical Medicine","volume":"72 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121036441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Long- Term Retrospective Study on the Incidence of Urinary Stones in Wuwei City, Gansu Province, China from 1995 to 2016 1995 - 2016年中国甘肃省武威市尿路结石发病率的长期回顾性研究

MEDS Clinical Medicine Pub Date : 1900-01-01 DOI: 10.23977/medsc.2023.040114

Shuyuan Zhang, Qiling Liu, Shuxuan Song, Z. Ji, Weilu Zhang, Yong Long

{"title":"A Long- Term Retrospective Study on the Incidence of Urinary Stones in Wuwei City, Gansu Province, China from 1995 to 2016","authors":"Shuyuan Zhang, Qiling Liu, Shuxuan Song, Z. Ji, Weilu Zhang, Yong Long","doi":"10.23977/medsc.2023.040114","DOIUrl":"https://doi.org/10.23977/medsc.2023.040114","url":null,"abstract":": This retrospective longitudinal study investigated the reasons for the increased morbidity of urinary stones in Wuwei City, China, between 1995 and 2016. To extract the case history of patients with urinary stones from 12 hospitals in Wuwei City, and analyze them with Excel 2019, Joinpoint v10.2 and SPSS v22.0. ArcGIS v10.2 was used to map the geographical distriburinary stoneson and SaTScan v9.6 was used for spatial-temporal analysis to identify clusters of occurrence. Clusters of outbreaks were identified using SaTScan v9.6. Of the 5497 urinary stones patients (43.07 ± 15.95 years), male (3843, 69.9%) with a Gender ratio of 2.32:1. The morbidity of urinary stones in men and women shows total growth trend. From 1995 to 2016, the annual percentage change (APC) is 15.1% (95% confidence interval (CI): 12.3–18.1%) and 19.4% (19.4% (95% CI: 16.4-22.5%), respectively. Identifying four clusters that dynamically develop and monitor urinary stones in Uwajima. To discover and prevent the occurrence of acute and severe diseases in time, and to prevent and manage urinary stones. The study could be guide local authorities in initiating urinary stones prevention and management activities.","PeriodicalId":328259,"journal":{"name":"MEDS Clinical Medicine","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121228147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Progress in the Treatment of Motor Neurone Disease with Traditional Chinese and Western Medicine 中西医结合治疗运动神经元疾病的研究进展

MEDS Clinical Medicine Pub Date : 1900-01-01 DOI: 10.23977/medsc.2023.040402

Yanhong Liu, Bingcang Yan

引用次数: 0

Research Progress on Helicobacter Pylori Infection and Autoimmune Thyroid Disease 幽门螺杆菌感染与自身免疫性甲状腺疾病的研究进展

MEDS Clinical Medicine Pub Date : 1900-01-01 DOI: 10.23977/medsc.2023.040212

引用次数: 0

The Role of Mucosal Immunity in the Pathogenesis of IgA Nephropathy and the Progress of Chinese Medicine Research 黏膜免疫在IgA肾病发病机制中的作用及中医药研究进展

MEDS Clinical Medicine Pub Date : 1900-01-01 DOI: 10.23977/medsc.2022.030512

Rongrong Ou, Jian Shi

引用次数: 0

Research Progress of Central Insulin Resistance and Cognitive Impairment 中枢性胰岛素抵抗与认知障碍的研究进展

MEDS Clinical Medicine Pub Date : 1900-01-01 DOI: 10.23977/medsc.2022.030414

Tong Yu, Hai Lin, Yunyun Li

{"title":"Research Progress of Central Insulin Resistance and Cognitive Impairment","authors":"Tong Yu, Hai Lin, Yunyun Li","doi":"10.23977/medsc.2022.030414","DOIUrl":"https://doi.org/10.23977/medsc.2022.030414","url":null,"abstract":": With the acceleration of the aging of the world's population, the number of patients with cognitive dysfunction has increased significantly, resulting in more and more serious social problems, economic problems, family problems and public health problems, how to better prevention and treatment of cognitive dysfunction is also a hot spot of clinical research. Studies have shown that insulin resistance and compensatory hyperinsulinemia (HI) exist in many patients with cognitive dysfunction, which also provides new ideas for the prevention and treatment of dysfunction. At present, more attention has been paid to peripheral insulin resistance, but there is little discussion on cognitive dysfunction caused by central insulin resistance. Insulin receptors (InsRs) are widely distributed in the brain region, especially in the hippocampus. Insulin can be through the blood - brain barrier to enter the central nervous system, adjust the structure of cerebral glucose metabolism and brain plasticity, protect nerve cells, improve memory, in order to protect the nervous system and cognitive function, while type 2 diabetes mellitus (T2DM) patients with insulin resistance, in turn, cause central insulin resistance can cause cognitive dysfunction [1]. Therefore, the effects of central insulin resistance on cognitive function and related mechanisms have gradually become a research hotspot. This paper summarizes the current research situation.","PeriodicalId":328259,"journal":{"name":"MEDS Clinical Medicine","volume":"35 129","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132973008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Muscle Fatigue Judgement Based on Neck Electromyogram Signals 基于颈部肌电图信号的肌肉疲劳判断

MEDS Clinical Medicine Pub Date : 1900-01-01 DOI: 10.23977/medsc.2023.040507

Yujie Liu

{"title":"Muscle Fatigue Judgement Based on Neck Electromyogram Signals","authors":"Yujie Liu","doi":"10.23977/medsc.2023.040507","DOIUrl":"https://doi.org/10.23977/medsc.2023.040507","url":null,"abstract":": Chronic cervical flexion can have serious effects on the cervical spine. In order to quantitatively assess the effects of prolonged bowing on cervical fatigue, 16 healthy participants were selected and maintained normal working posture for 3h. The sternocleidomastoid muscle, the neck clamp muscle and the shoulder trapezius muscle were selected to measure the surface EMG signal. After filtering and amplitude standardization, the EMG value of every 60s is integrated and its mean power frequency is calculated. It was found that the integrated EMG value fluctuated regularly, and the decrease after the initial increase indicated that the muscle entered the fatigue state. The mean power frequency (MPF) value of different muscles is significantly different, which determines the duration of fatigue tolerance of the muscles, and MPF is not a simple linear relationship in the whole process of neck flexion. The results show that the negative accumulation of MPF can be a good judge of muscle fatigue. Therefore, the EMG sensor can be programmed to connect to the computer. When the negative accumulation of MPF is detected, the program can display a pop-up window to prompt people to take a proper rest, thus reducing the probability of cervical spine injury.","PeriodicalId":328259,"journal":{"name":"MEDS Clinical Medicine","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128810508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation between handgrip strength and nutritional indicators and its influencing factors in patients with stable COPD: a cross-sectional study 稳定期COPD患者握力与营养指标的相关性及其影响因素的横断面研究

MEDS Clinical Medicine Pub Date : 1900-01-01 DOI: 10.23977/medsc.2023.040408

Yue’e Ma, Miaoling Cui, Qingmei Chen, Diandian Jiang, Zhenjiao Yang

{"title":"Correlation between handgrip strength and nutritional indicators and its influencing factors in patients with stable COPD: a cross-sectional study","authors":"Yue’e Ma, Miaoling Cui, Qingmei Chen, Diandian Jiang, Zhenjiao Yang","doi":"10.23977/medsc.2023.040408","DOIUrl":"https://doi.org/10.23977/medsc.2023.040408","url":null,"abstract":": This study aimed to explore the Correlation between handgrip strength and nutritional indicators and its influencing factors in patients with stable chronic obstructive pulmonary disease (COPD) to provide evidence for early nutritional intervention. Stable COPD patients who visited the respiratory department clinic of a Tertiary Grade A hospital in Guangxi from January 2021 to March 2022 were chosen using a convenient sampling method. The general information questionnaire and mini nutritional assessment short-form (MNA-SF) were used for investigation, and the HGS, anthropometric, and laboratory indicators were collected. Correlation analysis was used to analyze the relationship between HGS and nutritional indicators in patients with stable COPD. Multiple linear regression analysis was used to examine the factors influencing HGS in patients with stable COPD. A total of 232 patients with stable COPD were included, and the HGS was (25.18±7.95)kg. Correlation analysis showed that height, body weight, body mass index (BMI), calf circumference, hemoglobin concentration, total protein concentration","PeriodicalId":328259,"journal":{"name":"MEDS Clinical Medicine","volume":"75 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131288426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Characteristics of Kawasaki Disease Combined with Liver Function Impairment in Children 川崎病合并儿童肝功能损害的临床特点

MEDS Clinical Medicine Pub Date : 1900-01-01 DOI: 10.23977/medsc.2023.040504

Pengfei Lv

引用次数: 0