Mediterranean Journal of Rheumatology最新文献_第5页

Interferon Inhibition in SLE: From Bench to Bedside. 系统性红斑狼疮的干扰素抑制：从工作台到床边

Mediterranean Journal of Rheumatology Pub Date : 2024-06-30 eCollection Date: 2024-06-01 DOI: 10.31138/mjr.010324.iis

Dimitrios Deligeorgakis, Elpida Skouvaklidou, Christina Adamichou

引用次数: 0

The NYMERIA Study: A Real-World, Multicentre Contemporary Assessment of Disease- and Patient-Related Burden and Treatment Strategies in Patients with Systemic Lupus Erythematosus. NYMERIA 研究：系统性红斑狼疮患者与疾病和患者相关的负担及治疗策略的真实世界多中心当代评估。

Mediterranean Journal of Rheumatology Pub Date : 2024-06-30 eCollection Date: 2024-06-01 DOI: 10.31138/mjr.160524.tns

George Bertsias, Antonis Fanouriakis, Marina Bartsakoulia, Petros Galanakis, Dimitrios T Boumpas

{"title":"The NYMERIA Study: A Real-World, Multicentre Contemporary Assessment of Disease- and Patient-Related Burden and Treatment Strategies in Patients with Systemic Lupus Erythematosus.","authors":"George Bertsias, Antonis Fanouriakis, Marina Bartsakoulia, Petros Galanakis, Dimitrios T Boumpas","doi":"10.31138/mjr.160524.tns","DOIUrl":"10.31138/mjr.160524.tns","url":null,"abstract":"Systemic lupus erythematosus (SLE) has a spectrum of phenotypes. Its management should target remission or low disease activity, prevention of relapses and organ damage, minimisation of drug-related harms, and optimisation of health-related quality of life. Advances in our understanding of the disease pathophysiology have expanded the treatment armamentarium with targeted biologics that demonstrate superiority over conventional drugs in controlling activity, reducing flares and glucocorticoid exposure, and improving patient-related outcomes. In view of this, there is a critical need for real-world evidence providing insight into the spectrum of activity, the treatment landscape, and unmet needs among SLE patients. Such information can support regulatory and reimbursement decision-making. The primary objective of the NYMERIA multicentre study is to generate real-world evidence on the activity state of SLE patients treated in routine care settings in Greece. The overarching aim is to capture the disease burden based on both clinical aspects and the patient perspective.","PeriodicalId":32816,"journal":{"name":"Mediterranean Journal of Rheumatology","volume":"35 Suppl 2","pages":"392-401"},"PeriodicalIF":0.0,"publicationDate":"2024-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11345607/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142081952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rapid and Remarkable Response to Rituximab in a Case of Lupus Enteritis: Challenging the Norm. 狼疮肠炎病例对利妥昔单抗的快速和显著反应：挑战常规。

Mediterranean Journal of Rheumatology Pub Date : 2024-06-08 eCollection Date: 2024-03-01 DOI: 10.31138/mjr.080624.rar

Albader Hamza Hussein, Bayan Lafi Altamimi

引用次数: 0

Fractional Carbon Dioxide Laser for Treatment of Microstomia and Rhytids in Systemic Sclerosis Patients. 点阵二氧化碳激光治疗系统性硬化症患者的小口畸形和韵律畸形。

Mediterranean Journal of Rheumatology Pub Date : 2024-05-21 eCollection Date: 2024-09-01 DOI: 10.31138/mjr.101223.fcd

Elias Salimi, Shirin Assar, Aram Salimi, Dena Mohamadzadeh

{"title":"Fractional Carbon Dioxide Laser for Treatment of Microstomia and Rhytids in Systemic Sclerosis Patients.","authors":"Elias Salimi, Shirin Assar, Aram Salimi, Dena Mohamadzadeh","doi":"10.31138/mjr.101223.fcd","DOIUrl":"10.31138/mjr.101223.fcd","url":null,"abstract":"Background: Systemic sclerosis (SSc) is an autoimmune disorder characterised by skin fibrosis leading to skin tightening and disfigurement. However, there is no definite treatment for SSc and its skin complications. Fractional carbon dioxide laser has been widely used for different cutaneous pathologies. This study aims to evaluate the benefits of CO2 laser resurfacing on microstomia and peri-oral rhytids in systemic sclerosis patients.Method and patients: 33 systemic sclerosis patients were enrolled. Four sessions of CO2 laser treatment were performed at an interval of four weeks. Patients were evaluated monthly. The interincisal distance (IID) measurement was used to evaluate maximal mouth opening capacity, and the mouth handicap in systemic sclerosis (MHISS) scale was used to assess the improvement after treatment.Results: All of the participants were female with a mean age of 47.46 and a standard deviation of 7.11. The mean disease duration was 12.35. The mean total core of the MHISS scale was 25.24, and the mean IID was 48.11 millimetres before the treatment with CO2 laser. The MHISS score decreased, and patient satisfaction increased after treatment. However, observed differences in the results of IID were not statistically significant.Conclusion: In conclusion, it seems that the fractional carbon dioxide laser is effective in the improvement of perioral rhytids, patient satisfaction based on the MHISS score, and mouth disability in SSc patients.","PeriodicalId":32816,"journal":{"name":"Mediterranean Journal of Rheumatology","volume":"35 3","pages":"459-463"},"PeriodicalIF":0.0,"publicationDate":"2024-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11500117/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142509463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pneumomediastinum in MDA5+ Dermatomyositis: A Case Series.

Mediterranean Journal of Rheumatology Pub Date : 2024-05-21 eCollection Date: 2024-12-01 DOI: 10.31138/mjr.060124.pim

Ramaswamy Subramanian, Rupal Prasad, Mamadapur Mahabaleshwar, Anjum Siddiqui, Digvijay Ekbote, Urmila Dhakad

引用次数: 0

Sjögren's Syndrome Masquerading as Testicular Vasculitis. 伪装成睾丸血管炎的斯约格伦综合征

Mediterranean Journal of Rheumatology Pub Date : 2024-05-21 eCollection Date: 2024-09-01 DOI: 10.31138/mjr.250323.ssm

Rajaie Namas, Hamdan Alawadhi, Priti Joshi, Esat Memisoglu

引用次数: 0

Cutaneous Ulcers and Response to Treatment in a Child with Anti-MDA5 Dermatomyositis. 一名抗MDA5皮肌炎患儿的皮肤溃疡和治疗反应

Mediterranean Journal of Rheumatology Pub Date : 2024-05-21 eCollection Date: 2024-06-01 DOI: 10.31138/mjr.191123.cua

Mamadapur Mahabaleshwar, Ramaswamy Subramanian

引用次数: 0

Spectrum of Central Nervous System Involvement in Childhood-Onset Sjögren's Syndrome: A Case-Based Review. 儿童期发病的斯约格伦综合征的中枢神经系统受累谱：基于病例的综述。

Mediterranean Journal of Rheumatology Pub Date : 2024-05-21 eCollection Date: 2024-06-01 DOI: 10.31138/mjr.241123.soc

Furkan Can Yilmaz, Hakan Kisaoglu, Ozge Baba, Mukaddes Kalyoncu

{"title":"Spectrum of Central Nervous System Involvement in Childhood-Onset Sjögren's Syndrome: A Case-Based Review.","authors":"Furkan Can Yilmaz, Hakan Kisaoglu, Ozge Baba, Mukaddes Kalyoncu","doi":"10.31138/mjr.241123.soc","DOIUrl":"https://doi.org/10.31138/mjr.241123.soc","url":null,"abstract":"Sjögren's syndrome (SS) is less frequently diagnosed in childhood than in adults, and central nervous system (CNS) disease is among the rarest systemic involvements. Thus, the clinical spectrum of CNS diseases and their management strategies have not been fully defined. In this article, we present the case of a 16-year-old girl who was referred for severe headache and diagnosed with SS with CNS involvement. Several immunosuppressive treatments failed to improve her neurological symptoms until the rituximab treatment. When we systematically reviewed the literature on cases of CNS involvement in childhood-onset SS, we found that CNS involvement was the presenting feature at the diagnosis of SS in the majority of published cases. While headache and fever were the most frequent complaints at presentation, most of the children displayed features of neuromyelitis optica spectrum disorder. CNS disease showed a variable response to immunosuppressives, and residual neurological deficits were not rare. Additionally, a significant number of cases required treatment with rituximab due to the treatment failures or subsequent flares. Sjögren's syndrome should be considered in children presenting with predominant neurological symptoms, and careful evaluation of glandular features might help in the prompt diagnosis of childhood-onset SS in children with CNS disease.","PeriodicalId":32816,"journal":{"name":"Mediterranean Journal of Rheumatology","volume":"35 2","pages":"298-304"},"PeriodicalIF":0.0,"publicationDate":"2024-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11350415/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142112737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

COVID-19-Induced Rheumatoid Arthritis: Case Series and Systematic Review of the Literature. COVID-19诱发的类风湿性关节炎：病例系列和文献系统性综述。

Mediterranean Journal of Rheumatology Pub Date : 2024-05-21 eCollection Date: 2024-06-01 DOI: 10.31138/mjr.171223.cir

Selma Bouden, Hiba Ben Ayed, Leila Rouached, Aicha Ben Tekaya, Ines Mahmoud, Raoudha Tekaya, Olfa Saidane, Leila Abdelmoula

引用次数: 0

Adult-Onset Still's Disease with Distinctive Skin Signs and Elevated LDH. 伴有明显皮肤症状和 LDH 升高的成年型 Still's 病。

Mediterranean Journal of Rheumatology Pub Date : 2024-05-21 eCollection Date: 2024-06-01 DOI: 10.31138/mjr.200224.aod

Eleni Klimi, Evaggelia Kataxaki

引用次数: 0