Mediterranean Journal of Rheumatology最新文献

{"title":"The Bonding Force of Juvenile Idiopathic Arthritis-Families Transforming through JIA: A Qualitative Research Study.","authors":"Foteini Galani, Maria Magdalini Delliou, Christina Papachristou","doi":"10.31138/mjr.080424.qsr","DOIUrl":"10.31138/mjr.080424.qsr","url":null,"abstract":"<p><strong>Objectives: </strong>Central aim of this research was to investigate the experience of parents with a child diagnosed with Juvenile Idiopathic Arthritis (JIA) and the interplay of JIA, family dynamics, everyday life, and the developing coping mechanisms to deal with potential life changes.</p><p><strong>Methods: </strong>A qualitative psychology-based research methodology was applied. Data were collected through online in-depth semi-structured interviews with parents of one offspring with JIA. The anonymised interview transcripts were analysed following the principles of interpretative phenomenological analysis. Nine parents (M:F, 3:6) aged 39-51 years (mean=47), were included in the study with their children having the diagnosis of different JIA subtypes.</p><p><strong>Results: </strong>JIA appears to have led our sample to the creation of strong bonding between parents, siblings, and the patient (9/9). Additionally, JIA altered the family members' daily life by shifting their focus on the disease management (9/9). The upcoming stress led parents to develop a variety of coping mechanisms (9/9) with 3/9 parents sought reliable information from health professionals, 7/9 looked for psychological support and 6/9 shared their experience with other JIA affected families. Impressively, 5/9 reported that JIA eventually has a positive impact on their family, with JIA minors presented as disciplined and empathetic fighters (4/9).</p><p><strong>Conclusion: </strong>JIA was found to be a great challenge from the parents' perspective, especially during the post-diagnosis period. However, most of the interviewed family members gradually accommodated to JIA and acknowledged even its beneficial contribution.</p>","PeriodicalId":32816,"journal":{"name":"Mediterranean Journal of Rheumatology","volume":"36 2","pages":"210-214"},"PeriodicalIF":0.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12312471/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144776364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interventions Related to Takayasu Arteritis, their Clinical and Angiographic Associations, and Prognostic Relevance - A Cohort Study.","authors":"Sandeep Balakrishnan, Upendra Rathore, Mishra Prabhaker, Darpan R Thakare, Kritika Singh, Tooba Qamar, Deeksha Singh, Juhi Dixit, Manas Ranjan Behera, Neeraj Jain, Manish Ora, Dharmendra Singh Bhadauria, Sanjay Gambhir, Vikas Agarwal, Sudeep Kumar, Sudeep Durga Prasanna Misra","doi":"10.31138/mjr.030924.has","DOIUrl":"10.31138/mjr.030924.has","url":null,"abstract":"<p><strong>Objectives: </strong>We analysed interventions related to TAK, their pre-treatment clinical and angiographic associations, and prognostic relevance from a large ambispective, monocentric cohort of TAK from India.</p><p><strong>Methods: </strong>Information regarding endovascular or open surgical interventions (aortoplasty, nephrectomy for refractory hypertension) was retrieved from a cohort of patients with TAK. Demographic characteristics, clinical features, and angiographic involvement were compared between patients with TAK who had undergone interventions with the rest of the cohort using multivariable-adjusted odds ratios (OR, with 95% CI). Hazard ratios were used to compare the mortality rate among TAK who had undergone interventions.</p><p><strong>Results: </strong>Among 238 patients with TAK in the cohort, 41(17.23%) had undergone 69 interventions related to TAK (64 endovascular procedures, one open surgical aortoplasty, 4 nephrectomies) across 55 sittings (a single intervention sitting in 31, two in seven, three in two, and four in one). The most common arterial territories undergoing intervention were the renal arteries (n=21), subclavian arteries (n=8), and descending thoracic aorta (n=6). Six patients with TAK required repeated interventions in the same arterial territories. Patients with TAK who underwent interventions more frequently had abdominal angina (OR 5.12, 95%CI 1.36-19.26), and less often had constitutional features (OR 0.39, 0.18-0.84) at presentation without significant differences in angiography. Survival was similar in TAK who had undergone interventions to those without (hazard ratio for mortality 0.91, 95%CI 0.23-3.55).</p><p><strong>Conclusion: </strong>About one-sixth of our cohort of TAK had undergone interventions, most often endovascular interventions. One-fourth required multiple interventions. Survival was similar in TAK with or without interventions.</p>","PeriodicalId":32816,"journal":{"name":"Mediterranean Journal of Rheumatology","volume":"36 2","pages":"220-228"},"PeriodicalIF":0.0,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12312459/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144776349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Cognitive Impairment in Rheumatoid Arthritis.","authors":"Olfa Saidane, Khaoula Zouaoui, Selma Bouden, Leila Rouached, Rawdha Tekaya, Ines Mahmoud, Aicha Ben Tekaya, Leila Abdelmoula","doi":"10.31138/mjr.290724.sah","DOIUrl":"10.31138/mjr.290724.sah","url":null,"abstract":"<p><strong>Objective: </strong>The objectives of our study were to assess the prevalence of cognitive impairment in Rheumatoid arthritis (RA) and to identify its predictive factors.</p><p><strong>Methods: </strong>A 6-month cross-sectional case-control study englobing patients with RA was carried out. The cognitive evaluation was performed using the Mini Mental State Examination (MMSE), the frontal efficiency battery, the 5-word test, the clock drawing test and the Trail Making Test part-A (TMT-A). Linear regression analyses were conducted to identify predictors of cognitive impairment.</p><p><strong>Results: </strong>We included 35 RA patients and 35 controls. Concerning the RA group, the mean duration of the disease was 12.3 years [1-29 years]. RA was immunopositive in 80% of cases and erosive in 83% of cases. The global cognitive dysfunction assessed by MMSE score was 49%. Depending on the test used, the prevalence of cognitive impairment in RA ranged from 34% to 54%. RA patients presented poorer results regarding the TMT-A than the controls (p = 0.03). The other cognitive tests were comparable between the 2 groups. The main predictive independent factors of cognitive impairment among RA patients were advanced age (p = 0.002), rural environment (p = 0.007), low income (p = 0.01), recent course of RA (p = 0.006), low disease activity (p = 0.002) and low blood sugar (p = 0.003).</p><p><strong>Conclusion: </strong>Global cognitive impairment in RA concerned 49% of our patients. Early identification of the factors associated with this cognitive dysfunction is necessary in order to improve the quality of life of patients.</p>","PeriodicalId":32816,"journal":{"name":"Mediterranean Journal of Rheumatology","volume":"36 2","pages":"236-241"},"PeriodicalIF":0.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12312458/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144776341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum Albumin as an Early Predictor of Proteinuria Recovery in Lupus Nephritis.","authors":"Fadi Kharouf, Taraneh Tofighi, Heather N Reich, Qixuan Li, Jiandong Su, Dafna D Gladman, Zahi Touma","doi":"10.31138/mjr.040924.sai","DOIUrl":"10.31138/mjr.040924.sai","url":null,"abstract":"<p><strong>Background/purpose: </strong>Proteinuria, a slowly changing marker, is considered the best predictor of long-term renal outcomes in lupus nephritis (LN). In this study, we aimed to determine if serum albumin can serve as an early predictor of combined proteinuria recovery in LN.</p><p><strong>Methods: </strong>We studied patients diagnosed with LN with baseline and follow-up visits at 6-9 and 18-21 months. Receiver operating characteristic (ROC) curves were generated and the area under the curve (AUC) was analysed at different time points to test if serum albumin was a predictor of combined proteinuria recovery response (complete and partial proteinuria recovery, CPR+PPR) and primary efficacy proteinuria recovery (PEPR) at 6-9 and 18-21 months.</p><p><strong>Results: </strong>ROC curves for serum albumin level at baseline did not predict combined proteinuria recovery or PEPR at 6-9 or 18-21 months. However, serum albumin level at 6-9 months predicted combined proteinuria recovery at 6-9 months (AUC 0.77) and PEPR at 6-9 (AUC 0.83) and 18-21 months (AUC 0.83). Serum albumin absolute change (AUC=0.82) and percent change (AUC=0.81) from baseline to 6-9 months predicted the 6-9-month combined proteinuria recovery. Similarly, serum albumin absolute change (AUC=0.84) and percent change (AUC=0.82) from baseline to 18-21 months predicted the 18-21-month combined proteinuria recovery. A less pronounced, but similar signal was observed when PEPR was used as the endpoint at 6-9 (AUC 0.70 and 0.68, respectively) and 18-21 months (AUC 0.73 and 0.71, respectively).</p><p><strong>Conclusion: </strong>Serum albumin may serve as an accessible adjunct to proteinuria in assessing the clinical course and treatment response in LN.</p>","PeriodicalId":32816,"journal":{"name":"Mediterranean Journal of Rheumatology","volume":"36 2","pages":"242-250"},"PeriodicalIF":0.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12312462/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144776362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psoriatic Onycho-Pachydermo Periostitis (POPP).","authors":"Aline Serfaty, Flavia Costa, Luiza Feres, Alessandro Severo, Edson Marchiori, Clarissa Canella","doi":"10.31138/mjr.310724.iia","DOIUrl":"10.31138/mjr.310724.iia","url":null,"abstract":"","PeriodicalId":32816,"journal":{"name":"Mediterranean Journal of Rheumatology","volume":"36 2","pages":"347-349"},"PeriodicalIF":0.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12312468/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144776358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diffuse Idiopathic Skeletal Hyperostosis, beyond the Axial Skeleton: Extra-spinal DISH.","authors":"Eleftherios Pelechas, Aliki I Venetsanopoulou, Paraskevi V Voulgari, Alexandros A Drosos","doi":"10.31138/mjr.211024.bas","DOIUrl":"10.31138/mjr.211024.bas","url":null,"abstract":"","PeriodicalId":32816,"journal":{"name":"Mediterranean Journal of Rheumatology","volume":"36 1","pages":"144-146"},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12183440/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144486319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical Modalities for the Treatment of Pain in Patients with Fibromyalgia.","authors":"Ilke Coskun Benlidayi","doi":"10.31138/mjr.041124.pht","DOIUrl":"10.31138/mjr.041124.pht","url":null,"abstract":"<p><p>Generalised pain is the major symptom in patients with fibromyalgia. The management of pain includes both pharmacological and non-pharmacological options. Exercise, meditative movement therapies and mindfulness-based stress reduction are examples of non-pharmacological treatments. Over the last decades, there is growing evidence regarding the role of physical modalities in the management of fibromyalgia-related pain. Physical modalities demonstrate their effects by using several energy types such as electrical, thermal, acoustic, or radiant energy. They may act through the alteration of blood flow, cellular activity, and nerve excitability. By reviewing the recent literature, the current article aimed to provide a comprehensive insight to the potential effects of physical modalities in the treatment of fibromyalgia-related pain. Evidence regarding the potential therapeutic role of transcutaneous electrical nerve stimulation, interferential current, therapeutic ultrasound, non-invasive brain stimulation techniques (e.g. transcranial direct current stimulation, transcranial magnetic stimulation), photobiomodulation therapy [e.g. Light Amplification by Stimulated Emission of Radiation (LASER)], the use of therapeutic cold (e.g. whole-body cryotherapy) was discussed.</p>","PeriodicalId":32816,"journal":{"name":"Mediterranean Journal of Rheumatology","volume":"36 1","pages":"12-27"},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12183450/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144486323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Anti-Synthetase Syndrome in Patients of Interstitial Lung Disease with Connective Tissue Diseases and Autoimmune Features: A Cross-Sectional Study.","authors":"Indu Mb, Desh Deepak, Ajay Bhatta, Gunjan Lalwani, Brijesh Sharma, Vardhini Somayya, Mala Chhabra, Nandini Duggal","doi":"10.31138/mjr.180324.dtc","DOIUrl":"10.31138/mjr.180324.dtc","url":null,"abstract":"<p><strong>Objective: </strong>Anti-synthetase syndrome (ASS) is a rare autoimmune disease with heterogenous manifestations. Interstitial lung disease (ILD) is one among its common manifestations. The aim of this study was to evaluate the prevalence of ASS in cases of ILD associated with autoimmune features and describe the clinical, serological, and radiological profile in them.</p><p><strong>Methods: </strong>This cross-sectional study included a total of 100 patients: 50 cases each of connective tissue disease-related ILD (CTD-ILD) and interstitial pneumonia with autoimmune features (IPAF).</p><p><strong>Results: </strong>Four cases of CTD-ILD and 7 cases of IPAF had anti-ARS auto-antibodies. All eleven of them fulfilled Connor's criteria for ASS. The classic triad of arthritis, myositis, and ILD was present only in two cases. Anti-nuclear antibody (ANA) was positive in 63.6%. Anti-Jo1 (54.56%), Anti-PL12(27.3%), anti-PL7(18.2%), and anti-EJ(18.2%) were the anti ARS autoantibodies. Though generally considered to be mutually exclusive, anti-PL12 and anti-EJ antibodies were found together in two cases. Myalgia was associated with all four ARS antibodies. Anti-Jo1 antibody was associated with Raynaud's phenomenon, polyarthralgia, polyarthritis, and myopathy. Anti-PL7 antibody was associated with myopathy and mechanic's hands. Anti-PL12 and anti-EJ antibodies were associated with inflammatory poly-arthritis, polyarthralgia, and unexplained fever. Non-specific interstitial pneumonia (NSIP) was the most common radiologic pattern of ILD (81.8%). The remaining two had Usual interstitial pneumonia (UIP) pattern and were positive for anti-Jo1 antibody.</p><p><strong>Conclusion: </strong>ASS can present in many ways, often incomplete at the onset without the classic clinical triad. Anti-ARS autoantibodies can be found in established CTDs. Anti-cytoplasmic antibodies (not ANA) must be used to screen for ASS in suspected cases.</p>","PeriodicalId":32816,"journal":{"name":"Mediterranean Journal of Rheumatology","volume":"36 1","pages":"107-115"},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12183454/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144486326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Weight Loss, but Not at Any Cost: Risks and Challenges in Patients with Osteoarthritis.","authors":"Tsvetoslav Georgiev, Plamena Kabakchieva","doi":"10.31138/mjr.121224.wlc","DOIUrl":"10.31138/mjr.121224.wlc","url":null,"abstract":"<p><p>Osteoarthritis (OA) is a prevalent joint disorder characterised by the deterioration of the entire joint. Among its primary risk factors, obesity significantly contributes to OA onset and progression. Weight reduction in individuals with OA can alleviate pain, enhance joint function, and potentially delay or prevent the need for surgical interventions. However, despite these benefits, the potential risks and detriments associated with weight loss in OA patients warrant careful evaluation. This review synthesises available data on the multifaceted effects of weight loss interventions in OA patients, including risks of weight regain, malnutrition, sarcopenia, joint instability, bone density reduction, and psychoemotional stress due to fluctuating weight. A comprehensive search was conducted across major databases, identifying studies that assessed the physical, mental, and quality of life impacts of weight loss in knee and hip OA populations. Rapid weight loss may destabilise joints, lead to muscle and bone loss, and increase the risk of malnutrition and osteoporosis. Additionally, psychological distress from weight loss failures or fluctuations can adversely affect mental health and quality of life, underscoring the need for balanced weight management strategies. Long-term weight loss maintenance remains a challenge, with high rates of weight regain observed in OA patients. Emerging anti-obesity drugs hold potential for more sustained outcomes, albeit with uncertainties remaining. By adopting a holistic approach that addresses both physical and mental aspects, healthcare providers can improve outcomes and quality of life for OA patients, tailoring strategies to reduce the potential harms associated with aggressive or unsupervised weight reduction efforts.</p>","PeriodicalId":32816,"journal":{"name":"Mediterranean Journal of Rheumatology","volume":"36 1","pages":"28-35"},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12183455/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144486330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary Recommendations from the Moroccan Society for Rheumatology (SMR) for Patients with Chronic Inflammatory Rheumatic Diseases.","authors":"Hind El-Kasmi, Samira Rostom, Salma Zemrani, Bouchra Amine, Latifa Tahiri, Nessrine Akasbi, Kawtar Nassar, Soumiya Mehdioui, Sara Wakrim, Racha Lahlou, Nada Bensaoud, Rachina Bahiri","doi":"10.31138/mjr.030624.dra","DOIUrl":"10.31138/mjr.030624.dra","url":null,"abstract":"<p><p>This work was conducted under the auspices of the Moroccan Society of Rheumatology (SMR) with the aim of developing best practice medical guidelines for the dietary management of patients with Chronic Inflammatory Rheumatic Diseases (IRDs). A working group composed of rheumatology experts and two nutritionists was formed. This group relied on a synthesis of the literature and expert opinions. These guidelines were then validated by a group of rheumatology experts. The methodology followed the procedure proposed by the European League Against Rheumatism (EULAR). Five general principles and eleven recommendations were established. These principles emphasise that diet should complement, rather than replace, pharmacological treatment and should be integrated into the overall management of patients with IRDs. Additionally, it should be associated with appropriate physical activity and take cultural and socio-economic context into account. These recommendations highlight the importance of weight loss for overweight or obese patients and advocate for the Mediterranean diet as well as a diet rich in omega-3. However, exclusion diets such as gluten-free, vegetarian, and dairy-free diets, as well as supplementation with probiotics or spices, are currently not recommended for patients with IRDs. Supplementation with vitamins or trace elements is not systematically recommended, and the data concerning Ramadan fasting or intermittent fasting are limited or contradictory. Furthermore, two specific recommendations for the Moroccan diet were proposed. These recommendations standardise dietary management in IRDs, making it accessible for practitioners and patients.</p>","PeriodicalId":32816,"journal":{"name":"Mediterranean Journal of Rheumatology","volume":"36 1","pages":"36-49"},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12183447/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144486318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}