Mediterranean Journal of Rheumatology最新文献

{"title":"An Observational Study on Clinical Insights and Outcome Prediction of Lupus Enteritis in Indian Systemic Lupus Erythematosus Patients.","authors":"Sowmya Kotha, Ritasman Baisya, Keerthi Vardhan Yerram, Arjun Kumar Ramavath, G S R Murthy, Phani Kumar Devarasetti, Liza Rajasekhar","doi":"10.31138/mjr.300924.ioe","DOIUrl":"10.31138/mjr.300924.ioe","url":null,"abstract":"<p><strong>Background: </strong>Lupus enteritis (LE) is the most common serious gastrointestinal manifestation of SLE. Indian literature on LE is limited, while most of the data comes from China and Western series with recent efforts on developing prediction models for its occurrence & recurrence<b>.</b></p><p><strong>Objectives: </strong>The objectives of the study were to analyse clinical and laboratory parameters of LE, to compare recurrent versus non-recurrent LE and to identify predictors of its recurrence and mortality.</p><p><strong>Method: </strong>Patients with LE who were admitted to the Rheumatology ward from 2018-2022 were considered cases. For cases, symptoms, abdominal CT findings, and outcome (recurrence or death) were recorded. Logistic regression was used for the prediction of recurrence and mortality.</p><p><strong>Result: </strong>Among 48 LE patients, 45 were female. The mean (± SD) age of the first enteritis episode was 27.04± 8.92 years. The most frequent extra-gastrointestinal manifestations were nephritis and arthritis (54% of cases). Mean disease duration, lupus nephritis, arthritis, and mean SLEDAI were higher in non-LE patients. Thirteen (27.1%) patients had recurrent LE & hydroureteronephrosis was more prevalent in them (p = 0.002). The logistic regression model using dsDNA complements and albumin failed to predict recurrence. Multiple repetitions of the confusion matrix for the mortality prediction model yielded variable ρ scores, suggesting insignificant accuracy prediction.</p><p><strong>Conclusion: </strong>Colon and bladder involvement is more frequent in recurrent LE. Anti-dsDNA antibodies, complement, disease activity index, and serum albumin failed to predict recurrence and mortality in our cohort.</p>","PeriodicalId":32816,"journal":{"name":"Mediterranean Journal of Rheumatology","volume":"36 2","pages":"251-258"},"PeriodicalIF":0.0,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12312470/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144776340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Value and Predictive Factors for a Positive Labial Minor Salivary Gland Biopsy for Sjögren's Syndrome in a Tunisian Population.","authors":"Dhouha Bacha, Mourad Touati, Zeineb Meddeb, Ahlem Lahmar, Salwa Hamzaoui, Sana Ben Slama","doi":"10.31138/mjr.080724.hba","DOIUrl":"10.31138/mjr.080724.hba","url":null,"abstract":"<p><strong>Objectives: </strong>To examine the performance of the minor salivary gland biopsy (MSGB) to diagnose Sjögren's syndrome (SS) and to identify predictive factors for MSGB's positivity in Tunisian SS-suspected patients.</p><p><strong>Methods: </strong>In a retrospective study, histopathological evaluation of MSGB from SS suspected- patients were examined. The classifications of the American-European Consensus Group (AECG, 2002) and the American College of Rheumatology/European League Against Rheumatism (ACR/EULAR, 2016) have been applied. We classified a positive MSGB when a focus score ≥ 1 and/or Chisholm and Mason grading ≥ 3 were observed. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of MSGB were assessed, and the area under the ROC curve was performed to evaluate its diagnostic accuracy.</p><p><strong>Results: </strong>One hundred and two MSGBs were examined. They were positive in 48 patients (47%). For the positive diagnosis of SS, MSGB had 77,6% sensitivity, 93,2% specificity, 93,8% PPV and 75,9% NPV. With an air under the curve (AUC) of 0.854, MSGB was considered an excellent discriminating test in SS diagnosis. Keratoconjunctivitis sicca (p=0.04), elevated erythrocyte sedimentation rate (p=0.036), leukopenia (p=0.025), positive antibodies: anti-Ro/SSA (p=0.029), anti-Ro/SSA, anti-La/SSB (p=0.037), antinuclear (p=0.01), anti-extractable nuclear antigen (p=0.04), positive rheumatoid factor (p=0.032), positive elevated IgG levels (p=0.03) and abnormal unstimulated whole salivary flow rate (p=0.002) were predictive of a positive MSGB.</p><p><strong>Conclusion: </strong>In cases of suspected SS, a predictive scoring system incorporating these clinical and biological factors will streamline MSGB indications and serve as a diagnostic tool for positive SS diagnosis in research studies.</p>","PeriodicalId":32816,"journal":{"name":"Mediterranean Journal of Rheumatology","volume":"36 2","pages":"259-267"},"PeriodicalIF":0.0,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12312473/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144776347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Our Three Musketeers: A Case Series of NLRP-3 Associated Cryopyrinopathies.","authors":"Sumanth Madan, Spoorthy Raj, Sudeep Rath, Joslyn M Thattil, Ashvin Pillai, Mithun Cb, Suma Balan","doi":"10.31138/mjr.240624.eyr","DOIUrl":"10.31138/mjr.240624.eyr","url":null,"abstract":"<p><p>Autoinflammatory diseases affecting the NLRP3 gene are rare autosomal dominant disorders presenting with episodic organ limited and systemic inflammation. We report three patients with cryopyrinopathies. Our first case is a 4-year-old boy with a history of periodic fever, failure to thrive, and raised intracranial pressure. The second case is a 6-year-old boy with similar complaints, also with bilateral uveitis. The third is a 24-year-old gentleman with periodic fever and early hearing loss, also with a novel presentation of sacroiliitis. Our case series demonstrates that there should be a low clinical threshold indicating genetic testing in any child who displays features of autoinflammation in combination with an urticarial rash, musculoskeletal manifestations, hearing loss, and chronic aseptic meningitis with macrocephaly. Furthermore, despite anakinra being a cornerstone in treating NLRP-3 AID, there is an unmet clinical need to provide access to alternatives such as colchicine and thalidomide in resource-limited settings.</p>","PeriodicalId":32816,"journal":{"name":"Mediterranean Journal of Rheumatology","volume":"36 2","pages":"329-334"},"PeriodicalIF":0.0,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12312474/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144776356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Secukinumab-Induced Severe Palmoplantar Psoriasis treated with Guselkumab: A Case Report.","authors":"Ibrahim Al-Homood, Nourah Alaboon, Hoda E Draz","doi":"10.31138/mjr.110525.ary","DOIUrl":"10.31138/mjr.110525.ary","url":null,"abstract":"<p><strong>Background: </strong>Secukinumab is a monoclonal antibody targeting interleukin-17A (IL-17A), approved for the treatment of moderate-to-severe plaque psoriasis and psoriatic arthritis. While effective for many patients, it has been associated with paradoxical reactions such as exacerbation of psoriasis or drug-induced dermatitis. This case report presents a unique occurrence of severe palmoplantar psoriasis triggered by Secukinumab in a patient with psoriatic arthritis and multiple sclerosis (MS), necessitating a switch to another biologic therapy.</p><p><strong>Case presentation: </strong>A 41-year-old female with a complex medical history including MS presented with severe desquamation and erythematous skin lesions on the hands, feet, and legs following treatment with secukinumab for psoriatic arthritis that necessitated discontinuation of secukinumab. A biopsy suggested drug eruption, with a differential diagnosis including palmoplantar pustular psoriasis. After multidisciplinary consultation, treatment was switched to guselkumab, an IL-23 inhibitor, which resulted in clinical improvement.</p><p><strong>Conclusion: </strong>This case highlights the potential for paradoxical reactions to IL-17 inhibitors and the efficacy of IL-23 inhibitors as an alternative therapy. Multidisciplinary approach was crucial for optimal patient management.</p>","PeriodicalId":32816,"journal":{"name":"Mediterranean Journal of Rheumatology","volume":"36 2","pages":"343-346"},"PeriodicalIF":0.0,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12312460/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144776361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and Impact of Central Sensitisation and Kinesiophobia on Functional Capacity and Quality of Life in Behçet's Disease: A Cross-Sectional Study.","authors":"Gülay Alp, Fulden Sari","doi":"10.31138/mjr.061124.oal","DOIUrl":"10.31138/mjr.061124.oal","url":null,"abstract":"<p><strong>Objective: </strong>Behçet's disease (BD) may experience heightened pain sensitivity, potentially related to central sensitisation (CS). The hypersensitive central nervous system causes physical inactivity and kinesiophobia due to overreacting to stimuli that would not usually cause pain. This study aims to determine the frequency of CS in patients with BD and to evaluate the relationship between CS and kinesiophobia, exercise capacity, disease activity, and quality of life (QoL).</p><p><strong>Methods: </strong>The study, which included 55 patients with BD and 55 healthy controls (HCs), employed a comprehensive approach. All participants were administered the Tampa Kinesiophobia Scale (TKS), the 6-minute walk test (6MWT), and the central sensitisation inventory.</p><p><strong>Results: </strong>CS was detected in 61.4% of with BD. Among the 55 patients, 24 (45.5%) were male, with a median age of 42 years (IQR 17) and a median disease duration of 8 years (IQR 10). Compared to age- and gender-matched HCs, patients with BD exhibited higher CS, increased kinesiophobia, and shorter walking distances. There were moderate correlations between CS scores and the 6MWT, TKS, BDCAF, and BDQoL in patients with BD (Rho = 0.51, Rho = 0.56, Rho = 0.48, and Rho = 0.56, respectively; all p-values < .001). Hierarchical linear regression analysis demonstrated a significant association between QoL and the presence of CS (95% Confidence Interval (CI) 0.033-0.562, p=0.028) and kinesiophobia (95% CI 0.245-0.766, p < 0.001).</p><p><strong>Conclusion: </strong>The prevalence of CS and kinesiophobia in BD patients is a significant finding, shedding light on the factors contributing to reduced QoL and functional exercise capacity.</p>","PeriodicalId":32816,"journal":{"name":"Mediterranean Journal of Rheumatology","volume":"36 2","pages":"274-281"},"PeriodicalIF":0.0,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12312461/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144776357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Calcinosis Universalis: An Atypical Presentation of Mi-2 Positive Juvenile Dermatomyositis - A Case-Based Review.","authors":"Rajat Kumar Sahu, Abhishek Gollarahalli Patel, Rajat Gupta, Kishan Majithiya, Urmila Dhakad","doi":"10.31138/mjr.291024.cua","DOIUrl":"10.31138/mjr.291024.cua","url":null,"abstract":"<p><strong>Background: </strong>Juvenile Dermatomyositis (JDM) is a systemic autoimmune disease in children, characterised by skin and muscle inflammation, with incidence of 1.6 to 4 cases per million children annually. Calcinosis, affecting 20% to 70% of JDM patients, can lead to significant morbidity. The association of calcinosis with anti-Mi-2 antibodies is rare and complicates management.</p><p><strong>Case: </strong>We present a rare case of a 12-year-old girl diagnosed with JDM, extensive calcinosis, and positive anti-Mi-2 antibodies. The patient exhibited significant muscle weakness, skin manifestations, and painful calcinosis leading to contractures. Initial management included tofacitinib and intravenous pamidronate, resulting in no new calcinosis formation.</p><p><strong>Discussion: </strong>A comprehensive review of existing literature highlights the rarity of calcinosis in anti-Mi-2 positive patients. While traditional treatments have shown variable effectiveness, emerging therapies like JAK (Janus Kinase) inhibitors may offer new avenues for management. The literature underscores the need for personalised treatment strategies given the atypical presentations and outcomes.</p><p><strong>Conclusion: </strong>This case adds to the limited documentation of calcinosis in JDM with anti-Mi-2 antibodies, emphasising the need for increased awareness and research. Personalised treatment approaches are crucial, and future studies should focus on larger datasets and emerging therapeutic modalities to optimise management and improve patient outcomes.</p>","PeriodicalId":32816,"journal":{"name":"Mediterranean Journal of Rheumatology","volume":"36 2","pages":"308-315"},"PeriodicalIF":0.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12312478/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144776343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Behçet's Disease with Intestinal Involvement can be Distinguished from Inflammatory Bowel Diseases by Measurement of Common Femoral Vein Wall Thickness.","authors":"Gizem Sevik, Rabia Ergelen, Ilkay Ergenc, Efe Soydemir, Fatma Temiz, Ozlen Atug, Haner Direskeneli, Fatma Alibaz-Oner","doi":"10.31138/mjr.120824.dfh","DOIUrl":"10.31138/mjr.120824.dfh","url":null,"abstract":"<p><strong>Objective/aim: </strong>Differentiating the gastrointestinal (GI) involvement of Behçet's disease (BD) and inflammatory bowel diseases (IBD) can be a diagnostic challenge. We previously reported that the wall thickness of the common femoral vein (CFV) is higher in BD patients compared to Crohn's disease (CD) with a limited number of IBD patients with only CD. This study aimed to evaluate the CFV thickness measurement in BD patients and in a larger group of IBD patients including both ulcerative colitis (UC) and CD.</p><p><strong>Methods: </strong>The study included patients with BD (n=117), IBD (n=87, [53 CD, 34 UC]), and healthy gender-matched controls (HC) (n=85). CFV wall thicknesses were measured with Doppler ultrasonography.</p><p><strong>Results: </strong>Among BD patients, 70 (59.8%) had major organ (48[41.0%] vascular, 21[30.0%] ocular, 11[15.7%] gastrointestinal, and 8[11.4%] neurological) involvement. The mean right CFV thickness was 0.75±0.21 mm, 0.32±0.08 mm, and 0.28±0.13 mm for BD, IBD, and HC, respectively (p<0.001). BD patients had significantly higher CFV wall thicknesses compared to IBD patients and HC (adj. p<0.001 for both), and CFV thicknesses in IBD were comparable to HC (adj.p>0.05). Among BD patients, CFV thicknesses did not differ in patients with and without GI involvement. CFV thicknesses were also similar in patients with CD and UC.</p><p><strong>Conclusion: </strong>CFV thickness was significantly higher in BD compared to CD and UC patients. These results suggest that the CFV wall thickness measurement may be used in daily practice to differentiate GIBD from IBD.</p>","PeriodicalId":32816,"journal":{"name":"Mediterranean Journal of Rheumatology","volume":"36 2","pages":"268-272"},"PeriodicalIF":0.0,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12312481/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144776342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Individual Cortisol Production in Active Rheumatoid Arthritis Associates with Treatment Responses: A Pilot, Two-Year Study.","authors":"Maria G Filippa, Maria P Yavropoulou, Nikolaos I Vlachogiannis, George E Fragoulis, Aimilia Mantzou, Aggeliki Papapanagiotou, Maria G Tektonidou, George P Chrousos, Petros P Sfikakis","doi":"10.31138/mjr.131224.ipc","DOIUrl":"10.31138/mjr.131224.ipc","url":null,"abstract":"<p><strong>Introduction: </strong>Inadequate production of cortisol in relation to increased demands of chronic inflammation, a phenomenon coined as the \"disproportion-principle\", occurs in some patients with active rheumatoid arthritis (RA). Moreover, relatively lower diurnal cortisol production prior to antirheumatic treatment initiation/escalation for active RA has been associated with inadequate corresponding treatment responses after 6-months.</p><p><strong>Objective: </strong>To evaluate whether individual levels of endogenous cortisol in active RA patients followed in an Academic Rheumatology Unit may predict the type of response to subsequent antirheumatic treatment regimens after two years.</p><p><strong>Methods: </strong>We measured morning circulating ACTH, cortisol and DHEAS blood levels, as well as saliva diurnal-cortisol levels (collected samples at 08:00, 12:00, 18:00, 22:00), prior to treatment initiation/escalation in RA patients with active disease. In a pilot study, we prospectively examined for possible associations between these measurements and treatment responses at two years in those 24 patients who were under optimal management according to standard protocols.</p><p><strong>Results: </strong>The ratio of circulating cortisol/ACTH, as well as diurnal cortisol production at baseline were significantly lower in patients with moderate response or no response to treatment (7/24, 29%), than in those having disease remission at two-years (17/24, 71 %). Baseline diurnal-cortisol-production greater than 81.3 (calculated as area-under-the-curve) could predict remission at 24 months with 86% specificity and 65% sensitivity, independently of age, sex and baseline CRP levels (p=0.03).</p><p><strong>Conclusions: </strong>Further studies to confirm that lower diurnal cortisol production prior to treatment initiation/escalation in patients with active RA may predict inadequate corresponding responses in the long-term, are warranted.</p>","PeriodicalId":32816,"journal":{"name":"Mediterranean Journal of Rheumatology","volume":"36 2","pages":"193-199"},"PeriodicalIF":0.0,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12312476/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144776348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lupus Enteritis: Presentation as an Apparent Surgical Emergency - A Case Report.","authors":"Aarti A Zope, Shashank M Akerkar, Pooja G Binnani, Prajakti S Akerkar","doi":"10.31138/mjr.090324.ari","DOIUrl":"10.31138/mjr.090324.ari","url":null,"abstract":"<p><p>Systemic Lupus Erythematosus (SLE) is an autoimmune disease with varied organ involvement. Gastrointestinal (GI) involvement in SLE is common, with oral mucosal lesions being the most frequently seen. Acute abdomen as a surgical emergency in SLE patients can have multiple causes. Lupus enteritis (LE)/Intestinal pseudo-obstruction (IPO) can present as acute abdomen, thereby requiring surgical reference. We hereby present a case of SLE presenting with acute abdomen due to LE/IPO, which prompted the surgeon for surgical intervention. Timely diagnosis and prompt response to steroids lead to resolution of symptoms in our case, and avoided unnecessary surgical exploration and further complications. One should keep a high degree of suspicion while managing SLE patients presenting with acute abdominal pain. Our case underscores the clinical significance of discerning lupus-related GI complications, aligning with existing literature emphasising the need for heightened clinical suspicion in acute abdominal scenarios in SLE. In this case, the patient's acute abdomen prompted surgical consideration, reflecting the challenges in differentiating lupus-related complications from surgical emergencies.</p>","PeriodicalId":32816,"journal":{"name":"Mediterranean Journal of Rheumatology","volume":"36 2","pages":"335-338"},"PeriodicalIF":0.0,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12312463/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144776354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rheumatic Manifestations in Patients with Idiopathic Inflammatory Bowel Disease: A Single Tertiary Centre, Interdisciplinary Study.","authors":"Athanasios Kavvadias, Maria Karavasili, Eleftherios Pelechas, Maria Veatriki Christodoulou, Voulgari Paraskevi V, Konstantinos H Katsanos, Dimitrios K Christodoulou","doi":"10.31138/mjr.291123.ept","DOIUrl":"10.31138/mjr.291123.ept","url":null,"abstract":"<p><strong>Background: </strong>Inflammatory bowel disease is closely associated with extraintestinal manifestations. Among them, joint involvement and enthesitis are the most frequent resembling a spondyloarthropathy. Enthesitis may be clinically silent in a high proportion of these patients without any clinical signs or a diagnosis of spondyloarthritis.</p><p><strong>Objectives: </strong>To evaluate, with the use of musculo-skeletal ultrasound, the frequency and location of musculoskeletal manifestations in patients with inflammatory bowel disease.</p><p><strong>Methods: </strong>Fifty patients with a definite diagnosis of inflammatory bowel disease were prospectively recruited and clinically evaluated by a rheumatologist for relevant musculoskeletal symptoms. All of the patients underwent a thorough musculo-skeletal ultrasound examination of both knees, patellae, as well as upper and lower limbs, in order to identify synovitis, and enthesitis. Musculo-skeletal ultrasound examination was performed at 12 entheses. The ultrasound abnormalities were scored according to the Madrid Ankylosing Spondylitis Enthesitis Index. Results: The musculo-skeletal ultrasound examination performed, revealed the presence of synovitis in 24% and enthesitis in 64% of these patients. More specifically, in 6.3% of the \"Quadriceps tendon\", in 40.6% in the \"Achilles tendon\", in 40.6% in the \"Quadriceps and Achilles\", in 9.4% in the \"Triceps, Quadriceps and Achilles' and at a rate of 3.1% in the 'Patella'.</p><p><strong>Conclusions: </strong>The musculo-skeletal ultrasound verified that a significant percentage of the patients exhibit some type of \"musculoskeletal manifestations\", with enthesitis to be the most common of them in patients suffering from inflammatory bowel disease.</p>","PeriodicalId":32816,"journal":{"name":"Mediterranean Journal of Rheumatology","volume":"36 2","pages":"215-219"},"PeriodicalIF":0.0,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12312475/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144776359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}