Heart Views最新文献

{"title":"Attending Art is Not Medicine.","authors":"Christos Voucharas, Anysia Koukouthaki","doi":"10.4103/heartviews.heartviews_3_24","DOIUrl":"https://doi.org/10.4103/heartviews.heartviews_3_24","url":null,"abstract":"","PeriodicalId":32654,"journal":{"name":"Heart Views","volume":"25 4","pages":"288"},"PeriodicalIF":0.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12139648/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144249949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Repurposing Cyclic Guanosine Monophosphate Pathway Medications, from Vasodilation toward Changing the Face of Heart Failure.","authors":"Antoine Fakhry AbdelMassih, Buthaina Ramadan, Jana Tarek ElDemerdash, Monia Mostafa Zayed, M Wasim Soued, Nadine El-Husseiny, Yousef M Husseiny, Passant Saad","doi":"10.4103/heartviews.heartviews_122_24","DOIUrl":"10.4103/heartviews.heartviews_122_24","url":null,"abstract":"<p><p>Advanced heart failure (HF) is characterized by repeated hospital admissions due to recurring need for intravenous inotropes. Among the most commonly used medications used in this context, is milrinone, which increases the myocardial relaxation velocity, what is known as lusitropy. This effect is mediated by increasing cyclic adenosine monophosphate, which in turn switches on phospholamban (PLB) activity, an enzyme promoting calcium reuptake by the sarcoplasmic reticulum. The aim of this review is to shed light on oral medications that can play a similar role by alternative pathways. PLB can be as well stimulated by cyclic guanosine monophosphate (cGMP), the latter is known to be increased by medications which inhibit phosphodiesterase 5. Two well-established drugs can perform this action and are currently exclusively used as vasodilators, namely sildenafil and tadalafil. Another emerging hope is vericiguat; a medication that can directly stimulate guanylyl cyclase, leading to increase in cGMP. We speculate that the possible introduction of these oral medications is thought to replace the need for repeated hospital and intensive care admissions. This also might mean delaying the necessity for mechanical support or transplantations, which can change the face of advanced or end-stage HF.</p>","PeriodicalId":32654,"journal":{"name":"Heart Views","volume":"25 4","pages":"255-259"},"PeriodicalIF":0.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12139643/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144249969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of Platelet Volume Indices and their utility in Acute Coronary Syndrome.","authors":"Aadil Ahmed Mir, Afaq Ahmed Khan, Jan Mohd Sheikh, Mohd Iqbal Dar, Hilal Ahmed Rather, Aijaz Ahmed Lone, Imran Hafeez, Aamir Rashid","doi":"10.4103/heartviews.heartviews_61_24","DOIUrl":"10.4103/heartviews.heartviews_61_24","url":null,"abstract":"<p><strong>Background: </strong>Higher Mean Platelet Volume (MPV) may become useful marker for early detection and prognostication of Acute Coronary Syndrome (ACS) along with other biomarkers.</p><p><strong>Aim of the study: </strong>To study and analyse platelet volume indices (PVI) in ACS patients.</p><p><strong>Material and methods: </strong>The blood samples of patients diagnosed as acute coronary syndrome were analysed and complete blood count analysis were done including PVI. The PVI of different groups of acute coronary syndromes were compared with each other and to age and sex matched healthy controls.</p><p><strong>Results: </strong>The mean MPV of ACS group was 11.2±1.45 fL and was significantly higher than control group 8.9±1.12 fL. Among ACS cases mean MPV of STEMI was 11.51±1.44fL, in NSTEMI it was 10.83±1.51fL and in unstable angina (UA) it was 9.21±1.36 fL. Significantly higher in STEMI followed by NSTEMI than unstable angina. The mean PDW of ACS cases was 18.2±1.52fL and was significantly higher than control group 16.8±1.28fL. Among ACS cases it was significantly higher in STEMI 18.37±1.48fL than NSTEMI 17.91±1.46fL and it was significantly higher than UA group 17.04±1.88 fL. The mean PCT of ACS cases was 0.231±0.042% was significantly higher than controls 0.173±0.023%.</p><p><strong>Conclusion: </strong>PVI provides an important, simple, effortless, and cost-effective tool, which can be useful in predicting and prognosticating an acute coronary event. MPV and PDW has the potential to be used as a preliminary test to identify high-risk patients for myocardial infarction.</p>","PeriodicalId":32654,"journal":{"name":"Heart Views","volume":"25 4","pages":"229-235"},"PeriodicalIF":0.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12139637/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144249948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Navigating a Case of Swyer Syndrome with Congenital Heart Disease.","authors":"K Subramanyam, Dilip Johny, Amita Rao, Aditya Ojha","doi":"10.4103/heartviews.heartviews_139_24","DOIUrl":"10.4103/heartviews.heartviews_139_24","url":null,"abstract":"<p><p>A 38-year-old female underwent septal closure for a large ostium secundum atrial septal defect (ASD) as she had progressive dyspnea. She was also found to have primary amenorrhea, for which she was evaluated. The clinical examination and investigations revealed a female phenotype and a male karyotype (46 XY). She was diagnosed with Swyer syndrome and subsequently started on hormone replacement therapy. This case highlights the presence of congenital heart disease and large ostium secundum ASD with left to right shunt in patients with Swyer syndrome, which has not been reported in the literature.</p>","PeriodicalId":32654,"journal":{"name":"Heart Views","volume":"25 4","pages":"283-287"},"PeriodicalIF":0.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12139638/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144249965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Different Facets of Myocarditis by Cardiac Magnetic Resonance Imaging.","authors":"Reem Alwasiah, Rana Saklou, Yazeed Almalki, Abdulrahman Alharbi, Ahmed Alsaileek, Ahmed Aljizeeri","doi":"10.4103/heartviews.heartviews_83_24","DOIUrl":"10.4103/heartviews.heartviews_83_24","url":null,"abstract":"<p><p>Myocarditis is an inflammatory condition affecting the myocardium and may have different etiologies. Patients usually present with chest pain and elevated levels of cardiac enzymes, mainly troponin. Cardiac magnetic resonance (CMR) imaging has emerged as the cornerstone test in the diagnosis of myocarditis. In this article, we present different CMR findings in cases of myocarditis.</p>","PeriodicalId":32654,"journal":{"name":"Heart Views","volume":"25 4","pages":"236-240"},"PeriodicalIF":0.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12139652/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144249970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coronary Stent Graft for Treatment of Right Internal Mammary Artery Pseudoaneurysm.","authors":"Abhay Krishna, Priti Singhania","doi":"10.4103/heartviews.heartviews_69_24","DOIUrl":"10.4103/heartviews.heartviews_69_24","url":null,"abstract":"<p><p>We report a case of partially thrombosed pseudoaneurysm of the right internal mammary artery (IMA) in a 20-year-old male, following penetrating chest wall trauma with a steel wire. He presented with a swelling over the anterior aspect of the right side of the chest. Ultrasonography showed that swelling was communicating with the right IMA. Computed tomography angiography of the chest further revealed it to be partially thrombosed pseudoaneurysm of the right IMA. Pseudoaneurysm was successfully treated percutaneously using 2.75 mm × 19 mm coronary stent graft (GraftMaster, Abbott Vascular). This case highlights the successful use of less invasive percutaneous technique for the management of IMA pseudoaneurysm.</p>","PeriodicalId":32654,"journal":{"name":"Heart Views","volume":"25 4","pages":"264-266"},"PeriodicalIF":0.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12139646/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144249961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Value of Normal Triglyceride Levels among Patients with Target Low-density Lipoproteins Presenting with First Acute Coronary Syndrome.","authors":"Ahmed Aljizeeri, Abdulkareem M Aloqbawi, Fahad Mohammed Albaqami, Mohammed Hamad Alhelal, Mohammed K Altoyan, Faisal A Bin Talib, Amjad Ahmed, Alwaleed Altuwaijri, Ahmed Alsahhaf, Waleed Aljasser, Nawaf Ziyad Alotaibi, Abdullah Moteb Albaz, Abdulaziz Algethami, Ahmed Alsaileek","doi":"10.4103/heartviews.heartviews_70_24","DOIUrl":"10.4103/heartviews.heartviews_70_24","url":null,"abstract":"<p><strong>Introduction: </strong>Hypercholesterolemia, mainly low-density lipoprotein cholesterol (LDL-C) and triglycerides (TGs), is a major risk factor for coronary artery disease (CAD). The prognostic value of lowering LDL-C and TG in patients with CAD is well studied. We sought to examine the prognostic value of TG among patients presenting with acute coronary syndrome (ACS) and target LDL-C level.</p><p><strong>Methods: </strong>This is a retrospective study of patients admitted with first-presentation ACS. We included patients with first-presentation ACS who had lipid profiles measured within 3 months before the presentation. Patients with prior ACS, congenital heart disease, and those without baseline lipid profiles were excluded. Target LDL-C level was defined as LDL-C <1.8 mmol/L, and normal TG level was defined as <1.7 mmol/L. The study subjects were followed up for major adverse cardiac events (MACE) (cardiac death and nonfatal myocardial infarction [MI]).</p><p><strong>Results: </strong>Among the 7020 patients admitted with ACS, 393 met the inclusion criteria. Of whom, 106 (mean age: 70.3 ± 10.7 years, 76% of males) had target LDL-C level and were included. CAD risk factors were prevalent among the cohort. The mean total cholesterol, LDL-C, and TG were 3.6 ± 0.9, 1.4 ± 0.3, and 1.7 ± 1.5 mmol/L, respectively. Most patients presented with non-ST-elevation MI (54.7%), followed by unstable angina (36.8%). Over a median follow-up of 5.6 years, 17 (16%) patients had MACE, of which 14.2% were nonfatal MI and 1.9% of patients had cardiac death. There was no statistically significant difference in MACE between those with normal and high levels of TG.</p><p><strong>Conclusions: </strong>In this retrospective cohort of patients presenting with first-presentation ACS, TG level did not confer an increased risk of MACE among patients with target LDL-C level.</p>","PeriodicalId":32654,"journal":{"name":"Heart Views","volume":"25 4","pages":"219-222"},"PeriodicalIF":0.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12139651/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144249968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Juvenile Mitral Stenosis Presenting as Acute Pulmonary Edema Treated with Balloon Mitral Valvotomy.","authors":"Newton Ghosh, Priyavardhan Mishra, Kshitij Balwaik, Anant Patil","doi":"10.4103/heartviews.heartviews_136_24","DOIUrl":"10.4103/heartviews.heartviews_136_24","url":null,"abstract":"<p><p>Juvenile mitral stenosis is defined by poor left atrial emptying due to limited opening of the mitral-valve orifice in patients under the age of 20 years. Balloon mitral valvotomy is the current treatment of choice for juvenile mitral stenosis. Here we report a case of a 14-year-old female presenting with signs of acute pulmonary oedema. Later on, underlying mitral stenosis was revealed on echocardiography. After evaluation, she was successfully managed by percutaneous balloon mitral valvotomy. Screening young patients with pulmonary oedema by two-dimensional echocardiography is necessary to evaluate the underlying cardiac cause.</p>","PeriodicalId":32654,"journal":{"name":"Heart Views","volume":"25 4","pages":"280-282"},"PeriodicalIF":0.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12139653/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144249963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Harnessing Artificial Intelligence in Cardiology: Advancements in Diagnosis, Treatment, and Patient Care.","authors":"Muhammad Hamza Shuja, Firzah Shakil, Syed Hasan Shuja, Minal Hasan, Maliha Edhi, Abeera Farooq Abbasi, Afia Jawaid, Shajia Shakil","doi":"10.4103/heartviews.heartviews_103_24","DOIUrl":"10.4103/heartviews.heartviews_103_24","url":null,"abstract":"<p><p>Heart disease remains a leading cause of morbidity and mortality globally, straining healthcare systems worldwide. Artificial intelligence (AI) offers transformative solutions in cardiology, enhancing early diagnosis, personalized treatment, and surgical precision. This review examines the impact of AI on cardiology, focusing on its role in analyzing medical images, predicting risk, and managing chronic diseases. AI algorithms and intense learning models have demonstrated exceptional proficiency in interpreting imaging modalities, surpassing human diagnostic capabilities. Predictive analytics models utilizing electronic health records, genomic data, and lifestyle information significantly improve early detection and risk prediction of heart conditions. In addition, AI facilitates personalized treatment plans by predicting patient responses to specific medications and adjusting therapies in real time. In chronic disease management, AI-powered wearable devices and telehealth platforms enable continuous monitoring and timely interventions, reducing hospital readmissions. Furthermore, AI enhances surgical outcomes through real-time assistance and precision. While AI's potential in cardiology is vast, ethical considerations and challenges such as data privacy, bias, and the \"black box\" nature of some algorithms must be addressed. AI stands poised to revolutionize cardiovascular medicine, offering promising avenues for improved patient outcomes and healthcare efficiency.</p>","PeriodicalId":32654,"journal":{"name":"Heart Views","volume":"25 4","pages":"241-248"},"PeriodicalIF":0.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12139645/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144249962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case Series Examining the 1-year Follow-up Outcomes of Myocarditis Associated with COVID-19 Vaccination.","authors":"Mohammed Thamer Ali, Ammar Chapra, Samah F A Mohamed, Abdel Naser Ghareeb, Maryam Al Kuwari, Sabir Abdul Karim, Tahir Hamid, Emad Ahmed Ali Hassan, Awad Al Qahtani, Nidal Asaad, Jassim Al Suwaidi","doi":"10.4103/heartviews.heartviews_62_24","DOIUrl":"10.4103/heartviews.heartviews_62_24","url":null,"abstract":"<p><strong>Background: </strong>COVID-19 messenger RNA (mRNA) vaccine-related myocarditis, though rare, primarily affects young males and often presents its symptoms within the 1st week postvaccination.</p><p><strong>Aims and objectives: </strong>To assess the long-term outcomes of individuals diagnosed with myocarditis following COVID-19 vaccination.</p><p><strong>Materials and methods: </strong>We conducted a case series analysis involving 17 patients diagnosed with inflammatory myocarditis.</p><p><strong>Results: </strong>Symptoms in these patients typically appeared 24-96 h after receiving the COVID-19 mRNA vaccine. Fortunately, the prognosis for these patients is generally favorable, characterized by good short-term recovery and minimal long-term consequences. Follow-up cardiac magnetic resonance imaging (CMR) among our patients revealed alongside a preserved ejection fraction, the absence of fibrosis in 7 out of 13 (54%) patients with minimal residual fibrosis in 5 (38%) patients, whereas the remaining one patient demonstrated fibrosis consistent with hypertrophic cardiomyopathy.</p><p><strong>Conclusion: </strong>Despite the seemingly benign nature of COVID-19 mRNA vaccine-related myocarditis thus far, it is crucial to emphasize the necessity of prolonged clinical and CMR follow-up exceeding 1 year. Extended monitoring is essential to gain a deeper understanding of the true nature of this condition and its potential implications. This comprehensive approach will contribute significantly to ensuring the ongoing safety and efficacy of COVID-19 vaccination programs.</p>","PeriodicalId":32654,"journal":{"name":"Heart Views","volume":"25 4","pages":"197-211"},"PeriodicalIF":0.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12139649/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144249946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}